Oxiracetam (BioDeep_00000181978)
human metabolite blood metabolite
代谢物信息卡片
2-(4-hydroxy-2-oxopyrrolidin-1-yl)ethanimidic acid
化学式: C6H10N2O3 (158.069139)
中文名称: 奥拉西坦
谱图信息:
最多检出来源 Homo sapiens(blood) 20.97%
分子结构信息
SMILES: C1C(CN(C1=O)CC(=O)N)O
InChI: InChI=1S/C6H10N2O3/c7-5(10)3-8-2-4(9)1-6(8)11/h4,9H,1-3H2,(H2,7,10)
描述信息
N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents
C26170 - Protective Agent > C1509 - Neuroprotective Agent
Oxiracetam is a cyclic derivative of γ-aminobutyric acid (GABA) which has been commonly used as nootropic agent to treat cognitive impairments.
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:134788
- PubChem: 4626
- HMDB: HMDB0255986
- DrugBank: DB13601
- ChEMBL: CHEMBL36633
- Wikipedia: Oxiracetam
- chemspider: 4465
- CAS: 62613-82-5
- medchemexpress: HY-B1715
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dahu Liang, Jie Shen, Yuanwei Jia, Min Dai, Xianghong Li, Lixiang Zhou, Weijia Wang, Bin Yang, Jing Shao, Yan Jiang, Haitang Xie, Hua Sun. Pharmacokinetic Properties of S-oxiracetam After Single and Multiple Intravenous Infusions in Healthy Volunteers.
European journal of drug metabolism and pharmacokinetics.
2021 Nov; 46(6):793-805. doi:
10.1007/s13318-021-00718-9. [PMID: 34549388] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Xiu-Xiu Li, Shi-Hui Liu, Su-Jing Zhuang, Shi-Feng Guo, Shou-Liang Pang. Effects of oxiracetam combined with ginkgo biloba extract in the treatment of acute intracerebral hemorrhage: A clinical study.
Brain and behavior.
2020 08; 10(8):e01661. doi:
10.1002/brb3.1661. [PMID: 32533644] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
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Xenobiotica; the fate of foreign compounds in biological systems.
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
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Acta pharmaceutica (Zagreb, Croatia).
2016 Jun; 66(2):279-87. doi:
10.1515/acph-2016-0013. [PMID: 27279070] - Qiuyang Zhang, Wei Yang, Qing Zhang, Yue Yang, Junxiu Li, Yang Lu, Yi Zheng, Jiake He, Di Zhao, Xijing Chen. Enantioselective HPLC determination of oxiracetam enantiomers and application to a pharmacokinetic study in beagle dogs.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Jul; 993-994(?):9-13. doi:
10.1016/j.jchromb.2015.04.033. [PMID: 25978861] - Xinhuan Wan, He Wang, Panqin Ma, Long Xi, Jin Sun, Zhonggui He, Xiangrong Zhang, Xiaohong Liu. Simultaneous determination of oxiracetam and its degraded substance in rat plasma by HPLC-MS/MS and its application to pharmacokinetic study after a single high-dose intravenous administration.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Oct; 969(?):95-100. doi:
10.1016/j.jchromb.2014.07.041. [PMID: 25168792] - Xianqin Wang, Jiayin Zhu, Renai Xu, Xuezhi Yang, Haiya Wu, Dan Lin, Faqing Ye, Lufeng Hu. Determination of piracetam in rat plasma by LC-MS/MS and its application to pharmacokinetics.
Biomedical chromatography : BMC.
2010 Oct; 24(10):1108-12. doi:
10.1002/bmc.1412. [PMID: 20352612] - Kirti S Kulkarni, S B Kasture, S A Mengi. Efficacy study of Prunus amygdalus (almond) nuts in scopolamine-induced amnesia in rats.
Indian journal of pharmacology.
2010 Jun; 42(3):168-73. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Junghyun Son, Jaeick Lee, Mijin Lee, Eunyoung Lee, Jung Hwa Lee, Sookie La, Dong-Hyun Kim. Rapid quantitative analysis of oxiracetam in human plasma by liquid chromatography/electrospray tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2004 Nov; 36(3):657-61. doi:
10.1016/j.jpba.2004.07.031. [PMID: 15522546] - Junghyun Son, Jaeick Lee, Mijin Lee, Eunyoung Lee, Kyung Tae Lee, Sookie La, Dong-Hyun Kim. Rapid quantitative analysis of oxiracetam in human plasma by liquid chromatography/electrospray tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2004 Sep; 36(1):183-7. doi:
10.1016/j.jpba.2004.05.010. [PMID: 15351064] - X L Jiao, D H Yu, A Q Zou, Y Q Lou. [Methodological study on the determination of oxiracetam concentration in serum and urine by HPLC].
Yao xue xue bao = Acta pharmaceutica Sinica.
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Journal of chromatography.
1993 Feb; 631(1-2):227-32. doi:
10.1016/0021-9673(93)80526-e. [PMID: 8450015] - H P Gschwind, H Schütz, N Wigger, P Bentley. Absorption and disposition of 14C-labelled oxiracetam in rat, dog and man.
European journal of drug metabolism and pharmacokinetics.
1992 Jan; 17(1):67-82. doi:
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Clinical therapeutics.
1990 Sep; 12(5):376-84. doi:
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European journal of drug metabolism and pharmacokinetics.
1990 Jul; 15(3):231-7. doi:
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European journal of drug metabolism and pharmacokinetics.
1990 Jul; 15(3):223-30. doi:
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Clinical pharmacokinetics.
1990 Apr; 18(4):332-8. doi:
10.2165/00003088-199018040-00006. [PMID: 2108837] - L Parnetti, P Mecocci, A Gaiti, D Cadini, F Lombardi, M Visconti, U Senin. Comparative kinetics of oxiracetam in serum and CSF of patients with dementia of Alzheimer type.
European journal of drug metabolism and pharmacokinetics.
1990 Jan; 15(1):75-8. doi:
10.1007/bf03190131. [PMID: 2384121] - J B Lecaillon, C Souppart, F Le Duigou, J P Dubois. Determination of oxiracetam in plasma and urine by column-switching high-performance liquid chromatography.
Journal of chromatography.
1989 Dec; 497(?):223-30. doi:
10.1016/0378-4347(89)80021-0. [PMID: 2625458] - S Perini, M Brunetti, L Parnetti, G E De Medio, G Trovarelli, S Banfi, L Dorigotti, A Gaiti. The effect of oxiracetam treatment on alterations of lipid metabolism in brain areas from spontaneously hypertensive rats.
Pharmacological research.
1989 May; 21(3):313-23. doi:
10.1016/s1043-6618(89)80009-x. [PMID: 2748513] - M Visconti, R Spalluto, T Crolla, G Pifferi, M Pinza. Determination of oxiracetam in human serum and urine by high-performance liquid chromatography.
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1987 May; 416(2):433-8. doi:
10.1016/0378-4347(87)80532-7. [PMID: 3611276] - E Perucca, J Parini, A Albrici, M Visconti, E Ferrero. Oxiracetam pharmacokinetics following single and multiple dose administration in the elderly.
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1987 Apr; 12(2):145-8. doi:
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Clinical neuropharmacology.
1986; 9 Suppl 3(?):S56-64. doi:
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1984 Dec; 317(?):493-506. doi:
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