1-[3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxyimidazole-4-carboxamide (BioDeep_00000181827)

   

human metabolite blood metabolite natural product


代谢物信息卡片


1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-1H-imidazole-4-carboxamide

  化学式: C9H13N3O6 (259.0804)
中文名称:
  谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=NC(=C(N1C2C(C(C(O2)CO)O)O)O)C(=O)N
InChI: InChI=1S/C9H13N3O6/c10-7(16)4-8(17)12(2-11-4)9-6(15)5(14)3(1-13)18-9/h2-3,5-6,9,13-15,17H,1H2,(H2,10,16)


描述信息

同义名列表

3 个代谢物同义名

1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-1H-imidazole-4-carboxamide; 1-[3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxyimidazole-4-carboxamide; mizoribine



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Hidetoshi Kagawa, Tsutomu Hiromasa, Takayuki Hara, Ayako Takaki, Ryutaro Yamanaka, Ken-ei Sada, Hirofumi Makino. Mizoribine, tacrolimus, and corticosteroid combination therapy successfully induces remission in patients with lupus nephritis. Clinical and experimental nephrology. 2012 Oct; 16(5):760-6. doi: 10.1007/s10157-012-0632-4. [PMID: 22492013]
  • Kazuya Ishida, Osamu Motoyama, Seiichiro Shishido, Kazuo Tsuzuki, Yukiya Hashimoto. Population pharmacokinetics of mizoribine in pediatric recipients of renal transplantation. Clinical and experimental nephrology. 2012 Oct; 16(5):799-804. doi: 10.1007/s10157-012-0616-4. [PMID: 22367565]
  • Takashi Hashimoto, Tamihiro Kawakami, Norito Ishii, Kaori Ishii, Tadashi Karashima, Takekuni Nakama, Daisuke Tsuruta, Teruki Dainichi, Michihiro Hide, Takahiro Hamada. Mizoribine treatment for antihistamine-resistant chronic autoimmune urticaria. Dermatologic therapy. 2012 Jul; 25(4):379-81. doi: 10.1111/j.1529-8019.2012.01468.x. [PMID: 22950565]
  • M Shinoda, M Tanabe, S Kawachi, Y Ono, T Hayakawa, O Iketani, M Kojima, O Itano, H Obara, M Kitago, T Hibi, K Matsubara, N Shimojima, Y Fuchimoto, K Hoshino, G Wakabayashi, M Shimazu, Y Tanigawara, T Kuroda, Y Morikawa, M Kitajima, Y Kitagawa. Pharmacokinetics of mizoribine in adult living donor liver transplantation. Transplantation proceedings. 2012 Jun; 44(5):1329-35. doi: 10.1016/j.transproceed.2012.01.139. [PMID: 22664010]
  • Osamu Motoyama, Akira Hasegawa, Atsushi Aikawa, Seiichirou Shishido, Masataka Honda, Kazuo Tsuzuki, Tsuneo Kinukawa, Motoshi Hattori, Osamu Ogawa, Toshio Yanagihara, Kazuhide Saito, Kota Takahashi, Shinichi Ohshima. Final height in a prospective trial of late steroid withdrawal after pediatric renal transplantation treated with cyclosporine and mizoribine. Pediatric transplantation. 2012 Feb; 16(1):78-82. doi: 10.1111/j.1399-3046.2011.01614.x. [PMID: 22122015]
  • Risa Ueno, Hiroshi Kado, Yayoi Shiotsu, Masayuki Hara, Mai Otani, Hiroyoshi Segawa, Katsunori Sawada, Tsuguru Hatta. [Case of lupus nephritis complicated with hemophagocytic syndrome]. Nihon Jinzo Gakkai shi. 2012; 54(5):629-36. doi: NULL. [PMID: 22991844]
  • Tomoya Nishino, Takeaki Shinzato, Yuuki Ohta, Hiroshi Yamashita, Yoko Obata, Ken Shinzato, Shigeru Kohno. A case of acute kidney injury with marked hyperuricemia during mizoribine administration. Internal medicine (Tokyo, Japan). 2012; 51(10):1239-43. doi: 10.2169/internalmedicine.51.7230. [PMID: 22687797]
  • N Nakamura, H Mikami, H Matsuoka, S Irie, Y Abe, Y Sasatomi, S Ogawara, T Saitoh, M Tanaka. Experiences of high-dose mizoribine as antimetabolite immunosuppressants for kidney transplantation. Transplantation proceedings. 2012 Jan; 44(1):150-3. doi: 10.1016/j.transproceed.2011.11.020. [PMID: 22310602]
  • Hideaki Yamabe, Michiko Shimada, Reiichi Murakami, Takeshi Fujita, Yuko Shimaya, Norio Nakamura. Mizoribine suppresses proliferation of rat glomerular epithelial cells in culture and inhibits increase of monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 stimulated by thrombin. Biological & pharmaceutical bulletin. 2012; 35(5):705-8. doi: 10.1248/bpb.35.705. [PMID: 22687405]
  • Michitoshi Yamashita, Takuro Saito, Kazuya Ise, Show Ishii, Yoshihiro Satoh, Takaharu Saito, Ikuro Oshibe, Hirofumi Shimizu, Akira Kenjo, Takashi Kimura, Mitsukazu Gotoh. Mizoribine as sole immunosuppressive agent in islet xenotransplantation models: a candidate immunosuppressant causing no adverse effects on islets. Cell transplantation. 2012; 21(2-3):535-45. doi: 10.3727/096368911x605457. [PMID: 22793062]
  • Yun-Jie Dang, Han-Zhou Feng, Limei Zhang, Chun-Hui Hu, Chun-Yan Zhu. In situ absorption in rat intestinal tract of solid dispersion of annonaceous acetogenins. Gastroenterology research and practice. 2012; 2012(?):879676. doi: 10.1155/2012/879676. [PMID: 22536222]
  • Kazuya Ishida, Masahiko Okamoto, Michio Ishibashi, Yukiya Hashimoto. Population pharmacokinetics of mizoribine in adult recipients of renal transplantation. Clinical and experimental nephrology. 2011 Dec; 15(6):900-6. doi: 10.1007/s10157-011-0487-0. [PMID: 21751083]
  • Kei Takahashi, Toshiaki Oharaseki, Tomokazu Nagao, Yuki Yokouchi, Hitomi Yamada, Noriko Nagi-Miura, Naohito Ohno, Tsutomu Saji, Tomio Okazaki, Kazuo Suzuki. Mizoribine provides effective treatment of sequential histological change of arteritis and reduction of inflammatory cytokines and chemokines in an animal model of Kawasaki disease. Pediatric rheumatology online journal. 2011 Sep; 9(1):30. doi: 10.1186/1546-0096-9-30. [PMID: 21958311]
  • Se Jin Park, Jae Il Shin. Complications of nephrotic syndrome. Korean journal of pediatrics. 2011 Aug; 54(8):322-8. doi: 10.3345/kjp.2011.54.8.322. [PMID: 22087198]
  • Takahisa Hiramitsu, Hiroko Ota, Yoshihiko Watarai, Masahito Achiha, Harue Fukami, Shin-ichi Sakasegawa, Emisa Hino, Tamami Yamaguchi, Shigeru Ueda, Yoshitaka Kagimoto, Tomohiro Tamura, Kazuharu Uchida. Enzymatic assay method for measuring mizoribine levels in serum. Journal of bioscience and bioengineering. 2011 Aug; 112(2):205-7. doi: 10.1016/j.jbiosc.2011.03.017. [PMID: 21530390]
  • Tatsuhiro Yaginuma, Hiroyasu Yamamoto, Jun Mitome, Akimitsu Kobayashi, Izumi Yamamoto, Yudo Tanno, Hiroshi Hayakawa, Youichi Miyazaki, Keitaro Yokoyama, Yasunori Utsunomiya, Jun Miki, Hiroki Yamada, Nozomu Furuta, Yutaka Yamaguchi, Tatsuo Hosoya. Successful treatment of nephrotic syndrome caused by recurrent IgA nephropathy with chronic active antibody-mediated rejection three years after kidney transplantation. Clinical transplantation. 2011 Jul; 25 Suppl 23(?):28-33. doi: 10.1111/j.1399-0012.2011.01456.x. [PMID: 21623911]
  • K Koshino, M Okamoto, K Sakai, T Suzuki, S Nobori, M Matsuyama, H Ushigome, H Okajima, N Yoshimura. The excellent outcomes of ABO-incompatible kidney transplantation with high titer (>×2048) using anti-CD20 and anti-CD25 antibody without splenectomy: two case reports. Transplantation proceedings. 2011 Jul; 43(6):2379-82. doi: 10.1016/j.transproceed.2011.05.031. [PMID: 21839272]
  • Yuansheng Xie, Songmin Huang, Li Wang, Lining Miao, Aiping Zhang, Ying Li, Xiongfei Wu, Lining Wang, Shuxin Liu, Caihua Lie, Pu Chen, Xiangmei Chen. Efficacy and safety of mizoribine combined with losartan in the treatment of IgA nephropathy: a multicenter, randomized, controlled study. The American journal of the medical sciences. 2011 May; 341(5):367-72. doi: 10.1097/maj.0b013e318207e02d. [PMID: 21293249]
  • Yukihiko Kawasaki, Kazuhide Suyama, Koichi Hashimoto, Mitsuaki Hosoya. Methylprednisolone pulse plus mizoribine in children with Henoch-Schoenlein purpura nephritis. Clinical rheumatology. 2011 Apr; 30(4):529-35. doi: 10.1007/s10067-010-1572-6. [PMID: 20844911]
  • N Mori, Y Shimomukai, T Yokooji, M Ishiguro, Y Kamio, T Murakami. Modulation in concentrative nucleoside transporters-mediated intestinal absorption of mizoribine, an immunosuppressive agent, in lipopolysaccharide-treated rats. Die Pharmazie. 2011 Mar; 66(3):207-11. doi: . [PMID: 21553652]
  • Tomohiro Kaneko, Akio Hirama, Kae Ueda, Teppei Fujino, Koichi Utsumi, Yasuhiko Iino, Yasuo Katayama. Methylprednisolone pulse therapy combined with mizoribine following tonsillectomy for immunoglobulin A nephropathy: clinical remission rate, steroid sparing effect, and maintenance of renal function. Clinical and experimental nephrology. 2011 Feb; 15(1):73-8. doi: 10.1007/s10157-010-0356-2. [PMID: 20972695]
  • Hiroaki Kanai, Emi Sawanobori, Anna Kobayashi, Kyoko Matsushita, Kanji Sugita, Kosuke Higashida. Early treatment with methylprednisolone pulse therapy combined with tonsillectomy for heavy proteinuric henoch-schönlein purpura nephritis in children. Nephron extra. 2011 Jan; 1(1):101-11. doi: 10.1159/000333010. [PMID: 22470384]
  • Kazuya Ishida, Hisashi Kaneda, Osamu Uemura, Katsumi Ushijima, Kazuhide Ohta, Yoshimitsu Goto, Kenichi Satomura, Masaki Shimizu, Mikiya Fujieda, Masashi Morooka, Takuji Yamada, Masayoshi Yamada, Naohiro Wada, Mari Takaai, Yukiya Hashimoto. Evaluation of limited sampling designs to estimate maximal concentration and area under the curve of mizoribine in pediatric patients with renal disease. Drug metabolism and pharmacokinetics. 2011; 26(1):71-8. doi: 10.2133/dmpk.dmpk-10-rg-077. [PMID: 20978362]
  • Tadahiro Kajiyama, Yusuke Suzuki, Masao Kihara, Hitoshi Suzuki, Satoshi Horikoshi, Yasuhiko Tomino. Different pathological roles of toll-like receptor 9 on mucosal B cells and dendritic cells in murine IgA nephropathy. Clinical & developmental immunology. 2011; 2011(?):819646. doi: 10.1155/2011/819646. [PMID: 21765852]
  • Yuko Shima, Koichi Nakanishi, Koichi Kamei, Hiroko Togawa, Kandai Nozu, Ryojiro Tanaka, Satoshi Sasaki, Kazumoto Iijima, Norishige Yoshikawa. Disappearance of glomerular IgA deposits in childhood IgA nephropathy showing diffuse mesangial proliferation after 2 years of combination/prednisolone therapy. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2011 Jan; 26(1):163-9. doi: 10.1093/ndt/gfq387. [PMID: 20601366]
  • Miki Fukao, Kazuya Ishida, Takuya Sakamoto, Masato Taguchi, Hiroyoshi Matsukura, Toshio Miyawaki, Yukiya Hashimoto. Effect of genetic polymorphisms of SLC28A1, ABCG2, and ABCC4 on bioavailability of mizoribine in healthy Japanese males. Drug metabolism and pharmacokinetics. 2011; 26(5):538-43. doi: 10.2133/dmpk.dmpk-11-nt-040. [PMID: 21727755]
  • H Kishikawa, K Nishimura, T Soda, K Yamanaka, T Hirai, M Kyo, M Takeda, M Fujisawa, Y Kokado, Y Ichikawa. Low-dose steroid maintenance for renal transplant recipients. Transplantation proceedings. 2010 Dec; 42(10):4030-2. doi: 10.1016/j.transproceed.2010.09.084. [PMID: 21168618]
  • Shoichi Iida, Hideki Ishida, Tadahiko Tokumoto, Kazuya Omoto, Hiroki Shirakawa, Tomokazu Shimizu, Hiroyuki Amano, Kiyoshi Setoguchi, Taiji Nozaki, Daisuke Toki, Daisuke Tokita, Kazunari Tanabe. New-onset diabetes after transplantation in tacrolimus-treated, living kidney transplantation: long-term impact and utility of the pre-transplant OGTT. International urology and nephrology. 2010 Dec; 42(4):935-45. doi: 10.1007/s11255-010-9712-0. [PMID: 20169408]
  • Y Utsunomiya, Y Hara, H Ito, H Okonogi, Y Miyazaki, Y Hashimoto, T Hosoya. Effects of probenecid on the pharmacokinetics of mizoribine and co-administration of the two drugs in patients with nephrotic syndrome. International journal of clinical pharmacology and therapeutics. 2010 Nov; 48(11):751-5. doi: 10.5414/cpp48751. [PMID: 20979934]
  • Ya-nan Zhao, Jing-jing Yang, Xiang-hong Li, Guo-guang Mao, Xiao-quan Liu. A sensitive and practical LC-MS/MS method for the determination of mizoribine in human serum and its bioequivalence study on Chinese healthy volunteers. Yao xue xue bao = Acta pharmaceutica Sinica. 2010 Sep; 45(9):1149-54. doi: NULL. [PMID: 21348426]
  • H B Guo. Acute allograft renal failure with marked hyperuricemia developing during mizoribine administration: a case report with review of the literature. Transplantation proceedings. 2010 Sep; 42(7):2804-7. doi: 10.1016/j.transproceed.2010.05.148. [PMID: 20832593]
  • Hiroshi Tanaka, Eishin Oki, Kazushi Tsuruga, Tomomi Aizawa-Yashiro, Yuya Ito, Norihiro Sato, Yukihiko Kawasaki, Junzo Suzuki. Mizoribine attenuates renal injury and macrophage infiltration in patients with severe lupus nephritis. Clinical rheumatology. 2010 Sep; 29(9):1049-54. doi: 10.1007/s10067-010-1484-5. [PMID: 20490589]
  • Kenichi Suga, Shuji Kondo, Sato Matsuura, Yukiko Kinoshita, Etsuko Kitano, Michiyo Hatanaka, Hajime Kitamura, Yoshihiko Hidaka, Takashi Oda, Shoji Kagami. A case of dense deposit disease associated with a group A streptococcal infection without the involvement of C3NeF or complement factor H deficiency. Pediatric nephrology (Berlin, Germany). 2010 Aug; 25(8):1547-50. doi: 10.1007/s00467-010-1479-0. [PMID: 20221776]
  • N Mori, T Yokooji, Y Kamio, T Murakami. Increased intestinal absorption of mizoribine, an immunosuppressive agent, in cholestatic rats. Die Pharmazie. 2010 Jul; 65(7):457-60. doi: NULL. [PMID: 20662310]
  • Takeshi Kuroda, Daisuke Kobayashi, Hiroe Sato, Akihisa Oyanagi, Yoko Wada, Syuichi Murakami, Masaaki Nakano, Ichiei Narita. Mizoribine therapy in a patient with lupus nephritis: the association between mizoribine concentration and peritoneal dialysis. Modern rheumatology. 2010 Jun; 20(3):296-300. doi: 10.1007/s10165-009-0267-9. [PMID: 20082109]
  • María T Grande, Fernando Pérez-Barriocanal, José M López-Novoa. Role of inflammation in túbulo-interstitial damage associated to obstructive nephropathy. Journal of inflammation (London, England). 2010 Apr; 7(?):19. doi: 10.1186/1476-9255-7-19. [PMID: 20412564]
  • Takafumi Naito, Shunsuke Tokashiki, Yasuaki Mino, Atsushi Otsuka, Seiichiro Ozono, Yoshiyuki Kagawa, Junichi Kawakami. Impact of concentrative nucleoside transporter 1 gene polymorphism on oral bioavailability of mizoribine in stable kidney transplant recipients. Basic & clinical pharmacology & toxicology. 2010 Apr; 106(4):310-6. doi: 10.1111/j.1742-7843.2009.00489.x. [PMID: 19912163]
  • Nobuhiro Mori, Tomoharu Yokooji, Yoshihiro Kamio, Teruo Murakami. Study on intestinal absorption sites of mizoribine and ribavirin, substrates for concentrative nucleoside transporter(s), in rats. European journal of pharmacology. 2010 Feb; 628(1-3):214-9. doi: 10.1016/j.ejphar.2009.11.048. [PMID: 19961845]
  • Osamu Motoyama, Jiro Takasu, Takeshi Kawamura, Atushi Aikawa, Yukari Shigetomi, Chiharu Nara, Akira Ohara, Kikuo Iitaka, Akira Hasegawa. A male patient with malignant lymphoma and thyroid papillary carcinoma after pediatric renal transplantation. Clinical and experimental nephrology. 2010 Feb; 14(1):94-6. doi: 10.1007/s10157-009-0210-6. [PMID: 19603248]
  • Yuki Nanke, Tsuyoshi Kobashigawa, Toru Yago, Naoyuki Kamatani, Shigeru Kotake. A case of Mikulicz's disease, IgG4-related plasmacytic syndrome, successfully treated by corticosteroid and mizoribine, followed by mizoribine alone. Internal medicine (Tokyo, Japan). 2010; 49(14):1449-53. doi: 10.2169/internalmedicine.49.3101. [PMID: 20647666]
  • Kunihiro Ichinose, Tomoki Origuchi, Shin-ya Kawashiri, Naoki Iwamoto, Keita Fujikawa, Toshiyuki Aramaki, Makoto Kamachi, Kazuhiko Arima, Mami Tamai, Hideki Nakamura, Hiroaki Ida, Atsushi Kawakami, Toshiaki Tsukada, Yukitaka Ueki, Katsumi Eguchi. Efficacy and safety of mizoribine by one single dose administration for patients with rheumatoid arthritis. Internal medicine (Tokyo, Japan). 2010; 49(20):2211-8. doi: 10.2169/internalmedicine.49.3810. [PMID: 20962439]
  • Yohei Ikezumi, Toshiaki Suzuki, Tamaki Karasawa, Hiroya Hasegawa, Hiroshi Kawachi, David J Nikolic-Paterson, Makoto Uchiyama. Contrasting effects of steroids and mizoribine on macrophage activation and glomerular lesions in rat thy-1 mesangial proliferative glomerulonephritis. American journal of nephrology. 2010; 31(3):273-82. doi: 10.1159/000279163. [PMID: 20110667]
  • Tadashi Uramatsu, Akira Furusu, Tomoya Nishino, Yoko Obata, Yasuhide Kanamoto, Satoru Komuro, Masahiro Ito, Takashi Taguchi, Shigeru Kohno. Membranous nephropathy complicating nasopharyngeal carcinoma. Internal medicine (Tokyo, Japan). 2010; 49(6):585-8. doi: 10.2169/internalmedicine.49.2762. [PMID: 20228596]
  • M M Löwik, P J Groenen, E N Levtchenko, L A Monnens, L P van den Heuvel. Molecular genetic analysis of podocyte genes in focal segmental glomerulosclerosis--a review. European journal of pediatrics. 2009 Nov; 168(11):1291-304. doi: 10.1007/s00431-009-1017-x. [PMID: 19562370]
  • Takahiko Saida. [Treatment of NMO]. Rinsho shinkeigaku = Clinical neurology. 2009 Nov; 49(11):902-5. doi: 10.5692/clinicalneurol.49.902. [PMID: 20030244]
  • Satoshi Hara, Daisuke Umino, Tomonosuke Someya, Shuichiro Fujinaga, Yoshiyuki Ohtomo, Hitohiko Murakami, Toshiaki Shimizu. Protective effects of Mizoribine on Cyclosporine A nephropathy in rats. Pediatric research. 2009 Nov; 66(5):524-7. doi: 10.1203/pdr.0b013e3181b9b48a. [PMID: 19668109]
  • Sung-Shin Park, Won-Ho Hahn, Sung-Do Kim, Byoung-Soo Cho. Remission of refractory minimal change nephrotic syndrome after basiliximab therapy. Pediatric nephrology (Berlin, Germany). 2009 Jul; 24(7):1403-7. doi: 10.1007/s00467-009-1145-6. [PMID: 19242727]
  • Shinya Kawashiri, Atsushi Kawakami, Naoki Iwamoto, Keita Fujikawa, Toshiyuki Aramaki, Kunihiro Ichinose, Makoto Kamachi, Mami Tamai, Kazuhiko Arima, Hideki Nakamura, Masako Kita, Hiroaki Ida, Tomoki Origuchi, Katsumi Eguchi. [A case of microscopic polyangiitis relapsed with diffuse alveolar hemorrhage and rapidly progressive glomerulonephritis]. Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology. 2009 Jun; 32(3):189-94. doi: 10.2177/jsci.32.189. [PMID: 19564716]
  • Satoshi Ito. [Renal involvement in connective tissue diseases]. Nihon rinsho. Japanese journal of clinical medicine. 2009 Mar; 67(3):550-4. doi: NULL. [PMID: 19280931]
  • Masaki Tokunaga, Masahito Tamura, Narutoshi Kabashima, Ryota Serino, Tatsuya Shibata, Mika Matsumoto, Tetsu Miyamoto, Mieko Miyazaki, Yumi Furuno, Shinji Fujimatsu, Toshiyuki Muta, Masaaki Takeuchi, Haruhiko Abe, Masahiro Okazaki, Yutaka Otsuji. A case report of steroid-resistant antineutrophil cytoplasmic antibody-related vasculitis successfully treated by mizoribine in a hemodialysis patient. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2009 Feb; 13(1):77-9. doi: 10.1111/j.1744-9987.2009.00601.x. [PMID: 19379174]
  • Shuichi Ito, Tomonori Harada, Tomoko Nakamura, Tomoyuki Imagawa, Kiyotaka Nagahama, Takeshi Sasaki, Shuichiro Fujinaga, Yukoh Aihara, Shumpei Yokota. Mizoribine for renal sarcoidosis: effective steroid tapering and prevention of recurrence. Pediatric nephrology (Berlin, Germany). 2009 Feb; 24(2):411-4. doi: 10.1007/s00467-008-0995-7. [PMID: 18791743]
  • Kazushi Tsuruga, Eishin Oki, Kouichi Suzuki, Yoshihiro Takahashi, Hiroshi Tanaka. [Early initiation of peritoneal dialysis for the treatment of a patient with refractory nephrotic syndrome]. Nihon Jinzo Gakkai shi. 2009; 51(1):68-73. doi: NULL. [PMID: 19238911]
  • Yukihiko Kawasaki. Mizoribine: a new approach in the treatment of renal disease. Clinical & developmental immunology. 2009; 2009(?):681482. doi: 10.1155/2009/681482. [PMID: 20052390]
  • Yunbi Xu, Debra J Skinner, Huixia Wu, Natalia Palacios-Rojas, Jose Luis Araus, Jianbing Yan, Shibin Gao, Marilyn L Warburton, Jonathan H Crouch. Advances in maize genomics and their value for enhancing genetic gains from breeding. International journal of plant genomics. 2009; 2009(?):957602. doi: 10.1155/2009/957602. [PMID: 19688107]
  • Q Sun, D Cheng, J Wen, J Chen, D Gong, Z Liu, L Li. Successful renal transplantation in a patient with antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis: effect of early plasma exchange and mycophenolate mofetil. Transplantation proceedings. 2008 Dec; 40(10):3764-6. doi: 10.1016/j.transproceed.2008.04.023. [PMID: 19100484]
  • J Wen, L Li, J Chen, S Ji, C Zheng, Z Liu. Tripterygium wilfordii hook f increase the blood concentration of tacrolimus. Transplantation proceedings. 2008 Dec; 40(10):3679-82. doi: 10.1016/j.transproceed.2008.08.132. [PMID: 19100464]
  • Naoto Miura, Yuki Mori, Masabumi Yoshino, Norihiro Suga, Wataru Kitagawa, Harutaka Yamada, Kazuhiro Nishikawa, Hirokazu Imai. Membranous nephropathy (bubbling appearance and spike formation) without immunoglobulin deposition in a patient with systemic lupus erythematosus. Clinical and experimental nephrology. 2008 Dec; 12(6):475-8. doi: 10.1007/s10157-008-0096-8. [PMID: 18839061]
  • Yukihiko Kawasaki. The pathogenesis and treatment of IgA nephropathy. Fukushima journal of medical science. 2008 Dec; 54(2):43-60. doi: 10.5387/fms.54.43. [PMID: 19418967]
  • Su Jin Choi, Hye Jung Hur, Sang-Bong Lee, Mi-Sun Choi, Hyo-Jeong Kuh, Young-Hee Shin, Hwa Jeong Lee. A simple HPLC method for the quantification of mizoribine in human serum: pharmacokinetic applications. Biomedical chromatography : BMC. 2008 Nov; 22(11):1259-64. doi: 10.1002/bmc.1055. [PMID: 18661478]
  • Hiroko Ota, Yuko Yasuda, Shin-ichi Sakasegawa, Shigeyuki Imamura, Tomohiro Tamura. A novel enzymatic method for measuring mizoribine 5'-monophosphate levels in serum. Journal of bioscience and bioengineering. 2008 Nov; 106(5):511-4. doi: 10.1263/jbb.106.511. [PMID: 19111650]
  • Kentaro Sugiyama, Kazuya Isogai, Akira Toyama, Hiroshi Satoh, Kazuhide Saito, Yuki Nakagawa, Masayuki Tasaki, Kota Takahashi, Noriko Saito, Toshihiko Hirano. Pharmacodynamic parameters of immunosuppressive drugs are not correlated with age, duration of dialysis, percentage of lymphocytes or lymphocyte stimulation index in renal transplant recipients. Biological & pharmaceutical bulletin. 2008 Nov; 31(11):2146-9. doi: 10.1248/bpb.31.2146. [PMID: 18981589]
  • M Tokunaga, M Tamura, N Kabashima, R Serino, T Shibata, M Matsumoto, T Miyamoto, M Miyazaki, Y Furuno, J Nakamata, M Takeuchi, H Abe, M Okazaki, Y Otsuji. Mizoribine for relapsed proteinuria in an adult IgA nephropathy patient. Clinical nephrology. 2008 Nov; 70(5):445-6. doi: 10.5414/cnp70445. [PMID: 19000548]
  • Yoshifusa Abe, Takeshi Mikawa, Toshiya Fuke, Masataka Hisano, Yuichiro Tsuji, Shuichiro Watanabe, Kazuo Itabashi. Pharmacokinetic study of mizoribine in child-onset glomerulonephritis. Pediatrics international : official journal of the Japan Pediatric Society. 2008 Oct; 50(5):615-9. doi: 10.1111/j.1442-200x.2008.02624.x. [PMID: 19261105]
  • Y Funahashi, R Hattori, T Kinukawa, H Kimura, Y Nishiyama, M Gotoh. Conversion from mycophenolate mofetil to mizoribine for patients with positive polyomavirus type BK in urine. Transplantation proceedings. 2008 Sep; 40(7):2268-70. doi: 10.1016/j.transproceed.2008.07.069. [PMID: 18790209]
  • Norishige Yoshikawa, Koichi Nakanishi, Kenji Ishikura, Hiroshi Hataya, Kazumoto Iijima, Masataka Honda. Combination therapy with mizoribine for severe childhood IgA nephropathy: a pilot study. Pediatric nephrology (Berlin, Germany). 2008 May; 23(5):757-63. doi: 10.1007/s00467-007-0731-8. [PMID: 18224343]
  • Kiyokazu Akioka, Masahiko Okamoto, Hidetaka Ushigome, Shuji Nobori, Satoshi Kaihara, Norio Yoshimura. BK virus-associated nephropathy in a kidney transplant recipient successfully treated with cidofovir, the first case in Japan. International journal of urology : official journal of the Japanese Urological Association. 2008 Apr; 15(4):369-71. doi: 10.1111/j.1442-2042.2008.01998.x. [PMID: 18380832]
  • Yohei Ikezumi, Toshiaki Suzuki, Tamaki Karasawa, Hiroshi Kawachi, David J Nikolic-Paterson, Makoto Uchiyama. Use of mizoribine as a rescue drug for steroid-resistant pediatric IgA nephropathy. Pediatric nephrology (Berlin, Germany). 2008 Apr; 23(4):645-50. doi: 10.1007/s00467-007-0664-2. [PMID: 18038158]
  • E M Hodson, N S Willis, J C Craig. Non-corticosteroid treatment for nephrotic syndrome in children. The Cochrane database of systematic reviews. 2008 Jan; ?(1):CD002290. doi: 10.1002/14651858.cd002290.pub3. [PMID: 18254005]
  • Hiroshi Tanaka, Eishin Oki, Kazushi Tsuruga, Norihiro Sato, Hiroyoshi Matsukura, Akira Matsunaga, Yoshiaki Kondo, Junzo Suzuki. Mizoribine treatment of young patients with severe lupus nephritis: a clinicopathologic study by the tohoku pediatric study group. Nephron. Clinical practice. 2008; 110(2):c73-9. doi: 10.1159/000151721. [PMID: 18758186]
  • Seung-Ki Kwok, June-Yong Lee, Se-Ho Park, Mi-La Cho, So-Youn Min, Sung-Hwan Park, Ho-Youn Kim, Young-Gyu Cho. Dysfunctional interferon-alpha production by peripheral plasmacytoid dendritic cells upon Toll-like receptor-9 stimulation in patients with systemic lupus erythematosus. Arthritis research & therapy. 2008; 10(2):R29. doi: 10.1186/ar2382. [PMID: 18321389]
  • Hiroshi Tanaka, Koji Tsugawa, Eishin Oki, Koichi Suzuki, Etsuro Ito. Mizoribine intermittent pulse protocol for induction therapy for systemic lupus erythematosus in children: an open-label pilot study with five newly diagnosed patients. Clinical rheumatology. 2008 Jan; 27(1):85-9. doi: 10.1007/s10067-007-0635-9. [PMID: 17483980]
  • Yasunori Tsubouchi, Wataru Fukuda, Yutaka Kawahito, Masataka Kohno, Makoto Wada, Hidetaka Ishino, Masahide Hamaguchi, Aihiro Yamamoto, Masatoshi Kadoya, Mikiko Niimi, Toshikazu Yoshikawa. A case of lupus nephritis improved after appropriately adjusting the dosage of mizoribine. Modern rheumatology. 2008; 18(1):91-5. doi: 10.1007/s10165-007-0012-1. [PMID: 18159569]
  • Kazunari Tanabe. Japanese experience of ABO-incompatible living kidney transplantation. Transplantation. 2007 Dec; 84(12 Suppl):S4-7. doi: 10.1097/01.tp.0000296008.08452.4c. [PMID: 18162988]
  • Aya Nakajo, Jamshid Khoshnoodi, Hitoshi Takenaka, Emi Hagiwara, Takashi Watanabe, Hayato Kawakami, Ryota Kurayama, Yuji Sekine, Fumio Bessho, Shori Takahashi, Agnieszka Swiatecka-Urban, Karl Tryggvason, Kunimasa Yan. Mizoribine corrects defective nephrin biogenesis by restoring intracellular energy balance. Journal of the American Society of Nephrology : JASN. 2007 Sep; 18(9):2554-64. doi: 10.1681/asn.2006070732. [PMID: 17687078]
  • Masahide Hamaguchi, Yutaka Kawahito, Yasunori Tsubouchi, Masataka Kohno, Aihiro Yamamoto, Hidetaka Ishino, Makoto Wada, Toshikazu Yoshikawa. Combination therapy of prednisolone and mizoribine improves cryoglobulinemic vasculitis with purpura and skin ulcers. Clinical rheumatology. 2007 Jul; 26(7):1170-2. doi: 10.1007/s10067-006-0295-1. [PMID: 16614792]
  • Shuichiro Fujinaga, Yoshiyuki Ohtomo, Daisuke Umino, Hiroshi Mochizuki, Hitohiko Murakami, Toshiaki Shimizu, Yuichiro Yamashiro, Kazunari Kaneko. Plasma exchange combined with immunosuppressive treatment in a child with rapidly progressive IgA nephropathy. Pediatric nephrology (Berlin, Germany). 2007 Jun; 22(6):899-902. doi: 10.1007/s00467-006-0428-4. [PMID: 17285293]
  • Daria Stypinski, Mohammad Obaidi, Michelle Combs, Meg Weber, Adrian J Stewart, Hiroaki Ishikawa. Safety, tolerability and pharmacokinetics of higher-dose mizoribine in healthy male volunteers. British journal of clinical pharmacology. 2007 Apr; 63(4):459-68. doi: 10.1111/j.1365-2125.2006.02779.x. [PMID: 17096684]
  • DaGe Liu, Takaaki Kobayashi, Takaharu Nagasaka, Yuko Miwa, Yong Ma, Itsuo Yokoyama, Takafumi Kuzuya, Tadashi Oikawa, Kunio Morozumi, Kazuharu Uchida, Akimasa Nakao. Prophylactic treatment of antibody-mediated rejection with high-dose mizoribine and pharmacokinetic study. Transplant international : official journal of the European Society for Organ Transplantation. 2007 Apr; 20(4):365-70. doi: 10.1111/j.1432-2277.2006.00444.x. [PMID: 17326777]
  • Yukihiko Kawasaki, Kazuhide Suyama, Ayumi Matsumoto, Kei Takano, Koichi Hashimoto, Sigeo Suzuki, Junzo Suzuki, Hitoshi Suzuki, Mitsuaki Hosoya. Efficacy of tonsillectomy plus methylprednisolone pulse therapy for a child with Henoch-Schoenlein purpura nephritis. The Tohoku journal of experimental medicine. 2007 Mar; 211(3):291-5. doi: 10.1620/tjem.211.291. [PMID: 17347555]
  • Takeshi Kuroda, Shintaro Hirose, Naohito Tanabe, Hiroe Sato, Takeshi Nakatsue, Jyunya Ajiro, Yoko Wada, Syuichi Murakami, Hisashi Hasegawa, Satoshi Ito, Minoru Sakatsume, Masaaki Nakano, Fumitake Gejyo. Mizoribine therapy for patients with lupus nephritis: the association between peak mizoribine concentration and clinical efficacy. Modern rheumatology. 2007; 17(3):206-12. doi: 10.1007/s10165-007-0567-x. [PMID: 17564775]
  • Eishin Oki, Koji Tsugawa, Koichi Suzuki, Hiroshi Tanaka. [Effective treatment of a refractory case of systemic lupus erythematosus with low-dose tacrolimus]. Nihon Jinzo Gakkai shi. 2007; 49(8):1020-4. doi: NULL. [PMID: 18186231]
  • Yukihiko Kawasaki, Kei Takano, Masato Isome, Junzo Suzuki, Kazuhide Suyama, Hiroyuki Kanno, Tomoo Fujiki, Hitoshi Suzuki, Mitsuaki Hosoya. Efficacy of single dose of oral mizoribine pulse therapy two times per week for frequently relapsing nephrotic syndrome. Journal of nephrology. 2007 Jan; 20(1):52-6. doi: NULL. [PMID: 17347973]
  • Yukihiko Kawasaki, Kei Takano, Kazuhide Suyama, Masato Isome, Hideki Suzuki, Hiroko Sakuma, Tomoo Fujiki, Hitoshi Suzuki, Mitsuaki Hosoya. Efficacy of tonsillectomy pulse therapy versus multiple-drug therapy for IgA nephropathy. Pediatric nephrology (Berlin, Germany). 2006 Nov; 21(11):1701-6. doi: 10.1007/s00467-006-0272-6. [PMID: 16932894]
  • Hiroaki Shimmura, Kazunari Tanabe, Katsuyoshi Habiro, Ryo Abe, Hiroshi Toma. Combination effect of mycophenolate mofetil with mizoribine on cell proliferation assays and in a mouse heart transplantation model. Transplantation. 2006 Jul; 82(2):175-9. doi: 10.1097/01.tp.0000226227.79142.31. [PMID: 16858279]
  • Koichi Suzuki, Hiroshi Tanaka, Koji Tsugawa, Eturo Ito. Effective treatment with cyclosporine A of a child with systemic lupus erythematosus resistant to cyclophosphamide pulse therapy. The Tohoku journal of experimental medicine. 2006 Apr; 208(4):355-9. doi: 10.1620/tjem.208.355. [PMID: 16565599]
  • Yoshiaki Nishioka, Yoshio Horita, Masato Tadokoro, Koichi Taura, Naofumi Suyama, Masanobu Miyazaki, Takashi Harada, Shigeru Kohno. Mizoribine induces remission of relapsed ANCA-associated renal vasculitis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2006 Apr; 21(4):1087-8. doi: 10.1093/ndt/gfi295. [PMID: 16326748]
  • Makoto Okada, Kimihiro Suzuki, Masahiro Nakashima, Takashi Nakanishi, Noriyasu Fujioka. The nucleotide derivatives inosine and inosinic acid inhibit intestinal absorption of mizoribine in rats. European journal of pharmacology. 2006 Feb; 531(1-3):140-4. doi: 10.1016/j.ejphar.2005.12.013. [PMID: 16438959]
  • Miwa Goto, Masahiro Ikeda, Hiroshi Hataya, Kenji Ishikura, Yuko Hamasaki, Masataka Honda. [Beneficial and adverse effects of high-dosage MZR therapy in the management of children with frequently relapsing nephrotic syndrome]. Nihon Jinzo Gakkai shi. 2006; 48(4):365-70. doi: NULL. [PMID: 16780106]
  • T Nakamura, T Sugaya, Y Kawagoe, Y Ueda, S Osada, H Koide. Urinary liver-type fatty acid-binding protein levels for differential diagnosis of idiopathic focal glomerulosclerosis and minor glomerular abnormalities and effect of low-density lipoprotein apheresis. Clinical nephrology. 2006 Jan; 65(1):1-6. doi: 10.5414/cnp65001. [PMID: 16429835]
  • Takuya Kotani, Tohru Takeuchi, Michiyo Sakamoto, Yoshiko Kawasaki, Suzue Hirano, Yoko Tabushi, Maki Kagitani, Shigeki Makino, Fumio Terasaki, Toshiaki Hanafusa. [A case of systemic lupus erythematosus associated with hypertrophic cardiomyopathy]. Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology. 2005 Dec; 28(6):413-7. doi: 10.2177/jsci.28.413. [PMID: 16394645]
  • Hiroaki Shimmura, Kazunari Tanabe, Hideki Ishida, Tadahiko Tokumoto, Nobuo Ishikawa, Naoshi Miyamoto, Hiroki Shirakawa, Kiyoshi Setoguchi, Ichiro Nakajima, Shouhei Fuchinoue, Satoshi Teraoka, Hiroshi Toma. Lack of correlation between results of ABO-incompatible living kidney transplantation and anti-ABO blood type antibody titers under our current immunosuppression. Transplantation. 2005 Oct; 80(7):985-8. doi: 10.1097/01.tp.0000173647.43616.78. [PMID: 16249749]
  • Yukihiko Kawasaki, Mitsuaki Hosoya, Schogo Kobayashi, Shinichirou Ohara, Noriko Onishi, Ai Takahashi, Masato Isome, Hitoshi Suzuki. Oral mizoribine pulse therapy for patients with steroid-resistant and frequently relapsing steroid-dependent nephrotic syndrome. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2005 Oct; 20(10):2243-7. doi: 10.1093/ndt/gfh996. [PMID: 16030039]
  • Shuichiro Fujinaga, Kazunari Kaneko, Yoshiyuki Ohtomo, Hitohiko Murakami, Masaru Takada, Shunji Akashi, Mayako Hira, Yuichiro Yamashiro. Induction therapy with low-dose intravenous cyclophosphamide, oral mizoribine, and steroids for severe lupus nephritis in children. Pediatric nephrology (Berlin, Germany). 2005 Oct; 20(10):1500-3. doi: 10.1007/s00467-005-1983-9. [PMID: 16021476]
  • A Aikawa, K Arai, T Kawamura, K Sugiyama, M Muramatsu, Y Itabashi, T Ohara, O Motoyama, A Hasegawa. First living related kidney transplantation results in excellent outcomes for small children. Transplantation proceedings. 2005 Sep; 37(7):2947-50. doi: 10.1016/j.transproceed.2005.06.095. [PMID: 16213270]
  • Yuichi Kikuchi, Toshihiko Imakiire, Muneharu Yamada, Takamitsu Saigusa, Toshitake Hyodo, Naomi Hyodo, Shigenobu Suzuki, Soichiro Miura. Mizoribine reduces renal injury and macrophage infiltration in non-insulin-dependent diabetic rats. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2005 Aug; 20(8):1573-81. doi: 10.1093/ndt/gfh888. [PMID: 15905195]
  • Hiroaki Kaji, Takayoshi Maiguma, Yoko Inukai, Hiroshige Ono, Ritsuko Taniguchi, Kazutaka Makino, Yoshinobu Tagawa, Daisuke Teshima. A simple determination of mizoribine in human plasma by liquid chromatography with UV detection. Journal of AOAC International. 2005 Jul; 88(4):1114-7. doi: 10.1093/jaoac/88.4.1114. [PMID: 16152929]
  • W Yumura, S Suganuma, K Uchida, T Moriyama, S Otsubo, T Takei, M Naito, M Koike, K Nitta, H Nihei. Effects of long-term treatment with mizoribine in patients with proliferative lupus nephritis. Clinical nephrology. 2005 Jul; 64(1):28-34. doi: 10.5414/cnp64028. [PMID: 16047642]
  • H Tanaka, K Tsugawa, T Nakahata, M Kudo, K Suzuki, E Ito. Implication of the peak serum level of mizoribine for control of the serum anti-dsDNA antibody titer in patients with lupus nephritis. Clinical nephrology. 2005 Jun; 63(6):417-22. doi: 10.5414/cnp63417. [PMID: 15960142]
  • Kentaro Sugiyama, Hiroshi Satoh, Kazuhide Saito, Kota Takahashi, Noriko Saito, Toshihiko Hirano. Immunosuppressive efficacy of mycophenolate mofetil when compared with azathioprine and mizoribine against peripheral lymphocytes from renal transplant recipients. Transplant international : official journal of the European Society for Organ Transplantation. 2005 May; 18(5):590-5. doi: 10.1111/j.1432-2277.2005.00093.x. [PMID: 15819809]