Fluoxetine (BioDeep_00000018171)

human metabolite blood metabolite

代谢物信息卡片

N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine

化学式: C17H18F3NO (309.1340414)
中文名称: 氟西汀
谱图信息: 最多检出来源 Homo sapiens(blood) 97.3%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Fluoxetine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/fluoxetine (retrieved 2024-11-08) (BioDeep RN: BioDeep_00000018171). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F
InChI: InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3

描述信息

Fluoxetine hydrochloride is the first agent of the class of antidepressants known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D₂ or histamine H₁ receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT_1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT_1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that lead to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction, and headache. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Fluoxetine may be used to treat major depressive disorder (MDD), moderate to severe bulimia nervosa, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), panic disorder with or without agoraphobia, and, in combination with olanzapine, for treatment-resistant or bipolar I depression. Fluoxetine is the most anorexic and stimulating SSRI.
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065690 - Cytochrome P-450 CYP2D6 Inhibitors
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AB - Selective serotonin reuptake inhibitors
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017367 - Selective Serotonin Reuptake Inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
C78272 - Agent Affecting Nervous System > C94725 - Selective Serotonin Reuptake Inhibitor
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
D049990 - Membrane Transport Modulators
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

8 个代谢物同义名

N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine; methyl({3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl})amine; Fluoxetine Hydrochloride; fluoxetine; Fluoxetin; Sarafem; Symbyax; Prozac

数据库引用编号

11 个数据库交叉引用编号

ChEBI: CHEBI:86990
ChEBI: CHEBI:5118
PubChem: 3386
HMDB: HMDB0014615
DrugBank: DB00472
ChEMBL: CHEMBL41
MeSH: Fluoxetine
chemspider: 3269
CAS: 54910-89-3
PMhub: MS000003472
RefMet: Fluoxetine

分类词条

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

Fluoxetine Action Pathway: Fluoxetine + NADH + Oxygen ⟶ Formaldehyde + NAD + Norfluoxetine + Water
Fluoxetine Metabolism Pathway: Fluoxetine + NADH + Oxygen ⟶ Formaldehyde + NAD + Norfluoxetine + Water

PharmGKB(0)

2 个相关的物种来源信息

9606 - Homo sapiens: -
4513 - Hordeum vulgare: 10.1016/S0031-9422(00)90704-0

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Su-Ting Jiang, Shu-Ying Lian, Yao-Huan Sun, Mei-Bo Pan, Bin Wang, Hui Wang, Jun Hua, Yi-Chen Wang, Qiu-Ling Wang, Yin-Feng Dong. The oxytocin receptor is essential for the protective effect of pair housing on post-stroke depression in mice. Experimental gerontology. 2024 Jun; 190(?):112432. doi: 10.1016/j.exger.2024.112432. [PMID: 38614224]
Gülüzar Atli, Yusuf Sevgiler. Binary effects of fluoxetine and zinc on the biomarker responses of the non-target model organism Daphnia magna. Environmental science and pollution research international. 2024 Apr; 31(19):27988-28006. doi: 10.1007/s11356-024-32846-5. [PMID: 38528217]
Junliang Shen, Chongyao Hao, Shiwei Yuan, Wenjie Chen, Tao Tong, Yiping Chen, Muhammad Shahzad Aslam, Simin Yan, Jianguo Li, Jingyu Zeng, Siyu Liu, Yiwen Chen, Yanqin Jiang, Peng Li, Xianjun Meng. Acupuncture alleviates CUMS-induced depression-like behaviors of rats by regulating oxidative stress, neuroinflammation and ferroptosis. Brain research. 2024 03; 1826(?):148715. doi: 10.1016/j.brainres.2023.148715. [PMID: 38142722]
Mahesh I Sirasangi, Tamsheel Fatima Roohi, K L Krishna, Nabeel Kinattingal, Shahid Ud Din Wani, Seema Mehdi. Dietary Co-supplements attenuate the chronic unpredictable mild stress-induced depression in mice. Behavioural brain research. 2024 02; 459(?):114788. doi: 10.1016/j.bbr.2023.114788. [PMID: 38036263]
Huina Ma, Hehua Huang, Chenyu Li, Shasha Li, Juefang Gan, Chunrong Lian, Yanwu Ling. The antidepressive mechanism of Longya Lilium combined with Fluoxetine in mice with depression-like behaviors. NPJ systems biology and applications. 2024 Jan; 10(1):5. doi: 10.1038/s41540-024-00329-5. [PMID: 38218856]
Tao Tong, Chongyao Hao, Junliang Shen, Siyu Liu, Simin Yan, Muhammad Shahzad Aslam, Yiping Chen, Wenjie Chen, Jianguo Li, Yuhan Li, Jingyu Zeng, Meng Li, Zhuoran You, Tuergong Gulizhaerkezi, Simiao Wei, Anning Zhu, Xianjun Meng. Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats. Brain research bulletin. 2024 Jan; 206(?):110838. doi: 10.1016/j.brainresbull.2023.110838. [PMID: 38123022]
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim. Acori Tatarinowii Rhizoma prevents the fluoxetine-induced multiple-drug resistance of Escherichia coli against antibiotics. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155232. doi: 10.1016/j.phymed.2023.155232. [PMID: 38006809]
Y Yusha'u, Aisha Aminu Hanafi, Umar Muhammad Adam. Antidepressant-Like Effects of Cinnamomum verum on Open-Space Forced Swim-Induced Depression in Mice. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. 2023 Dec; 38(2):223-227. doi: 10.54548/njps.v38i2.11. [PMID: 38696678]
Chan-Young Kwon, Boram Lee. The effectiveness and safety of herbal medicine on suicidal behavior: A PRISMA-compliant systematic review and meta-analysis. Medicine. 2023 Nov; 102(44):e34796. doi: 10.1097/md.0000000000034796. [PMID: 37932986]
Sanjana Chahuan, Sania Grover, Shamsher Singh. Amelioration of modified chronic unpredictable stress using Celastrus paniculatus seed oil alone and in combination with fluoxetine. Drug and chemical toxicology. 2023 Nov; 46(5):879-894. doi: 10.1080/01480545.2022.2105862. [PMID: 35943180]
Diego Freitas de Araujo, Bianca Feitosa Holanda, Francisco Lucas Faustino do Nascimento, Alice Brito Martins, Alefe Lopes Macario Silva, Maria Gonçalves Pereira, Alana de Freitas Pires, Ana Maria Sampaio Assreuy. Polysaccharide-rich extract of Genipa americana leaves exerts anti-inflammatory effects modulated by platelet mediators. Journal of ethnopharmacology. 2023 Oct; 319(Pt 2):117234. doi: 10.1016/j.jep.2023.117234. [PMID: 37793578]
Tamara T Haque, Marcela T Taruselli, Sydney A Kee, Jordan M Dailey, Neha Pondicherry, Paula A Gajewski-Kurdziel, Matthew P Zellner, Daniel J Stephenson, H Patrick MacKnight, David B Straus, Roma Kankaria, Kaitlyn G Jackson, Alena P Chumanevich, Yoshihiro Fukuoka, Lawrence B Schwartz, Randy D Blakely, Carole A Oskeritzian, Charles E Chalfant, Rebecca K Martin, John J Ryan. Fluoxetine restrains allergic inflammation by targeting an FcɛRI-ATP positive feedback loop in mast cells. Science signaling. 2023 Sep; 16(802):eabc9089. doi: 10.1126/scisignal.abc9089. [PMID: 37699080]
Burcu Ersoy, Marie-Louise Herzog, Wen Pan, Simone Schilling, Matthias Endres, Ria Göttert, Golo D Kronenberg, Karen Gertz. The atypical antidepressant tianeptine confers neuroprotection against oxygen-glucose deprivation. European archives of psychiatry and clinical neuroscience. 2023 Sep; ?(?):. doi: 10.1007/s00406-023-01685-9. [PMID: 37653354]
Aline Giuli Melaré, Francisco Contini Barreto, Martin Kassio Leme Silva, Rafael Plana Simões, Ivana Cesarino. Determination of Fluoxetine in Weight Loss Herbal Medicine Using an Electrochemical Sensor Based on rGO-CuNPs. Molecules (Basel, Switzerland). 2023 Aug; 28(17):. doi: 10.3390/molecules28176361. [PMID: 37687190]
Maedeh Rahati Quchani, Elham Farmanesh, Asieh Esmaili, Ali Moghimi, Masoud Fereidoni, Saeed Rahati Quchani. Behavioral and electrophysiological (ECoG) effects of haplophyllum robustum and TRPA1 antagonist in adult male wistar rats. Toxicon : official journal of the International Society on Toxinology. 2023 Aug; ?(?):107233. doi: 10.1016/j.toxicon.2023.107233. [PMID: 37541601]
Siming Wang, Qihan Cai, Lu Xu, Yanan Sun, Mengmeng Wang, Yu Wang, Lili Zhang, Keqing Li, Zhiyu Ni. Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis. Psychopharmacology. 2023 Aug; 240(8):1775-1787. doi: 10.1007/s00213-023-06413-8. [PMID: 37400661]
Weiwei Tao, Guangda Yao, Qiyu Yue, Chunyan Xu, Yue Hu, XiaoLan Cheng, Tong Zhao, Mingming Qi, Gang Chen, Min Zhao, Yue Yu. 14-3-3ζ Plays a key role in the modulation of neuroplasticity underlying the antidepressant-like effects of Zhi-Zi-Chi-Tang. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jul; 116(?):154888. doi: 10.1016/j.phymed.2023.154888. [PMID: 37257329]
Abishek Arora, Martin Becker, Cátia Marques, Marika Oksanen, Danyang Li, Francesca Mastropasqua, Michelle Evelyn Watts, Manish Arora, Anna Falk, Carsten Oliver Daub, Ingela Lanekoff, Kristiina Tammimies. Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Scientific reports. 2023 06; 13(1):10519. doi: 10.1038/s41598-023-37488-0. [PMID: 37386098]
Rozielly Aparecida Lemes Dos Santos, Silvia Regina de Lima Reis, Patrícia Cristiane Gibbert, Cristina Maria de Arruda, Diego Luiz Doneda, Yohan Alves Victor de Matos, Giordano Gubert Viola, Fabrício Rios Santos, Eliângela de Lima, Ziliani da Silva Buss, Samuel Vandresen-Filho. Guanosine treatment prevents lipopolysaccharide-induced depressive-like behavior in mice. Journal of psychiatric research. 2023 Jun; 164(?):296-303. doi: 10.1016/j.jpsychires.2023.06.022. [PMID: 37392719]
Débora Jesabel Pérez, Lucas Rodrigo Lombardero, William Joseph Doucette. Influence of exposure time, physicochemical properties, and plant transpiration on the uptake dynamics and translocation of pharmaceutical and personal care products in the aquatic macrophyte Typha latifolia. The Science of the total environment. 2023 Jun; ?(?):165107. doi: 10.1016/j.scitotenv.2023.165107. [PMID: 37364828]
Zenab Aldurrah, Farah Syazwani Mohd Kauli, Nurhidayah Abdul Rahim, Zurina Zainal, Adlin Afzan, Ragdhaa Hamdan Al Zarzour, Salizawati Muhamad Salhimi, Mohamad Shazeli Che Zain, Fauziahanim Zakaria. Antidepressant evaluation of Andrographis paniculata Nees extract and andrographolide in chronic unpredictable stress zebrafish model. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023 Jun; 271(?):109678. doi: 10.1016/j.cbpc.2023.109678. [PMID: 37301417]
Erin S McCallum, Daniel Cerveny, Aneesh P H Bose, Jerker Fick, Tomas Brodin. Cost-Effective Pharmaceutical Implants in Fish: Validating the Performance of Slow-Release Implants for the Antidepressant Fluoxetine. Environmental toxicology and chemistry. 2023 06; 42(6):1326-1336. doi: 10.1002/etc.5613. [PMID: 36942382]
Tao Tong, Yiping Chen, Chonyao Hao, Junliang Shen, Wenjie Chen, Wenjing Cheng, Simin Yan, Jianguo Li, Yuhan Li, Tuergong Gulizhaerkezi, Xianjun Meng. The effects of acupuncture on depression by regulating BDNF-related balance via lateral habenular nucleus BDNF/TrkB/CREB signaling pathway in rats. Behavioural brain research. 2023 May; ?(?):114509. doi: 10.1016/j.bbr.2023.114509. [PMID: 37244435]
Long Li, Shanbo Ma, Jin Wang, Yuhan Chen, Feiyan Wang, Meiling Zheng, Kun Zhang, Shan Miao, Xiaopeng Shi. Inflammatory Factors Predicted the Resilient Phenotype in Social Defeat-induced Depression of Male Mouse. Neuroscience. 2023 05; 519(?):38-46. doi: 10.1016/j.neuroscience.2023.02.022. [PMID: 36893981]
Rivka Ihejirika-Lomedico, Karan Patel, Daniel B Buchalter, David J Kirby, Devan Mehta, John F Dankert, Emma Muiños-López, Yael Ihejirika, Philipp Leucht. Non-psychoactive Cannabidiol Prevents Osteoporosis in an Animal Model and Increases Cell Viability, Proliferation, and Osteogenic Gene Expression in Human Skeletal Stem and Progenitor Cells. Calcified tissue international. 2023 Apr; ?(?):. doi: 10.1007/s00223-023-01083-2. [PMID: 37093268]
Rajeshwari Parasuraman, Dheepthi Jayamurali, Nivedita Manoharan, Sathya Narayanan Govindarajalu. Effect of Bromelain on Chronic Unpredictable Stress-induced Behavioral, Biochemical, and Monoamine Changes in Wistar Albino Rat Model of Depression. Protein and peptide letters. 2023 Apr; ?(?):. doi: 10.2174/0929866530666230419093531. [PMID: 37076960]
Aaron L Nichols, Zack Blumenfeld, Laura Luebbert, Hailey J Knox, Anand K Muthusamy, Jonathan S Marvin, Charlene H Kim, Stephen N Grant, David P Walton, Bruce N Cohen, Rebekkah Hammar, Loren Looger, Per Artursson, Dennis A Dougherty, Henry A Lester. Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023 03; 43(13):2222-2241. doi: 10.1523/jneurosci.1519-22.2022. [PMID: 36868853]
Bin Xie, Shumin Yang. Effect of Fluoxetine on the Surface Behavior of the Lipid Monolayers at Different Surface Pressures. The Journal of membrane biology. 2023 02; 256(1):43-50. doi: 10.1007/s00232-022-00249-7. [PMID: 35907027]
Ziwei Chen, Jinping Gu, Susu Lin, Zijin Xu, Hongyu Xu, Jiajing Zhao, Peishi Feng, Yi Tao, Suhong Chen, Ping Wang. Saffron essential oil ameliorates CUMS-induced depression-like behavior in mice via the MAPK-CREB1-BDNF signaling pathway. Journal of ethnopharmacology. 2023 Jan; 300(?):115719. doi: 10.1016/j.jep.2022.115719. [PMID: 36126781]
Donatus Wewura Adongo, Priscilla Kolibea Mante, Kennedy Kwami Edem Kukuia, Charles Kwaku Benneh, Robert Peter Biney, Eric Boakye-Gyasi, Hilda Amekyeh, Benjamin Kingsley Harley, Augustine Tandoh, Prince Dagadu Okyere, Eric Woode. Fast-onset effects of Pseudospondias microcarpa (A. Rich) Engl. (Anacardiaceae) hydroethanolic leaf extract on behavioral alterations induced by chronic mild stress in mice. PloS one. 2023; 18(2):e0278231. doi: 10.1371/journal.pone.0278231. [PMID: 36730151]
Peng Li, Wenya Huang, Yiping Chen, Muhammad Shahzad Aslam, Wenjing Cheng, Yang Huang, Wenjie Chen, Yanxun Huang, Xinnan Wu, Yining Yan, Junliang Shen, Tao Tong, Shuqiong Huang, Xianjun Meng. Acupuncture Alleviates CUMS-Induced Depression-Like Behaviors by Restoring Prefrontal Cortex Neuroplasticity. Neural plasticity. 2023; 2023(?):1474841. doi: 10.1155/2023/1474841. [PMID: 37179843]
Helmut Stremmel, Linda Weiss, Gema Parra, Eloísa Ramos-Rodríguez, Cristiano V M Araújo. Ecotoxicological assessment of the effects of fluoxetine on Daphnia magna based on acute toxicity, multigenerational reproduction effects, and attraction-repellence responses. Chemosphere. 2023 Jan; 312(Pt 1):137028. doi: 10.1016/j.chemosphere.2022.137028. [PMID: 36323386]
Xiansu Chi, Xiaoyan Xue, Jin Pan, Jiang Wu, Huishan Shi, Yong Wang, Yanting Lu, Zhe Zhang, Ke Ma. Mechanism of lily bulb and Rehmannia decoction in the treatment of lipopolysaccharide-induced depression-like rats based on metabolomics study and network pharmacology. Pharmaceutical biology. 2022 Dec; 60(1):1850-1864. doi: 10.1080/13880209.2022.2121843. [PMID: 36205539]
Jing Zhang, Naiwen Zhang, Jianfeng Lei, Bin Jing, Mengyuan Li, Huiling Tian, Bing Xue, Xiaoli Li. Fluoxetine shows neuroprotective effects against LPS-induced neuroinflammation via the Notch signaling pathway. International immunopharmacology. 2022 Dec; 113(Pt A):109417. doi: 10.1016/j.intimp.2022.109417. [PMID: 36461606]
Grigorios Megariotis, Georgios Mikaelian, Aggelos Avramopoulos, Nikolaos Romanos, Doros N Theodorou. Molecular simulations of fluoxetine in hydrated lipid bilayers, as well as in aqueous solutions containing β-cyclodextrin. Journal of molecular graphics & modelling. 2022 12; 117(?):108305. doi: 10.1016/j.jmgm.2022.108305. [PMID: 35987186]
Pedro Pauletto, Marco Bortoli, Folorunsho Omage Bright, Cássia Pereira Delgado, Pablo Andrei Nogara, Laura Orian, João Batista Teixeira da Rocha. In silico analysis of the antidepressant fluoxetine and similar drugs as inhibitors of the human protein acid sphingomyelinase: a related SARS-CoV-2 inhibition pathway. Journal of biomolecular structure & dynamics. 2022 Nov; ?(?):1-14. doi: 10.1080/07391102.2022.2148124. [PMID: 36447407]
Lin Huang, Weixia Zhang, Yu Han, Yu Tang, Weishang Zhou, Guangxu Liu, Wei Shi. Anti-Depressant Fluoxetine Hampers Olfaction of Goldfish by Interfering with the Initiation, Transmission, and Processing of Olfactory Signals. Environmental science & technology. 2022 11; 56(22):15848-15859. doi: 10.1021/acs.est.2c02987. [PMID: 36260920]
Jiahui Wu, Zhitian Peng, Qiyun Wu, Roy Wai Lun Tang, Tingxia Dong, Huaiyou Wang, Karl Wah Keung Tsim. The water extract of Aloe vera prevents fluoxetine-induced multiple-drug resistance of E. coli by inhibiting reactive oxygen species formation and membrane permeability. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154421. doi: 10.1016/j.phymed.2022.154421. [PMID: 36054995]
Di Deng, Yongfei Cui, Shu Gan, Zedan Xie, Sainan Cui, Kerun Cao, Shanshan Wang, Guoqi Shi, Lei Yang, Shasha Bai, Yafei Shi, Zhongqiu Liu, Jinlan Zhao, Rong Zhang. Sinisan alleviates depression-like behaviors by regulating mitochondrial function and synaptic plasticity in maternal separation rats. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154395. doi: 10.1016/j.phymed.2022.154395. [PMID: 36103769]
Tian-Ze Li, Jing Hu, Jin-Jin Sun, Xiao-Yan Huang, Chang-An Geng, Shu-Bai Liu, Xue-Mei Zhang, Ji-Jun Chen. Synthesis and biological evaluation of paeoveitol D derivatives as new melatonin receptor agonists with antidepressant activities. RSC medicinal chemistry. 2022 Oct; 13(10):1212-1224. doi: 10.1039/d2md00156j. [PMID: 36325395]
Tayebeh Beigi, Amir Safi, Mahdi Satvati, Ali Kalantari-Hesari, Reza Ahmadi, Mohammad-Hassan Meshkibaf. Protective role of ellagic acid and taurine against fluoxetine induced hepatotoxic effects on biochemical and oxidative stress parameters, histopathological changes, and gene expressions of IL-1β, NF-κB, and TNF-α in male Wistar rats. Life sciences. 2022 Sep; 304(?):120679. doi: 10.1016/j.lfs.2022.120679. [PMID: 35662648]
Yiping Chen, Chongyao Hao, Wenjie Chen, Wenjing Cheng, Peng Li, Junliang Shen, Tao Tong, Simin Yan, Shuqiong Huang, Tianwei He, Zhiyong Huang, Xianjun Meng. Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation. Neuroscience letters. 2022 Aug; 785(?):136787. doi: 10.1016/j.neulet.2022.136787. [PMID: 35820551]
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Nadeem, Shumaila Usman, Rehan Imad, Uzair Nisar, Irfan Khan, Ghulam Abbas. Pre-weaning fluoxetine exposure caused anti-depressant like behavior at adulthood via perturbing tryptophan metabolism in rats. Metabolic brain disease. 2022 06; 37(5):1415-1422. doi: 10.1007/s11011-022-00951-4. [PMID: 35303245]
Nurhidayah Abdul Rahim, Nurfatihah Nordin, Nur Izzatun Shahira Ahmad Rasedi, Farah Syazwani Mohd Kauli, Wan Norhamidah Wan Ibrahim, Fauziahanim Zakaria. Behavioral and cortisol analysis of the anti-stress effect of Polygonum minus (Huds) extracts in chronic unpredictable stress (CUS) zebrafish model. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Jun; 256(?):109303. doi: 10.1016/j.cbpc.2022.109303. [PMID: 35202824]
Ahmed Ayyash, Alison C Holloway. Fluoxetine-induced hepatic lipid accumulation is mediated by prostaglandin endoperoxide synthase 1 and is linked to elevated 15-deoxy-Δ12,14 PGJ2. Journal of applied toxicology : JAT. 2022 06; 42(6):1004-1015. doi: 10.1002/jat.4272. [PMID: 34897744]
Udo Bonnet, Georg Juckel. COVID-19 Outcomes: Does the Use of Psychotropic Drugs Make a Difference? Accumulating Evidence of a Beneficial Effect of Antidepressants-A Scoping Review. Journal of clinical psychopharmacology. 2022 May; 42(3):284-292. doi: 10.1097/jcp.0000000000001543. [PMID: 35420565]
Antonio Flores-Burgess, Carmelo Millón, Belen Gago, Laura García-Durán, Noelia Cantero-García, Araceli Puigcerver, José Angel Narváez, Kjell Fuxe, Luis Santín, Zaida Díaz-Cabiale. Galanin (1-15) Enhances the Behavioral Effects of Fluoxetine in the Olfactory Bulbectomy Rat, Suggesting a New Augmentation Strategy in Depression. The international journal of neuropsychopharmacology. 2022 04; 25(4):307-318. doi: 10.1093/ijnp/pyab089. [PMID: 34891163]
Carly Colville, Alper James Alcaraz, Derek Green, Bradley Park, Jianguo Xia, Othman Soufan, Pavel Hruṧka, David Potěšil, Zbyněk Zdráhal, Doug Crump, Niladri Basu, Natacha Hogan, Markus Hecker. Characterizing toxicity pathways of fluoxetine to predict adverse outcomes in adult fathead minnows (Pimephales promelas). The Science of the total environment. 2022 Apr; 817(?):152747. doi: 10.1016/j.scitotenv.2021.152747. [PMID: 35026279]
Shvetank Bhatt, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Sridevi Chigurupati, Amira Saber Ahmed, Sreelakshmi Bada V Gari. Investigation of Cochlospermum religiosum leaves for antidepressant and anxiolytic activities and its synergistic effect with imipramine and fluoxetine. Environmental science and pollution research international. 2022 Apr; 29(18):27172-27181. doi: 10.1007/s11356-021-18359-5. [PMID: 34981394]
Mohamed Mahdi, Levente Hermán, János M Réthelyi, Bálint László Bálint. Potential Role of the Antidepressants Fluoxetine and Fluvoxamine in the Treatment of COVID-19. International journal of molecular sciences. 2022 Mar; 23(7):. doi: 10.3390/ijms23073812. [PMID: 35409171]
Patricia I Pinto, L Anjos, M D Estêvão, S Santos, C Santa, B Manadas, T Monsinjon, Adelino V M Canário, D M Power. Proteomics of sea bass skin-scales exposed to the emerging pollutant fluoxetine compared to estradiol. The Science of the total environment. 2022 Mar; 814(?):152671. doi: 10.1016/j.scitotenv.2021.152671. [PMID: 34968595]
Karema Abu-Elfotuh, Aya H Al-Najjar, Asmaa A Mohammed, Amany S Aboutaleb, Ghada A Badawi. Fluoxetine ameliorates Alzheimer's disease progression and prevents the exacerbation of cardiovascular dysfunction of socially isolated depressed rats through activation of Nrf2/HO-1 and hindering TLR4/NLRP3 inflammasome signaling pathway. International immunopharmacology. 2022 Mar; 104(?):108488. doi: 10.1016/j.intimp.2021.108488. [PMID: 35042170]
Dasa Seveljevic-Jaran, Otto Kalliokoski, Klas S P Abelson, Jann Hau. Antidepressant Fluoxetine Does Not Appear to Interfere With Key Translational Parameters in the Rat Adjuvant-induced Arthritis Model. In vivo (Athens, Greece). 2022 Mar; 36(2):635-642. doi: 10.21873/invivo.12747. [PMID: 35241516]
José Manuel Orozco-Hernández, Leobardo Manuel Gómez-Oliván, Gustavo Axel Elizalde-Velázquez, Gerardo Heredia-García, Jesús Daniel Cardoso-Vera, Octavio Dublán-García, Hariz Islas-Flores, Nely SanJuan-Reyes, Marcela Galar-Martínez. Effects of oxidative stress induced by environmental relevant concentrations of fluoxetine on the embryonic development on Danio rerio. The Science of the total environment. 2022 Feb; 807(Pt 3):151048. doi: 10.1016/j.scitotenv.2021.151048. [PMID: 34673069]
Josef Vaclavik, Pavla Sehonova, Jana Blahova, Denisa Medkova, Eva Postulkova, Ondrej Maly, Michaela Charvatova, Kamil Stastny, Jiri Lenz, Jan Mares, Ales Franc, Zdenka Svobodova. Foodborne fluoxetine impacts the immune response in rainbow trout (Oncorhynchus mykkis). Environmental toxicology and pharmacology. 2022 Feb; 90(?):103818. doi: 10.1016/j.etap.2022.103818. [PMID: 35074562]
Kan Gao, Aitak Farzi, Xueqin Ke, Yunxia Yu, Cailin Chen, Su Chen, Tengfei Yu, Haifeng Wang, Yanjun Li. Oral administration of Lactococcus lactis WHH2078 alleviates depressive and anxiety symptoms in mice with induced chronic stress. Food & function. 2022 Jan; 13(2):957-969. doi: 10.1039/d1fo03723d. [PMID: 35006225]
Ana Belen Ramos-Hryb, Francis L Pazini, Ana Paula Costa, Mauricio P Cunha, Manuella P Kaster, Ana Lúcia S Rodrigues. Role of heme oxygenase-1 in the antidepressant-like effect of ursolic acid in the tail suspension test. The Journal of pharmacy and pharmacology. 2022 Jan; 74(1):13-21. doi: 10.1093/jpp/rgab128. [PMID: 34791376]
Ibrahim Ethem Torun, Yasemin Baranoglu Kılınc, Erkan Kilinc. Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats. Arquivos de neuro-psiquiatria. 2022 01; 80(1):48-55. doi: 10.1590/0004-282x-anp-2021-0101. [PMID: 35239805]
Amin Nozari, Remi Gagné, Chunyu Lu, Carole Yauk, Vance L Trudeau. Brief Developmental Exposure to Fluoxetine Causes Life-Long Alteration of the Brain Transcriptome in Zebrafish. Frontiers in endocrinology. 2022; 13(?):847322. doi: 10.3389/fendo.2022.847322. [PMID: 35573988]
Min Wang, Yingying Sun, Bingying Hu, Zhisheng He, Shanshan Chen, Dake Qi, Hai An, Yang Wei. Organic Cation Transporters are Involved in Fluoxetine Transport Across the Blood-Brain Barrier In Vivo and In Vitro. Current drug delivery. 2022; 19(4):508-517. doi: 10.2174/1567201818666210708122326. [PMID: 34238184]
Ke-Yu Chen, Ruo-Yang Li. Efficacy and safety of different antidepressants and anticonvulsants in central poststroke pain: A network meta-analysis and systematic review. PloS one. 2022; 17(10):e0276012. doi: 10.1371/journal.pone.0276012. [PMID: 36227855]
Mohsen Khosravi. Candidate Psychotropics against SARS - CoV - 2: A Narrative Review. Pharmacopsychiatry. 2022 Jan; 55(1):16-23. doi: 10.1055/a-1551-3756. [PMID: 34399430]
Laura H Waitt Wolker, Charles A Veltri, Krista Pearman, Maria Lozoya, Jeffrey W Norris. Pharmacokinetics of fluoxetine in horses following oral administration. Journal of veterinary pharmacology and therapeutics. 2022 Jan; 45(1):63-68. doi: 10.1111/jvp.13029. [PMID: 34747024]
Yuan Hu, Yichen Wang, Chao Chen, Wenshan Yang, Weiyu Zhu, Yuanbo Wang, Ping Liu. A randomized, placebo-controlled, double-blind study on the effects of SZL on patients with mild to moderate depressive disorder with comparison to fluoxetine. Journal of ethnopharmacology. 2021 Dec; 281(?):114549. doi: 10.1016/j.jep.2021.114549. [PMID: 34438029]
Li Zhang, Liwen Wang, Li Huang, Yanni Zhao, Hongling Ding, Binglong Li, Lingmiao Wen, Wei Xiong, Yanjun Liu, Tinglan Zhang, Liudai Zhang, Lanlan Wu, Qing Xu, Yuqing Fan, Guihua Wei, Qiaozhi Yin, Yunhui Chen, Tiane Zhang, Zhiyong Yan. Antidepressant effects of total iridoids of Valeriana jatamansi via the intestinal flora-blood-brain barrier pathway. Pharmaceutical biology. 2021 Dec; 59(1):912-921. doi: 10.1080/13880209.2021.1944222. [PMID: 34236293]
Bin Xie, Changchun Hao, Runguang Sun. The impact of fluoxetine and pH values on relaxation of the ternary lipid monolayers. Biochimica et biophysica acta. Biomembranes. 2021 12; 1863(12):183760. doi: 10.1016/j.bbamem.2021.183760. [PMID: 34499884]
Zsófia Klára Németh, Anna Szûcs, József Vitrai, Dóra Juhász, János Pál Németh, András Holló. Fluoxetine use is associated with improved survival of patients with COVID-19 pneumonia: A retrospective case-control study. Ideggyogyaszati szemle. 2021 Nov; 74(11-12):389-396. doi: 10.18071/isz.74.0389. [PMID: 34856085]
Yuan Xu, Jian Lu, Bingyi Yao, Yuanjin Zhang, Shengbo Huang, Jie Liu, Yanfang Zhang, Yuanqing Guo, Xin Wang. P-glycoprotein mediates the pharmacokinetic interaction of olanzapine with fluoxetine in rats. Toxicology and applied pharmacology. 2021 11; 431(?):115735. doi: 10.1016/j.taap.2021.115735. [PMID: 34610281]
Karema Abu-Elfotuh, Ghada M Ragab, Ahmad Salahuddin, Lubna Jamil, Ekram Nemr Abd Al Haleem. Attenuative Effects of Fluoxetine and Triticum aestivum against Aluminum-Induced Alzheimer's Disease in Rats: The Possible Consequences on Hepatotoxicity and Nephrotoxicity. Molecules (Basel, Switzerland). 2021 Nov; 26(21):. doi: 10.3390/molecules26216752. [PMID: 34771159]
Yasin Bez, Barbara J Coffey. Fluoxetine-Induced Serum Sickness-Like Reaction in an Adolescent with Obsessive Compulsive Disorder and Diabetes. Journal of child and adolescent psychopharmacology. 2021 11; 31(9):646-649. doi: 10.1089/cap.2021.29211.bjc. [PMID: 34784233]
Nicolas Hoertel. Do the Selective Serotonin Reuptake Inhibitor Antidepressants Fluoxetine and Fluvoxamine Reduce Mortality Among Patients With COVID-19?. JAMA network open. 2021 11; 4(11):e2136510. doi: 10.1001/jamanetworkopen.2021.36510. [PMID: 34779851]
Tomiko Oskotsky, Ivana Maric, Alice Tang, Boris Oskotsky, Ronald J Wong, Nima Aghaeepour, Marina Sirota, David K Stevenson. Mortality Risk Among Patients With COVID-19 Prescribed Selective Serotonin Reuptake Inhibitor Antidepressants. JAMA network open. 2021 11; 4(11):e2133090. doi: 10.1001/jamanetworkopen.2021.33090. [PMID: 34779847]
Hyeon-Cheol Jeong, Yoon-Jee Chae, Sooyeun Lee, Wonku Kang, Hwi-Yeol Yun, Kwang-Hee Shin. Prediction of Fluoxetine and Norfluoxetine Pharmacokinetic Profiles Using Physiologically Based Pharmacokinetic Modeling. Journal of clinical pharmacology. 2021 11; 61(11):1505-1513. doi: 10.1002/jcph.1927. [PMID: 34118174]
Zihong Liang, Yanbo Jia, Lizhen Zhao, Runxiu Zhu, Xuemei He, Bagen Tong, Fan Yang, Lixia Hao, Pengfei Cui, Jun Yuan. Agomelatine might be more appropriate for elderly, depressed, type 2 diabetes mellitus patients than paroxetine/fluoxetine. Aging. 2021 10; 13(19):22934-22946. doi: 10.18632/aging.203586. [PMID: 34610580]
Julia Sagahón-Azúa, Susanna Edith Medellín-Garibay, Cinthya Eloisa Chávez-Castillo, César Guillermo González-Salinas, Rosa Del Carmen Milán-Segovia, Silvia Romano-Moreno. Factors associated with fluoxetine and norfluoxetine plasma concentrations and clinical response in Mexican patients with mental disorders. Pharmacology research & perspectives. 2021 10; 9(5):e00864. doi: 10.1002/prp2.864. [PMID: 34523245]
Shaymaa Elsayed Khater, Ahmed El-Khouly, Hend Mohamed Abdel-Bar, Abdulaziz Mohsen Al-Mahallawi, Dalia Mahmoud Ghorab. Fluoxetine hydrochloride loaded lipid polymer hybrid nanoparticles showed possible efficiency against SARS-CoV-2 infection. International journal of pharmaceutics. 2021 Sep; 607(?):121023. doi: 10.1016/j.ijpharm.2021.121023. [PMID: 34416332]
Janine Naß, Thomas Efferth. Withanone Ameliorates Stress Symptoms in Caenorhabditis Elegans by Acting through Serotonin Receptors. Pharmacopsychiatry. 2021 Sep; 54(5):215-223. doi: 10.1055/a-1349-3870. [PMID: 33957677]
Syed Muzaffar Ali, Sumbul Shamim, Ishrat Younus, Laila Anwer, Sheikh Abdul Khaliq. Anxiolytic, antidepressant and inhibitory effect on MAO isoenzymes by Bougainvillea glabra flower extract in rats. Pakistan journal of pharmaceutical sciences. 2021 Sep; 34(5(Supplementary)):1963-1968. doi: ". [PMID: 34836867]
Ahmed Ayyash, Alison C Holloway. Fluoxetine-induced hepatic lipid accumulation is linked to elevated serotonin production. Canadian journal of physiology and pharmacology. 2021 Sep; 99(9):983-988. doi: 10.1139/cjpp-2020-0721. [PMID: 33517848]
Yen-Ju Chiu, Ho-Hsiang Tu, Mei-Lang Kung, Hung-Ju Wu, Yun-Wen Chen. Fluoxetine ameliorates high-fat diet-induced metabolic abnormalities partially via reduced adipose triglyceride lipase-mediated adipocyte lipolysis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Sep; 141(?):111848. doi: 10.1016/j.biopha.2021.111848. [PMID: 34198047]
Jakub Staroń, Wojciech Pietruś, Ryszard Bugno, Rafał Kurczab, Grzegorz Satała, Dawid Warszycki, Tomasz Lenda, Anna Wantuch, Adam S Hogendorf, Agata Hogendorf, Beata Duszyńska, Andrzej J Bojarski. Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands - Fluoxetine and fluvoxamine. European journal of medicinal chemistry. 2021 Aug; 220(?):113533. doi: 10.1016/j.ejmech.2021.113533. [PMID: 34049262]
John Sebastiani, M Danielle McDonald. The role of uptake and degradation in the regulation of peripheral serotonin dynamics in Gulf toadfish, Opsanus beta. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2021 08; 258(?):110980. doi: 10.1016/j.cbpa.2021.110980. [PMID: 34023534]
Shuanghui Lu, Zhiyuan Ma, Yong Gu, Ping Li, Yingchun Chen, Mengru Bai, Hui Zhou, Xi Yang, Huidi Jiang. Downregulation of glucose-6-phosphatase expression contributes to fluoxetine-induced hepatic steatosis. Journal of applied toxicology : JAT. 2021 08; 41(8):1232-1240. doi: 10.1002/jat.4109. [PMID: 33179799]
Wansu Qiu, Kimberly A Go, Yvonne Lamers, Liisa A M Galea. Postpartum corticosterone and fluoxetine shift the tryptophan-kynurenine pathway in dams. Psychoneuroendocrinology. 2021 08; 130(?):105273. doi: 10.1016/j.psyneuen.2021.105273. [PMID: 34051656]
Anna Tkachev, Elena Stekolshchikova, Daniil M Bobrovskiy, Nickolay Anikanov, Polina Ogurtsova, Dong Ik Park, Anja K E Horn, Daria Petrova, Ekaterina Khrameeva, Mari S Golub, Christoph W Turck, Philipp Khaitovich. Long-Term Fluoxetine Administration Causes Substantial Lipidome Alteration of the Juvenile Macaque Brain. International journal of molecular sciences. 2021 Jul; 22(15):. doi: 10.3390/ijms22158089. [PMID: 34360852]
Merve Sarıkaya, Halil Ibrahim Ulusoy, Ummugulsum Morgul, Songül Ulusoy, Angela Tartaglia, Erkan Yılmaz, Mustafa Soylak, Marcello Locatelli, Abuzar Kabir. Sensitive determination of Fluoxetine and Citalopram antidepressants in urine and wastewater samples by liquid chromatography coupled with photodiode array detector. Journal of chromatography. A. 2021 Jul; 1648(?):462215. doi: 10.1016/j.chroma.2021.462215. [PMID: 34000593]
Fatemeh Kazemi, Iraj Vosough, Samaneh Sepahi, Seyed Ahmad Mohajeri. Effect of crocin versus fluoxetine in treatment of mild to moderate obsessive-compulsive disorder: A double blind randomized clinical trial. Human psychopharmacology. 2021 07; 36(4):e2780. doi: 10.1002/hup.2780. [PMID: 33599345]
Hubert J Sijben, Wieke M van Oostveen, Peter B R Hartog, Laura Stucchi, Andrea Rossignoli, Giovanna Maresca, Lia Scarabottolo, Adriaan P IJzerman, Laura H Heitman. Label-free high-throughput screening assay for the identification of norepinephrine transporter (NET/SLC6A2) inhibitors. Scientific reports. 2021 06; 11(1):12290. doi: 10.1038/s41598-021-91700-7. [PMID: 34112854]
Mo Chen, Yan Zhang, Hongqian Wang, Hao Yang, Wen Yin, Saihong Xu, Tao Jiang, Mansi Wang, Feixiang Wu, Weifeng Yu. Inhibition of the norepinephrine transporter rescues vascular hyporeactivity to catecholamine in obstructive jaundice. European journal of pharmacology. 2021 Jun; 900(?):174055. doi: 10.1016/j.ejphar.2021.174055. [PMID: 33775645]
Sebastian Schloer, Linda Brunotte, Angeles Mecate-Zambrano, Shuyu Zheng, Jing Tang, Stephan Ludwig, Ursula Rescher. Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS-CoV-2 infection in vitro. British journal of pharmacology. 2021 06; 178(11):2339-2350. doi: 10.1111/bph.15418. [PMID: 33825201]
Justin Fortune Creeden, Ali Sajid Imami, Hunter M Eby, Cassidy Gillman, Kathryn N Becker, Jim Reigle, Elissar Andari, Zhixing K Pan, Sinead M O'Donovan, Robert E McCullumsmith, Cheryl B McCullumsmith. Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infection. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jun; 138(?):111437. doi: 10.1016/j.biopha.2021.111437. [PMID: 33691249]
Yaser Pashaei. Drug repurposing of selective serotonin reuptake inhibitors: Could these drugs help fight COVID-19 and save lives?. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2021 Jun; 88(?):163-172. doi: 10.1016/j.jocn.2021.03.010. [PMID: 33992179]
Dylan J Terstege, Debra S MacDonald, R Andrew Tasker. Standardised ginseng extract G115® potentiates the antidepressant-like properties of fluoxetine in the forced swim test. Acta neuropsychiatrica. 2021 Jun; 33(3):141-147. doi: 10.1017/neu.2021.2. [PMID: 33478610]
Fatemeh Sadat Zolfaghari, Fardad Pirri, Evan Gauvin, Maghsoud Peeri, Shayan Amiri. Exercise and fluoxetine treatment during adolescence protect against early life stress-induced behavioral abnormalities in adult rats. Pharmacology, biochemistry, and behavior. 2021 06; 205(?):173190. doi: 10.1016/j.pbb.2021.173190. [PMID: 33865889]
Peng Li, Wenya Huang, Yi-Ning Yan, Wenjing Cheng, Siyu Liu, Yang Huang, Wenjie Chen, Yi-Ping Chen, Yuxun Gao, Weicheng Lu, Yijing Xu, Xianjun Meng. Acupuncture Can Play an Antidepressant Role by Regulating the Intestinal Microbes and Neurotransmitters in a Rat Model of Depression. Medical science monitor : international medical journal of experimental and clinical research. 2021 May; 27(?):e929027. doi: 10.12659/msm.929027. [PMID: 34039946]
Katherine Callaghan, David I Rappaport. False-Positive Urine Drug Screen for Benzodiazepines in a Child Taking Fluoxetine. Pediatric emergency care. 2021 05; 37(5):e283. doi: 10.1097/pec.0000000000002434. [PMID: 33903296]