Netoglitazone (BioDeep_00000181633)
human metabolite blood metabolite
代谢物信息卡片
化学式: C21H16FNO3S (381.08348780000006)
中文名称: 萘格列酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C(=C1)COC2=CC3=C(C=C2)C=C(C=C3)CC4C(=O)NC(=O)S4)F
InChI: InChI=1S/C21H16FNO3S/c22-18-4-2-1-3-16(18)12-26-17-8-7-14-9-13(5-6-15(14)11-17)10-19-20(24)23-21(25)27-19/h1-9,11,19H,10,12H2,(H,23,24,25)
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C98241 - Thiazolidinedione Antidiabetic Agent
Netoglitazone is a dual agonist of PPARα and PPARγ with antihyperglycemic activity[1].
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- PubChem: 204109
- HMDB: HMDB0255551
- DrugBank: DB09199
- ChEMBL: CHEMBL93747
- Wikipedia: Netoglitazone
- CAS: 161600-01-7
- medchemexpress: HY-100428
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Ning Sun, Guocai Lu, Mei Lin, Guorong Fan, Yutian Wu. High-throughput quantification of a novel thiazolidinedione MCC-555 in rat plasma by ultra-fast liquid chromatography and its application in pharmacokinetic studies.
Talanta.
2009 Apr; 78(2):506-12. doi:
10.1016/j.talanta.2008.11.044. [PMID: 19203616] - Erin E Kershaw, Michael Schupp, Hong-Ping Guan, Noah P Gardner, Mitchell A Lazar, Jeffrey S Flier. PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo.
American journal of physiology. Endocrinology and metabolism.
2007 Dec; 293(6):E1736-45. doi:
10.1152/ajpendo.00122.2007. [PMID: 17848638] - Cynthia Lee Richard, Jonathan Blay. Thiazolidinedione drugs down-regulate CXCR4 expression on human colorectal cancer cells in a peroxisome proliferator activated receptor gamma-dependent manner.
International journal of oncology.
2007 May; 30(5):1215-22. doi:
. [PMID: 17390024] - Ning Sun, Mei Lin, Guorong Fan, Zhanying Hong, Guocai Lu. Quantitative determination of MCC-555, a novel insulin sensitizer in beagle dog plasma by high-performance liquid chromatography with fluorescence detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 May; 835(1-2):35-9. doi:
10.1016/j.jchromb.2006.03.009. [PMID: 16563883] - T Yamanouchi. [KRP-297, MCC-555].
Nihon rinsho. Japanese journal of clinical medicine.
2001 Nov; 59(11):2200-6. doi:
NULL. [PMID: 11712408] - R Upton, P S Widdowson, S Ishii, H Tanaka, G Williams. Improved metabolic status and insulin sensitivity in obese fatty (fa/fa) Zucker rats and Zucker Diabetic Fatty (ZDF) rats treated with the thiazolidinedione, MCC-555.
British journal of pharmacology.
1998 Dec; 125(8):1708-14. doi:
10.1038/sj.bjp.0702245. [PMID: 9886762] - L Pickavance, P S Widdowson, P King, S Ishii, H Tanaka, G Williams. The development of overt diabetes in young Zucker Diabetic Fatty (ZDF) rats and the effects of chronic MCC-555 treatment.
British journal of pharmacology.
1998 Oct; 125(4):767-70. doi:
10.1038/sj.bjp.0702158. [PMID: 9831913]