Neosalacinol (BioDeep_00000181618)
human metabolite blood metabolite
代谢物信息卡片
化学式: C9H18O6S (254.0824048)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 95.24%
分子结构信息
SMILES: C1C(C(C([S+]1CC(C(CO)[O-])O)CO)O)O
InChI: InChI=1S/C9H18O6S/c10-1-5(12)6(13)3-16-4-7(14)9(15)8(16)2-11/h5-11,13-15H,1-4H2
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Toshio Morikawa, Kiyofumi Ninomiya, Genzoh Tanabe, Hisashi Matsuda, Masayuki Yoshikawa, Osamu Muraoka. A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia.
Journal of natural medicines.
2021 Jun; 75(3):449-466. doi:
10.1007/s11418-021-01522-0. [PMID: 33900535] - Toshiyuki Homma, Shigeki Kageyama, Atsushi Nishikawa, Kozo Nagata. Anti-melanogenic activity of salacinol by inhibition of tyrosinase oligosaccharide processing.
Journal of biochemistry.
2020 May; 167(5):503-511. doi:
10.1093/jb/mvz115. [PMID: 31883005] - Genzoh Tanabe, Youya Matsuda, Misato Oka, Yousuke Kunikata, Nozomi Tsutsui, Weija Xie, Gorre Balakishan, Mumen F A Amer, Shinsuke Marumoto, Osamu Muraoka. Highly Diastereoselective Route to α-Glucosidase Inhibitors, Neosalacinol and Neoponkoranol.
The Journal of organic chemistry.
2016 Apr; 81(8):3407-15. doi:
10.1021/acs.joc.5b02894. [PMID: 27015084] - Sidney J Stohs, Sidhartha Ray. Anti-diabetic and Anti-hyperlipidemic Effects and Safety of Salacia reticulata and Related Species.
Phytotherapy research : PTR.
2015 Jul; 29(7):986-95. doi:
10.1002/ptr.5382. [PMID: 26031882] - Toshio Morikawa, Junji Akaki, Kiyofumi Ninomiya, Eri Kinouchi, Genzoh Tanabe, Yutana Pongpiriyadacha, Masayuki Yoshikawa, Osamu Muraoka. Salacinol and related analogs: new leads for type 2 diabetes therapeutic candidates from the Thai traditional natural medicine Salacia chinensis.
Nutrients.
2015 Feb; 7(3):1480-93. doi:
10.3390/nu7031480. [PMID: 25734563] - Junji Akaki, Toshio Morikawa, Sohachiro Miyake, Kiyofumi Ninomiya, Mayumi Okada, Genzoh Tanabe, Yutana Pongpiriyadacha, Masayuki Yoshikawa, Osamu Muraoka. Evaluation of Salacia species as anti-diabetic natural resources based on quantitative analysis of eight sulphonium constituents: a new class of α-glucosidase inhibitors.
Phytochemical analysis : PCA.
2014 Nov; 25(6):544-50. doi:
10.1002/pca.2525. [PMID: 24816820] - Genzoh Tanabe, Shinya Nakamura, Nozomi Tsutsui, Gorre Balakishan, Weijia Xie, Satoshi Tsuchiya, Junji Akaki, Toshio Morikawa, Kiyofumi Ninomiya, Isao Nakanishi, Masayuki Yoshikawa, Osamu Muraoka. In silico design, synthesis and evaluation of 3'-O-benzylated analogs of salacinol, a potent α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine 'Salacia'.
Chemical communications (Cambridge, England).
2012 Sep; 48(69):8646-8. doi:
10.1039/c2cc34144a. [PMID: 22820468] - Lyann Sim, Kumarasamy Jayakanthan, Sankar Mohan, Ravindranath Nasi, Blair D Johnston, B Mario Pinto, David R Rose. New glucosidase inhibitors from an ayurvedic herbal treatment for type 2 diabetes: structures and inhibition of human intestinal maltase-glucoamylase with compounds from Salacia reticulata.
Biochemistry.
2010 Jan; 49(3):443-51. doi:
10.1021/bi9016457. [PMID: 20039683] - Genzoh Tanabe, Weijia Xie, Ai Ogawa, Changnian Cao, Toshie Minematsu, Masayuki Yoshikawa, Osamu Muraoka. Facile synthesis of de-O-sulfated salacinols: revision of the structure of neosalacinol, a potent alpha-glucosidase inhibitor.
Bioorganic & medicinal chemistry letters.
2009 Apr; 19(8):2195-8. doi:
10.1016/j.bmcl.2009.02.103. [PMID: 19307117] - Sankar Mohan, B Mario Pinto. Zwitterionic glycosidase inhibitors: salacinol and related analogues.
Carbohydrate research.
2007 Sep; 342(12-13):1551-80. doi:
10.1016/j.carres.2007.05.014. [PMID: 17559821] - Masayuki Yoshikawa, Toshio Morikawa, Hisashi Matsuda, Genzoh Tanabe, Osamu Muraoka. Absolute stereostructure of potent alpha-glucosidase inhibitor, Salacinol, with unique thiosugar sulfonium sulfate inner salt structure from Salacia reticulata.
Bioorganic & medicinal chemistry.
2002 May; 10(5):1547-54. doi:
10.1016/s0968-0896(01)00422-9. [PMID: 11886816] - A Ghavami, B D Johnston, M T Jensen, B Svensson, B M Pinto. Synthesis of nitrogen analogues of salacinol and their evaluation as glycosidase inhibitors.
Journal of the American Chemical Society.
2001 Jul; 123(26):6268-71. doi:
10.1021/ja0103750. [PMID: 11427050] - A Ghavami, B D Johnston, B M Pinto. A new class of glycosidase inhibitor: synthesis of salacinol and its stereoisomers.
The Journal of organic chemistry.
2001 Apr; 66(7):2312-7. doi:
10.1021/jo001444g. [PMID: 11281771]