Nefopam (BioDeep_00000181602)

   

human metabolite blood metabolite


代谢物信息卡片


5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine

化学式: C17H19NO (253.14665639999998)
中文名称: 奈福泮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCOC(C2=CC=CC=C2)C2=CC=CC=C2C1
InChI: InChI=1S/C17H19NO/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18/h2-10,17H,11-13H2,1H3

描述信息

C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D002491 - Central Nervous System Agents > D000700 - Analgesics
N - Nervous system > N02 - Analgesics

同义名列表

12 个代谢物同义名

5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine; Biocodex brand OF nefopam hydrochloride; Krewel brand OF nefopam hydrochloride; 3m Brand OF nefopam hydrochloride; Hydrochloride, nefopam; Nefopam hydrochloride; Nefopam, silentan; Silentan nefopam; Fenazoxine; nefopam; Acupan; Ajan



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Aravind Mittur. A Simultaneous Mixed-Effects Pharmacokinetic Model for Nefopam, N-desmethylnefopam, and Nefopam N-Oxide in Human Plasma and Urine. European journal of drug metabolism and pharmacokinetics. 2018 Aug; 43(4):391-404. doi: 10.1007/s13318-017-0457-3. [PMID: 29305813]
  • Mahesh Gokara, Vidadala V Narayana, Vineet Sadarangani, Shatabdi Roy Chowdhury, Sreelaxmi Varkala, Dhevalapally B Ramachary, Rajagopal Subramanyam. Unravelling the binding mechanism and protein stability of human serum albumin while interacting with nefopam analogues: a biophysical and insilico approach. Journal of biomolecular structure & dynamics. 2017 Aug; 35(10):2280-2292. doi: 10.1080/07391102.2016.1216895. [PMID: 27453381]
  • N E Baka, F Vial, G Iohom, P Guerci, C Hubert, M Rouabah, H Bouaziz. The effect of nefopam on lactation after caesarean section: a single-blind randomised trial. International journal of obstetric anesthesia. 2017 May; 31(?):84-90. doi: 10.1016/j.ijoa.2017.02.005. [PMID: 28347572]
  • Jian Yu, Eric Solon, Helen Shen, Nishit B Modi, Aravind Mittur. Pharmacokinetics, distribution, metabolism, and excretion of the dual reuptake inhibitor [(14)C]-nefopam in rats. Xenobiotica; the fate of foreign compounds in biological systems. 2016 Nov; 46(11):1026-48. doi: 10.3109/00498254.2016.1145755. [PMID: 26927982]
  • Madhu Sanga, John Banach, Aaron Ledvina, Nishit B Modi, Aravind Mittur. Pharmacokinetics, metabolism, and excretion of nefopam, a dual reuptake inhibitor in healthy male volunteers. Xenobiotica; the fate of foreign compounds in biological systems. 2016 Nov; 46(11):1001-16. doi: 10.3109/00498254.2015.1136989. [PMID: 26796604]
  • S Y Kim, K H Huh, Y H Roh, Y J Oh, J Park, Y S Choi. Nefopam as an adjunct to intravenous patient-controlled analgesia after renal transplantation: a randomised trial. Acta anaesthesiologica Scandinavica. 2015 Sep; 59(8):1068-75. doi: 10.1111/aas.12519. [PMID: 25903742]
  • L Nitin Seetohul, Giorgia De Paoli, Gail Drummond, Peter D Maskell. Nefopam Hydrochloride: A Fatal Overdose. Journal of analytical toxicology. 2015 Jul; 39(6):486-9. doi: 10.1093/jat/bkv036. [PMID: 25855761]
  • Meng Lv, Xuetao Wang, Wendong Qu, Mengjie Liu, Yuelan Wang. Nefopam for the prevention of perioperative shivering: a meta-analysis of randomized controlled trials. BMC anesthesiology. 2015 Jun; 15(?):87. doi: 10.1186/s12871-015-0068-y. [PMID: 26055978]
  • Sun Young Lee, Min-Gul Kim. The effect of modulated electro-hyperthermia on the pharmacokinetic properties of nefopam in healthy volunteers: A randomised, single-dose, crossover open-label study. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 2015; 31(8):869-74. doi: 10.3109/02656736.2015.1095358. [PMID: 26507458]
  • Tingting Hong, Cuijie Chi, Yibing Ji. Pepsin-modified chiral monolithic column for affinity capillary electrochromatography. Journal of separation science. 2014 Nov; 37(22):3377-83. doi: 10.1002/jssc.201400424. [PMID: 25146884]
  • O K Levchenko, E M Shulutko, É G Gemdzhian, V M Gorodetskiĭ. [Thrombocytopenia and postoperative analgesia]. Anesteziologiia i reanimatologiia. 2014 Sep; 59(5):27-32. doi: NULL. [PMID: 25842937]
  • Zoubir Djerada, Aurélie Fournet-Fayard, Claire Gozalo, Chantal Lelarge, Denis Lamiable, Hervé Millart, Jean-Marc Malinovsky. Population pharmacokinetics of nefopam in elderly, with or without renal impairment, and its link to treatment response. British journal of clinical pharmacology. 2014 Jun; 77(6):1027-38. doi: 10.1111/bcp.12291. [PMID: 24252055]
  • Lee Jae Dam, Lin Hai, Yoon Myung Ha. Role of the 5-HT(7) receptor in the effects of intrathecal nefopam in neuropathic pain in rats. Neuroscience letters. 2014 Apr; 566(?):50-4. doi: 10.1016/j.neulet.2014.02.021. [PMID: 24561091]
  • T Podranski, T W Bouillon, T Riva, A M Kurz, M J Oehmke. Compartmental pharmacokinetics of nefopam during mild hypothermia. British journal of anaesthesia. 2012 May; 108(5):784-91. doi: 10.1093/bja/aer517. [PMID: 22331396]
  • Tarek Dendane, Khalid Abidi, Naoufel Madani, Asmae Benthami, Fatima-Zohra Gueddari, Redoune Abouqal, Amine-Ali Zeggwagh. Reversible myocarditis after black widow spider envenomation. Case reports in medicine. 2012; 2012(?):794540. doi: 10.1155/2012/794540. [PMID: 22319538]
  • Mahmood Ahmad, Muhammad Yaqoob, Ghulam Murtaza. Study of pharmacokinetics and comparative bioavailability of nefopam 30 mg tablets in twelve fasting healthy Pakistani male young subjects: single-dose, randomized, two-period, two-treatment and two-way cross-over design. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2012; 21(3):271-6. doi: 10.1159/000333560. [PMID: 22123270]
  • Olivier Mimoz, Stéphane Chauvet, Nicolas Grégoire, Sandrine Marchand, Marie-Emmanuelle Le Guern, Ashraf Saleh, William Couet, Bertrand Debaene, René H Levy. Nefopam pharmacokinetics in patients with end-stage renal disease. Anesthesia and analgesia. 2010 Nov; 111(5):1146-53. doi: 10.1213/ane.0b013e3181f33488. [PMID: 20971961]
  • Marc Vergnolles, Hervé Wallerand, Francis Gadrat, Sylvie Maurice-Tison, Edouard Deti, Philippe Ballanger, Jean-Marie Ferriere, Grégoire Robert. Predictive risk factors for pain during extracorporeal shockwave lithotripsy. Journal of endourology. 2009 Dec; 23(12):2021-7. doi: 10.1089/end.2009.0111. [PMID: 19821695]
  • Xiaofan Sui, Jin Sun, Haiyan Li, Yongjun Wang, Jianfang Liu, Xiaohong Liu, Wenping Zhang, Lijiang Chen, Zhonggui He. Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry. 2009 Nov; 44(11):4455-60. doi: 10.1016/j.ejmech.2009.06.004. [PMID: 19586686]
  • Pintu De, N Damodharan, Subrata Mallick, Biswajit Mukherjee. Development and evaluation of nefopam transdermal matrix patch system in human volunteers. PDA journal of pharmaceutical science and technology. 2009 Nov; 63(6):537-46. doi: NULL. [PMID: 20169860]
  • K S Reid. Positive interference of the analgesic nefopam in the urine immunoassay for benzodiazepines in a secure setting. Journal of psychopharmacology (Oxford, England). 2009 Nov; 23(8):997. doi: 10.1177/0269881108094298. [PMID: 18635712]
  • Lukás Chytil, Martin Stícha, Olga Matousková, Frantisek Perlík, Ondrej Slanar. Enatiomeric determination of tramadol and O-desmethyltramadol in human urine by gas chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Jul; 877(20-21):1937-42. doi: 10.1016/j.jchromb.2009.04.042. [PMID: 19482526]
  • Hong Wan, Madeleine Ahman, Anders G Holmén. Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry. 2009 Mar; 52(6):1693-700. doi: 10.1021/jm801441s. [PMID: 19256501]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • M Ould-Ahmed, I Drouillard, A El-Kartouti, P-F Wey, C Lions, J-Y Martinez. [Nefopam by continuous intravenous injection and adverse drug reactions: which causality assessment?]. Annales francaises d'anesthesie et de reanimation. 2007 Jan; 26(1):74-6. doi: 10.1016/j.annfar.2006.07.080. [PMID: 17158020]
  • Oliver Kimberger, Syed Z Ali, Monica Markstaller, Sandra Zmoos, Rolf Lauber, Corinne Hunkeler, Andrea Kurz. Meperidine and skin surface warming additively reduce the shivering threshold: a volunteer study. Critical care (London, England). 2007; 11(1):R29. doi: 10.1186/cc5709. [PMID: 17316456]
  • Guillaume Hoizey, Anne Goglin, Jean-Marc Malinovsky, Arnaud Robinet, Laurent Binet, Matthieu L Kaltenbach, Hervé Millart, Denis Lamiable. Specific and sensitive analysis of nefopam and its main metabolite desmethyl-nefopam in human plasma by liquid chromatography-ion trap tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2006 Nov; 42(5):593-600. doi: 10.1016/j.jpba.2006.05.024. [PMID: 16842961]
  • Pascal Alfonsi, Frederic Adam, Andrea Passard, Bruno Guignard, Daniel I Sessler, Marcel Chauvin. Nefopam, a nonsedative benzoxazocine analgesic, selectively reduces the shivering threshold in unanesthetized subjects. Anesthesiology. 2004 Jan; 100(1):37-43. doi: 10.1097/00000542-200401000-00010. [PMID: 14695722]
  • Veniero Gambaro, Claudio Benvenuti, Lucia De Ferrari, Lucia Dell'Acqua, Fiorenza Farè. Validation of a GC/MS method for the determination of tramadol in human plasma after intravenous bolus. Farmaco (Societa chimica italiana : 1989). 2003 Sep; 58(9):947-50. doi: 10.1016/s0014-827x(03)00153-8. [PMID: 13679190]
  • Guy Aymard, Dominique Warot, Pierre Démolis, Jean François Giudicelli, Philippe Lechat, Marie Emmanuelle Le Guern, Christine Alquier, Bertrand Diquet. Comparative pharmacokinetics and pharmacodynamics of intravenous and oral nefopam in healthy volunteers. Pharmacology & toxicology. 2003 Jun; 92(6):279-86. doi: 10.1034/j.1600-0773.2003.920605.x. [PMID: 12787260]
  • Jyoti Chawla, Marie-Emmanuelle Le Guern, Christine Alquier, Thomas F Kalhorn, René H Levy. Effect of route of administration on the pharmacokinetic behavior of enantiomers of nefopam and desmethylnefopam. Therapeutic drug monitoring. 2003 Apr; 25(2):203-10. doi: 10.1097/00007691-200304000-00010. [PMID: 12657915]
  • G Aymard, D Warot, P Demolis, I Laville, B Diquet. Sensitive determination of nefopam and its metabolite desmethyl-nefopam in human biological fluids by HPLC. Journal of pharmaceutical and biomedical analysis. 2002 Nov; 30(4):1013-21. doi: 10.1016/s0731-7085(02)00443-0. [PMID: 12408892]
  • G G Mather, R Labroo, M E Le Guern, F Lepage, J M Gillardin, R H Levy. Nefopam enantiomers: preclinical pharmacology/toxicology and pharmacokinetic characteristics in healthy subjects after intravenous administration. Chirality. 2000 Mar; 12(3):153-9. doi: 10.1002/(sici)1520-636x(2000)12:3<153::aid-chir9>3.0.co;2-v. [PMID: 10689295]
  • L C Burton, N J Loftus, D W Vere, R Whelpton. Determination of plasma nefopam by liquid chromatography and electrochemical detection. Journal of chromatography. 1990 Mar; 526(1):159-68. doi: 10.1016/s0378-4347(00)82493-7. [PMID: 2341527]
  • S Conigliaro, R Rosà, F Osimo, E Fumagalli, G Cavaliere, G Arrigo. [Chronic headache]. Minerva medica. 1987 Jul; 78(14):1089-92. doi: NULL. [PMID: 2885789]
  • D T Liu, J M Savage, D Donnell. Nefopam excretion in human milk. British journal of clinical pharmacology. 1987 Jan; 23(1):99-101. doi: 10.1111/j.1365-2125.1987.tb03017.x. [PMID: 3814467]
  • U Bondesson, I M Johansson. Determination of nefopam in equine plasma by gas chromatography-mass spectrometry with chemical ionization. Journal of chromatography. 1986 Apr; 377(?):379-83. doi: 10.1016/s0378-4347(00)80797-5. [PMID: 3711231]
  • S F Chang, C S Hansen, J M Fox, R E Ober. Quantitative determination of nefopam in human plasma, saliva and cerebrospinal fluid by gas-liquid chromatography using a nitrogen-selective detector. Journal of chromatography. 1981 Nov; 226(1):79-89. doi: 10.1016/s0378-4347(00)84208-5. [PMID: 7320157]
  • D Schuppan, C S Hansen, R E Ober. GLC determination of nanogram quantities of a new analgesic, nefopam, in human plasma. Journal of pharmaceutical sciences. 1978 Dec; 67(12):1720-3. doi: 10.1002/jps.2600671223. [PMID: 722488]
  • S Ebel, H Schütz. [Biotransformation of nefopam (Ajan), I: isolation and identification of the main metabolite and some other metabolites (author's transl)]. Archiv der Pharmazie. 1978 Jun; 311(6):547-52. doi: 10.1002/ardp.19783110616. [PMID: 678062]
  • H Ehrsson, S Eksborg. Quantitative gas chromatographic determination of nefopam in plasma. Journal of chromatography. 1977 Jun; 136(1):154-8. doi: 10.1016/s0021-9673(00)83004-6. [PMID: 885955]
  • B J Baltes. Gastrointestinal blood loss study with a new analgesic compound: nefopam hydrochloride. Journal of clinical pharmacology. 1977 Feb; 17(2-3):120-4. doi: 10.1002/j.1552-4604.1977.tb04597.x. [PMID: 319121]
  • K C Lasseter, A Cohen, E L Back. Nefopam HCl interaction study with eight other drugs. The Journal of international medical research. 1976; 4(3):195-201. doi: 10.1177/030006057600400308. [PMID: 16799]