Nebicapone (BioDeep_00000181594)

   

human metabolite blood metabolite


代谢物信息卡片


1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethan-1-one

化学式: C14H11NO5 (273.0637)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)CC(=O)C2=CC(=C(C(=C2)O)O)[N+](=O)[O-]
InChI: InChI=1S/C14H11NO5/c16-12(6-9-4-2-1-3-5-9)10-7-11(15(19)20)14(18)13(17)8-10/h1-5,7-8,17-18H,6H2

描述信息

C78272 - Agent Affecting Nervous System > C38149 - Antiparkinsonian Agent
C471 - Enzyme Inhibitor

同义名列表

4 个代谢物同义名

1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethan-1-one; 1-(3,4-Dihydroxy-5-nitrophenyl)-2-phenylethanone; Nebicapone; BIA 3-202



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Daniela Gonçalves, Gilberto Alves, Patrício Soares-da-Silva, Amílcar Falcão. Bioanalytical chromatographic methods for the determination of catechol-O-methyltransferase inhibitors in rodents and human samples: a review. Analytica chimica acta. 2012 Jan; 710(?):17-32. doi: 10.1016/j.aca.2011.10.026. [PMID: 22123108]
  • José Paulo Sousa e Silva, José S Lobo, Maria J Bonifácio, Rita Machado, Amílcar Falcão, Patrício Soares-da-Silva. In-vivo evaluation of prolonged release bilayer tablets of anti-Parkinson drugs in Göttingen minipigs. The Journal of pharmacy and pharmacology. 2011 Jun; 63(6):780-5. doi: 10.1111/j.2042-7158.2011.01278.x. [PMID: 21585375]
  • Lyndon C Wright, Joana Maia, Ana I Loureiro, Luis Almeida, Patrício Soares-Da-Silva. Pharmacokinetics, disposition, and metabolism of [14C]-nebicapone in humans. Drug metabolism letters. 2010 Aug; 4(3):149-62. doi: 10.2174/187231210791698465. [PMID: 20642448]
  • Luis Almeida, Ana I Loureiro, Manuel Vaz-da-Silva, Leonel Torrão, Joana Maia, Carlos Fernandes-Lopes, Amílcar Falcão, Bruno Igreja, Lyndon Wright, Patricio Soares-da-Silva. Chronopharmacology of nebicapone, a new catechol-O-methyltransferase inhibitor. Current medical research and opinion. 2010 May; 26(5):1097-108. doi: 10.1185/03007991003694472. [PMID: 20225994]
  • Maria João Bonifácio, Ana I Loureiro, Leonel Torrão, Carlos Fernandes-Lopes, Lyndon Wright, Maria João Pinho, Patrício Soares-da-Silva. Species differences in pharmacokinetic and pharmacodynamic properties of nebicapone. Biochemical pharmacology. 2009 Oct; 78(8):1043-51. doi: 10.1016/j.bcp.2009.05.036. [PMID: 19505437]
  • Teresa Nunes, Rita Machado, José F Rocha, Carlos Fernandes-Lopes, Raquel Costa, Leonel Torrão, Ana I Loureiro, Amílcar Falcão, Manuel Vaz-da-Silva, Lyndon Wright, Luis Almeida, Patricio Soares-da-Silva. Pharmacokinetic-pharmacodynamic interaction between nebicapone and controlled-release levodopa/benserazide: a single-center, Phase I, double-blind, randomized, placebo-controlled, four-way crossover study in healthy subjects. Clinical therapeutics. 2009 Oct; 31(10):2258-71. doi: 10.1016/j.clinthera.2009.10.019. [PMID: 19922897]
  • Manuel Vaz-da-Silva, Ana I Loureiro, Teresa Nunes, Carlos Lopes, José Rocha, Rita Machado, Raquel Costa, Leonel Torrão, Amílcar Falcão, Lyndon Wright, Luis Almeida, Patrício Soares-da-Silva. Pharmacokinetic-pharmacodynamic interaction between nebicapone, a novel catechol-o-methyltransferase inhibitor, and controlled-release levodopa/carbidopa 200 mg/50 mg : randomized, double-blind, placebo-controlled, crossover study in healthy subjects. Drugs in R&D. 2008; 9(6):435-46. doi: 10.2165/0126839-200809060-00006. [PMID: 18989992]
  • Joaquim J Ferreira, Luis Almeida, Luis Cunha, Marina Ticmeanu, Mário M Rosa, Cristina Januário, Cristina-Elena Mitu, Miguel Coelho, Leonor Correia-Guedes, Ana Morgadinho, Teresa Nunes, Lyndon C Wright, Amílcar Falcão, Cristina Sampaio, Patrício Soares-da-Silva. Effects of nebicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity, and motor fluctuations in patients with Parkinson disease. Clinical neuropharmacology. 2008 Jan; 31(1):2-18. doi: 10.1097/wnf.0b013e3180645cb0. [PMID: 18303486]
  • A I Loureiro, M J Bonifácio, C Fernandes-Lopes, L Almeida, L C Wright, P Soares-Da-Silva. Human metabolism of nebicapone (BIA 3-202), a novel catechol-o-methyltransferase inhibitor: characterization of in vitro glucuronidation. Drug metabolism and disposition: the biological fate of chemicals. 2006 Nov; 34(11):1856-62. doi: 10.1124/dmd.106.010447. [PMID: 16790555]
  • Luis Almeida, Manuel Vaz-da-Silva, Pedro Silveira, Amilcar Falcão, Joana Maia, Ana Loureiro, Leonel Torrão, Rita Machado, Lyndon Wright, Patrício Soares-da-Silva. Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/carbidopa. Clinical neuropharmacology. 2004 Jan; 27(1):17-24. doi: 10.1097/00002826-200401000-00007. [PMID: 15090932]
  • Luis Almeida, Patrício Soares-da-Silva. Pharmacokinetic and pharmacodynamic profiles of BIA 3-202, a novel catechol-O-methyltransferase (COMT) inhibitor, during multiple-dose administration to healthy subjects. Journal of clinical pharmacology. 2003 Dec; 43(12):1350-60. doi: 10.1177/0091270003258666. [PMID: 14615471]
  • Pedro Silveira, Manuel Vaz-da-Silva, Luis Almeida, Joana Maia, Amilcar Falcão, Ana Loureiro, Leonel Torrão, Rita Machado, Lyndon Wright, Patrício Soares-da-Silva. Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/benserazide. European journal of clinical pharmacology. 2003 Nov; 59(8-9):603-9. doi: 10.1007/s00228-003-0680-5. [PMID: 14517707]
  • Luis Almeida, Patrício Soares-da-Silva. Pharmacokinetics and pharmacodynamics of BIA 3-202, a novel COMT inhibitor, during first administration to humans. Drugs in R&D. 2003; 4(4):207-17. doi: 10.2165/00126839-200304040-00001. [PMID: 12848585]
  • A Parada, A I Loureiro, M A Vieira-Coelho, D Hainzl, P Soares-da-Silva. BIA 3-202, a novel catechol-O-methyltransferase inhibitor, enhances the availability of L-DOPA to the brain and reduces its O-methylation. European journal of pharmacology. 2001 May; 420(1):27-32. doi: 10.1016/s0014-2999(01)01020-2. [PMID: 11412836]