Naphthoxylactic acid (BioDeep_00000181556)
human metabolite blood metabolite
代谢物信息卡片
化学式: C13H12O4 (232.0735552)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 50%
分子结构信息
SMILES: C1=CC=C2C(=C1)C=CC=C2OCC(C(=O)O)O
InChI: InChI=1S/C13H12O4/c14-11(13(15)16)8-17-12-7-3-5-9-4-1-2-6-10(9)12/h1-7,11,14H,8H2,(H,15,16)
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 115274
- HMDB: HMDB0255452
- ChEMBL: CHEMBL3544711
- chemspider: 103139
- CAS: 94537-05-0
- CAS: 10476-54-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- M J Ruiz-Angel, P Fernández-López, J A Murillo-Pulgarín, M C García-Alvarez-Coque. Control of propranolol intake by direct chromatographic detection of alpha-naphthoxylactic acid in urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2002 Feb; 767(2):277-83. doi:
10.1016/s1570-0232(01)00571-2
. [PMID: 11885857] - J A Murillo Pulgarín, A Alañón Molina. Direct determination of 1-naphthoxylactic acid in biological fluids by non-protected fluid room temperature phosphorimetry.
Fresenius' journal of analytical chemistry.
2000 Nov; 368(5):505-10. doi:
10.1007/s002160000496
. [PMID: 11227534] - T Walle, K Walle, R S Mathur, Y Y Palesch, E C Conradi. Propranolol metabolism in normal subjects: association with sex steroid hormones.
Clinical pharmacology and therapeutics.
1994 Aug; 56(2):127-32. doi:
10.1038/clpt.1994.115
. [PMID: 8062488] - T Ogiso, M Iwaki, T Tanino, R Kawafuchi, S Hata. Effect of food on propranolol oral clearance and a possible mechanism of this food effect.
Biological & pharmaceutical bulletin.
1994 Jan; 17(1):112-6. doi:
10.1248/bpb.17.112
. [PMID: 8148797] - T Walle, U K Walle, T D Cowart, E C Conradi, T E Gaffney. Selective induction of propranolol metabolism by smoking: additional effects on renal clearance of metabolites.
The Journal of pharmacology and experimental therapeutics.
1987 Jun; 241(3):928-33. doi:
NULL
. [PMID: 3598909] - P M Harrison, A M Tonkin, S T Dixon, A J McLean. Determination of alpha-naphthoxylactic acid, a major metabolite of propranolol, in plasma by high-performance liquid chromatography.
Journal of chromatography.
1986 Jan; 374(1):223-5. doi:
10.1016/s0378-4347(00)83277-6
. [PMID: 3949934] - M W Lo, S M Pond, D J Effeney, B M Silber, S Riegelman, T N Tozer. Nonlinear formation of propranolol metabolites in dogs after portacaval transpositions.
Journal of pharmacokinetics and biopharmaceutics.
1984 Aug; 12(4):401-12. doi:
10.1007/bf01062665
. [PMID: 6527232] - H Takei, H Ogata, A Ejima. Determination of propranolol and its major metabolite, naphthoxylactic acid, in human plasma by high performance liquid chromatography.
Chemical & pharmaceutical bulletin.
1983 Apr; 31(4):1392-4. doi:
10.1248/cpb.31.1392
. [PMID: 6627514] - M T Smith, I Livingstone, W D Hooper, M J Eadie, E J Triggs. Propranolol, propranolol glucuronide, and naphthoxylactic acid in breast milk and plasma.
Therapeutic drug monitoring.
1983; 5(1):87-93. doi:
10.1097/00007691-198303000-00008
. [PMID: 6845404] - I Livingstone, P W Craswell, E B Bevan, M T Smith, M J Eadie. Propranolol in pregnancy three year prospective study.
Clinical and experimental hypertension. Part B, Hypertension in pregnancy.
1983; 2(2):341-50. doi:
10.3109/10641958309006092
. [PMID: 6872291] - D E Easterling, T Walle, E C Conradi, T E Gaffney. Quantitative analysis of naphthoxylactic acid, a major metabolite of propranolol in plasma in man.
Journal of chromatography.
1979 Mar; 162(3):439-45. doi:
10.1016/s0378-4347(00)81533-9
. [PMID: 528611] - F Pritchard, D Schneck, A Hayes. Measurement of naphthoxylactic and naphtoxyacetic acid in human plasma following propranolol administration.
Research communications in chemical pathology and pharmacology.
1979 Feb; 23(2):279-86. doi:
. [PMID: 461953]