2,3-Diethylbut-2-enedioic acid (BioDeep_00000181509)
human metabolite blood metabolite
代谢物信息卡片
diethylbut-2-enedioic acid
化学式: C8H12O4 (172.0736)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: CCC(C(O)=O)=C(CC)C(O)=O
InChI: InChI=1S/C8H12O4/c1-3-5(7(9)10)6(4-2)8(11)12/h3-4H2,1-2H3,(H,9,10)(H,11,12)
描述信息
同义名列表
相关代谢途径
Reactome()
BioCyc()
PlantCyc()
代谢反应
个相关的代谢反应过程信息。
Reactome()
BioCyc()
WikiPathways()
Plant Reactome()
INOH()
PlantCyc()
COVID-19 Disease Map()
PathBank()
PharmGKB()
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Alison L Wadey, Hakan Muyderman, Perrin T Kwek, Neil R Sims. Mitochondrial glutathione uptake: characterization in isolated brain mitochondria and astrocytes in culture.
Journal of neurochemistry.
2009 May; 109 Suppl 1(?):101-8. doi:
10.1111/j.1471-4159.2009.05936.x. [PMID: 19393015] - Quynh T Tran, Lijing Xu, Vinhthuy Phan, Shirlean B Goodwin, Mostafizur Rahman, Victor X Jin, Carrie H Sutter, Bill D Roebuck, Thomas W Kensler, E Olusegun George, Thomas R Sutter. Chemical genomics of cancer chemopreventive dithiolethiones.
Carcinogenesis.
2009 Mar; 30(3):480-6. doi:
10.1093/carcin/bgn292. [PMID: 19126641] - Laura E Randle, Chris E P Goldring, Craig A Benson, Peter N Metcalfe, Neil R Kitteringham, B Kevin Park, Dominic P Williams. Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice.
Toxicology.
2008 Jan; 243(3):249-60. doi:
10.1016/j.tox.2007.10.011. [PMID: 18078705] - Toshiharu Oba, Yoshitaka Maeno, Masataka Nagao, Nagahiko Sakuma, Takashi Murayama. Cellular redox state protects acetaldehyde-induced alteration in cardiomyocyte function by modifying Ca2+ release from sarcoplasmic reticulum.
American journal of physiology. Heart and circulatory physiology.
2008 Jan; 294(1):H121-33. doi:
10.1152/ajpheart.00520.2007. [PMID: 17982019] - Bettina Ebert, Albrecht Seidel, Alfonso Lampen. Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
Toxicological sciences : an official journal of the Society of Toxicology.
2007 Apr; 96(2):227-36. doi:
10.1093/toxsci/kfl147. [PMID: 17077187] - Yoshiji Ohta, Mutsumi Kongo-Nishimura, Takahiro Hayashi, Akira Kitagawa, Tatsuya Matsura, Kazuo Yamada. Saikokeishito Extract Exerts a Therapeutic Effect on alpha-Naphthylisothiocyanate-Induced Liver Injury in Rats through Attenuation of Enhanced Neutrophil Infiltration and Oxidative Stress in the Liver Tissue.
Journal of clinical biochemistry and nutrition.
2007 Jan; 40(1):31-41. doi:
10.3164/jcbn.40.31. [PMID: 18437211] - Andrew J Phimister, Kurt J Williams, Laura S Van Winkle, Charles G Plopper. Consequences of abrupt glutathione depletion in murine Clara cells: ultrastructural and biochemical investigations into the role of glutathione loss in naphthalene cytotoxicity.
The Journal of pharmacology and experimental therapeutics.
2005 Aug; 314(2):506-13. doi:
10.1124/jpet.105.084533. [PMID: 15845860] - Hyekyung Yang, Mi Kyeong Lee, Young Choong Kim. Protective activities of stilbene glycosides from Acer mono leaves against H2O2-induced oxidative damage in primary cultured rat hepatocytes.
Journal of agricultural and food chemistry.
2005 May; 53(10):4182-6. doi:
10.1021/jf050093+. [PMID: 15884857] - Gerard Dijkstra, Hans Blokzijl, Lisette Bok, Manon Homan, Harry van Goor, Klaas Nico Faber, Peter L M Jansen, Han Moshage. Opposite effect of oxidative stress on inducible nitric oxide synthase and haem oxygenase-1 expression in intestinal inflammation: anti-inflammatory effect of carbon monoxide.
The Journal of pathology.
2004 Nov; 204(3):296-303. doi:
10.1002/path.1656. [PMID: 15476266] - Tetsuro Ishii, Ken Itoh, Emilio Ruiz, David S Leake, Hiroyuki Unoki, Masayuki Yamamoto, Giovanni E Mann. Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal.
Circulation research.
2004 Mar; 94(5):609-16. doi:
10.1161/01.res.0000119171.44657.45. [PMID: 14752028] - B F Kerimov. [Glutathione-deficient state of nervous tissues in starved animals intensifies lipid peroxidation and oxidation of protein SH-groups].
Ukrains'kyi biokhimichnyi zhurnal (1999 ).
2004 Jan; 76(1):108-13. doi:
". [PMID: 15909425] - Seung Hyun Kim, Young Pyo Jang, Sang Hyun Sung, Chang Jong Kim, Jin Woong Kim, Young Choong Kim. Hepatoprotective dibenzylbutyrolactone lignans of Torreya nucifera against CCl4-induced toxicity in primary cultured rat hepatocytes.
Biological & pharmaceutical bulletin.
2003 Aug; 26(8):1202-5. doi:
10.1248/bpb.26.1202. [PMID: 12913279] - Franca Esposito, Giuseppa Chirico, Nicola Montesano Gesualdi, Inmaculada Posadas, Rosario Ammendola, Tommaso Russo, Giuseppe Cirino, Filiberto Cimino. Protein kinase B activation by reactive oxygen species is independent of tyrosine kinase receptor phosphorylation and requires SRC activity.
The Journal of biological chemistry.
2003 Jun; 278(23):20828-34. doi:
10.1074/jbc.m211841200. [PMID: 12682076] - Christopher J Mingone, Sachin A Gupte, Shuo Quan, Nader G Abraham, Michael S Wolin. Influence of heme and heme oxygenase-1 transfection of pulmonary microvascular endothelium on oxidant generation and cGMP.
Experimental biology and medicine (Maywood, N.J.).
2003 May; 228(5):535-9. doi:
10.1177/15353702-0322805-22. [PMID: 12709582] - Yongmei Chen, Raymond A Swanson. The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures.
Journal of neurochemistry.
2003 Mar; 84(6):1332-9. doi:
10.1046/j.1471-4159.2003.01630.x. [PMID: 12614333] - M Vairetti, P Griffini, G Pietrocola, P Richelmi, I Freitas. Cold-induced apoptosis in isolated rat hepatocytes: protective role of glutathione.
Free radical biology & medicine.
2001 Oct; 31(8):954-61. doi:
10.1016/s0891-5849(01)00670-0. [PMID: 11595380] - M Takahashi, M Shibata, E Niki. Estimation of lipid peroxidation of live cells using a fluorescent probe, diphenyl-1-pyrenylphosphine.
Free radical biology & medicine.
2001 Jul; 31(2):164-74. doi:
10.1016/s0891-5849(01)00575-5. [PMID: 11440828] - A Zanovello, R Tolando, R Ferrara, S Bortolato, M Manno. Bioactivation to free radicals and cytotoxicity of 1,1-dichloro-1-fluoroethane (HCFC-141b).
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