2-Ethylicosa-2,4,6,8,10-pentaenoic acid (BioDeep_00000181496)
human metabolite blood metabolite
代谢物信息卡片
2-Ethylicosa-2,4,6,8,10-pentaenoic acid
化学式: C22H34O2 (330.2558664)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: CCCCCCCCCC=CC=CC=CC=CC=C(CC)C(O)=O
InChI: InChI=1S/C22H34O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21(4-2)22(23)24/h12-20H,3-11H2,1-2H3,(H,23,24)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
INOH(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- D W Luchtman, Q Meng, C Song. Ethyl-eicosapentaenoate (E-EPA) attenuates motor impairments and inflammation in the MPTP-probenecid mouse model of Parkinson's disease.
Behavioural brain research.
2012 Jan; 226(2):386-96. doi:
10.1016/j.bbr.2011.09.033. [PMID: 21971013] - Ellen Mozurkewich, Julie Chilimigras, Chelsea Klemens, Kristie Keeton, Lucy Allbaugh, Susan Hamilton, Deborah Berman, Delia Vazquez, Sheila Marcus, Zora Djuric, Anjel Vahratian. The mothers, Omega-3 and mental health study.
BMC pregnancy and childbirth.
2011 Jun; 11(?):46. doi:
10.1186/1471-2393-11-46. [PMID: 21696635] - Marija Bošković, Tomaž Vovk, Blanka Kores Plesničar, Iztok Grabnar. Oxidative stress in schizophrenia.
Current neuropharmacology.
2011 Jun; 9(2):301-12. doi:
10.2174/157015911795596595. [PMID: 22131939] - Mariska Bot, François Pouwer, Johanna Assies, Eugène H J M Jansen, Aartjan T F Beekman, Peter de Jonge. Supplementation with eicosapentaenoic omega-3 fatty acid does not influence serum brain-derived neurotrophic factor in diabetes mellitus patients with major depression: a randomized controlled pilot study.
Neuropsychobiology.
2011; 63(4):219-23. doi:
10.1159/000321804. [PMID: 21422768] - QingJia Meng, Dirk W Luchtman, Bouchaib El Bahh, Jeffrey A Zidichouski, Jun Yang, Cai Song. Ethyl-eicosapentaenoate modulates changes in neurochemistry and brain lipids induced by parkinsonian neurotoxin 1-methyl-4-phenylpyridinium in mouse brain slices.
European journal of pharmacology.
2010 Dec; 649(1-3):127-34. doi:
10.1016/j.ejphar.2010.09.046. [PMID: 20868657] - David Mischoulon, George I Papakostas, Christina M Dording, Amy H Farabaugh, Shamsah B Sonawalla, A Monica Agoston, Juliana Smith, Erin C Beaumont, Liat E Dahan, Jonathan E Alpert, Andrew A Nierenberg, Maurizio Fava. A double-blind, randomized controlled trial of ethyl-eicosapentaenoate for major depressive disorder.
The Journal of clinical psychiatry.
2009 Dec; 70(12):1636-44. doi:
10.4088/jcp.08m04603. [PMID: 19709502] - Nahoko Nemoto, Satoe Suzuki, Hiroyuki Kikuchi, Hitomi Okabe, Shuji Sassa, Shinobu Sakamoto. Ethyl-eicosapentaenoic acid reduces liver lipids and lowers plasma levels of lipids in mice fed a high-fat diet.
In vivo (Athens, Greece).
2009 Sep; 23(5):685-9. doi:
NULL. [PMID: 19779101] - Cai Song, Xiang Yang Zhang, Mehar Manku. Increased phospholipase A2 activity and inflammatory response but decreased nerve growth factor expression in the olfactory bulbectomized rat model of depression: effects of chronic ethyl-eicosapentaenoate treatment.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2009 Jan; 29(1):14-22. doi:
10.1523/jneurosci.3569-08.2009. [PMID: 19129380] - Paul E Keck, Jim Mintz, Susan L McElroy, Marlene P Freeman, Trisha Suppes, Mark A Frye, Lori L Altshuler, Ralph Kupka, Willem A Nolen, Gabriele S Leverich, Kirk D Denicoff, Heinz Grunze, Naihua Duan, Robert M Post. Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder.
Biological psychiatry.
2006 Nov; 60(9):1020-2. doi:
10.1016/j.biopsych.2006.03.056. [PMID: 16814257] - C B Joy, R Mumby-Croft, L A Joy. Polyunsaturated fatty acid supplementation for schizophrenia.
The Cochrane database of systematic reviews.
2006 Jul; ?(3):CD001257. doi:
10.1002/14651858.cd001257.pub2. [PMID: 16855961] - Gregor E Berger, Stefan Smesny, G Paul Amminger. Bioactive lipids in schizophrenia.
International review of psychiatry (Abingdon, England).
2006 Apr; 18(2):85-98. doi:
10.1080/09540260600583072. [PMID: 16777663] - M Kobayakawa, S Yamawaki, K Hamazaki, T Akechi, M Inagaki, Y Uchitomi. Levels of omega-3 fatty acid in serum phospholipids and depression in patients with lung cancer.
British journal of cancer.
2005 Dec; 93(12):1329-33. doi:
10.1038/sj.bjc.6602877. [PMID: 16306875] - Cai Song, Xuwen Li, Brian E Leonard, David F Horrobin. Effects of dietary n-3 or n-6 fatty acids on interleukin-1beta-induced anxiety, stress, and inflammatory responses in rats.
Journal of lipid research.
2003 Oct; 44(10):1984-91. doi:
10.1194/jlr.m300217-jlr200. [PMID: 12837849] - David Horrobin, M Rebecca Fokkema, Frits A J Muskiet. The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism.
Prostaglandins, leukotrienes, and essential fatty acids.
2003 May; 68(5):301-4. doi:
10.1016/s0952-3278(03)00007-3. [PMID: 12711245]