2-(Hydroxymethyl)pentanedial (BioDeep_00000181475)
human metabolite blood metabolite
代谢物信息卡片
化学式: C6H10O3 (130.062991)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CC(CO)C=O)C=O
InChI: InChI=1S/C6H10O3/c7-3-1-2-6(4-8)5-9/h3-4,6,9H,1-2,5H2
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Melissa M Kaczmarczyk, Michael J Miller, Gregory G Freund. The health benefits of dietary fiber: beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer.
Metabolism: clinical and experimental.
2012 Aug; 61(8):1058-66. doi:
10.1016/j.metabol.2012.01.017
. [PMID: 22401879] - Martin H Ellis, Lior Baraf, Aviv Shaish, Adi Har-Zahav, Dror Harats, Osnat Ashur-Fabian. Alteration of lipids and the transcription of lipid-related genes in myelodysplastic syndromes via a TP53-related pathway.
Experimental hematology.
2012 Jul; 40(7):540-547.e1. doi:
10.1016/j.exphem.2012.02.003
. [PMID: 22381680] - Idit Ginzberg, Muddarangappa Thippeswamy, Edna Fogelman, Ufuk Demirel, Alice M Mweetwa, James Tokuhisa, Richard E Veilleux. Induction of potato steroidal glycoalkaloid biosynthetic pathway by overexpression of cDNA encoding primary metabolism HMG-CoA reductase and squalene synthase.
Planta.
2012 Jun; 235(6):1341-53. doi:
10.1007/s00425-011-1578-6
. [PMID: 22205426] - Peng Zhang, Yanwei Hu, Junyao Yang, Lei Zheng, Qian Wang. The orphan nuclear receptor Nur77 regulates hepatic cholesterol metabolism through the suppression of LDLR and HMGCR expression.
Molecular medicine reports.
2012 06; 5(6):1541-7. doi:
10.3892/mmr.2012.850
. [PMID: 22470048] - Siddhartha S Saha, Anirban Chakraborty, Santinath Ghosh, Mahua Ghosh. Comparative study of hypocholesterolemic and hypolipidemic effects of conjugated linolenic acid isomers against induced biochemical perturbations and aberration in erythrocyte membrane fluidity.
European journal of nutrition.
2012 Jun; 51(4):483-95. doi:
10.1007/s00394-011-0233-0
. [PMID: 21814874] - Roger E Morgan, Stuart E Campbell, Kazuhito Suehira, Craig A Sponseller, Christine Y Yu, Matthew M Medlock. Effects of steady-state lopinavir/ritonavir on the pharmacokinetics of pitavastatin in healthy adult volunteers.
Journal of acquired immune deficiency syndromes (1999).
2012 Jun; 60(2):158-64. doi:
10.1097/qai.0b013e318251addb
. [PMID: 22627182] - Marisa Cabeza, Barak Naranjo, Yvonne Heuze, Araceli Sánchez, Mercedes Hernández, Teresita Sainz, Eugene Bratoeff. Molecular interactions of natural and synthetic steroids in female hamsters' flank organs.
Journal of dermatological science.
2012 May; 66(2):119-26. doi:
10.1016/j.jdermsci.2012.02.014
. [PMID: 22464229] - Xia Rui, Li Caiqin, Lu Wangjin, Du Juan, Wang Zehuai, Li Jianguo. 3-Hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) is highly associated with the cell division during the early stage of fruit development which determines the final fruit size in Litchi chinensis.
Gene.
2012 Apr; 498(1):28-35. doi:
10.1016/j.gene.2012.01.079
. [PMID: 22326527] - Nicole van Deenen, Anne-Lena Bachmann, Thomas Schmidt, Hubert Schaller, Jennifer Sand, Dirk Prüfer, Christian Schulze Gronover. Molecular cloning of mevalonate pathway genes from Taraxacum brevicorniculatum and functional characterisation of the key enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Molecular biology reports.
2012 Apr; 39(4):4337-49. doi:
10.1007/s11033-011-1221-4
. [PMID: 21833516] - Jingnan Chen, Yue Jiang, Yintong Liang, Xiaoyu Tian, Cheng Peng, Ka Ying Ma, Jian Liu, Yu Huang, Zhen-Yu Chen. DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and aortic function in hamsters fed a high cholesterol diet.
Atherosclerosis.
2012 Apr; 221(2):397-404. doi:
10.1016/j.atherosclerosis.2012.01.005
. [PMID: 22284366] - Nina Gårevik, Cristine Skogastierna, Anders Rane, Lena Ekström. Single dose testosterone increases total cholesterol levels and induces the expression of HMG CoA reductase.
Substance abuse treatment, prevention, and policy.
2012 Mar; 7(?):12. doi:
10.1186/1747-597x-7-12
. [PMID: 22433938] - Seung-Min Lee, Jiyoung Moon, Hyun Ju Do, Ji Hyung Chung, Kyung-Hea Lee, Yong-Jun Cha, Min-Jeong Shin. Onion peel extract increases hepatic low-density lipoprotein receptor and ATP-binding cassette transporter A1 messenger RNA expressions in Sprague-Dawley rats fed a high-fat diet.
Nutrition research (New York, N.Y.).
2012 Mar; 32(3):210-7. doi:
10.1016/j.nutres.2012.01.004
. [PMID: 22464808] - Xue-Zhong Zhao, Xu-Wen Li, Yong-Ri Jin, Xiao-Feng Yu, Shao-Chun Qu, Da-Yuan Sui. Hypolipidemic effects of kaempferide-7-O-(4''-O-acetylrhamnosyl)-3-O-rutinoside in hyperlipidemic rats induced by a high-fat diet.
Molecular medicine reports.
2012 03; 5(3):837-41. doi:
10.3892/mmr.2011.714
. [PMID: 22179545] - Janina Post, Nicole van Deenen, Julia Fricke, Natalie Kowalski, David Wurbs, Hubert Schaller, Wolfgang Eisenreich, Claudia Huber, Richard M Twyman, Dirk Prüfer, Christian Schulze Gronover. Laticifer-specific cis-prenyltransferase silencing affects the rubber, triterpene, and inulin content of Taraxacum brevicorniculatum.
Plant physiology.
2012 Mar; 158(3):1406-17. doi:
10.1104/pp.111.187880
. [PMID: 22238421] - Leigh Goedeke, Carlos Fernández-Hernando. Regulation of cholesterol homeostasis.
Cellular and molecular life sciences : CMLS.
2012 Mar; 69(6):915-30. doi:
10.1007/s00018-011-0857-5
. [PMID: 22009455] - Jae Yong Chung, Sung Kweon Cho, Eun Sil Oh, Dong Hwan Lee, Lay Ahyoung Lim, Seong Bok Jang, Yoon Jung Lee, Kyungsoo Park, Min Soo Park. Effect of HMGCR variant alleles on low-density lipoprotein cholesterol-lowering response to atorvastatin in healthy Korean subjects.
Journal of clinical pharmacology.
2012 Mar; 52(3):339-46. doi:
10.1177/0091270011398239
. [PMID: 21427285] - Gionata Scalcinati, Christoph Knuf, Siavash Partow, Yun Chen, Jérôme Maury, Michel Schalk, Laurent Daviet, Jens Nielsen, Verena Siewers. Dynamic control of gene expression in Saccharomyces cerevisiae engineered for the production of plant sesquitepene α-santalene in a fed-batch mode.
Metabolic engineering.
2012 Mar; 14(2):91-103. doi:
10.1016/j.ymben.2012.01.007
. [PMID: 22330799] - Dimitri Heintz, Sebastien Gallien, Vincent Compagnon, Anne Berna, Masashi Suzuki, Shigeo Yoshida, Toshiya Muranaka, Alain Van Dorsselaer, Christine Schaeffer, Thomas J Bach, Hubert Schaller. Phosphoproteome exploration reveals a reformatting of cellular processes in response to low sterol biosynthetic capacity in Arabidopsis.
Journal of proteome research.
2012 Feb; 11(2):1228-39. doi:
10.1021/pr201127u
. [PMID: 22182420] - Young Jun Kim, Soung-Jin Houng, Jae Hoon Kim, Young-Rok Kim, Hong Geun Ji, Sung-Joon Lee. Nanoemulsified green tea extract shows improved hypocholesterolemic effects in C57BL/6 mice.
The Journal of nutritional biochemistry.
2012 Feb; 23(2):186-91. doi:
10.1016/j.jnutbio.2010.11.015
. [PMID: 21447439] - H Robert Superko, Kathryn M Momary, Yonghong Li. Statins personalized.
The Medical clinics of North America.
2012 Jan; 96(1):123-39. doi:
10.1016/j.mcna.2011.11.004
. [PMID: 22391257] - K Mäkynen, C Chitchumroonchokchai, S Adisakwattana, M Failla, T Ariyapitipun. Effect of gamma-oryzanol on the bioaccessibility and synthesis of cholesterol.
European review for medical and pharmacological sciences.
2012 Jan; 16(1):49-56. doi:
"
. [PMID: 22338548] - Chan-Min Liu, Jie-Qiong Ma, Yun-Zhi Sun. Protective role of puerarin on lead-induced alterations of the hepatic glutathione antioxidant system and hyperlipidemia in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2011 Dec; 49(12):3119-27. doi:
10.1016/j.fct.2011.09.007
. [PMID: 22001170] - Tanya G Marsh, Rachel K Straub, Fatima Villalobos, Mee Young Hong. Soy protein supports cardiovascular health by downregulating hydroxymethylglutaryl-coenzyme A reductase and sterol regulatory element-binding protein-2 and increasing antioxidant enzyme activity in rats with dextran sodium sulfate-induced mild systemic inflammation.
Nutrition research (New York, N.Y.).
2011 Dec; 31(12):922-8. doi:
10.1016/j.nutres.2011.09.027
. [PMID: 22153518] - Su-Kyung Shin, Tae-Youl Ha, Robin A McGregor, Myung-Sook Choi. Long-term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism.
Molecular nutrition & food research.
2011 Dec; 55(12):1829-40. doi:
10.1002/mnfr.201100440
. [PMID: 22058071] - M Salman Khan, Salman Akhtar, Othman A Al-Sagair, Jamal M Arif. Protective effect of dietary tocotrienols against infection and inflammation-induced hyperlipidemia: an in vivo and in silico study.
Phytotherapy research : PTR.
2011 Nov; 25(11):1586-95. doi:
10.1002/ptr.3448
. [PMID: 21394808] - Sajesh Parathath, Stephanie L Mick, Jonathan E Feig, Victor Joaquin, Lisa Grauer, David M Habiel, Max Gassmann, Lawrence B Gardner, Edward A Fisher. Hypoxia is present in murine atherosclerotic plaques and has multiple adverse effects on macrophage lipid metabolism.
Circulation research.
2011 Oct; 109(10):1141-52. doi:
10.1161/circresaha.111.246363
. [PMID: 21921268] - Zhi-Hong Yang, Hiroko Miyahara, Jiro Takeo, Akimasa Hatanaka, Masashi Katayama. Pollock oil supplementation modulates hyperlipidemia and ameliorates hepatic steatosis in mice fed a high-fat diet.
Lipids in health and disease.
2011 Oct; 10(?):189. doi:
10.1186/1476-511x-10-189
. [PMID: 22027268] - Fahed Parvaiz, Sobia Manzoor, Huma Tariq, Farakh Javed, Kaneez Fatima, Ishtiaq Qadri. Hepatitis C virus infection: molecular pathways to insulin resistance.
Virology journal.
2011 Oct; 8(?):474. doi:
10.1186/1743-422x-8-474
. [PMID: 22008087] - John S Burg, Peter J Espenshade. Regulation of HMG-CoA reductase in mammals and yeast.
Progress in lipid research.
2011 Oct; 50(4):403-10. doi:
10.1016/j.plipres.2011.07.002
. [PMID: 21801748] - Iris Tiski, Pierre Marraccini, David Pot, Luiz Gonzaga Esteves Vieira, Luiz Filipe Protasio Pereira. Characterization and expression of two cDNA encoding 3-Hydroxy-3-methylglutaryl coenzyme A reductase isoforms in coffee (Coffea arabica L.).
Omics : a journal of integrative biology.
2011 Oct; 15(10):719-27. doi:
10.1089/omi.2010.0140
. [PMID: 21751872] - Koneni V Sashidhara, Suriya P Singh, Anuj Srivastava, Anju Puri, Yashpal S Chhonker, Rabi S Bhatta, Priyanka Shah, Mohammad Imran Siddiqi. Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent.
European journal of medicinal chemistry.
2011 Oct; 46(10):5206-11. doi:
10.1016/j.ejmech.2011.08.012
. [PMID: 21872367] - Huiming Guo, Xixiang Pei, Fanghao Wan, Hongmei Cheng. Molecular cloning of allelopathy related genes and their relation to HHO in Eupatorium adenophorum.
Molecular biology reports.
2011 Oct; 38(7):4651-6. doi:
10.1007/s11033-010-0599-8
. [PMID: 21127986] - Pravej Alam, M Z Abdin. Over-expression of HMG-CoA reductase and amorpha-4,11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content.
Plant cell reports.
2011 Oct; 30(10):1919-28. doi:
10.1007/s00299-011-1099-6
. [PMID: 21655998] - Bhaskar C Das, Xiaoping Zhao, Xiang-Ying Tang, Fajun Yang. Design, synthesis and biological study of pinacolyl boronate-substituted stilbenes as novel lipogenic inhibitors.
Bioorganic & medicinal chemistry letters.
2011 Sep; 21(18):5638-41. doi:
10.1016/j.bmcl.2011.05.124
. [PMID: 21798740] - Jennifer L Jones, Youngki Park, Jiyoung Lee, Robert H Lerman, Maria Luz Fernandez. A Mediterranean-style, low-glycemic-load diet reduces the expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in mononuclear cells and plasma insulin in women with metabolic syndrome.
Nutrition research (New York, N.Y.).
2011 Sep; 31(9):659-64. doi:
10.1016/j.nutres.2011.08.011
. [PMID: 22024489] - Daniel J Conklin, Russell A Prough, Peter Juvan, Tadeja Rezen, Damjana Rozman, Petra Haberzettl, Sanjay Srivastava, Aruni Bhatnagar. Acrolein-induced dyslipidemia and acute-phase response are independent of HMG-CoA reductase.
Molecular nutrition & food research.
2011 Sep; 55(9):1411-22. doi:
10.1002/mnfr.201100225
. [PMID: 21812109] - Ali Cm Johnson, Lorraine B Ware, Jonathan Himmelfarb, Richard A Zager. HMG-CoA reductase activation and urinary pellet cholesterol elevations in acute kidney injury.
Clinical journal of the American Society of Nephrology : CJASN.
2011 Sep; 6(9):2108-13. doi:
10.2215/cjn.02440311
. [PMID: 21799150] - Wei Gu, Bei-Li Xi, Qi-Nan Wu, Jian-Guo Chao, Lin Li, Xiu-Yuan Shen. [Cloning and distribution pattern of HMGR gene conserved fragment in Alisma orientale].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2011 Sep; 34(9):1335-9. doi:
"
. [PMID: 22259996] - Takumi Yamane, Kazuo Kobayashi-Hattori, Yuichi Oishi. A high-fat diet reduces ceramide synthesis by decreasing adiponectin levels and decreases lipid content by modulating HMG-CoA reductase and CPT-1 mRNA expression in the skin.
Molecular nutrition & food research.
2011 Sep; 55 Suppl 2(?):S186-92. doi:
10.1002/mnfr.201100144
. [PMID: 21732532] - Masato Fukushima, Joaquin Villar, Chon-Hwa Tsai-Morris, Maria L Dufau. Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25), a negative regulator of luteinizing/chorionic gonadotropin hormone-induced steroidogenesis in Leydig cells: central role of steroidogenic acute regulatory protein (StAR).
The Journal of biological chemistry.
2011 Aug; 286(34):29932-40. doi:
10.1074/jbc.m111.236083
. [PMID: 21719703] - Meritxell Antolín-Llovera, Pablo Leivar, Montserrat Arró, Albert Ferrer, Albert Boronat, Narciso Campos. Modulation of plant HMG-CoA reductase by protein phosphatase 2A: positive and negative control at a key node of metabolism.
Plant signaling & behavior.
2011 Aug; 6(8):1127-31. doi:
10.4161/psb.6.8.16363
. [PMID: 21701259] - Karen E Porter, Neil A Turner. Statins and myocardial remodelling: cell and molecular pathways.
Expert reviews in molecular medicine.
2011 Jul; 13(?):e22. doi:
10.1017/s1462399411001931
. [PMID: 21718586] - Hyung Sik Yoon, Sung Ho Kim, Jeong Kyung Kim, Sang Hun Ko, Jae Ee Ko, Soo Jin Park, Moon Gi Park, Jae Hwan Lee, Min Soo Hyon. Comparison of effects of morning versus evening administration of ezetimibe/simvastatin on serum cholesterol in patients with primary hypercholesterolemia.
The Annals of pharmacotherapy.
2011 Jul; 45(7-8):841-9. doi:
10.1345/aph.1p511
. [PMID: 21693699] - Yang Yuan, Lei Zhao, Yaxi Chen, John F Moorhead, Zac Varghese, Stephen H Powis, Shane Minogue, Zilin Sun, Xiong Z Ruan. Advanced glycation end products (AGEs) increase human mesangial foam cell formation by increasing Golgi SCAP glycosylation in vitro.
American journal of physiology. Renal physiology.
2011 Jul; 301(1):F236-43. doi:
10.1152/ajprenal.00646.2010
. [PMID: 21511699] - Ji Ho Park, Jae-Chul Choi, Moon-Hee Sung, Jae-Heon Kang, Moon-Jeong Chang. High molecular weight poly-gamma-glutamic acid regulates lipid metabolism in rats fed a high-fat diet and humans.
Journal of microbiology and biotechnology.
2011 Jul; 21(7):766-75. doi:
10.4014/jmb.1104.04047
. [PMID: 21791965] - Laura Trapani, Marco Segatto, Veronica Simeoni, Valentina Balducci, Ashish Dhawan, Virinder S Parmar, Ashok K Prasad, Luciano Saso, Sandra Incerpi, Valentina Pallottini. Short- and long-term regulation of 3-hydroxy 3-methylglutaryl coenzyme A reductase by a 4-methylcoumarin.
Biochimie.
2011 Jul; 93(7):1165-71. doi:
10.1016/j.biochi.2011.04.009
. [PMID: 21530605] - Hana Bak, Seung-Phil Hong, Se-Kyoo Jeong, Eung-Ho Choi, Sang E Lee, Seung-Hun Lee, Sung-Ku Ahn. Altered epidermal lipid layers induced by long-term exposure to suberythemal-dose ultraviolet.
International journal of dermatology.
2011 Jul; 50(7):832-7. doi:
10.1111/j.1365-4632.2010.04789.x
. [PMID: 21699519] - P V Luoma. Gene-activation mechanisms in the regression of atherosclerosis, elimination of diabetes type 2, and prevention of dementia.
Current molecular medicine.
2011 Jul; 11(5):391-400. doi:
10.2174/156652411795976556
. [PMID: 21568932] - Jingnan Chen, Yue Jiang, Ka Ying Ma, Feng Chen, Zhen-Yu Chen. Microalga decreases plasma cholesterol by down-regulation of intestinal NPC1L1, hepatic LDL receptor, and HMG-CoA reductase.
Journal of agricultural and food chemistry.
2011 Jun; 59(12):6790-7. doi:
10.1021/jf200757h
. [PMID: 21561085] - Chun-Hua Zeng, Ping Zeng, Yan-Hong Deng, Neng Shen, Ming-Li Peng, Qi Liu, Hong Ren. [The effects of curcumin derivative on experimental steatohepatitis].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2011 Jun; 19(6):454-9. doi:
NULL
. [PMID: 22053378] - Jiao Guo, Weijian Bei, Yinming Hu, Chunping Tang, Wei He, Xiaobo Liu, Lihua Huang, Yang Cao, Xuguang Hu, Xunlong Zhong, Le Cao. A new TCM formula FTZ lowers serum cholesterol by regulating HMG-CoA reductase and CYP7A1 in hyperlipidemic rats.
Journal of ethnopharmacology.
2011 May; 135(2):299-307. doi:
10.1016/j.jep.2011.03.012
. [PMID: 21396994] - Oni M Mapp, Gregory S Walsh, Cecilia B Moens, Masazumi Tada, Victoria E Prince. Zebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity.
Development (Cambridge, England).
2011 May; 138(10):2121-32. doi:
10.1242/dev.060442
. [PMID: 21521740] - Lei Zhao, Yaxi Chen, Renkuan Tang, Yao Chen, Qing Li, Jianping Gong, Ailong Huang, Zac Varghese, John F Moorhead, Xiong Z Ruan. Inflammatory stress exacerbates hepatic cholesterol accumulation via increasing cholesterol uptake and de novo synthesis.
Journal of gastroenterology and hepatology.
2011 May; 26(5):875-83. doi:
10.1111/j.1440-1746.2010.06560.x
. [PMID: 21488946] - K Patel, R Jhaveri, J George, G Qiang, C Kenedi, K Brown, C Cates, A Zekry, H L Tillmann, L Elliott, R Kilaru, J Albrecht, A Conrad, J G McHutchison. Open-label, ascending dose, prospective cohort study evaluating the antiviral efficacy of Rosuvastatin therapy in serum and lipid fractions in patients with chronic hepatitis C.
Journal of viral hepatitis.
2011 May; 18(5):331-7. doi:
10.1111/j.1365-2893.2010.01310.x
. [PMID: 20367801] - Jui-Hung Yen, Ching-Yi Weng, Shiming Li, Ya-Hsuan Lo, Min-Hsiung Pan, Shih-Hang Fu, Chi-Tang Ho, Ming-Jiuan Wu. Citrus flavonoid 5-demethylnobiletin suppresses scavenger receptor expression in THP-1 cells and alters lipid homeostasis in HepG2 liver cells.
Molecular nutrition & food research.
2011 May; 55(5):733-48. doi:
10.1002/mnfr.201000226
. [PMID: 21225617] - Massimiliano Cuccioloni, Matteo Mozzicafreddo, Michele Spina, Chi Nhan Tran, Maurizio Falconi, Anna Maria Eleuteri, Mauro Angeletti. Epigallocatechin-3-gallate potently inhibits the in vitro activity of hydroxy-3-methyl-glutaryl-CoA reductase.
Journal of lipid research.
2011 May; 52(5):897-907. doi:
10.1194/jlr.m011817
. [PMID: 21357570] - Qixians Rong, Qiaoxian Xu, Chunsheng Liu, Luqi Huang. [Cloning and characterization of 3-hydroxy-3-methylglutary CoA reductase cDNA of Glycyrrhiza uralensis].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2011 May; 36(10):1275-9. doi:
"
. [PMID: 21837964] - Jenna Waldron, Craig Webster. Liquid chromatography-tandem mass spectrometry method for the measurement of serum mevalonic acid: a novel marker of hydroxymethylglutaryl coenzyme A reductase inhibition by statins.
Annals of clinical biochemistry.
2011 May; 48(Pt 3):223-32. doi:
10.1258/acb.2010.010182
. [PMID: 21355014] - Marisa Wong Medina, Feng Gao, Devesh Naidoo, Lawrence L Rudel, Ryan E Temel, Allison L McDaniel, Stephanie M Marshall, Ronald M Krauss. Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake.
PloS one.
2011 Apr; 6(4):e19420. doi:
10.1371/journal.pone.0019420
. [PMID: 21559365] - Marcus O W Grimm, Johanna Kuchenbecker, Sven Grösgen, Verena K Burg, Benjamin Hundsdörfer, Tatjana L Rothhaar, Petra Friess, Martijn C de Wilde, Laus M Broersen, Botond Penke, Mária Péter, László Vígh, Heike S Grimm, Tobias Hartmann. Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms.
The Journal of biological chemistry.
2011 Apr; 286(16):14028-39. doi:
10.1074/jbc.m110.182329
. [PMID: 21324907] - Wei Xia, Caihong Sun, Yan Zhao, Lijie Wu. Hypolipidemic and antioxidant activities of sanchi (radix notoginseng) in rats fed with a high fat diet.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Apr; 18(6):516-20. doi:
10.1016/j.phymed.2010.09.007
. [PMID: 21036582] - Yan Lu, Linda J Savage, Matthew D Larson, Curtis G Wilkerson, Robert L Last. Chloroplast 2010: a database for large-scale phenotypic screening of Arabidopsis mutants.
Plant physiology.
2011 Apr; 155(4):1589-600. doi:
10.1104/pp.110.170118
. [PMID: 21224340] - Vincenzo Mollace, Iolanda Sacco, Elzbieta Janda, Claudio Malara, Domenica Ventrice, Carmen Colica, Valeria Visalli, Saverio Muscoli, Salvatore Ragusa, Carolina Muscoli, Domenicantonio Rotiroti, Franco Romeo. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies.
Fitoterapia.
2011 Apr; 82(3):309-16. doi:
10.1016/j.fitote.2010.10.014
. [PMID: 21056640] - Pablo Leivar, Meritxell Antolín-Llovera, Sergi Ferrero, Marta Closa, Montserrat Arró, Albert Ferrer, Albert Boronat, Narciso Campos. Multilevel control of Arabidopsis 3-hydroxy-3-methylglutaryl coenzyme A reductase by protein phosphatase 2A.
The Plant cell.
2011 Apr; 23(4):1494-511. doi:
10.1105/tpc.110.074278
. [PMID: 21478440] - Wing-Fat Yiu, Pui-Long Kwan, Cho-Yee Wong, Tsz-Shan Kam, Sin-Ming Chiu, Shun-Wan Chan, Robbie Chan. Attenuation of fatty liver and prevention of hypercholesterolemia by extract of Curcuma longa through regulating the expression of CYP7A1, LDL-receptor, HO-1, and HMG-CoA reductase.
Journal of food science.
2011 Apr; 76(3):H80-9. doi:
10.1111/j.1750-3841.2011.02042.x
. [PMID: 21535835] - Saloni Gill, Julian Stevenson, Ika Kristiana, Andrew J Brown. Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase.
Cell metabolism.
2011 Mar; 13(3):260-73. doi:
10.1016/j.cmet.2011.01.015
. [PMID: 21356516] - Nan Wu, Lindsei K Sarna, Yaw L Siow, Karmin O. Regulation of hepatic cholesterol biosynthesis by berberine during hyperhomocysteinemia.
American journal of physiology. Regulatory, integrative and comparative physiology.
2011 Mar; 300(3):R635-43. doi:
10.1152/ajpregu.00441.2010
. [PMID: 21178122] - Kwang Kon Koh, Ichiro Sakuma, Michael J Quon. Differential metabolic effects of distinct statins.
Atherosclerosis.
2011 Mar; 215(1):1-8. doi:
10.1016/j.atherosclerosis.2010.10.036
. [PMID: 21130454] - Antonio Pirodda, Gian Gaetano Ferri, Umberto Caliceti, Claudio Borghi. Could statins exert a protective effect on epistaxis of systemic origin?.
Medical hypotheses.
2011 Mar; 76(3):445-6. doi:
10.1016/j.mehy.2010.11.017
. [PMID: 21134722] - Asaf A Qureshi, Julia C Reis, Nilofer Qureshi, Christopher J Papasian, David C Morrison, Daniel M Schaefer. δ-Tocotrienol and quercetin reduce serum levels of nitric oxide and lipid parameters in female chickens.
Lipids in health and disease.
2011 Feb; 10(?):39. doi:
10.1186/1476-511x-10-39
. [PMID: 21356098] - Mônica Testoni Cardozo, Aline de Conti, Thomas Prates Ong, Clarissa Scolastici, Eduardo Purgatto, Maria Aderuza Horst, Bruna Kempfer Bassoli, Fernando Salvador Moreno. Chemopreventive effects of β-ionone and geraniol during rat hepatocarcinogenesis promotion: distinct actions on cell proliferation, apoptosis, HMGCoA reductase, and RhoA.
The Journal of nutritional biochemistry.
2011 Feb; 22(2):130-5. doi:
10.1016/j.jnutbio.2009.12.007
. [PMID: 20435455] - Parshuram J Sonawane, Bhavani S Sahu, Binu K Sasi, Parimala Geedi, Govinda Lenka, Nitish R Mahapatra. Functional promoter polymorphisms govern differential expression of HMG-CoA reductase gene in mouse models of essential hypertension.
PloS one.
2011 Jan; 6(1):e16661. doi:
10.1371/journal.pone.0016661
. [PMID: 21304971] - Guiyuan Ji, Xihong Zhao, Liang Leng, Peiyi Liu, Zhuoqin Jiang. Comparison of dietary control and atorvastatin on high fat diet induced hepatic steatosis and hyperlipidemia in rats.
Lipids in health and disease.
2011 Jan; 10(?):23. doi:
10.1186/1476-511x-10-23
. [PMID: 21269482] - S K Maurya, A K Srivastava. Glycyrrhizic acid attenuates the expression of HMG-CoA reductase mRNA in high fructose diet induced dyslipidemic hamsters.
Prague medical report.
2011; 112(1):29-37. doi:
. [PMID: 21470496]
- Yunjiu Cheng, Kai Tang, Suhua Wu, Lijuan Liu, Cancan Qiang, Xiaoxiong Lin, Bingqing Liu. Astragalus polysaccharides lowers plasma cholesterol through mechanisms distinct from statins.
PloS one.
2011; 6(11):e27437. doi:
10.1371/journal.pone.0027437
. [PMID: 22110652] - Gaofu Zhang, Qiu Li, Li Wang, Yaxi Chen, Lijia Wang, Wei Zhang. Interleukin-1β enhances the intracellular accumulation of cholesterol by up-regulating the expression of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase in podocytes.
Molecular and cellular biochemistry.
2011 Jan; 346(1-2):197-204. doi:
10.1007/s11010-010-0605-4
. [PMID: 20936497] - Nishant P Visavadiya, A V R L Narasimhacharya. Ameliorative effects of herbal combinations in hyperlipidemia.
Oxidative medicine and cellular longevity.
2011; 2011(?):160408. doi:
10.1155/2011/160408
. [PMID: 21941605] - Amir A Zeki, Nicholas J Kenyon, Tzipora Goldkorn. Statin drugs, metabolic pathways, and asthma: a therapeutic opportunity needing further research.
Drug metabolism letters.
2011 Jan; 5(1):40-4. doi:
10.2174/187231211794455217
. [PMID: 21198438] - O Weingärtner, D Lütjohann, M Böhm, U Laufs. [Cholesterol homeostasis and cardiovascular risk].
Deutsche medizinische Wochenschrift (1946).
2011 Jan; 136(1-2):34-8. doi:
10.1055/s-0030-1269438
. [PMID: 21181614] - Jessica P Otis, Daisy Sahoo, Victor A Drover, Chi-Liang Eric Yen, Hannah V Carey. Cholesterol and lipoprotein dynamics in a hibernating mammal.
PloS one.
2011; 6(12):e29111. doi:
10.1371/journal.pone.0029111
. [PMID: 22195001] - Claudia Tovar-Palacio, Armando R Tovar, Nimbe Torres, Cristino Cruz, Rogelio Hernández-Pando, Gerardo Salas-Garrido, José Pedraza-Chaverri, Ricardo Correa-Rotter. Proinflammatory gene expression and renal lipogenesis are modulated by dietary protein content in obese Zucker fa/fa rats.
American journal of physiology. Renal physiology.
2011 Jan; 300(1):F263-71. doi:
10.1152/ajprenal.00171.2010
. [PMID: 20962115] - Ruei-Lan Tsai, Bing-Ying Ho, Tzu-Ming Pan. Red Mold Rice Mitigates Oral Carcinogenesis in 7,12-Dimethyl-1,2-Benz[a]anthracene-Induced Oral Carcinogenesis in Hamster.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):245209. doi:
10.1093/ecam/nep215
. [PMID: 20019075] - Asaf A Qureshi, Julia C Reis, Christopher J Papasian, David C Morrison, Nilofer Qureshi. Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice.
Lipids in health and disease.
2010 Dec; 9(?):143. doi:
10.1186/1476-511x-9-143
. [PMID: 21162750] - Venkata M Alla, Kishlay Anand, Mandeep Hundal, Aimin Chen, Showri Karnam, Tom Hee, Claire Hunter, Aryan N Mooss, Dennis Esterbrooks, Syed M Mohiuddin. Impact of moderate to severe renal impairment on mortality and appropriate shocks in patients with implantable cardioverter defibrillators.
Cardiology research and practice.
2010 Dec; 2010(?):150285. doi:
10.4061/2010/150285
. [PMID: 21197424] - K Karthikesan, L Pari, V P Menon. Antihyperlipidemic effect of chlorogenic acid and tetrahydrocurcumin in rats subjected to diabetogenic agents.
Chemico-biological interactions.
2010 Dec; 188(3):643-50. doi:
10.1016/j.cbi.2010.07.026
. [PMID: 20696151] - Safdar Jawaid, Monica Gertz, Carlin Corsino, Jamie Cheung, Heather Seidle, Robin D Couch. Human hydroxymethylglutaryl-coenzyme A reductase (HMGCR) and statin sensitivity.
Indian journal of biochemistry & biophysics.
2010 Dec; 47(6):331-9. doi:
NULL
. [PMID: 21355415] - Lylia Miranda-Velasquez, Azucena Oranday-Cardenas, Hector Lozano-Garza, Catalina Rivas-Morales, German Chamorro-Cevallos, Delia Elva Cruz-Vega. Hypocholesterolemic activity from the leaf extracts of Cnidoscolus chayamansa.
Plant foods for human nutrition (Dordrecht, Netherlands).
2010 Dec; 65(4):392-5. doi:
10.1007/s11130-010-0202-4
. [PMID: 21104318] - Ravi S Singh, Rishi K Gara, Pardeep K Bhardwaj, Anish Kaachra, Sonia Malik, Ravi Kumar, Madhu Sharma, Paramvir S Ahuja, Sanjay Kumar. Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston].
BMC molecular biology.
2010 Nov; 11(?):88. doi:
10.1186/1471-2199-11-88
. [PMID: 21092138] - Mitsuru Watanabe, Jun Ayugase. Effects of buckwheat sprouts on plasma and hepatic parameters in type 2 diabetic db/db mice.
Journal of food science.
2010 Nov; 75(9):H294-9. doi:
10.1111/j.1750-3841.2010.01853.x
. [PMID: 21535603] - N Zaiden, W N Yap, S Ong, C H Xu, V H Teo, C P Chang, X W Zhang, K Nesaretnam, S Shiba, Y L Yap. Gamma delta tocotrienols reduce hepatic triglyceride synthesis and VLDL secretion.
Journal of atherosclerosis and thrombosis.
2010 Oct; 17(10):1019-32. doi:
10.5551/jat.4911
. [PMID: 20702976] - Aruna Poduri, Madhu Khullar, Ajay Bahl, B S Sehrawat, Yashpaul Sharma, Kewal K Talwar. Common variants of HMGCR, CETP, APOAI, ABCB1, CYP3A4, and CYP7A1 genes as predictors of lipid-lowering response to atorvastatin therapy.
DNA and cell biology.
2010 Oct; 29(10):629-37. doi:
10.1089/dna.2009.1008
. [PMID: 20578904] - H X Cui, S Y Yang, H Y Wang, J P Zhao, R R Jiang, G P Zhao, J L Chen, M Q Zheng, X H Li, J Wen. The effect of a mutation in the 3-UTR region of the HMGCR gene on cholesterol in Beijing-you chickens.
Animal biotechnology.
2010 Oct; 21(4):241-51. doi:
10.1080/10495398.2010.514777
. [PMID: 20967643] - Hyun Ju Kim, Jun Yuan, Keith Norris, Nosratola D Vaziri. High-calorie diet partially ameliorates dysregulation of intrarenal lipid metabolism in remnant kidney.
The Journal of nutritional biochemistry.
2010 Oct; 21(10):999-1007. doi:
10.1016/j.jnutbio.2009.08.006
. [PMID: 19954950] - Madalina Rujoi, Nina H Pipalia, Frederick R Maxfield. Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells.
PloS one.
2010 Sep; 5(9):e12788. doi:
10.1371/journal.pone.0012788
. [PMID: 20877719] - Maho Watanabe, Hitoshi Nakashima, Kenji Ito, Katsuhisa Miyake, Takao Saito. Improvement of dyslipidemia in OLETF rats by the prostaglandin I(2) analog beraprost sodium.
Prostaglandins & other lipid mediators.
2010 Sep; 93(1-2):14-9. doi:
10.1016/j.prostaglandins.2010.04.003
. [PMID: 20450981] - Renata N Freitas, Kay-Tee Khaw, Kelvin Wu, Richard Bowman, Hannah Jeffery, Robert Luben, Nicolas J Wareham, Sheila A Bingham. A single nucleotide polymorphism in the 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene ( HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk) study.
The British journal of nutrition.
2010 Sep; 104(5):765-72. doi:
10.1017/s0007114510001145
. [PMID: 20540816] - Wenwen Huang, Xiaoli Ye, Xuegang Li, Zhongqi Zhao, Ping Lan, Liang Wang, Ming Liu, Ying Gao, Jiaying Zhu, Ping Li, Ping Feng. [The inhibition activity of chemical constituents in hawthorn fruit and their synergistic action to HMG-CoA reductase].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2010 Sep; 35(18):2428-31. doi:
10.4268/cjcmm20101815
. [PMID: 21141493] - Matteo Mozzicafreddo, Massimiliano Cuccioloni, Anna Maria Eleuteri, Mauro Angeletti. Rapid reverse phase-HPLC assay of HMG-CoA reductase activity.
Journal of lipid research.
2010 Aug; 51(8):2460-3. doi:
10.1194/jlr.d006155
. [PMID: 20418539] - Maxi Meissner, Rick Havinga, Renze Boverhof, Ido Kema, Albert K Groen, Folkert Kuipers. Exercise enhances whole-body cholesterol turnover in mice.
Medicine and science in sports and exercise.
2010 Aug; 42(8):1460-8. doi:
10.1249/mss.0b013e3181cfcb02
. [PMID: 20139791]