Tadalafil (BioDeep_00000018143)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0³,⁸.0¹¹,¹⁶]heptadeca-1(10),11,13,15-tetraene-4,7-dione

化学式: C22H19N3O4 (389.13754940000007)
中文名称: 西力士
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CC(=O)N2C(C1=O)CC3=C(C2C4=CC5=C(C=C4)OCO5)NC6=CC=CC=C36
InChI: InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1

描述信息

Tadalafil is an orally adminstered drug used to treat male erectile dysfunction (impotence). It is marketed worldwide under the brand name Cialis. It is a phosphodiesterase 5 (PDE5) inhibitor. Tadalafils distinguishing pharmacologic feature is its longer half-life (17.5 hours) compared with Viagra and Levitra (4-5 hours). This longer half-life results in a longer duration of action and is, in part, responsible for the Cialis nickname of the weekend pill. This longer half-life also is the basis of current investigation for tadalafils use in pulmonary arterial hypertension as a once-daily therapy. [Wikipedia]
G - Genito urinary system and sex hormones > G04 - Urologicals > G04B - Urologicals > G04BE - Drugs used in erectile dysfunction
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors > D058986 - Phosphodiesterase 5 Inhibitors
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor > C2127 - cGMP Phosphodiesterase Inhibitor
D000089162 - Genitourinary Agents > D064804 - Urological Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents

同义名列表

12 个代谢物同义名

(2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0³,⁸.0¹¹,¹⁶]heptadeca-1(10),11,13,15-tetraene-4,7-dione; (6R,12AR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1,2:1,6)pyrido(3,4-b)indole-1,4-dione; (6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino(1,2:1,6)pyrido(3,4-b)indole-1,4-dione; 6-BENZO[1,3]dioxol-5-yl-2-methyl-2,3,6,7,12,12a-hexahydro-pyrazino[1,2:1,6]pyrido[3,4-b]indole-1,4-dione; CHEMBL1671905; Tadanafil; Tadalafil; ICOS 351; 351, IC; Zalutia; Adcirca; Cialis



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Doaa M Abdel-Rahman, Basim Anwar Shehata Messiha, Fares E M Ali, Amany A Azouz. Regulation of renal nitric oxide and eNOS/iNOS expression by tadalafil participates in the mitigation of amphotericin B-induced renal injury: Down-regulation of NF-κB/iNOS/caspase-3 signaling. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Oct; ?(?):. doi: 10.1007/s00210-023-02787-w. [PMID: 37891258]
  • Qing-Heng Wu, Peng-Chao Li, Fang-Hua Zhang, Zhong Hua, Xing-Hua Zhang, Zi-Xue Sun. [To evaluate the efficacy of Yishen Tongluo decoction combined with low-dose tadalafil in the treatment of diabetic erectile dysfunction with kidney deficiency and blood stasis syndrome]. Zhonghua nan ke xue = National journal of andrology. 2023 Jun; 29(6):527-532. doi: ". [PMID: 38602726]
  • Rakesh C Kukreja, Rui Wang, Saisudha Koka, Anindita Das, Arun Samidurai, Lei Xi. Treating diabetes with combination of phosphodiesterase 5 inhibitors and hydroxychloroquine-a possible prevention strategy for COVID-19?. Molecular and cellular biochemistry. 2023 Mar; 478(3):679-696. doi: 10.1007/s11010-022-04520-2. [PMID: 36036333]
  • Milos Krivokapic, Israpil Alisultanovich Omarov, Vladimir Zivkovic, Tamara Nikolic Turnic, Vladimir Jakovljevic. Changes in Left Ventricular Ejection Fraction and Oxidative Stress after Phosphodiesterase Type-5 Inhibitor Treatment in an Experimental Model of Retrograde Rat Perfusion. Medicina (Kaunas, Lithuania). 2023 Feb; 59(3):. doi: 10.3390/medicina59030458. [PMID: 36984459]
  • Xing-Hua Zhang, Peng-Chao Li, Zi-Xue Sun, Zheng-Guo Zhang, Jun-Ge DU, Xing-Xing Wei. [Dumai moxibustion combined with low-dose tadalafil for erectile dysfunction: Evaluation of therapeutic effect]. Zhonghua nan ke xue = National journal of andrology. 2023 Jan; 29(1):83-87. doi: ". [PMID: 37846838]
  • Wu Pan, Huiyun Xiao, Haizhu Li, Yongrui Li, Bin Zhang, Bowen Liu, Longliang Yang. Terahertz spectroscopic detection of antifatigue illegal additives in health care product matrices. Applied optics. 2022 Nov; 61(33):9904-9910. doi: 10.1364/ao.462727. [PMID: 36606822]
  • Jialing Liu, Jian Sun, Huan Wei, Hong Yu, Xiangdong Dai, Qing Hu. Isolation and characterization of a novel tadalafil analogue adulterant, N-cyclohexyl nortadalafil, in a dietary supplement. Journal of pharmaceutical and biomedical analysis. 2022 Nov; 227(?):115144. doi: 10.1016/j.jpba.2022.115144. [PMID: 36841095]
  • Junchao Yao, Baojun Ju, Xiao Li, Miaomiao Ma, Luyu Li, Yongtao Zhang. Clinical study of comprehensive TCM therapy in the treatment of damp and hot stasis erectile dysfunction. Medicine. 2022 Oct; 101(43):e30776. doi: 10.1097/md.0000000000030776. [PMID: 36316841]
  • Mostafa AbdelRazek, Ahmad Abolyosr, Omar Mhammed, Atef Fathi, Mohammed Talaat, Ahmed Hassan. Prospective comparison of tadalafil 5 mg alone, silodosin 8 mg alone, and the combination of both in treatment of lower urinary tract symptoms related to benign prostatic hyperplasia. World journal of urology. 2022 Aug; 40(8):2063-2070. doi: 10.1007/s00345-022-04071-7. [PMID: 35773357]
  • Moustafa Mahmoud Hamdy, Mahran S Abdel-Rahman, Dalia M Badary, Mahmoud S Sabra. Effects of furosemide and tadalafil in both conventional and nanoforms against adenine-induced chronic renal failure in rats. European journal of medical research. 2022 Jul; 27(1):117. doi: 10.1186/s40001-022-00747-3. [PMID: 35820963]
  • Ahmed S Zaghloul, Abdelrahman M El-Nashaar, Shady Z Said, Ihab A Osman, Taymour Mostafa. Assessment of the intracavernosal injection platelet-rich plasma in addition to daily oral tadalafil intake in diabetic patients with erectile dysfunction non-responding to on-demand oral PDE5 inhibitors. Andrologia. 2022 Jul; 54(6):e14421. doi: 10.1111/and.14421. [PMID: 35301742]
  • Mona M Abdel Moneim. Green & Sensitive pH-dependent Spectrofluorimetric Assay of Tamsulosin Hydrochloride and Tadalafil in their New Combined Formulation for Benign Prostatic Hyperplasia: Application to Spiked Human Plasma. Journal of fluorescence. 2022 Jul; 32(4):1581-1590. doi: 10.1007/s10895-022-02938-x. [PMID: 35576092]
  • Naoki Wada, Noriyuki Abe, Kotona Miyauchi, Mayumi Ishikawa, Shogo Makino, Hidehiro Kakizaki. Dutasteride add-on treatment to tadalafil for patients with benign prostatic enlargement is similarly effective as dutasteride add-on treatment to alpha blocker: a propensity-score matching analysis. International urology and nephrology. 2022 Jun; 54(6):1193-1198. doi: 10.1007/s11255-022-03198-1. [PMID: 35362820]
  • Natsumi Tomita, Yuji Hotta, Aya Naiki-Ito, Akimasa Sanagawa, Tomoya Kataoka, Yoko Furukawa-Hibi, Satoru Takahashi, Kazunori Kimura. Protective effects of tadalafil on damaged podocytes in an adriamycin-induced nephrotic syndrome model. Journal of pharmacological sciences. 2022 Jun; 149(2):53-59. doi: 10.1016/j.jphs.2022.03.003. [PMID: 35512855]
  • Pankaj Bhatia, Nirmal Singh. Tadalafil ameliorates memory deficits, oxidative stress, endothelial dysfunction and neuropathological changes in rat model of hyperhomocysteinemia induced vascular dementia. The International journal of neuroscience. 2022 Apr; 132(4):384-396. doi: 10.1080/00207454.2020.1817009. [PMID: 32859137]
  • Rahmi Aslan, Kerem Taken, Akif Erbin, Hamit Hakan Alp, Recep Eryilmaz, Omer Sarilar, Zubeyir Huyut. The synergistic effects of testosterone and phophodiesterase-5 inhibitor combination on oxidative stress markers, matrix metalloproteinases and oxidative DNA damage: A randomized controlled experimental study. Revista internacional de andrologia. 2022 Apr; 20(2):73-79. doi: 10.1016/j.androl.2020.10.011. [PMID: 35115255]
  • Zi-Yang Han, Zi-Heng Zhang, Heng Wang, Yun Chen. [Efficacy of leech powder on hyperlipidaemia-associated erectile dysfunction in male rats]. Zhonghua nan ke xue = National journal of andrology. 2022 Apr; 28(4):332-338. doi: . [PMID: 37477455]
  • Silvia Limoncella, Clara Lazzaretti, Elia Paradiso, Sara D'Alessandro, Federica Barbagallo, Salvatore Pacifico, Remo Guerrini, Simonetta Tagliavini, Tommaso Trenti, Daniele Santi, Manuela Simoni, Marco Sola, Giulia Di Rocco, Livio Casarini. Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line. Molecular and cellular endocrinology. 2022 02; 542(?):111527. doi: 10.1016/j.mce.2021.111527. [PMID: 34875337]
  • Yuki Maruyama, Motoo Araki, Kengo Kidokoro, Yuji Sogawa, Kasumi Yoshinaga, Yosuke Mitsui, Takuya Sadahira, Koichiro Wada, Masami Watanabe, Toyohiko Watanabe, Naoki Kashihara, Yasutomo Nasu. Evaluation of Neutrophil Dynamics Change by Protective Effect of Tadalafil After Renal Ischemia/Reperfusion Using In Vivo Real-time Imaging. Transplantation. 2022 02; 106(2):280-288. doi: 10.1097/tp.0000000000003803. [PMID: 33908383]
  • Lisa Ferguson-Sells, Nieves Velez de Mendizabal, Baohui Li, David Small. Population Pharmacokinetics of Tadalafil in Pediatric Patients with Pulmonary Arterial Hypertension: A Combined Adult/Pediatric Model. Clinical pharmacokinetics. 2022 02; 61(2):249-262. doi: 10.1007/s40262-021-01052-8. [PMID: 34379314]
  • Rong Shao, Dan-Dan Yang, Zou-Rong Ruan, Jin-Liang Chen, Yin Hu, Bo Jiang, Hong-Gang Lou. Pharmacokinetic and Bioequivalence Evaluation of 2 Tadalafil Tablets in Healthy Male Chinese Subjects Under Fasting and Fed Conditions. Clinical pharmacology in drug development. 2022 02; 11(2):165-172. doi: 10.1002/cpdd.1007. [PMID: 34453416]
  • Aline Goncalves Mora, Douglas Rafael Andrade, Sabrina C Janussi, Tiago Tomazini Goncalves, Karla Krikorian, Fernanda B M Priviero, Mario Angelo Claudino. Tadalafil treatment improves cardiac, renal and lower urinary tract dysfunctions in rats with heart failure. Life sciences. 2022 Jan; 289(?):120237. doi: 10.1016/j.lfs.2021.120237. [PMID: 34922942]
  • Trevor Lane, Peter Hountras. A 65-Year-Old Man With Weight Loss, Peripheral Neuropathy, and Lower Extremity Swelling. Chest. 2022 01; 161(1):e29-e34. doi: 10.1016/j.chest.2021.07.054. [PMID: 35000714]
  • Arcangelo Sebastianelli, Simone Morselli, Pietro Spatafora, Andrea Liaci, Luca Gemma, Claudia Zaccaro, Linda Vignozzi, Mario Maggi, Kevin T McVary, Steven A Kaplan, Christopher Chapple, Stavros Gravas, Sergio Serni, Mauro Gacci. Outcomes of combination therapy with daily tadalafil 5 mg plus tamsulosin 0.4 mg to treat lower urinary tract symptoms and erectile dysfunction in men with or without metabolic syndrome. Minerva urology and nephrology. 2021 12; 73(6):836-844. doi: 10.23736/s2724-6051.20.04099-0. [PMID: 33200905]
  • Mélissa Yéléhé-Okouma, Elise Pape, Lisa Humbertjean, Marion Evrard, Rabih El Osta, Nadine Petitpain, Pierre Gillet, Souleiman El Balkhi, Julien Scala-Bertola. Drug adulteration of sexual enhancement supplements: a worldwide insidious public health threat. Fundamental & clinical pharmacology. 2021 Oct; 35(5):792-807. doi: 10.1111/fcp.12653. [PMID: 33484004]
  • Dénes Csonka, Vladislav Fishman, Jaya Natarajan, Hans Stieltjes, Danielle Armas, Victor Dishy, Juan Jose Perez Ruixo. Bioequivalence and food effect of a fixed-dose combination of macitentan and tadalafil: Adaptive design in the COVID-19 pandemic. Pharmacology research & perspectives. 2021 10; 9(5):e00846. doi: 10.1002/prp2.846. [PMID: 34624174]
  • Guglielmo Duranti, Roberta Ceci, Luigi Di Luigi, Cristina Antinozzi, Ivan Dimauro, Stefania Sabatini, Manuela Cervelli, Paolo Sgrò. Effect of Tadalafil Administration on Redox Homeostasis and Polyamine Levels in Healthy Men with High Level of Physical Activity. International journal of environmental research and public health. 2021 09; 18(19):. doi: 10.3390/ijerph18199962. [PMID: 34639267]
  • Ekram Nemr Abd Al Haleem, Fatma Al-Zahraa Mohamed Ibrahim, Sawsan Abo Bakr Zaytoon, Hossam Mohamed Mohamed Arafa. Possible protective effect of TNF-α inhibition and triad NO/cGMP/VEGF activation on gastric ulcer in rats. Canadian journal of physiology and pharmacology. 2021 Sep; 99(9):864-874. doi: 10.1139/cjpp-2020-0725. [PMID: 33400612]
  • Yan-Ping Huang, Zheng-Mu Wu, Nian-Qin Yang, Yu Peng, Wei-Jie Chen, Li Li, Lei Chen, Huai-Jin Cheng, Mu-Jun Lu. [Effect of Shanhaidan Granules combined with tadalafil on erectile dysfunction: A multi-center clinical trial]. Zhonghua nan ke xue = National journal of andrology. 2021 Sep; 27(9):819-824. doi: ". [PMID: 34914259]
  • Siu-Hin Wan, Paul M McKie, Joshua P Slusser, John C Burnett, David O Hodge, Horng H Chen. Effects of phosphodiesterase V inhibition alone and in combination with BNP on cardiovascular and renal response to volume load in human preclinical diastolic dysfunction. Physiological reports. 2021 08; 9(16):e14974. doi: 10.14814/phy2.14974. [PMID: 34405565]
  • Luis Fernando Valladales-Restrepo, Jorge Enrique Machado-Alba. Pharmacological treatment and inappropriate prescriptions for patients with erectile dysfunction. International journal of clinical pharmacy. 2021 Aug; 43(4):900-908. doi: 10.1007/s11096-020-01194-y. [PMID: 33180231]
  • P Sgrò, C Minganti, M Lista, C Antinozzi, M Cappa, Y Pitsiladis, F Pigozzi, L Di Luigi. Dihydrotestosterone (DHT) rapidly increase after maximal aerobic exercise in healthy males: the lowering effect of phosphodiesterase's type 5 inhibitors on DHT response to exercise-related stress. Journal of endocrinological investigation. 2021 Jun; 44(6):1219-1228. doi: 10.1007/s40618-020-01409-z. [PMID: 32946077]
  • Tomonori Minagawa, Tomohiko Oguchi, Tetsuichi Saitou, Ayumu Fukazawa, Iwao Hashida, Keiichiro Koiwai, Kazuyoshi Iijima, Haruaki Kato, Teruyuki Ogawa, Osamu Ishizuka. Impact of low-dose tadalafil on adverse events after low-dose-rate brachytherapy for prostate cancer: A bi-center randomized open-label trial. International journal of urology : official journal of the Japanese Urological Association. 2021 04; 28(4):432-438. doi: 10.1111/iju.14487. [PMID: 33550619]
  • Arcangelo Sebastianelli, Pietro Spatafora, Jacopo Frizzi, Omar Saleh, Cosimo De Nunzio, Andrea Tubaro, Linda Vignozzi, Mario Maggi, Sergio Serni, Kevin T McVary, Steven A Kaplan, Stavros Gravas, Christopher Chapple, Mauro Gacci. Which Drug to Discontinue 3 Months After Combination Therapy of Tadalafil plus Tamsulosin for Men with Lower Urinary Tract Symptom and Erectile Dysfunction? Results of a Prospective Observational Trial. European urology focus. 2021 03; 7(2):432-439. doi: 10.1016/j.euf.2019.09.015. [PMID: 31606473]
  • Adam Mieczkowski, Elżbieta Speina, Damian Trzybiński, Maria Winiewska-Szajewska, Patrycja Wińska, Ewelina M Borsuk, Małgorzata Podsiadła-Białoskórska, Tomasz Przygodzki, Krzysztof Drabikowski, Lidia Stanczyk, Igor Zhukov, Cezary Watala, Krzysztof Woźniak. Diketopiperazine-Based, Flexible Tadalafil Analogues: Synthesis, Crystal Structures and Biological Activity Profile. Molecules (Basel, Switzerland). 2021 Feb; 26(4):. doi: 10.3390/molecules26040794. [PMID: 33546456]
  • Saurabh K Chhonker, Divya Rawat, Raj Kumar Koiri. Protective and therapeutic effects of sildenafil and tadalafil on aflatoxin B1-induced hepatocellular carcinoma. Molecular and cellular biochemistry. 2021 Feb; 476(2):1195-1209. doi: 10.1007/s11010-020-03982-6. [PMID: 33216253]
  • Ahmed M Abdel-Raoof, Mohamed A Hasan, Ahmed W Madkour, Ashraf Abdel-Fattah, Maya S Eissa. Simultaneous determination of citalopram and tadalafil by the second derivative synchronous fluorescence method in biological fluids; application of Box-Behnken optimization design. Luminescence : the journal of biological and chemical luminescence. 2021 Feb; 36(1):57-65. doi: 10.1002/bio.3913. [PMID: 32678940]
  • Nikolaos Tzoumas, Tariq E Farrah, Neeraj Dhaun, David J Webb. Established and emerging therapeutic uses of PDE type 5 inhibitors in cardiovascular disease. British journal of pharmacology. 2020 12; 177(24):5467-5488. doi: 10.1111/bph.14920. [PMID: 31721165]
  • Simon Grill, Shirin Bruderer, Patricia N Sidharta, Mariya Antonova, Susanne Globig, James Carlson, Armin Schultz, Dénes Csonka. Bioequivalence of macitentan and tadalafil given as fixed-dose combination or single-component tablets in healthy subjects. British journal of clinical pharmacology. 2020 12; 86(12):2424-2434. doi: 10.1111/bcp.14347. [PMID: 32374030]
  • Yoshihisa Matsukawa, Yoshie Kanada, Shun Takai, Satoshi Inoue, Tsuyoshi Majima, Yasuhito Funahashi, Masashi Kato, Tokunori Yamamoto, Momokazu Gotoh. Pre-treatment serum testosterone level can be a useful factor to predict the improvement in bladder outlet obstruction by tadalafil for male patients with lower urinary tract symptoms induced by benign prostatic obstruction. The aging male : the official journal of the International Society for the Study of the Aging Male. 2020 Dec; 23(5):641-647. doi: 10.1080/13685538.2018.1563777. [PMID: 30651033]
  • A Sebastianelli, P Spatafora, S Morselli, L Vignozzi, S Serni, K T McVary, S Kaplan, S Gravas, C Chapple, Mauro Gacci. Tadalafil Alone or in Combination with Tamsulosin for the Management for LUTS/BPH and ED. Current urology reports. 2020 Oct; 21(12):56. doi: 10.1007/s11934-020-01009-7. [PMID: 33108544]
  • Fabrizio Dal Moro, Igor Vendramin, Ugolino Livi. The war against the SARS-CoV2 infection: Is it better to fight or mitigate it?. Medical hypotheses. 2020 Oct; 143(?):110129. doi: 10.1016/j.mehy.2020.110129. [PMID: 32721814]
  • Yaguang Li, Ning Yang, Binsu Wang, Xiulong Niu, Wei Cai, Yuanbin Li, Yuming Li, Shaobo Chen. Effect and mechanism of prophylactic use of tadalafil during pregnancy on l-NAME-induced preeclampsia-like rats. Placenta. 2020 09; 99(?):35-44. doi: 10.1016/j.placenta.2020.06.015. [PMID: 32750643]
  • Basel A Abdel-Wahab, Saad Ahmad Alkahtani, Ehab A M Elagab. Tadalafil alleviates cisplatin-induced reproductive toxicity through the activation of the Nrf2/HO-1 pathway and the inhibition of oxidative stress and apoptosis in male rats. Reproductive toxicology (Elmsford, N.Y.). 2020 09; 96(?):165-174. doi: 10.1016/j.reprotox.2020.06.015. [PMID: 32621855]
  • Amina Ahmed Sedky, Yosra Magdy. Tadalafil versus linaclotide in gastrointestinal dysfunction and depressive behavior in constipation-predominant irritable bowel syndrome. Life sciences. 2020 Sep; 256(?):117960. doi: 10.1016/j.lfs.2020.117960. [PMID: 32534033]
  • Andrei Mihai Iordache, Ana Maria Buga, Dana Albulescu, Ramona Constantina Vasile, Radu Mitrut, George Georgiadis, Ioannis-Erineos Zisis, Charalampos Mamoulakis, Aristidis Tsatsakis, Anca Oana Docea, Daniela Calina. Phosphodiesterase-5 inhibitors ameliorate structural kidney damage in a rat model of contrast-induced nephropathy. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Sep; 143(?):111535. doi: 10.1016/j.fct.2020.111535. [PMID: 32622850]
  • Natsumi Tomita, Yuji Hotta, Aya Naiki-Ito, Kana Hirano, Tomoya Kataoka, Yasuhiro Maeda, Satoru Takahashi, Kazunori Kimura. The phosphodiesterase 5 inhibitor tadalafil has renoprotective effects in a rat model of chronic kidney disease. Physiological reports. 2020 09; 8(17):e14556. doi: 10.14814/phy2.14556. [PMID: 32889777]
  • Yoshihisa Matsukawa, Yushi Naito, Yasuhito Funahashi, Shohei Ishida, Takashi Fujita, Kosuke Tochigi, Masashi Kato, Momokazu Gotoh. Comparison of cernitin pollen extract vs tadalafil therapy for refractory chronic prostatitis/chronic pelvic pain syndrome: A randomized, prospective study. Neurourology and urodynamics. 2020 09; 39(7):1994-2002. doi: 10.1002/nau.24454. [PMID: 32648985]
  • Ahmed M Abdel-Raoof, Ragab A M Said, Mohamed S Emara, Ebrahim A El-Desouky, Ahmed M Abdelzaher, Mohamed A Hasan, Ayman E Osman. D-optimal design as a useful tool response surface methodology for the optimization of signals from synchronous fluorescence prior to simultaneous determination of avanafil and tadalafil. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Jul; 235(?):118313. doi: 10.1016/j.saa.2020.118313. [PMID: 32251891]
  • Sophie Strindberg, Jakob Plum, Mai Bay Stie, Martin Lau Christiansen, Line Hagner Nielsen, Thomas Rades, Anette Müllertz. Effect of supersaturation on absorption of indomethacin and tadalafil in a single pass intestinal perfusion rat model, in the absence and presence of a precipitation inhibitor. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2020 Jun; 151(?):108-115. doi: 10.1016/j.ejpb.2020.03.019. [PMID: 32298758]
  • Nobuo Shinkai, Koji Ichihara, Ko Kobayashi, Hidetoshi Tabata, Kohei Hashimoto, Fumimasa Fukuta, Toshiaki Tanaka, Naoya Masumori. Long-term tadalafil administration can prevent functional and structural changes of the urinary bladder in male rats with partial bladder outlet obstruction. Neurourology and urodynamics. 2020 06; 39(5):1330-1337. doi: 10.1002/nau.24383. [PMID: 32401423]
  • Saisudha Koka, Lei Xi, Rakesh C Kukreja. Chronic inhibition of phosphodiesterase 5 with tadalafil affords cardioprotection in a mouse model of metabolic syndrome: role of nitric oxide. Molecular and cellular biochemistry. 2020 May; 468(1-2):47-58. doi: 10.1007/s11010-020-03710-0. [PMID: 32162053]
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