Ethoxyquin (BioDeep_00000018117)
human metabolite
代谢物信息卡片
6-Ethoxy-1,2-dihydro-2,2,4-trimethylquinoline, 9ci, 8ci
化学式: C14H19NO (217.14665639999998)
中文名称: 乙氧基喹啉
谱图信息:
最多检出来源 Bos taurus(not specific) 4.22%
分子结构信息
SMILES: CCOC1=CC2=C(C=C1)NC(C=C2C)(C)C
InChI: InChI=1S/C14H19NO/c1-5-16-11-6-7-13-12(8-11)10(2)9-14(3,4)15-13/h6-9,15H,5H2,1-4H3
描述信息
Ethoxyquin is an antioxidant used in animal feeds and for the preservation of colour in the production of chili powder, paprika and ground chilli. Ethoxyquin is formerly used as an agricultural pesticide/herbicide, now superseded. Also used as a post-harvest dip for apples and pears to prevent scald.
Antioxidant used in animal feeds and for the preservation of colour in the production of chili powder, paprika and ground chilli. Formerly used as an agricultural pesticide/herbicide, now superseded and is) also used as a post-harvest dip for apples and pears to prevent scald
C26170 - Protective Agent > C275 - Antioxidant
同义名列表
43 个代谢物同义名
6-Ethoxy-1,2-dihydro-2,2,4-trimethylquinoline, 9ci, 8ci; Ethyl 2,2,4-trimethyl-1,2-dihydro-6-quinolinyl ether; 6-(Ethyloxy)-2,2,4-trimethyl-1,2-dihydroquinoline; 6-Ethoxy-1,2-dihydro-2,2,4-trimethyl-quinoline; 6-Ethoxy-2,2,4-trimethyl-1, 2-dihydroquinoline; 2,2, 4-Trimethyl-6-ethoxy-1,2-dihydroquinoline; 6-Ethoxy-1, 2-dihydro-2,2,4-trimethylquinoline; 1,2-Dihydro-2,2,4-trimethyl-6-ethoxyquinoline; 2,2,4-Trimethyl-6-ethoxy-1,2-dihydroquinoline; 1,2-Dihydro-6-ethoxy-2,2,4-trimethylquinoline; 6-Ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline; 6-Ethoxy-1,2-dihydro-2,2,4-trimethylquinoline; Alterungsschutzmittel ec; DaweS nutrigard; Antioxidant ec; Santoflex aw; (-)-Lobeline; Permanax 103; Ethoxyquine; Santoflex a; Santoquineq; Aries antox; Nocrack aw; Ethoxychin; Stop-scald; Santoquine; ethoxyquin; Antage aw; Santoquin; Nocrac aw; Quinol ed; Santoflex; Nix-scald; Lobeline; Polyflex; Niflex D; 6-ETMDQ; Niflex; e 324; Antox; e324; EMQ; EQ
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:77323
- PubChem: 3293
- HMDB: HMDB0039531
- ChEMBL: CHEMBL172064
- Wikipedia: Ethoxyquin
- MeSH: Ethoxyquin
- foodb: FDB019147
- chemspider: 3177
- CAS: 63301-91-7
- CAS: 91-53-2
- PMhub: MS000002600
- RefMet: Ethoxyquin
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Masami Abe, Marie Sou, Yuta Matsuoka, Kazushi Morimoto, Ken-Ichi Yamada. Ethoxyquin, a Lipid Peroxidation Inhibitor, Has Protective Effects against White Matter Lesions in a Mouse Model of Chronic Cerebral Hypoperfusion.
Biological & pharmaceutical bulletin.
2024; 47(1):104-111. doi:
10.1248/bpb.b23-00538. [PMID: 38171771] - Tomonori Tadokoro, Masataka Ikeda, Ko Abe, Tomomi Ide, Hiroko Deguchi Miyamoto, Shun Furusawa, Kosei Ishimaru, Masatsugu Watanabe, Akihito Ishikita, Shouji Matsushima, Tomoko Koumura, Ken-Ichi Yamada, Hirotaka Imai, Hiroyuki Tsutsui. Ethoxyquin is a Competent Radical-Trapping Antioxidant for Preventing Ferroptosis in Doxorubicin Cardiotoxicity.
Journal of cardiovascular pharmacology.
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10.1097/fjc.0000000000001328. [PMID: 35881422] - Markus Stoeckelhuber, Max Scherer, Franz Bracher, Oliver Peschel, Edgar Leibold, Gerhard Scherer, Nikola Pluym. Development of a human biomonitoring method for assessing the exposure to ethoxyquin in the general population.
Archives of toxicology.
2020 12; 94(12):4209-4217. doi:
10.1007/s00204-020-02871-7. [PMID: 32840639] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
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Japanese journal of cancer research : Gann.
1990 Sep; 81(9):871-7. doi:
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American journal of veterinary research.
1989 Sep; 50(9):1642-6. doi:
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Cancer letters.
1989 Jul; 46(1):69-74. doi:
10.1016/0304-3835(89)90217-6. [PMID: 2567622] - S M Spaethe, W Hsueh, P Needleman. Pharmacological manipulation of inflammation in rabbit hydronephrosis: effects of a combined cyclooxygenase/lipoxygenase inhibitor ethoxyquin, a thromboxane synthase inhibitor RS-5186 and a PAF antagonist L-659,989.
The Journal of pharmacology and experimental therapeutics.
1989 Mar; 248(3):1308-16. doi:
NULL. [PMID: 2539462] - J C Travis, S Thornton, L Daignault. Effect of Santoquin on humoral immune function in mice: lack of interference with selenium utilization.
Immunology and cell biology.
1989 Feb; 67 ( Pt 1)(?):83-4. doi:
10.1038/icb.1989.11. [PMID: 2722209] - T Imazawa, K Toyoda, K Shinoda, H Okamiya, F Furukawa, K Imaida, M Takahashi, Y Hayashi. [Analysis of renal calcification and stone formation in rats treated with ethoxyquin using X-ray analytical scanning electron microscopy: ultrastructural observations and element analysis].
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences.
1989; ?(107):68-72. doi:
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Cancer research.
1987 Oct; 47(19):5218-23. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
1987 Jun; 17(6):679-84. doi:
10.3109/00498258709043975. [PMID: 3630203] - M M Manson, J A Green, H E Driver. Ethoxyquin alone induces preneoplastic changes in rat kidney whilst preventing induction of such lesions in liver by aflatoxin B1.
Carcinogenesis.
1987 May; 8(5):723-8. doi:
10.1093/carcin/8.5.723. [PMID: 2884050] - C A Power, S A Griffiths, J L Simpson, Y Laperche, G Guellaen, M M Manson. Induction of gamma-glutamyl transpeptidase mRNA by aflatoxin B1 and ethoxyquin in rat liver.
Carcinogenesis.
1987 May; 8(5):737-40. doi:
10.1093/carcin/8.5.737. [PMID: 2884051] - M Hirose, A Masuda, T Inoue, S Fukushima, N Ito. Modification by antioxidants and p,p'-diaminodiphenylmethane of 7,12-dimethylbenz[a]anthracene-induced carcinogenesis of the mammary gland and ear duct in CD rats.
Carcinogenesis.
1986 Jul; 7(7):1155-9. doi:
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American journal of veterinary research.
1985 Oct; 46(10):2179-83. doi:
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Life sciences.
1985 May; 36(18):1771-7. doi:
10.1016/0024-3205(85)90560-0. [PMID: 2858807] - T W Kensler, P A Egner, M A Trush, E Bueding, J D Groopman. Modification of aflatoxin B1 binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiothione.
Carcinogenesis.
1985 May; 6(5):759-63. doi:
10.1093/carcin/6.5.759. [PMID: 3924431] - H L Kim. Preparation and dietary effects of ethoxyquin hydrochloride.
Journal of toxicology and environmental health.
1985; 15(5):663-71. doi:
10.1080/15287398509530694. [PMID: 4046071] - R Kahl. Synthetic antioxidants: biochemical actions and interference with radiation, toxic compounds, chemical mutagens and chemical carcinogens.
Toxicology.
1984 Dec; 33(3-4):185-228. doi:
10.1016/0300-483x(84)90038-6. [PMID: 6393452] - H L Kim. Tissue thiol induction in mice and protective effect against pyrrolizidine alkaloids by dietary ethoxyquin and methionine hydroxy analog.
Veterinary and human toxicology.
1984 Aug; 26(4):314-6. doi:
NULL. [PMID: 6464350] - R T Lovell, T Miyazaki, S Rabegnator. Requirement for alpha-tocopherol by channel catfish fed diets low in polyunsaturated triglycerides.
The Journal of nutrition.
1984 May; 114(5):894-901. doi:
10.1093/jn/114.5.894. [PMID: 6726459] - S Fukushima, Y Kurata, M Shibata, E Ikawa, N Ito. Promotion by ascorbic acid, sodium erythorbate and ethoxyquin of neoplastic lesions in rats initiated with N-butyl-N-(4-hydroxybutyl) nitrosamine.
Cancer letters.
1984 May; 23(1):29-37. doi:
10.1016/0304-3835(84)90058-2. [PMID: 6744233] - H Tsuda, T Sakata, T Masui, K Imaida, N Ito. Modifying effects of butylated hydroxyanisole, ethoxyquin and acetaminophen on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine.
Carcinogenesis.
1984 Apr; 5(4):525-31. doi:
10.1093/carcin/5.4.525. [PMID: 6142774] - H Tsuda, S Fukushima, K Imaida, T Sakata, N Ito. Modification of carcinogenesis by antioxidants and other compounds.
Acta pharmacologica et toxicologica.
1984; 55 Suppl 2(?):125-43. doi:
10.1111/j.1600-0773.1984.tb02486.x. [PMID: 6148834] - H L Kim, B W Herrig, A C Anderson, L P Jones, M C Calhoun. Elimination of adverse effects of ethoxyquin (EQ) by methionine hydroxy analog (MHA). Protective effects of EQ and MHA for bitterweed poisoning in sheep.
Toxicology letters.
1983 Apr; 16(1-2):23-9. doi:
10.1016/0378-4274(83)90005-x. [PMID: 6836610] - M Langweiler, B E Sheffy, R D Schultz. Effect of antioxidants on the proliferative response of canine lymphocytes in serum from dogs with vitamin E deficiency.
American journal of veterinary research.
1983 Jan; 44(1):5-7. doi:
NULL. [PMID: 6824224] - N Ito, S Fukushima, H Tsuda, T Shirai, M Tatematsu, K Imaida. Modification of chemical carcinogenesis by antioxidants.
Princess Takamatsu symposia.
1983; 14(?):381-9. doi:
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American journal of veterinary research.
1982 Nov; 43(11):1945-50. doi:
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Research communications in chemical pathology and pharmacology.
1981 Aug; 33(2):365-8. doi:
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The Journal of nutrition.
1981 Apr; 111(4):648-57. doi:
10.1093/jn/111.4.648. [PMID: 7218038] - E Gabriel, L J Machlin, R Filipski, J Nelson. Influence of age on the vitamin E requirement for resolution of necrotizing myopathy.
The Journal of nutrition.
1980 Jul; 110(7):1372-9. doi:
10.1093/jn/110.7.1372. [PMID: 7381601] - R Kahl. Enhancement of epoxide hydratase activity in rat lung, kidney and liver by dietary antioxidants.
Cancer letters.
1980 Feb; 8(4):323-8. doi:
10.1016/0304-3835(80)90148-2. [PMID: 7370968] - G F Combs, J M Regenstein. Influence of selenium, vitamin E, and ethoxyquin on lipid peroxidation in muscle tissues from fowl during low temperature storage.
Poultry science.
1980 Feb; 59(2):347-51. doi:
10.3382/ps.0590347. [PMID: 7413563] - J U Skaare, E Solheim. Studies on the metabolism of the antioxidant ethoxyquin, 6-ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline in the rat.
Xenobiotica; the fate of foreign compounds in biological systems.
1979 Nov; 9(11):649-57. doi:
10.3109/00498257909042332. [PMID: 532214] - M K Samson, R L Stephens, S Rivkin, M Opipari, T Maloney, C W Groppe, R Fisher. Vinblastine, bleomycin, and cis-dichlorodiammineplatinum(II) in disseminated testicular cancer: preliminary report of a Southwest Oncology Group Study.
Cancer treatment reports.
1979 Sep; 63(9-10):1663-7. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
1979 Jun; 9(6):343-51. doi:
10.3109/00498257909038738. [PMID: 494664] - J U Skaare, I Nafstad. The distribution of 14C-ethoxyquin in rat.
Acta pharmacologica et toxicologica.
1979 Apr; 44(4):303-7. doi:
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