Chlorcyclizine (BioDeep_00000018113)

   

human metabolite


代谢物信息卡片


1-[(4-chlorophenyl)(phenyl)methyl]-4-methylpiperazine

化学式: C18H21ClN2 (300.1393176)
中文名称: 氯环嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1
InChI: InChI=1S/C18H21ClN2/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16/h2-10,18H,11-14H2,1H3

描述信息

R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AE - Piperazine derivatives
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
Chlorcyclizine is a first-generation piperazine H1-antihistamine.

同义名列表

17 个代谢物同义名

1-[(4-chlorophenyl)(phenyl)methyl]-4-methylpiperazine; N-Methyl-N-(4-chlorobenzhydryl)piperazine; (±)-Chlorcyclizine; Compound 47-282; Histachlorazine; Chlorocyclizin; chlorcyclizine; Chlorocycline; Chlorcycline; Di-Paralene; Pruresidine; Di-Paralen; Alergicide; NSC 25246; Trihistan; Mantadil; Perazyl



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zongyi Hu, Adam Rolt, Xin Hu, Christopher D Ma, Derek J Le, Seung Bum Park, Michael Houghton, Noel Southall, D Eric Anderson, Daniel C Talley, John R Lloyd, Juan C Marugan, T Jake Liang. Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1. Cell chemical biology. 2020 07; 27(7):780-792.e5. doi: 10.1016/j.chembiol.2020.04.006. [PMID: 32386595]
  • Christopher Koh, Preeti Dubey, Ma Ai Thanda Han, Peter J Walter, H Martin Garraffo, Pallavi Surana, Noel T Southall, Nathaniel Borochov, Susan L Uprichard, Scott J Cotler, Ohad Etzion, Theo Heller, Harel Dahari, T Jake Liang. A randomized, proof-of-concept clinical trial on repurposing chlorcyclizine for the treatment of chronic hepatitis C. Antiviral research. 2019 03; 163(?):149-155. doi: 10.1016/j.antiviral.2019.01.017. [PMID: 30711416]
  • Adam Rolt, Derek Le, Zongyi Hu, Amy Q Wang, Pranav Shah, Marc Singleton, Emma Hughes, Andrés E Dulcey, Shanshan He, Michio Imamura, Takuro Uchida, Kazuaki Chayama, Xin Xu, Juan J Marugan, T Jake Liang. Preclinical Pharmacological Development of Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection. The Journal of infectious diseases. 2018 05; 217(11):1761-1769. doi: 10.1093/infdis/jiy039. [PMID: 29373739]
  • Shanshan He, Jingbo Xiao, Andrés E Dulcey, Billy Lin, Adam Rolt, Zongyi Hu, Xin Hu, Amy Q Wang, Xin Xu, Noel Southall, Marc Ferrer, Wei Zheng, T Jake Liang, Juan J Marugan. Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection. Journal of medicinal chemistry. 2016 Feb; 59(3):841-53. doi: 10.1021/acs.jmedchem.5b00752. [PMID: 26599718]
  • Shanshan He, Billy Lin, Virginia Chu, Zongyi Hu, Xin Hu, Jingbo Xiao, Amy Q Wang, Cameron J Schweitzer, Qisheng Li, Michio Imamura, Nobuhiko Hiraga, Noel Southall, Marc Ferrer, Wei Zheng, Kazuaki Chayama, Juan J Marugan, T Jake Liang. Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection. Science translational medicine. 2015 Apr; 7(282):282ra49. doi: 10.1126/scitranslmed.3010286. [PMID: 25855495]
  • M A Martínez-Gómez, S Sagrado, R M Villanueva-Camañas, M J Medina-Hernández. Enantiomeric quality control of antihistamines in pharmaceuticals by affinity electrokinetic chromatography with human serum albumin as chiral selector. Analytica chimica acta. 2007 Jun; 592(2):202-9. doi: 10.1016/j.aca.2007.04.029. [PMID: 17512827]
  • M A Martínez-Gómez, M M Carril-Avilés, S Sagrado, R M Villanueva-Camañas, M J Medina-Hernández. Characterization of antihistamine-human serum protein interactions by capillary electrophoresis. Journal of chromatography. A. 2007 Apr; 1147(2):261-9. doi: 10.1016/j.chroma.2007.02.054. [PMID: 17339039]
  • Hiroshi Sawada, Kenji Takami, Satoru Asahi. A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicological sciences : an official journal of the Society of Toxicology. 2005 Feb; 83(2):282-92. doi: 10.1093/toxsci/kfh264. [PMID: 15342952]
  • M C Dumasia, L Grainger, E Houghton. Biotransformation of cyclizine in greyhounds. 1: Identification and analysis of cyclizine and some basic metabolites in canine urine by gas chromatography-mass spectrometry. Xenobiotica; the fate of foreign compounds in biological systems. 2002 Sep; 32(9):795-807. doi: 10.1080/00498250210144802. [PMID: 12396276]
  • K J Chou, M D Donovan. Distribution of antihistamines into the CSF following intranasal delivery. Biopharmaceutics & drug disposition. 1997 May; 18(4):335-46. doi: 10.1002/(sici)1099-081x(199705)18:4<335::aid-bdd22>3.0.co;2-w. [PMID: 9158881]
  • M J Ashton, A Ashford, A H Loveless, D Riddell, J Salmon, G V Stevenson. Heterocyclic analogues of chlorcyclizine with potent hypolipidemic activity. Journal of medicinal chemistry. 1984 Oct; 27(10):1245-53. doi: 10.1021/jm00376a002. [PMID: 6148419]
  • R KUNTZMAN, A KLUTCH, I TSAI, J J BURNS. PHYSIOLOGICAL DISTRIBUTION AND METABOLIC INACTIVATION OF CHLORCYCLIZINE AND CYCLIZINE. The Journal of pharmacology and experimental therapeutics. 1965 Jul; 149(?):29-35. doi: NULL. [PMID: 14334288]
  • J L SCHMIDT, D L MARTIN. THE EFFECT OF DIARYLAKYLPIPERAZINES AND RELATED COMPOUNDS ON PLASMA AND LIVER LIPIDS AND LIVER SIZE. Toxicology and applied pharmacology. 1965 Mar; 7(?):257-67. doi: 10.1016/0041-008x(65)90094-3. [PMID: 14298017]