Mergepta (BioDeep_00000180751)
human metabolite blood metabolite
代谢物信息卡片
3-({2-[(diaminomethylidene)amino]ethyl}sulfanyl)-2-(sulfanylmethyl)propanoic acid
化学式: C7H15N3O2S2 (237.0606)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CSCC(CS)C(=O)O)N=C(N)N
InChI: InChI=1S/C7H15N3O2S2/c8-7(9)10-1-2-14-4-5(3-13)6(11)12/h5,13H,1-4H2,(H,11,12)(H4,8,9,10)
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Kusumam Joseph, Tracy E Tholanikunnel, Allen P Kaplan. In vitro comparison of bradykinin degradation by aliskiren, a renin inhibitor, and an inhibitor of angiotensin-converting enzyme.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2015 Jun; 16(2):321-7. doi:
10.1177/1470320313491997. [PMID: 23764715] - Lynn N Thomas, Timothy J Morehouse, Catherine K L Too. Testosterone and prolactin increase carboxypeptidase-D and nitric oxide levels to promote survival of prostate cancer cells.
The Prostate.
2012 Mar; 72(4):450-60. doi:
10.1002/pros.21446. [PMID: 21688280] - Salma A Abdelmagid, Catherine K L Too. Prolactin and estrogen up-regulate carboxypeptidase-d to promote nitric oxide production and survival of mcf-7 breast cancer cells.
Endocrinology.
2008 Oct; 149(10):4821-8. doi:
10.1210/en.2008-0145. [PMID: 18535109] - Disney O Sivieri, Luiz B Bispo-da-Silva, Eduardo B Oliveira, Angela C Resende, Maria Cristina O Salgado. Potentiation of bradykinin effect by angiotensin-converting enzyme inhibition does not correlate with angiotensin-converting enzyme activity in the rat mesenteric arteries.
Hypertension (Dallas, Tex. : 1979).
2007 Jul; 50(1):110-5. doi:
10.1161/hypertensionaha.106.085761. [PMID: 17470724] - Yuko Muto, Kokichi Suzuki, Eriko Sato, Hidemi Ishii. Carboxypeptidase B inhibitors reduce tissue factor-induced renal microthrombi in rats.
European journal of pharmacology.
2003 Feb; 461(2-3):181-9. doi:
10.1016/s0014-2999(03)01297-4. [PMID: 12586213] - A Kuoppala, K A Lindstedt, J Saarinen, P T Kovanen, J O Kokkonen. Inactivation of bradykinin by angiotensin-converting enzyme and by carboxypeptidase N in human plasma.
American journal of physiology. Heart and circulatory physiology.
2000 Apr; 278(4):H1069-74. doi:
10.1152/ajpheart.2000.278.4.h1069. [PMID: 10749699] - N Kuno, S Mizutani, Y Ohno, K Goto, A Itakura, I Kondo, O Kurauchi, F Kikkawa, Y Tomoda. Possible involvement of placental proteases in bradykinin (BK) degradation.
Reproduction, fertility, and development.
1997; 9(6):633-9. doi:
10.1071/r96045. [PMID: 9551668] - M Ikai, M Itoh, T Joh, Y Yokoyama, N Okada, H Okada. Complement plays an essential role in shock following intestinal ischaemia in rats.
Clinical and experimental immunology.
1996 Oct; 106(1):156-9. doi:
10.1046/j.1365-2249.1996.d01-817.x. [PMID: 8870714] - M A Vieira, M F Moreira, T Maack, J A Guimarães. Conversion of T-kinin to bradykinin by the rat kidney.
Biochemical pharmacology.
1994 Apr; 47(9):1693-9. doi:
10.1016/0006-2952(94)90549-5. [PMID: 8185685] - A Nagae, M Abe, R P Becker, P A Deddish, R A Skidgel, E G Erdös. High concentration of carboxypeptidase M in lungs: presence of the enzyme in alveolar type I cells.
American journal of respiratory cell and molecular biology.
1993 Aug; 9(2):221-9. doi:
10.1165/ajrcmb/9.2.221. [PMID: 8338689] - A Nagae, P A Deddish, R P Becker, C H Anderson, M Abe, F Tan, R A Skidgel, E G Erdös. Carboxypeptidase M in brain and peripheral nerves.
Journal of neurochemistry.
1992 Dec; 59(6):2201-12. doi:
10.1111/j.1471-4159.1992.tb10112.x. [PMID: 1431901] - M Majima, H Y Jin, M Katori, N Sunahara. Increase in the kinin levels in the bronchial washings after intravenous injection of leukotriene C4 in guinea pigs.
Agents and actions. Supplements.
1992; 38 ( Pt 3)(?):467-74. doi:
. [PMID: 1462880] - P E Ward, A Chow, G Drapeau. Metabolism of bradykinin agonists and antagonists by plasma aminopeptidase P.
Biochemical pharmacology.
1991 Jul; 42(4):721-7. doi:
10.1016/0006-2952(91)90028-4. [PMID: 1651078] - H Ishida, A G Scicli, O A Carretero. Contributions of various rat plasma peptidases to kinin hydrolysis.
The Journal of pharmacology and experimental therapeutics.
1989 Dec; 251(3):817-20. doi:
. [PMID: 2557417] - D Hendriks, S Scharpé, M van Sande, M P Lommaert. Characterisation of a carboxypeptidase in human serum distinct from carboxypeptidase N.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie.
1989 May; 27(5):277-85. doi:
10.1515/cclm.1989.27.5.277. [PMID: 2760564] - M Majima, A Ueno, N Sunahara, M Katori. Measurement of des-Phe8-Arg9-bradykinin by enzyme-immunoassay--a useful parameter of plasma kinin release.
Advances in experimental medicine and biology.
1989; 247B(?):331-5. doi:
10.1007/978-1-4615-9546-5_55. [PMID: 2692413] - T Hoffmann, E C Böttger, H P Baum, M Messner, U Hadding, D Bitter-Suermann. In vivo effects of C3a on neutrophils and its contribution to inflammatory lung processes in a guinea-pig model.
Clinical and experimental immunology.
1988 Mar; 71(3):486-92. doi:
NULL. [PMID: 3260158] - D R Abendschein, H Serota, T H Plummer, K Amiraian, A W Strauss, B E Sobel, A S Jaffe. Conversion of MM creatine kinase isoforms in human plasma by carboxypeptidase N.
The Journal of laboratory and clinical medicine.
1987 Dec; 110(6):798-806. doi:
. [PMID: 3681119] - N Ura, O A Carretero, E G Erdös. Role of renal endopeptidase 24.11 in kinin metabolism in vitro and in vivo.
Kidney international.
1987 Oct; 32(4):507-13. doi:
10.1038/ki.1987.239. [PMID: 2828746] - F E Palmieri, H H Bausback, L Churchill, P E Ward. Kinin and enkephalin conversion by an endothelial, plasma membrane carboxypeptidase.
Biochemical pharmacology.
1986 Aug; 35(16):2749-56. doi:
10.1016/0006-2952(86)90185-1. [PMID: 3091032] - I von Zabern, R Nolte. Activation of the alternative pathway of complement by DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid (Mergetpa).
Complement (Basel, Switzerland).
1986; 3(2):97-104. doi:
10.1159/000467885. [PMID: 3095022] - C Davrinche, R Charlionet, C Rivat, A N Helal, G Lefranc. Inulin-induced activation of factor B in whole serum: description of structural modifications in the Ba fragment.
European journal of immunology.
1984 Oct; 14(10):957-61. doi:
10.1002/eji.1830141017. [PMID: 6567528]
