Meranzin hydrate (BioDeep_00000180746)
human metabolite blood metabolite natural product
代谢物信息卡片
8-(2,3-dihydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one
化学式: C15H18O5 (278.1154178)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C(CC1=C(C=CC2=C1OC(=O)C=C2)OC)O)O
InChI: InChI=1S/C15H18O5/c1-15(2,18)12(16)8-10-11(19-3)6-4-9-5-7-13(17)20-14(9)10/h4-7,12,16,18H,8H2,1-3H3
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:181662
- PubChem: 5070783
- HMDB: HMDB0254461
- ChEMBL: CHEMBL433093
- CAS: 5673-37-0
- LOTUS: LTS0247238
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
60 个相关的物种来源信息
- 4037 - Apiaceae: LTS0247238
- 2706 - Citrus: LTS0247238
- 43166 - Citrus aurantium: 10.1016/S0031-9422(00)83873-X
- 43166 - Citrus aurantium: 10.1021/JF950183M
- 135197 - Citrus junos: 10.1016/J.FOODCHEM.2014.10.010
- 135197 - Citrus junos: LTS0247238
- 37334 - Citrus maxima: 10.1016/S0031-9422(00)83873-X
- 37334 - Citrus maxima: LTS0247238
- 475932 - Citrus wilsonii: 10.1016/J.FOODCHEM.2014.10.010
- 475932 - Citrus wilsonii: LTS0247238
- 37656 - Citrus × paradisi: 10.1016/S0031-9422(00)83873-X
- 48110 - Cnidium: LTS0247238
- 94007 - Cnidium monnieri: 10.1021/NP990522W
- 94007 - Cnidium monnieri: LTS0247238
- 2759 - Eukaryota: LTS0247238
- 52470 - Ferula: LTS0247238
- 555413 - Ferula moschata: 10.1016/S0031-9422(99)00554-3
- 555413 - Ferula moschata: LTS0247238
- 371383 - Ferula sumbul: 10.1016/S0031-9422(99)00554-3
- 371383 - Ferula sumbul: LTS0247238
- 9606 - Homo sapiens: -
- 282621 - Leionema: LTS0247238
- 2981382 - Leionema coxii: LTS0247238
- 3398 - Magnoliopsida: LTS0247238
- 489429 - Magydaris: LTS0247238
- 681588 - Magydaris pastinacea: 10.1021/NP50050A046
- 681588 - Magydaris pastinacea: LTS0247238
- 43710 - Murraya: LTS0247238
- 159059 - Murraya exotica: 10.1002/JCCS.199400032
- 159059 - Murraya exotica: 10.1016/S0031-9422(00)86993-9
- 159059 - Murraya exotica: 10.1248/CPB.35.4277
- 159059 - Murraya exotica: 10.1248/CPB.37.358
- 2901850 - Murraya exotica: LTS0247238
- 43711 - Murraya paniculata: 10.1002/JCCS.199400032
- 43711 - Murraya paniculata: 10.1016/S0031-9422(00)80160-0
- 43711 - Murraya paniculata: 10.1016/S0031-9422(00)86993-9
- 43711 - Murraya paniculata: 10.1016/S0031-9422(00)97490-9
- 43711 - Murraya paniculata: 10.1055/S-2002-19874
- 43711 - Murraya paniculata: 10.1248/CPB.35.4277
- 43711 - Murraya paniculata: 10.1248/CPB.37.358
- 43711 - Murraya paniculata: LTS0247238
- 77003 - Phebalium: LTS0247238
- 282630 - Phebalium canaliculatum: 10.1016/0031-9422(92)83450-D
- 282630 - Phebalium canaliculatum: LTS0247238
- 282637 - Phebalium filifolium: 10.1021/NP50085A003
- 282637 - Phebalium filifolium: LTS0247238
- 282636 - Phebalium tuberculosum: 10.1016/0031-9422(92)83450-D
- 282636 - Phebalium tuberculosum: 10.1021/NP50085A003
- 282636 - Phebalium tuberculosum: LTS0247238
- 77016 - Pilocarpus: LTS0247238
- 23513 - Rutaceae: LTS0247238
- 76975 - Skimmia: LTS0247238
- 354517 - Skimmia reevesiana: 10.1016/S0031-9422(00)84814-1
- 354517 - Skimmia reevesiana: LTS0247238
- 35493 - Streptophyta: LTS0247238
- 58023 - Tracheophyta: LTS0247238
- 159069 - Triphasia: LTS0247238
- 159070 - Triphasia trifolia: 10.1016/0031-9422(88)80163-8
- 159070 - Triphasia trifolia: LTS0247238
- 33090 - Viridiplantae: LTS0247238
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ya-Lin Liu, Jian-Jun Xu, Lin-Ran Han, Xiang-Fei Liu, Mu-Hai Lin, Yun Wang, Zhe Xiao, Yun-Ke Huang, Ping Ren, Xi Huang. Meranzin Hydrate Improves Depression-Like Behaviors and Hypomotility via Ghrelin and Neurocircuitry.
Chinese journal of integrative medicine.
2022 Jul; ?(?):. doi:
10.1007/s11655-022-3308-2. [PMID: 35881212] - Kechao Nie, Lin Liu, Luqi Peng, Mei Zhang, Chunhu Zhang, Bo Xiao, Zian Xia, Wei Huang. Effects of Meranzin Hydrate On the LncRNA-miRNA-mRNA Regulatory Network in the Hippocampus of a Rat Model of Depression.
Journal of molecular neuroscience : MN.
2022 Apr; 72(4):910-922. doi:
10.1007/s12031-022-01971-6. [PMID: 35099722] - XiangFei Liu, JiaLing Zhou, Tian Zhang, Ken Chen, Min Xu, Lei Wu, Jin Liu, YunKe Huang, BinBin Nie, Xu Shen, Ping Ren, Xi Huang. Meranzin hydrate elicits antidepressant effects and restores reward circuitry.
Behavioural brain research.
2021 02; 398(?):112898. doi:
10.1016/j.bbr.2020.112898. [PMID: 32905810] - Shaoqi Shi, Han Yan, Ying Chen, Yalin Liu, Xueya Zhang, Ying Xie, Jianjun Xu, Lei Wu, Ken Chen, Xu Shen, Ping Ren, Xi Huang. Pharmacokinetic study of precisely representative antidepressant, prokinetic, anti-inflammatory and anti-oxidative compounds from Fructus aurantii and Magnolia Bark.
Chemico-biological interactions.
2020 Jan; 315(?):108851. doi:
10.1016/j.cbi.2019.108851. [PMID: 31614129] - Lan Li, Ai-Ling Yu, Zheng-Li Wang, Ken Chen, Wan Zheng, Jun-Jie Zhou, Qi Xie, Hong-Bin Yan, Ping Ren, Xi Huang. Chaihu-Shugan-San and absorbed meranzin hydrate induce anti-atherosclerosis and behavioral improvements in high-fat diet ApoE-/- mice via anti-inflammatory and BDNF-TrkB pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Jul; 115(?):108893. doi:
10.1016/j.biopha.2019.108893. [PMID: 31022598] - Xi Huang, Ying Guo, Wei-Hua Huang, Wei Zhang, Zhi-Rong Tan, Jing-Bo Peng, Yi-Cheng Wang, Dong-Li Hu, Dong-Sheng Ouyang, Jian Xiao, Yang Wang, Min Luo, Yao Chen. Searching the cytochrome p450 enzymes for the metabolism of meranzin hydrate: a prospective antidepressant originating from Chaihu-Shugan-San.
PloS one.
2014; 9(11):e113819. doi:
10.1371/journal.pone.0113819. [PMID: 25427198] - Ying Xie, Xi Huang, Sui-Yu Hu, Xin-Jian Qiu, Ying-Jin Zhang, Ping Ren, Yang Wang, Hui Ji, Chun-Hu Zhang, Wei-Bin Xie, Juan He, Meng-Zhou Xie, Hui-Yong Huang, Zhao-Qian Liu, Hong-Hao Zhou. Meranzin hydrate exhibits anti-depressive and prokinetic-like effects through regulation of the shared α2-adrenoceptor in the brain-gut axis of rats in the forced swimming test.
Neuropharmacology.
2013 Apr; 67(?):318-25. doi:
10.1016/j.neuropharm.2012.10.003. [PMID: 23063894] - Ying Xie, Xi Huang, Sui-yu Hu, Ying-jin Zhang, Yang Wang, Xin-jian Qiu, Ping Ren, Rong Fan, Chun-hu Zhang, Wei-bin Xie, Hui Ji, Juan He, Xiao Chen, Linhong Xie, Zhao-qian Liu, Hong-hao Zhou. The involvement of AMPA-ERK1/2-BDNF pathway in the mechanism of new antidepressant action of prokinetic meranzin hydrate.
Amino acids.
2013 Feb; 44(2):413-22. doi:
10.1007/s00726-012-1347-2. [PMID: 22782214] - Xin-Jian Qiu, Xi Huang, Ze-Qi Chen, Ping Ren, Wei Huang, Feng Qin, Si-Hang Hu, Jun Huang, Juan He, Zhao-Qian Liu, Hong-Hao Zhou. Pharmacokinetic study of the prokinetic compounds meranzin hydrate and ferulic acid following oral administration of Chaihu-Shugan-San to patients with functional dyspepsia.
Journal of ethnopharmacology.
2011 Sep; 137(1):205-13. doi:
10.1016/j.jep.2011.05.009. [PMID: 21605652] - Wei Huang, Xi Huang, Zhihua Xing, Xinjian Qiu, Yang Wang, Rong Fan, Weiping Liu, Ping Ren, Zhaoqian Liu, Honghao Zhou. Meranzin hydrate induces similar effect to Fructus Aurantii on intestinal motility through activation of H1 histamine receptors.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
2011 Jan; 15(1):87-96. doi:
10.1007/s11605-010-1374-9. [PMID: 21061180] - Régine Dondon, Paul Bourgeois, Suzanne Fery-Forgues. A new bicoumarin from the leaves and stems of Triphasia trifolia.
Fitoterapia.
2006 Feb; 77(2):129-33. doi:
10.1016/j.fitote.2005.11.006. [PMID: 16431036]