Medica 16 (BioDeep_00000180700)
human metabolite blood metabolite
代谢物信息卡片
化学式: C20H38O4 (342.277)
中文名称: 3,3,14,14-四甲基十六烷二酸
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: CC(C)(CCCCCCCCCCC(C)(C)CC(=O)O)CC(=O)O
InChI: InChI=1S/C20H38O4/c1-19(2,15-17(21)22)13-11-9-7-5-6-8-10-12-14-20(3,4)16-18(23)24/h5-16H2,1-4H3,(H,21,22)(H,23,24)
描述信息
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
D009676 - Noxae > D000963 - Antimetabolites
MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle, and this reduction is accompanied by an increase in insulin sensitivity. MEDICA16 is a selective agonist for GPR40 as well as selective partial agonists for GPR120[1][2].
同义名列表
18 个代谢物同义名
beta,Beta-tetramethylhexadecane-alpha,omega-dioic acid; beta,Beta-tetramethylhexadecane-alpha,omega-dioate; Β,beta-tetramethylhexadecane-α,omega-dioic acid; b,Beta-tetramethylhexadecane-a,omega-dioic acid; b,Beta-tetramethylhexadecane-a,omega-dioate; 3,3,14,14-Tetramethylhexanedecanedioic acid; Β,beta-tetramethylhexadecane-α,omega-dioate; beta,Beta-tetramethylhexadecanedioic acid; 3,3,14,14-tetramethylhexadecanedioic acid; Β,beta-tetramethylhexadecanedioic acid; b,Beta-tetramethylhexadecanedioic acid; beta,Beta-tetramethylhexadecanedioate; Β,beta-tetramethylhexadecanedioate; b,Beta-tetramethylhexadecanedioate; MEDICA 16; MEDICA-16; MEDIC-16; MEDICA16
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:149582
- PubChem: 121871
- HMDB: HMDB0254402
- ChEMBL: CHEMBL63829
- chemspider: 108722
- CAS: 87272-20-6
- medchemexpress: HY-P1123
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Carlotta Granchi. ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism.
European journal of medicinal chemistry.
2018 Sep; 157(?):1276-1291. doi:
10.1016/j.ejmech.2018.09.001. [PMID: 30195238] - Teresa Merino-Ramos, Ángela Vázquez-Calvo, Josefina Casas, Francisco Sobrino, Juan-Carlos Saiz, Miguel A Martín-Acebes. Modification of the Host Cell Lipid Metabolism Induced by Hypolipidemic Drugs Targeting the Acetyl Coenzyme A Carboxylase Impairs West Nile Virus Replication.
Antimicrobial agents and chemotherapy.
2016 01; 60(1):307-15. doi:
10.1128/aac.01578-15. [PMID: 26503654] - Sara Janssen, Jorien Laermans, Hiroshi Iwakura, Jan Tack, Inge Depoortere. Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein.
PloS one.
2012; 7(6):e40168. doi:
10.1371/journal.pone.0040168. [PMID: 22768248] - Bella Kalderon, Nina Mayorek, Limor Ben-Yaacov, Jacob Bar-Tana. Adipose tissue sensitization to insulin induced by troglitazone and MEDICA 16 in obese Zucker rats in vivo.
American journal of physiology. Endocrinology and metabolism.
2003 Apr; 284(4):E795-803. doi:
10.1152/ajpendo.00368.2002. [PMID: 12488241] - B Kalderon, V Sheena, S Shachrur, R Hertz, J Bar-Tana. Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry.
Journal of lipid research.
2002 Jul; 43(7):1125-32. doi:
10.1194/jlr.m200060-jlr200. [PMID: 12091497] - Laura L Atkinson, Sandra E Kelly, James C Russell, Jacob Bar-Tana, Gary D Lopaschuk. MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats.
Diabetes.
2002 May; 51(5):1548-55. doi:
10.2337/diabetes.51.5.1548. [PMID: 11978655] - R Hertz, V Sheena, B Kalderon, I Berman, J Bar-Tana. Suppression of hepatocyte nuclear factor-4alpha by acyl-CoA thioesters of hypolipidemic peroxisome proliferators.
Biochemical pharmacology.
2001 May; 61(9):1057-62. doi:
10.1016/s0006-2952(01)00578-0. [PMID: 11301038] - B Kalderon, N Mayorek, E Berry, N Zevit, J Bar-Tana. Fatty acid cycling in the fasting rat.
American journal of physiology. Endocrinology and metabolism.
2000 Jul; 279(1):E221-7. doi:
10.1152/ajpendo.2000.279.1.e221. [PMID: 10893343] - J C Russell, G Shillabeer, J Bar-Tana, D C Lau, M Richardson, L M Wenzel, S E Graham, P J Dolphin. Development of insulin resistance in the JCR:LA-cp rat: role of triacylglycerols and effects of MEDICA 16.
Diabetes.
1998 May; 47(5):770-8. doi:
10.2337/diabetes.47.5.770. [PMID: 9588449] - N Mayorek, B Kalderon, E Itach, J Bar-Tana. Sensitization to insulin induced by beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in obese Zucker rats in vivo.
Diabetes.
1997 Dec; 46(12):1958-64. doi:
10.2337/diab.46.12.1958. [PMID: 9392480] - J C Russell, R M Amy, S E Graham, P J Dolphin, G O Wood, J Bar-Tana. Inhibition of atherosclerosis and myocardial lesions in the JCR:LA-cp rat by beta, beta'-tetramethylhexadecanedioic acid (MEDICA 16).
Arteriosclerosis, thrombosis, and vascular biology.
1995 Jul; 15(7):918-23. doi:
10.1161/01.atv.15.7.918. [PMID: 7600124] - R Hertz, J Bishara-Shieban, J Bar-Tana. Mode of action of peroxisome proliferators as hypolipidemic drugs. Suppression of apolipoprotein C-III.
The Journal of biological chemistry.
1995 Jun; 270(22):13470-5. doi:
10.1074/jbc.270.22.13470. [PMID: 7768950] - B Frenkel, J Bishara-Shieban, J Bar-Tana. The effect of beta,beta'-tetramethylhexadecanedioic acid (MEDICA 16) on plasma very-low-density lipoprotein metabolism in rats: role of apolipoprotein C-III.
The Biochemical journal.
1994 Mar; 298 ( Pt 2)(?):409-14. doi:
10.1042/bj2980409. [PMID: 8135749] - N Mayorek, J Bar-Tana. Hypocholesterolaemic effect of beta beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in the male hamster.
The Biochemical journal.
1993 Feb; 289 ( Pt 3)(?):911-7. doi:
10.1042/bj2890911. [PMID: 8435085] - R G Elkin, J C Rogler, H D Lee, B A Watkins. Effect of beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16) on laying hen performance and egg yolk lipid composition.
British poultry science.
1992 Jul; 33(3):677-81. doi:
10.1080/00071669208417506. [PMID: 1643530] - J C Russell, P J Dolphin, M Hameed, B Stewart, D G Koeslag, G Rose-Kahn, J Bar-Tana. Hypolipidemic effect of beta, beta'-tetramethyl hexadecanedioic acid (MEDICA 16) in hyperlipidemic JCR:LA-corpulent rats.
Arteriosclerosis and thrombosis : a journal of vascular biology.
1991 May; 11(3):602-9. doi:
10.1161/01.atv.11.3.602. [PMID: 2029500] - G Rose-Kahn, J Bar-Tana. Inhibition of rat liver acetyl-CoA carboxylase by beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16).
Biochimica et biophysica acta.
1990 Feb; 1042(2):259-64. doi:
10.1016/0005-2760(90)90018-s. [PMID: 1967952] - R Tzur, E Smith, J Bar-Tana. Adipose reduction by beta,beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16).
International journal of obesity.
1989; 13(3):313-26. doi:
". [PMID: 2670791] - R Tzur, G Rose-Kahn, J H Adler, J Bar-Tana. Hypolipidemic, antiobesity, and hypoglycemic-hypoinsulinemic effects of beta,beta'-methyl-substituted hexadecanedioic acid in sand rats.
Diabetes.
1988 Dec; 37(12):1618-24. doi:
10.2337/diab.37.12.1618. [PMID: 3056760] - B Frenkel, N Mayorek, R Hertz, J Bar-Tana. The hypochylomicronemic effect of beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) is mediated by a decrease in apolipoprotein C-III.
The Journal of biological chemistry.
1988 Jun; 263(17):8491-7. doi:
10.1016/s0021-9258(18)68505-9. [PMID: 3372539] - J Bar-Tana, G Rose-Kahn, B Frenkel, Z Shafer, M Fainaru. Hypolipidemic effect of beta, beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in normal and nephrotic rats.
Journal of lipid research.
1988 Apr; 29(4):431-41. doi:
10.1016/s0022-2275(20)38517-5. [PMID: 3392461] - K L Clay, R C Murphy. On the metabolic acidosis of ethylene glycol intoxication.
Toxicology and applied pharmacology.
1977 Jan; 39(1):39-49. doi:
10.1016/0041-008x(77)90175-2. [PMID: 14421]
