Lidoflazine (BioDeep_00000180472)

   

human metabolite blood metabolite


代谢物信息卡片


2-{4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl}-N-(2,6-dimethylphenyl)ethanimidic acid

化学式: C30H35F2N3O (491.2748)
中文名称: 利多氟嗪
谱图信息: 最多检出来源 Rattus norvegicus(blood) 73.91%

分子结构信息

SMILES: CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
InChI: InChI=1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)

描述信息

C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
C - Cardiovascular system > C08 - Calcium channel blockers > C08E - Non-selective calcium channel blockers
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker

同义名列表

6 个代谢物同义名

2-{4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl}-N-(2,6-dimethylphenyl)ethanimidic acid; 2-{4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl}-N-(2,6-dimethylphenyl)ethanimidate; Ordiflazine; Lidoflazine; Clinium; Angex



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Alexander N Katchman, John Koerner, Toshimasa Tosaka, Raymond L Woosley, Steven N Ebert. Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs. The Journal of pharmacology and experimental therapeutics. 2006 Mar; 316(3):1098-106. doi: 10.1124/jpet.105.093393. [PMID: 16278312]
  • W J Flameng, P Herijgers, J Szécsi, P T Sergeant, W J Daenen, I Scheys. Determinants of early and late results of combined valve operations and coronary artery bypass grafting. The Annals of thoracic surgery. 1996 Feb; 61(2):621-8. doi: 10.1016/0003-4975(95)00970-1. [PMID: 8572777]
  • J Jacobsson, R Sundberg, H L Rilo, A Gasbarrini, T E Starzl, D Van Thiel. Protective effects of the lazaroid U74500A and lidoflazine on liver preservation with UW solution. Transplant international : official journal of the European Society for Organ Transplantation. 1993; 6(5):281-4. doi: 10.1007/bf00336028. [PMID: 8216705]
  • J Jacobsson, B Odlind, G Tufveson, J Wahlberg. Improvement of renal preservation by adding lidoflazine to University of Wisconsin solution. An experimental study in the rat. Cryobiology. 1992 Jun; 29(3):305-9. doi: 10.1016/0011-2240(92)90031-v. [PMID: 1499315]
  • D A Griffith, A R Conant, S M Jarvis. Differential inhibition of nucleoside transport systems in mammalian cells by a new series of compounds related to lidoflazine and mioflazine. Biochemical pharmacology. 1990 Nov; 40(10):2297-303. doi: 10.1016/0006-2952(90)90726-2. [PMID: 2244931]
  • R Hansson, S Bratell, P Burian, A C Bylund-Fellenius, O Jonsson, O Lundgren, S Lundstam, S Pettersson, T Schersten. Renal function during reperfusion after warm ischaemia in rabbits: an experimental study on the possible protective effects of pretreatment with oxygen radical scavengers or lidoflazine. Acta physiologica Scandinavica. 1990 May; 139(1):39-46. doi: 10.1111/j.1748-1716.1990.tb08895.x. [PMID: 2356757]
  • L Ver Donck, G Verellen, R Vandewiele, F De Clerck, M Borgers. Class IV Ca2+ antagonists do not affect lipid peroxidation in singlet oxygen challenged cardiomyocytes. Cell biology international reports. 1990 Apr; 14(4):399-406. doi: 10.1016/0309-1651(90)91209-m. [PMID: 2354524]
  • A P Ijzerman, K H Thedinga, A F Custers, B Hoos, H Van Belle. Inhibition of nucleoside transport by a new series of compounds related to lidoflazine and mioflazine. European journal of pharmacology. 1989 Aug; 172(3):273-81. doi: 10.1016/0922-4106(89)90057-6. [PMID: 2776845]
  • B Jakobsson, I A el Hag, C Erichsen, P I Christensson, P E Jönsson, U Stenram. Modulation of 5-fluorouracil and 5-fluorouridine toxicity by membrane transport inhibitors in normal tissues of rats with liver adenocarcinoma. Anticancer research. 1989 Mar; 9(2):285-90. doi: . [PMID: 2751255]
  • P G Plagemann, C Woffendin. Species differences in sensitivity of nucleoside transport in erythrocytes and cultured cells to inhibition by nitrobenzylthioinosine, dipyridamole, dilazep and lidoflazine. Biochimica et biophysica acta. 1988 Apr; 969(1):1-8. doi: 10.1016/0167-4889(88)90081-x. [PMID: 3349106]
  • N R Nayini, B C White, S D Aust, R R Huang, R J Indrieri, A T Evans, H Bialek, W A Jacobs, J Komara. Post resuscitation iron delocalization and malondialdehyde production in the brain following prolonged cardiac arrest. Journal of free radicals in biology & medicine. 1985; 1(2):111-6. doi: 10.1016/0748-5514(85)90014-5. [PMID: 3836237]
  • G Keren, D Tepper, B Butler, W Maguire, H Willens, D Miura, J C Somberg. Studies on the possible mechanisms of lidoflazine arrhythmogenicity. Journal of the American College of Cardiology. 1984 Oct; 4(4):742-7. doi: 10.1016/s0735-1097(84)80401-5. [PMID: 6481014]
  • A Verheyen, M Borgers, H Blaton, H Sowa. The ultrastructure of human livers after prolonged lidoflazine therapy. Toxicology and applied pharmacology. 1975 Nov; 34(2):224-32. doi: 10.1016/0041-008x(75)90027-7. [PMID: 1209621]
  • E Carmeliet, R Xhonneux, R S Reneman. Lidoplazine and Na and K distribution in normo-and hypokalaemic rats. European journal of pharmacology. 1975 Aug; 33(1):81-9. doi: 10.1016/0014-2999(75)90141-7. [PMID: 1175693]