levan n (BioDeep_00000180448)
human metabolite blood metabolite
代谢物信息卡片
5-({[5-({[3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}methyl)-3,4-dihydroxy-2-(hydroxymethyl)oxolan-2-yl]oxy}methyl)-2-(hydroxymethyl)oxolane-2,3,4-triol
化学式: C18H32O16 (504.1690272)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 66.67%
分子结构信息
SMILES: C(C1C(C(C(O1)(CO)OCC2C(C(C(O2)(CO)OCC3C(C(C(O3)(CO)O)O)O)O)O)O)O)O
InChI: InChI=1S/C18H32O16/c19-1-7-10(23)14(27)17(5-21,33-7)31-3-9-12(25)15(28)18(6-22,34-9)30-2-8-11(24)13(26)16(29,4-20)32-8/h7-15,19-29H,1-6H2
描述信息
D000970 - Antineoplastic Agents
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jiao Jiao, Trang Tran-Minh, Anam Nasir, Qinggang Guo, Jörg Stülke, Triinu Visnapuu, Noémie De Zutter, Barbara De Coninck, Wim Van den Ende. Exploring Synergistic Effects of Levan and Levan-Metabolizing Bacillaceae in Promoting Growth and Enhancing Immunity of Tomato and Wheat.
Physiologia plantarum.
2024 May; 176(3):e14325. doi:
10.1111/ppl.14325. [PMID: 38715548] - Simone Luti, Sara Campigli, Francesco Ranaldi, Paolo Paoli, Luigia Pazzagli, Guido Marchi. Lscβ and lscγ, two novel levansucrases of Pseudomonas syringae pv. actinidiae biovar 3, the causal agent of bacterial canker of kiwifruit, show different enzymatic properties.
International journal of biological macromolecules.
2021 May; 179(?):279-291. doi:
10.1016/j.ijbiomac.2021.02.189. [PMID: 33675829] - Silin Wu, Steffen Greiner, Chongjian Ma, Jiaxin Zhong, Xiaojia Huang, Thomas Rausch, Hongbo Zhao. A Fructan Exohydrolase from Maize Degrades Both Inulin and Levan and Co-Exists with 1-Kestotriose in Maize.
International journal of molecular sciences.
2021 May; 22(10):. doi:
10.3390/ijms22105149. [PMID: 34068004] - Xiaojia Huang, Wei Luo, Silin Wu, Yuming Long, Rui Li, Fenghua Zheng, Steffen Greiner, Thomas Rausch, Hongbo Zhao. Apoplastic maize fructan exohydrolase Zm-6-FEH displays substrate specificity for levan and is induced by exposure to levan-producing bacteria.
International journal of biological macromolecules.
2020 Nov; 163(?):630-639. doi:
10.1016/j.ijbiomac.2020.06.254. [PMID: 32622772] - Bassem M Salama, Wafaa A Helmy, Tamer I M Ragab, Mamdouh M Ali, Hanan A A Taie, Mona A Esawy. Characterization of a new efficient low molecular weight Bacillus subtilis NRC 16 levansucrase and its levan.
Journal of basic microbiology.
2019 Oct; 59(10):1004-1015. doi:
10.1002/jobm.201900170. [PMID: 31407369] - Onur Kırtel, Eveline Lescrinier, Wim Van den Ende, Ebru Toksoy Öner. Discovery of fructans in Archaea.
Carbohydrate polymers.
2019 Sep; 220(?):149-156. doi:
10.1016/j.carbpol.2019.05.064. [PMID: 31196534] - Jyoti Singh Jadaun, Lokesh Kumar Narnoliya, Neera Agarwal, Sudhir P Singh. Catalytic biosynthesis of levan and short-chain fructooligosaccharides from sucrose-containing feedstocks by employing the levansucrase from Leuconostoc mesenteroides MTCC10508.
International journal of biological macromolecules.
2019 Apr; 127(?):486-495. doi:
10.1016/j.ijbiomac.2019.01.070. [PMID: 30659880] - Artur Szwengiel, Ghomaka Lydia Nkongha. Influence of acid depolymerization parameters on levan molar mass distribution and its utilization by bacteria.
Carbohydrate polymers.
2019 Feb; 206(?):371-379. doi:
10.1016/j.carbpol.2018.11.029. [PMID: 30553334] - Onur Kirtel, Carmen Menéndez, Maxime Versluys, Wim Van den Ende, Lázaro Hernández, Ebru Toksoy Öner. Levansucrase from Halomonas smyrnensis AAD6T: first halophilic GH-J clan enzyme recombinantly expressed, purified, and characterized.
Applied microbiology and biotechnology.
2018 Nov; 102(21):9207-9220. doi:
10.1007/s00253-018-9311-z. [PMID: 30120521] - Yanli Tian, Yuqiang Zhao, Linye Shi, Zhongli Cui, Baishi Hu, Youfu Zhao. Type VI Secretion Systems of Erwinia amylovora Contribute to Bacterial Competition, Virulence, and Exopolysaccharide Production.
Phytopathology.
2017 06; 107(6):654-661. doi:
10.1094/phyto-11-16-0393-r. [PMID: 28421913] - Ebru Toksoy Öner, Lázaro Hernández, Joan Combie. Review of Levan polysaccharide: From a century of past experiences to future prospects.
Biotechnology advances.
2016 Sep; 34(5):827-844. doi:
10.1016/j.biotechadv.2016.05.002. [PMID: 27178733] - Susanne L Jensen, Mikkel B Diemer, Maria Lundmark, Flemming H Larsen, Andreas Blennow, Helle K Mogensen, Tom H Nielsen. Levanase from Bacillus subtilis hydrolyses β-2,6 fructosyl bonds in bacterial levans and in grass fructans.
International journal of biological macromolecules.
2016 Apr; 85(?):514-21. doi:
10.1016/j.ijbiomac.2016.01.008. [PMID: 26773563] - Cai-Xia Dong, Li-Jiao Zhang, Rong Xu, Gong Zhang, Ying-Biao Zhou, Xiao-Qiang Han, Ying Zhang, Yuan-Xia Sun. Structural characterization and immunostimulating activity of a levan-type fructan from Curcuma kwangsiensis.
International journal of biological macromolecules.
2015; 77(?):99-104. doi:
10.1016/j.ijbiomac.2015.03.009. [PMID: 25783019] - Hiroaki Matsuhira, Ken-ichi Tamura, Hideto Tamagake, Yutaka Sato, Hiroyuki Anzai, Midori Yoshida. High production of plant type levan in sugar beet transformed with timothy (Phleum pratense) 6-SFT genes.
Journal of biotechnology.
2014 Dec; 192 Pt A(?):215-22. doi:
10.1016/j.jbiotec.2014.09.025. [PMID: 25305472] - Jin sun Oh, Seung Ri Lee, Keum Taek Hwang, Geun Eog Ji. The anti-obesity effects of the dietary combination of fermented red ginseng with levan in high fat diet mouse model.
Phytotherapy research : PTR.
2014 Apr; 28(4):617-22. doi:
10.1002/ptr.5042. [PMID: 23873605] - Shaunak Khandekar, Abhishek Srivastava, Daniel Pletzer, Antje Stahl, Matthias S Ullrich. The conserved upstream region of lscB/C determines expression of different levansucrase genes in plant pathogen Pseudomonas syringae.
BMC microbiology.
2014 Mar; 14(?):79. doi:
10.1186/1471-2180-14-79. [PMID: 24670199] - Imen Dahech, Bahira Harrabi, Khaled Hamden, Abdelfattah Feki, Hafedh Mejdoub, Hafedh Belghith, Karima Srih Belghith. Antioxidant effect of nondigestible levan and its impact on cardiovascular disease and atherosclerosis.
International journal of biological macromolecules.
2013 Jul; 58(?):281-6. doi:
10.1016/j.ijbiomac.2013.04.058. [PMID: 23624165] - Jaco Franken, Bianca A Brandt, Siew L Tai, Florian F Bauer. Biosynthesis of levan, a bacterial extracellular polysaccharide, in the yeast Saccharomyces cerevisiae.
PloS one.
2013; 8(10):e77499. doi:
10.1371/journal.pone.0077499. [PMID: 24147008] - Karima Srih Belghith, Imen Dahech, Khaled Hamden, Abdelfattah Feki, Hafedh Mejdoub, Hafedh Belghith. Hypolipidemic effect of diet supplementation with bacterial levan in cholesterol-fed rats.
International journal of biological macromolecules.
2012 May; 50(4):1070-4. doi:
10.1016/j.ijbiomac.2012.02.024. [PMID: 22433476] - Imen Dahech, Karima Srih Belghith, Khaled Hamden, Abdelfattah Feki, Hafedh Belghith, Hafedh Mejdoub. Oral administration of levan polysaccharide reduces the alloxan-induced oxidative stress in rats.
International journal of biological macromolecules.
2011 Dec; 49(5):942-7. doi:
10.1016/j.ijbiomac.2011.08.011. [PMID: 21925206] - Alexander Banguela, Juan G Arrieta, Raisa Rodríguez, Luis E Trujillo, Carmen Menéndez, Lázaro Hernández. High levan accumulation in transgenic tobacco plants expressing the Gluconacetobacter diazotrophicus levansucrase gene.
Journal of biotechnology.
2011 Jun; 154(1):93-8. doi:
10.1016/j.jbiotec.2011.04.007. [PMID: 21540065] - Wim Van den Ende, Marlies Coopman, Stefan Clerens, Rudy Vergauwen, Katrien Le Roy, Willem Lammens, André Van Laere. Unexpected presence of graminan- and levan-type fructans in the evergreen frost-hardy eudicot Pachysandra terminalis (Buxaceae): purification, cloning, and functional analysis of a 6-SST/6-SFT enzyme.
Plant physiology.
2011 Jan; 155(1):603-14. doi:
10.1104/pp.110.162222. [PMID: 21037113] - Mónica Ordax, Ester Marco-Noales, María M López, Elena G Biosca. Exopolysaccharides favor the survival of Erwinia amylovora under copper stress through different strategies.
Research in microbiology.
2010 Sep; 161(7):549-55. doi:
10.1016/j.resmic.2010.05.003. [PMID: 20546893] - Jun Liu, Jianguang Luo, Yi Sun, Hong Ye, Zhaoxin Lu, Xiaoxiong Zeng. A simple method for the simultaneous decoloration and deproteinization of crude levan extract from Paenibacillus polymyxa EJS-3 by macroporous resin.
Bioresource technology.
2010 Aug; 101(15):6077-83. doi:
10.1016/j.biortech.2010.03.019. [PMID: 20346649] - Jessica M Koczan, Molly J McGrath, Youfu Zhao, George W Sundin. Contribution of Erwinia amylovora exopolysaccharides amylovoran and levan to biofilm formation: implications in pathogenicity.
Phytopathology.
2009 Nov; 99(11):1237-44. doi:
10.1094/phyto-99-11-1237. [PMID: 19821727] - Renata Angeli, Nathalia V N da Paz, Jackeline C Maciel, Flávia F B Araújo, Patrícia M G Paiva, Glícia M T Calazans, Ana Paula Valente, Fábio C L Almeida, Luana C B B Coelho, Luiz B Carvalho, Maria da Paz C Silva, Maria Tereza dos Santos Correia. Ferromagnetic levan composite: an affinity matrix to purify lectin.
Journal of biomedicine & biotechnology.
2009; 2009(?):179106. doi:
10.1155/2009/179106. [PMID: 19547713] - Soon Ah Kang, Kyunghee Hong, Ki-Hyo Jang, Yun-Young Kim, Ryowon Choue, Yoongho Lim. Altered mRNA expression of hepatic lipogenic enzyme and PPARalpha in rats fed dietary levan from Zymomonas mobilis.
The Journal of nutritional biochemistry.
2006 Jun; 17(6):419-26. doi:
10.1016/j.jnutbio.2005.08.012. [PMID: 16214330] - Q Xu, T Yajima, W Li, K Saito, Y Ohshima, Y Yoshikai. Levan (beta-2, 6-fructan), a major fraction of fermented soybean mucilage, displays immunostimulating properties via Toll-like receptor 4 signalling: induction of interleukin-12 production and suppression of T-helper type 2 response and immunoglobulin E production.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
2006 Jan; 36(1):94-101. doi:
10.1111/j.1365-2222.2006.02401.x. [PMID: 16393271] - Ingrid J Vereyken, Vladimir Chupin, Folkert A Hoekstra, Sjef C M Smeekens, Ben de Kruijff. The effect of fructan on membrane lipid organization and dynamics in the dry state.
Biophysical journal.
2003 Jun; 84(6):3759-66. doi:
10.1016/s0006-3495(03)75104-2. [PMID: 12770882] - Andrew J Cairns. Fructan biosynthesis in transgenic plants.
Journal of experimental botany.
2003 Jan; 54(382):549-67. doi:
10.1093/jxb/erg056. [PMID: 12508066] - H Li, M S Ullrich. Characterization and mutational analysis of three allelic lsc genes encoding levansucrase in Pseudomonas syringae.
Journal of bacteriology.
2001 Jun; 183(11):3282-92. doi:
10.1128/jb.183.11.3282-3292.2001. [PMID: 11344135] - D R Biggs, K R Hancock. Fructan 2000.
Trends in plant science.
2001 Jan; 6(1):8-9. doi:
10.1016/s1360-1385(00)01796-9. [PMID: 11252258] - U Hettwer, F R Jaeckel, J Boch, M Meyer, K Rudolph, M S Ullrich. Cloning, nucleotide sequence, and expression in Escherichia coli of levansucrase genes from the plant pathogens Pseudomonas syringae pv. glycinea and P. syringae pv. phaseolicola.
Applied and environmental microbiology.
1998 Sep; 64(9):3180-7. doi:
10.1128/aem.64.9.3180-3187.1998. [PMID: 9726857] - S Bereswill, K Geider. Characterization of the rcsB gene from Erwinia amylovora and its influence on exoploysaccharide synthesis and virulence of the fire blight pathogen.
Journal of bacteriology.
1997 Feb; 179(4):1354-61. doi:
10.1128/jb.179.4.1354-1361.1997. [PMID: 9023222] - . .
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