Jacarandic acid (BioDeep_00000180219)

human metabolite blood metabolite

代谢物信息卡片

1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid

化学式: C30H48O5 (488.3501558)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 98%

分子结构信息

SMILES: CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CC(C(C5(C)C)O)O)C)C)C2C1(C)O)C)C(=O)O
InChI: InChI=1S/C30H48O5/c1-17-10-13-30(24(33)34)15-14-27(5)18(22(30)29(17,7)35)8-9-21-26(4)16-19(31)23(32)25(2,3)20(26)11-12-28(21,27)6/h8,17,19-23,31-32,35H,9-16H2,1-7H3,(H,33,34)

描述信息

同义名列表

8 个代谢物同义名

1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid; 1,10,11-Trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate; 1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,7,8,8a,10,11,12,12b,13,14b-tetradecahydropicene-4a-carboxylic acid; (2alpha,3beta)-isomer of euscaphic acid; 2alpha-acetyl tormentic acid; Jacarandic acid; Euscaphic acid; Tormentate

数据库引用编号

3 个数据库交叉引用编号

PubChem: 13653335
HMDB: HMDB0253726
Wikipedia: Tormentic acid

分类词条

Triterpenoids

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

21 个相关的物种来源信息

714648 Rubus cochinchinensis: 10.1021/NP900237A
4146 Olea europaea:
616956 Rubus ellipticus var. obcordatus: 10.1016/S0031-9422(98)00598-6
59683 Ternstroemia: 10.1021/NP030069V
2604687 Sanguisorba tenuifolia var. alba: 10.3390/MOLECULES16064642
176135 Sanguisorba tenuifolia: 10.3390/MOLECULES16064642
74652 Rosa laevigata:
50507 Schisandra chinensis: 10.1016/J.TET.2008.02.085
74645 Rosa rugosa: 10.1248/BPB.28.101
59492 Rubus ellipticus: 10.1021/NP900237A
714648 Rubus cochinchinensis: 10.1021/NP900237A
4146 Olea europaea:
616956 Rubus ellipticus var. obcordatus: 10.1016/S0031-9422(98)00598-6
59683 Ternstroemia: 10.1021/NP030069V
2604687 Sanguisorba tenuifolia var. alba: 10.3390/MOLECULES16064642
176135 Sanguisorba tenuifolia: 10.3390/MOLECULES16064642
74652 Rosa laevigata:
50507 Schisandra chinensis: 10.1016/J.TET.2008.02.085
74645 Rosa rugosa: 10.1248/BPB.28.101
59492 Rubus ellipticus: 10.1021/NP900237A
9606 Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Yingying Shi, Dongdong Zhang, Shupei Li, Xiuxiu Xuan, Liuqiang Zhang, Yiming Li, Fujiang Guo. Inhibitors of BRD4 protein from the roots of Astilbe grandis stapf ex E.H. Wilson. Natural product research. 2021 Jun; 35(12):2044-2050. doi: 10.1080/14786419.2019.1655414. [PMID: 31437007]
Daniela Alejandra Torres-Ortiz, Rodríguez-deLeón Eloy, Bah Moustapha, Ibarra-Alvarado César, Mercado-Silva Edmundo, Castro-Ruiz Jesús Eduardo, Rivera-Pastrana Dulce María. Vasorelaxing effect and possible chemical markers of the flowers of the Mexican Crataegus gracilior. Natural product research. 2020 Dec; 34(24):3522-3525. doi: 10.1080/14786419.2019.1577833. [PMID: 30864868]
Yang Yang, Yawei Wang, Meng Zhao, Haobo Jia, Bing Li, Dan Xing. Tormentic acid inhibits IL-1β-induced chondrocyte apoptosis by activating the PI3K/Akt signaling pathway. Molecular medicine reports. 2018 03; 17(3):4753-4758. doi: 10.3892/mmr.2018.8425. [PMID: 29328385]
Wen-Ping Jiang, Shyh-Shyun Huang, Yoshikazu Matsuda, Hiroshi Saito, Naoto Uramaru, Hui-Ya Ho, Jin-Bin Wu, Guan-Jhong Huang. Protective Effects of Tormentic Acid, a Major Component of Suspension Cultures of Eriobotrya japonica Cells, on Acetaminophen-Induced Hepatotoxicity in Mice. Molecules (Basel, Switzerland). 2017 May; 22(5):. doi: 10.3390/molecules22050830. [PMID: 28524081]
Maria Ferhat, Zahia Kabouchea, Yoshinori Fujimoto, Hiroshi Araya. Two New Triterpenes and Other Compounds from Mentha aquatica (Lamiaceae). Natural product communications. 2017 Apr; 12(4):483-486. doi: ". [PMID: 30520576]
Yu-lu Li, Hua-nian Dai, Guo-xu Ma, Wen Zhang, Tong-yu Wu, Yun-qing Wang, Jie-ming Zou, Xiao-qing Zhong, Yan-lin Zhou, Jing-quan Yuan, Xu-dong Xu, Wei Yi. [A new triterpenic acid from the roots of Rosa laevigata]. Yao xue xue bao = Acta pharmaceutica Sinica. 2017 Mar; 52(3):425-9. doi: ". [PMID: 29979854]
Yu-Lun Wang, Gen-Yi Sun, Ying Zhang, Jia-Jun He, Shen Zheng, Jing-Na Lin. Tormentic acid inhibits H2O2-induced oxidative stress and inflammation in rat vascular smooth muscle cells via inhibition of the NF-κB signaling pathway. Molecular medicine reports. 2016 Oct; 14(4):3559-64. doi: 10.3892/mmr.2016.5690. [PMID: 27572426]
Dan Yang, Jian Liang, Haihui Xie, Xiaoyi Wei. Norsesquiterpenoids and triterpenoids from strawberry cv. Falandi. Food chemistry. 2016 Jul; 203(?):67-72. doi: 10.1016/j.foodchem.2016.02.036. [PMID: 26948590]
Shi-jun Liu, Zhi-xin Liao, Zhi-shu Tang, Chun-li Cui, Hong-bo Liu, Yan-ni Liang, Yu Zhang. [Chemical Constituents from Rubus stans]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2016 May; 39(5):1045-8. doi: . [PMID: 30133048]
Luis F Julio, Alejandro F Barrero, M Mar Herrador del Pino, Jesús F Arteaga, Jesús Burillo, Maria Fe Andres, Carmen E Díaz, Azucena González-Coloma. Phytotoxic and Nematicidal Components of Lavandula luisieri. Journal of natural products. 2016 Feb; 79(2):261-6. doi: 10.1021/acs.jnatprod.5b00501. [PMID: 26797293]
Qing Wang, Qiaomei Sun, Xiangling Ma, Zaisheng Rao, Hui Li. Probing the binding interaction of human serum albumin with three bioactive constituents of Eriobotrta japonica leaves: Spectroscopic and molecular modeling approaches. Journal of photochemistry and photobiology. B, Biology. 2015 Jul; 148(?):268-276. doi: 10.1016/j.jphotobiol.2015.04.030. [PMID: 25985147]
Flora Tolentino, Priscila Alves de Araújo, Eduardo de Souza Marques, Marcel Petreanu, Sérgio Faloni de Andrade, Rivaldo Niero, Fábio F Perazzo, Paulo César Pires Rosa, Edson Luis Maistro. In vivo evaluation of the genetic toxicity of Rubus niveus Thunb. (Rosaceae) extract and initial screening of its potential chemoprevention against doxorubicin-induced DNA damage. Journal of ethnopharmacology. 2015 Apr; 164(?):89-95. doi: 10.1016/j.jep.2015.02.013. [PMID: 25681544]
Pan Chen, Zhi-jian Fang, Han-jing Yan, Hong-bo Zhou, Quan-xi Mei. [Study on Chemical Constituents of Petroleum Ether Fraction from Rubus alceaefolius]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Jan; 38(1):93-6. doi: . [PMID: 26214876]
Jin-Bin Wu, Yueh-Hsiung Kuo, Cheng-Hsiu Lin, Hui-Ya Ho, Chun-Ching Shih. Tormentic acid, a major component of suspension cells of Eriobotrya japonica, suppresses high-fat diet-induced diabetes and hyperlipidemia by glucose transporter 4 and AMP-activated protein kinase phosphorylation. Journal of agricultural and food chemistry. 2014 Nov; 62(44):10717-26. doi: 10.1021/jf503334d. [PMID: 25317836]
Xiao-lu Chen, Quan-xi Mei, Hong-bo Zhou, Zhi-jian Fang, Ying-xin Zhu. [Chemical constituents from roots of Rubus parvifolius]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2014 Jun; 37(6):995-7. doi: . [PMID: 25470966]
Jing-jing Li, Yi Li, Min Bai, Jing-fu Tan, Qiang Wang, Jie Yang. Simultaneous determination of corosolic acid and euscaphic acid in the plasma of normal and diabetic rat after oral administration of extract of Potentilla discolor Bunge by high-performance liquid chromatography/electrospray ionization mass spectrometry. Biomedical chromatography : BMC. 2014 May; 28(5):717-24. doi: 10.1002/bmc.3098. [PMID: 24311372]
Xing Lin, Shijun Zhang, Renbin Huang, Shimei Tan, Shuang Liang, Xiaoyan Wu, Lang Zhuo, Quanfang Huang. Protective effect of tormentic acid from Potentilla chinensis against lipopolysaccharide/D-galactosamine induced fulminant hepatic failure in mice. International immunopharmacology. 2014 Apr; 19(2):365-72. doi: 10.1016/j.intimp.2014.02.009. [PMID: 24560903]
Masateru Ono, Shin Yasuda, Haruki Komatsu, Yukio Fujiwara, Motohiro Takeya, Toshihiro Nohara. Triterpenoids from the fruits and leaves of the blackberry (Rubus allegheniensis) and their inhibitory activities on foam cell formation in human monocyte-derived macrophage. Natural product research. 2014; 28(24):2347-50. doi: 10.1080/14786419.2014.939087. [PMID: 25033392]
Monica R Loizzo, Marco Bonesi, Nicodemo G Passalacqua, Antoine Saab, Francesco Menichini, Rosa Tundis. Antiproliferative activities on renal, prostate and melanoma cancer cell lines of Sarcopoterium spinosum aerial parts and its major constituent tormentic acid. Anti-cancer agents in medicinal chemistry. 2013 Jun; 13(5):768-76. doi: 10.2174/1871520611313050011. [PMID: 23157592]
Li-Jie Zhang, Jing-Jy Cheng, Chia-Ching Liao, Hui-Ling Cheng, Hung-Tse Huang, Li-Ming Yang Kuo, Yao-Haur Kuo. Triterpene acids from Euscaphis japonica and assessment of their cytotoxic and anti-NO activities. Planta medica. 2012 Sep; 78(14):1584-90. doi: 10.1055/s-0032-1315040. [PMID: 22814889]
Gleice da Graça Rocha, Marisol Simões, Rodrigo Rodrigues Oliveira, Maria Auxiliadora Coelho Kaplan, Cerli Rocha Gattass. 3β-acetyl tormentic acid induces apoptosis of resistant leukemia cells independently of P-gp/ABCB1 activity or expression. Investigational new drugs. 2012 Feb; 30(1):105-13. doi: 10.1007/s10637-010-9524-1. [PMID: 20814731]
Hyo-Jin An, In-Tae Kim, Hee-Juhn Park, Hyung-Min Kim, Jung-Hye Choi, Kyung-Tae Lee. Tormentic acid, a triterpenoid saponin, isolated from Rosa rugosa, inhibited LPS-induced iNOS, COX-2, and TNF-α expression through inactivation of the nuclear factor-κb pathway in RAW 264.7 macrophages. International immunopharmacology. 2011 Apr; 11(4):504-10. doi: 10.1016/j.intimp.2011.01.002. [PMID: 21237302]
Cheng-qin Liang, Xiao-jian Su, Xian-li Zhou, Jiang-ke Qin, Qing Xu, Rong-gan Liang, Ming-po Zheng. [Studies on the chemical constituents of Rubus parvifolius]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Jan; 34(1):64-6. doi: . [PMID: 21818969]
Zhenfeng Hong, Wang Chen, Jinyan Zhao, Zhisheng Wu, JianHeng Zhou, Tianjiao Li, Juan Hu. Hepatoprotective effects of Rubus aleaefolius Poir. and identification of its active constituents. Journal of ethnopharmacology. 2010 May; 129(2):267-72. doi: 10.1016/j.jep.2010.03.025. [PMID: 20362654]
You-sheng Cehn, Kun Zhang, Su-qing Zhao, Jian-hong Zhang. [Studies on the lowering blood sugar substances from agrimony (II)]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2010 May; 33(5):724-6. doi: . [PMID: 20873555]
Jian Chen, Wei-Lin Li, Ju-Lan Wu, Bing-Ru Ren, Han-Qing Zhang. Euscaphic acid, a new hypoglycemic natural product from Folium Eriobotryae. Die Pharmazie. 2008 Oct; 63(10):765-7. doi: . [PMID: 18972842]
Zhi-jing Ma, Zhi-juan Zhao. [Studies on chemical constituents from stem barks of Fraxinus paxiana]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Aug; 33(16):1990-3. doi: ". [PMID: 19086636]
Jong Min Kim, Dae Sik Jang, Yun Mi Lee, Jeong Lim Yoo, Young Sook Kim, Joo-Hwan Kim, Jin Sook Kim. Aldose-reductase- and protein-glycation-inhibitory principles from the whole plant of Duchesnea chrysantha. Chemistry & biodiversity. 2008 Feb; 5(2):352-6. doi: 10.1002/cbdv.200890034. [PMID: 18293434]
Gleice da Graça Rocha, Marisol Simões, Kelly Araujo Lúcio, Rodrigo Rodrigues Oliveira, Maria Auxiliadora Coelho Kaplan, Cerli Rocha Gattass. Natural triterpenoids from Cecropia lyratiloba are cytotoxic to both sensitive and multidrug resistant leukemia cell lines. Bioorganic & medicinal chemistry. 2007 Dec; 15(23):7355-60. doi: 10.1016/j.bmc.2007.07.020. [PMID: 17889544]
Lucia Helena Martini, Fernanda Jung, Felix Antunes Soares, Liane Nanci Rotta, Deusa Aparecida Vendite, Marcos Emilio dos Santos Frizzo, Rosendo A Yunes, João Batista Calixto, Susana Wofchuk, Diogo O Souza. Naturally occurring compounds affect glutamatergic neurotransmission in rat brain. Neurochemical research. 2007 Nov; 32(11):1950-6. doi: 10.1007/s11064-007-9393-y. [PMID: 17577666]
Ying Cui, Xue-mei Zhang, Ji-jun Chen, Yan Zhang, Xiu-kun Lin, Le Zhou. [Chemical constituents from root of Actinidia chinensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 Aug; 32(16):1663-5. doi: ". [PMID: 18027663]
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