Iophenoxic acid (BioDeep_00000180075)

   

human metabolite blood metabolite


代谢物信息卡片


2-[(3-hydroxy-2,4,6-triiodophenyl)methyl]butanoic acid

化学式: C11H11I3O3 (571.7842466)
中文名称: 碘芬酸
谱图信息: 最多检出来源 Rattus norvegicus(blood) 98.46%

分子结构信息

SMILES: CCC(CC1=C(C(=C(C=C1I)I)O)I)C(=O)O
InChI: InChI=1S/C11H11I3O3/c1-2-5(11(16)17)3-6-7(12)4-8(13)10(15)9(6)14/h4-5,15H,2-3H2,1H3,(H,16,17)

描述信息

同义名列表

8 个代谢物同义名

2-[(3-hydroxy-2,4,6-triiodophenyl)methyl]butanoic acid; alpha-Ethyl-3-hydroxy-2,4,6-triiodohydrocinnamic acid; 2-[(3-Hydroxy-2,4,6-triiodophenyl)methyl]butanoate; Iophenoxic acid; Iophenoic acid; Iophenoxate; Iophenoate; Teridax



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kyra Jacoblinnert, Christian Imholt, Detlef Schenke, Jens Jacob. Ethyl-iophenoxic acid as a quantitative bait marker for small mammals. Integrative zoology. 2022 Nov; 17(6):981-990. doi: 10.1111/1749-4877.12547. [PMID: 33876888]
  • Are R Berentsen, Richard B Chipman, Kathleen M Nelson, Kenneth S Gruver, Frank Boyd, Steven F Volker, Amy J Davis, Ad Vos, Steffen Ortmann, Amy T Gilbert. Placebo Oral Rabies Vaccine Bait Uptake by Small Indian Mongooses (Herpestes auropunctatus) in Southwestern Puerto Rico. Journal of wildlife diseases. 2020 04; 56(2):452-456. doi: 10.7589/2019-03-077. [PMID: 31750771]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Are R Berentsen, Robert T Sugihara, Cynthia G Payne, Israel Leinbach, Steven F Volker, Ad Vos, Steffen Ortmann, Amy T Gilbert. Analysis of Iophenoxic Acid Analogues in Small Indian Mongoose (Herpestes Auropunctatus) Sera for Use as an Oral Rabies Vaccination Biological Marker. Journal of visualized experiments : JoVE. 2019 05; ?(147):. doi: 10.3791/59373. [PMID: 31205294]
  • Sonya Gowtage, Gareth A Williams, Ray Henderson, Paul Aylett, Duncan MacMorran, Si Palmer, Andy Robertson, Sandrine Lesellier, Stephen P Carter, Mark A Chambers. Testing of a palatable bait and compatible vaccine carrier for the oral vaccination of European badgers (Meles meles) against tuberculosis. Vaccine. 2017 02; 35(6):987-992. doi: 10.1016/j.vaccine.2016.12.004. [PMID: 28077246]
  • Tam T T N Nguyen, Jesper Østergaard, Bente Gammelgaard. A method for studies on interactions between a gold-based drug and plasma proteins based on capillary electrophoresis with inductively coupled plasma mass spectrometry detection. Analytical and bioanalytical chemistry. 2015 Nov; 407(28):8497-503. doi: 10.1007/s00216-015-8997-3. [PMID: 26329282]
  • Julie Maria Dersch, Tam T T N Nguyen, Jesper Østergaard, Stefan Stürup, Bente Gammelgaard. Selective analysis of human serum albumin based on SEC-ICP-MS after labelling with iophenoxic acid. Analytical and bioanalytical chemistry. 2015 Apr; 407(10):2829-36. doi: 10.1007/s00216-015-8507-7. [PMID: 25650002]
  • Mickael Sage, Isabelle Fourel, Jennifer Lahoreau, Vivien Siat, Philippe Berny, Sophie Rossi. Iophenoxic acid derivatives as markers of oral baits to wildlife. New tools for their detection in tissues of a game species and safety considerations for human exposure. Environmental science and pollution research international. 2013 May; 20(5):2893-904. doi: 10.1007/s11356-012-1172-x. [PMID: 23001758]
  • K Kitamura, M Niinobu, A A Omran, S Takegami, T Kitade. Binding of diuretic antihypertensive bendroflumethiazide to human serum albumin studied by ¹⁹F nuclear magnetic resonance method. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2012 Jan; 45(1-2):195-200. doi: 10.1016/j.ejps.2011.11.010. [PMID: 22115868]
  • Ali J Ryan, Chun-Wa Chung, Stephen Curry. Crystallographic analysis reveals the structural basis of the high-affinity binding of iophenoxic acid to human serum albumin. BMC structural biology. 2011 Apr; 11(?):18. doi: 10.1186/1472-6807-11-18. [PMID: 21501503]
  • Cristina Ballesteros, Pablo R Camarero, Carles Cristòfol, Joaquín Vicente, Christian Gortazar, José de la Fuente, Rafael Mateo. Analysis by LC/ESI-MS of iophenoxic acid derivatives and evaluation as markers of oral baits to deliver pharmaceuticals to wildlife. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Jul; 878(22):1997-2002. doi: 10.1016/j.jchromb.2010.05.035. [PMID: 20542477]
  • Patricia A Zunszain, Jamie Ghuman, Antony F McDonagh, Stephen Curry. Crystallographic analysis of human serum albumin complexed with 4Z,15E-bilirubin-IXalpha. Journal of molecular biology. 2008 Aug; 381(2):394-406. doi: 10.1016/j.jmb.2008.06.016. [PMID: 18602119]
  • Keisuke Kitamura, Ahmed A Omran, Shigehiko Takegami, Rumi Tanaka, Tatsuya Kitade. (19)F NMR spectroscopic characterization of the interaction of niflumic acid with human serum albumin. Analytical and bioanalytical chemistry. 2007 Apr; 387(8):2843-8. doi: 10.1007/s00216-007-1162-x. [PMID: 17377783]
  • Francesca Cagnacci, Giovanna Massei, Julia Coats, Anton de Leeuw, David P Cowan. Long-lasting systemic bait markers for Eurasian badgers. Journal of wildlife diseases. 2006 Oct; 42(4):892-6. doi: 10.7589/0090-3558-42.4.892. [PMID: 17255463]
  • Melinda C Wiles, Tyler A Campbell. Liquid chromatography-electrospray ionization mass spectrometry for direct identification and quantification of iophenoxic acid in serum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Feb; 832(1):144-57. doi: 10.1016/j.jchromb.2005.12.017. [PMID: 16412709]
  • Carlo Bertucci, Samanta Cimitan. Inhibition of drug binding to human serum albumin by cholecystographic agents. Farmaco (Societa chimica italiana : 1989). 2003 Sep; 58(9):901-8. doi: 10.1016/s0014-827x(03)00148-4. [PMID: 13679185]
  • A Jones. High-performance liquid chromatographic determination of iophenoxic acid in serum. Journal of chromatography. B, Biomedical applications. 1994 Apr; 654(2):293-6. doi: 10.1016/0378-4347(94)00020-4. [PMID: 8044292]
  • C T Eason, C M Frampton. The plasma pharmacokinetics of iophenoxic and iopanoic acids in goat. Xenobiotica; the fate of foreign compounds in biological systems. 1992 Feb; 22(2):185-9. doi: 10.3109/00498259209046616. [PMID: 1632107]
  • U Kragh-Hansen. Evidence for a large and flexible region of human serum albumin possessing high affinity binding sites for salicylate, warfarin, and other ligands. Molecular pharmacology. 1988 Aug; 34(2):160-71. doi: . [PMID: 3412320]
  • E H Follmann, P J Savarie, D G Ritter, G M Baer. Plasma marking of arctic foxes with iophenoxic acid. Journal of wildlife diseases. 1987 Oct; 23(4):709-12. doi: 10.7589/0090-3558-23.4.709. [PMID: 3682104]
  • G H Mudge, N Desbiens, G R Stibitz. Binding of iophenoxate and iopanoate to human serum albumin. Drug metabolism and disposition: the biological fate of chemicals. 1978 Jul; 6(4):432-9. doi: . [PMID: 28924]
  • K J Fehske, W E Müller. The interaction of iopanoic and iophenoxic acids with human serum albumin. Research communications in chemical pathology and pharmacology. 1978 Jan; 19(1):119-27. doi: NULL. [PMID: 625581]
  • D J Birkett, J Kapitulnik. The interactions between iophenoxic acid, iopanoic acid, bilirubin and human serum albumin as studied by fluorescence and Sephadex gel filtration. Clinica chimica acta; international journal of clinical chemistry. 1976 Sep; 71(2):129-35. doi: 10.1016/0009-8981(76)90522-2. [PMID: 963887]
  • D E RALSTON, T T SCHATTENBERG, C A OWEN, W M MCCONAHEY. PROTEIN-BOUND IODINE IN SERUM AND THYROIDAL UPTAKE OF I-131. EFFECT OF IODOALPHIONIC, IOPANOIC AND IOPHENOXIC ACIDS. Postgraduate medicine. 1964 Aug; 36(?):141-8. doi: 10.1080/00325481.1964.11695217. [PMID: 14198105]
  • R SHAPIRO, E B MAN. Iophenoxic acid and serum-bound iodine values. JAMA. 1960 Jul; 173(?):1352. doi: 10.1001/jama.1960.73020300006019d. [PMID: 14445533]