Fluspirilene (BioDeep_00000018003)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

化学式: C29H31F2N3O (475.243506)
中文名称: 氟司必林
谱图信息: 最多检出来源 Mentha canadensis(plant) 2.33%

分子结构信息

SMILES: c1ccc(cc1)N1CNC(=O)C21CCN(CCCC(c1ccc(cc1)F)c1ccc(cc1)F)CC2
InChI: InChI=1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35)

描述信息

Fluspirilene is only found in individuals that have used or taken this drug. It is a long-acting injectable antipsychotic agent used for chronic schizophrenia.
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AG - Diphenylbutylpiperidine derivatives
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent

同义名列表

15 个代谢物同义名

8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one; Lindopharm brand OF fluspirilene; Betapharm brand OF fluspirilene; Hormosan brand OF fluspirilene; Janssen brand OF fluspirilene; Hexal brand OF fluspirilene; Beta, Fluspirilen; Fluspirilen lindo; Fluspirilen beta; Spirodiflamine; Fluspirilene; Redeptin; Fluspi; Kivat; Imap



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Marta M Wells, Tommy S Tillman, David D Mowrey, Tianmo Sun, Yan Xu, Pei Tang. Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptor α1 for the treatment of pain. Journal of medicinal chemistry. 2015 Apr; 58(7):2958-2966. doi: 10.1021/jm501873p. [PMID: 25790278]
  • Hui Li, Shuan-Cang Yu, Feng-Lan Zhang, Yang-Jun Yu, Xiu-Yun Zhao, De-Shuang Zhang, Xiang Zhao. [Development of molecular markers linked to the resistant QTL for downy mildew in Brassica rapa L. ssp. pekinensis]. Yi chuan = Hereditas. 2011 Nov; 33(11):1271-8. doi: 10.3724/sp.j.1005.2011.01271. [PMID: 22120085]
  • R Gomez-Huelgas, M R Bernal-López, A Villalobos, J Mancera-Romero, A J Baca-Osorio, S Jansen, R Guijarro, F Salgado, F J Tinahones, M Serrano-Ríos. Hypertriglyceridemic waist: an alternative to the metabolic syndrome? Results of the IMAP Study (multidisciplinary intervention in primary care). International journal of obesity (2005). 2011 Feb; 35(2):292-9. doi: 10.1038/ijo.2010.127. [PMID: 20548300]
  • Ana Jolly, Silvia Beatriz Colavecchia, Bárbara Fernández, Eloy Fernández, Silvia Leonor Mundo. Antibodies Induced by Lipoarabinomannan in Bovines: Characterization and Effects on the Interaction between Mycobacterium Avium Subsp. Paratuberculosis and Macrophages In Vitro. Veterinary medicine international. 2011; 2011(?):258479. doi: 10.4061/2011/258479. [PMID: 21772964]
  • Deborah L Diamond, Andrew J Syder, Jon M Jacobs, Christina M Sorensen, Kathie-Anne Walters, Sean C Proll, Jason E McDermott, Marina A Gritsenko, Qibin Zhang, Rui Zhao, Thomas O Metz, David G Camp, Katrina M Waters, Richard D Smith, Charles M Rice, Michael G Katze. Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics. PLoS pathogens. 2010 Jan; 6(1):e1000719. doi: 10.1371/journal.ppat.1000719. [PMID: 20062526]
  • Shiguo Zhou, Fusheng Wei, John Nguyen, Mike Bechner, Konstantinos Potamousis, Steve Goldstein, Louise Pape, Michael R Mehan, Chris Churas, Shiran Pasternak, Dan K Forrest, Roger Wise, Doreen Ware, Rod A Wing, Michael S Waterman, Miron Livny, David C Schwartz. A single molecule scaffold for the maize genome. PLoS genetics. 2009 Nov; 5(11):e1000711. doi: 10.1371/journal.pgen.1000711. [PMID: 19936062]
  • Young-Sun Yim, Patricia Moak, Hector Sanchez-Villeda, Theresa A Musket, Pamela Close, Patricia E Klein, John E Mullet, Michael D McMullen, Zheiwei Fang, Mary L Schaeffer, Jack M Gardiner, Edward H Coe, Georgia L Davis. A BAC pooling strategy combined with PCR-based screenings in a large, highly repetitive genome enables integration of the maize genetic and physical maps. BMC genomics. 2007 Feb; 8(?):47. doi: 10.1186/1471-2164-8-47. [PMID: 17291341]
  • Christine Zalejski, Sophie Paradis, Régis Maldiney, Yvette Habricot, Emile Miginiac, Jean-Pierre Rona, Emmanuelle Jeannette. Induction of abscisic acid-regulated gene expression by diacylglycerol pyrophosphate involves Ca2+ and anion currents in Arabidopsis suspension cells. Plant physiology. 2006 Aug; 141(4):1555-62. doi: 10.1104/pp.106.080218. [PMID: 16766676]
  • Ihsan Ergün, M Cenk Akbostanci, Başol Canbakan, Bilge Koçer, Arzu Ensari, Gökhan Nergizoglu, Kenan Keven. Minimal change nephrotic syndrome with stiff-person syndrome: is there a link?. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2005 Jul; 46(1):e11-4. doi: 10.1053/j.ajkd.2005.03.009. [PMID: 15983949]
  • Gayle M Volk, Lenora J Goss, Vincent R Franceschi. Calcium channels are involved in calcium oxalate crystal formation in specialized cells of Pistia stratiotes L. Annals of botany. 2004 Jun; 93(6):741-53. doi: 10.1093/aob/mch092. [PMID: 15087302]
  • Zhuomei Lu, Zhizhang Yin, Linda James, Rosalinda Syto, Jill M Stafford, Sandra Koseoglu, Todd Mayhood, Joseph Myers, William Windsor, Paul Kirschmeier, Ahmed A Samatar, Bruce Malcolm, Tammy C Turek-Etienne, C Chandra Kumar. Development of a fluorescence polarization bead-based coupled assay to target different activity/conformation states of a protein kinase. Journal of biomolecular screening. 2004 Jun; 9(4):309-21. doi: 10.1177/1087057104263506. [PMID: 15191648]
  • H Sanchez-Villeda, S Schroeder, M Polacco, M McMullen, S Havermann, G Davis, I Vroh-Bi, K Cone, N Sharopova, Y Yim, L Schultz, N Duru, T Musket, K Houchins, Z Fang, J Gardiner, E Coe. Development of an integrated laboratory information management system for the maize mapping project. Bioinformatics (Oxford, England). 2003 Nov; 19(16):2022-30. doi: 10.1093/bioinformatics/btg274. [PMID: 14594706]
  • Z Fang, K Cone, H Sanchez-Villeda, M Polacco, M McMullen, S Schroeder, J Gardiner, G Davis, S Havermann, Y Yim, I Vroh Bi, E Coe. iMap: a database-driven utility to integrate and access the genetic and physical maps of maize. Bioinformatics (Oxford, England). 2003 Nov; 19(16):2105-11. doi: 10.1093/bioinformatics/btg289. [PMID: 14594716]
  • M Rademaker. Do women have more adverse drug reactions?. American journal of clinical dermatology. 2001; 2(6):349-51. doi: 10.2165/00128071-200102060-00001. [PMID: 11770389]
  • K J Swart, F C Sutherland, G H van Essen, H K Hundt, A F Hundt. Determination of fluspirilene in human plasma by liquid chromatography-tandem mass spectrometry with electrospray ionisation. Journal of chromatography. A. 1998 Dec; 828(1-2):219-27. doi: 10.1016/s0021-9673(98)00635-9. [PMID: 9916308]
  • A B Sarmento, M C de Lima, C R Oliveira. Partition of dopamine antagonists into synthetic lipid bilayers: the effect of membrane structure and composition. The Journal of pharmacy and pharmacology. 1993 Jul; 45(7):601-5. doi: 10.1111/j.2042-7158.1993.tb05660.x. [PMID: 8105052]
  • V F King, M L Garcia, J L Shevell, R S Slaughter, G J Kaczorowski. Substituted diphenylbutylpiperidines bind to a unique high affinity site on the L-type calcium channel. Evidence for a fourth site in the cardiac calcium entry blocker receptor complex. The Journal of biological chemistry. 1989 Apr; 264(10):5633-41. doi: . [PMID: 2538426]
  • A Martinos, P Rinieris, D N Papachristou, A Souvatzoglou, D A Koutras, C Stefanis. Effects of six weeks' neuroleptic treatment on the pituitary-thyroid axis in schizophrenic patients. Neuropsychobiology. 1986; 16(2-3):72-7. doi: 10.1159/000118301. [PMID: 3108695]
  • C Gramsch, H M Emrich, S John, S Haas, H Beckmann, M Zaudig, D von Zerssen. The effect of neuroleptic treatment and of high dosage diazepam therapy on beta-endorphin immunoreactivity in plasma of schizophrenic patients. Journal of neural transmission. 1984; 59(2):133-41. doi: 10.1007/bf01255411. [PMID: 6144724]
  • A Koj, J Chudzik, A Dubin. Substrate specificity and modifications of the active centre of elastase-like neutral proteinases from horse blood leucocytes. The Biochemical journal. 1976 Feb; 153(2):397-402. doi: 10.1042/bj1530397. [PMID: 6009]