Imrecoxib (BioDeep_00000179988)
human metabolite blood metabolite
代谢物信息卡片
化学式: C21H23NO3S (369.1398568000001)
中文名称: 艾瑞昔布
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCN1CC(=C(C1=O)C1=CC=C(C)C=C1)C1=CC=C(C=C1)S(C)(=O)=O
InChI: InChI=1S/C21H23NO3S/c1-4-13-22-14-19(16-9-11-18(12-10-16)26(3,24)25)20(21(22)23)17-7-5-15(2)6-8-17/h5-12H,4,13-14H2,1-3H3
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 11682175
- HMDB: HMDB0253438
- DrugBank: DB12354
- ChEMBL: CHEMBL504535
- CAS: 395683-14-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yaqian Li, Jing Wang, Jie Huang, Jingjing Yu, Yan Wang, Hongyi Tan, Hao Zhang, Guoping Yang, Qi Pei. Dose investigation of imrecoxib in patients with renal insufficiency based on modelling and simulation.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2020 Sep; 152(?):105449. doi:
10.1016/j.ejps.2020.105449. [PMID: 32621967] - Haihao Jin. Imrecoxib Inhibits Paraquat-Induced Pulmonary Fibrosis through the NF-κB/Snail Signaling Pathway.
Computational and mathematical methods in medicine.
2020; 2020(?):6374014. doi:
10.1155/2020/6374014. [PMID: 33123215] - Qi Pei, Jin-Lian Xie, Jie Huang, Wen-Yu Liu, Xiao-Yan Yang, Yan Wang, Wei Li, Hong-Yi Tan, Hao Zhang, Guo-Ping Yang. Pharmacokinetic study of imrecoxib in patients with renal insufficiency.
European journal of clinical pharmacology.
2019 Oct; 75(10):1355-1360. doi:
10.1007/s00228-019-02698-x. [PMID: 31243478] - Xiangyu Hou, Xiaojian Dai, Yong Yang, Yifan Zhang, Dafang Zhong, Xiaoyan Chen. Simultaneous determination of imrecoxib and its two active metabolites in plasma of hepatic impairment patients by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Aug; 1122-1123(?):58-63. doi:
10.1016/j.jchromb.2019.05.018. [PMID: 31153132] - Xiangyu Hou, Jialan Zhou, Songda Yu, Lei Zhou, Yifan Zhang, Dafang Zhong, Xiaoyan Chen. Differences in the In Vivo and In Vitro Metabolism of Imrecoxib in Humans: Formation of the Rate-Limiting Aldehyde Intermediate.
Drug metabolism and disposition: the biological fate of chemicals.
2018 09; 46(9):1320-1328. doi:
10.1124/dmd.118.081182. [PMID: 29980580] - Cheng-Zi Zuo, Yi Gong, Xiang-Yu Hou, Yi-Fan Zhang, Wen-Xing Peng, Rong-Hua Zhu, Da-Fang Zhong, Xiao-Yan Chen. Effect of Fluconazole on the Pharmacokinetic Properties of Imrecoxib, a Novel NSAID: A Single-center, Open-label, Self-controlled Study in Healthy Chinese Male Volunteers.
Clinical therapeutics.
2018 08; 40(8):1347-1356. doi:
10.1016/j.clinthera.2018.06.009. [PMID: 30017171] - Guan-Min Gao, Yan-Min Li, Xiao-Long Zheng, Dong-Bin Jiang, Lei-Lei Zhang, Peng-Hui Xu, Sheng-Yun Liu, Zhao-Hui Zheng, Quan-Cheng Kan. The Efficacy of Imrecoxib and Celecoxib in Axial Spondyloarthritis and Their Influence on Serum Dickopff-Related Protein 1 (DKK-1) Levels.
Medical science monitor : international medical journal of experimental and clinical research.
2017 Jun; 23(?):2985-2992. doi:
10.12659/msm.901727. [PMID: 28626213] - H Xu, Y Zhang, Y Sun, P Zhang, F Chu, Z Guo, H Zhang, D Zhong. Metabolism and excretion of imrecoxib in rat.
Xenobiotica; the fate of foreign compounds in biological systems.
2006 May; 36(5):441-55. doi:
10.1080/00498250600595524. [PMID: 16854781]