Sulforidazine (BioDeep_00000017997)

   

human metabolite Endogenous natural product


代谢物信息卡片


2-Methanesulphonyl-10-[2-(1-methylpiperidin-2-yl)ethyl]-10H-phenothiazine

化学式: C21H26N2O2S2 (402.1436)
中文名称: 噻嗪类2-砜
谱图信息: 最多检出来源 Homo sapiens(not specific) 46.88%

分子结构信息

SMILES: CN1CCCCC1CCN1C2=CC=CC=C2SC2=C1C=C(C=C2)S(C)(=O)=O
InChI: InChI=1S/C21H26N2O2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)26-21-11-10-17(15-19(21)23)27(2,24)25/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3

描述信息

Sulforidazine belongs to the family of Phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent

同义名列表

10 个代谢物同义名

2-Methanesulphonyl-10-[2-(1-methylpiperidin-2-yl)ethyl]-10H-phenothiazine; 2-methanesulfonyl-10-[2-(1-methylpiperidin-2-yl)ethyl]-10H-phenothiazine; Thioridazine-2-sulfone; Thioridazine 2-Sulfone; TPN-12SULFORIDAZINE; Sulphoridazine; Sulforidazine; Psychoson; Imagotan; Inofal



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • R H K Thanacoody, A K Daly, J G Reilly, I N Ferrier, S H L Thomas. Factors affecting drug concentrations and QT interval during thioridazine therapy. Clinical pharmacology and therapeutics. 2007 Nov; 82(5):555-65. doi: 10.1038/sj.clpt.6100195. [PMID: 17460606]
  • Pedro Dorado, Roland Berecz, Eva M Peñas-Lledó, Alfredo de la Rubia, Adrián Llerena. No effect of the CYP1A2*1F genotype on thioridazine, mesoridazine, sulforidazine plasma concentrations in psychiatric patients. European journal of clinical pharmacology. 2007 May; 63(5):527-8. doi: 10.1007/s00228-007-0284-6. [PMID: 17345072]
  • Roland Berecz, Alfredo de la Rubia, Pedro Dorado, Pedro Fernández-Salguero, Marja-Liisa Dahl, Adrián LLerena. Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype. European journal of clinical pharmacology. 2003 May; 59(1):45-50. doi: 10.1007/s00228-003-0576-4. [PMID: 12682803]
  • A LLerena, R Berecz, A de la Rubia, P Fernández-Salguero, P Dorado. Effect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes. Therapeutic drug monitoring. 2001 Dec; 23(6):616-20. doi: 10.1097/00007691-200112000-00004. [PMID: 11802093]
  • W A Daniel, M Syrek, A Mach, J Wójcikowski, J Boksa. Pharmacokinetics of thioridazine and its metabolites in blood plasma and the brain of rats after acute and chronic treatment. Polish journal of pharmacology. 1997 Nov; 49(6):439-52. doi: NULL. [PMID: 9566048]
  • C B Eap, T W Guentert, M Schãublin-Loidl, M Stabl, L Koeb, K Powell, P Baumann. Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin. Clinical pharmacology and therapeutics. 1996 Mar; 59(3):322-31. doi: 10.1016/s0009-9236(96)80010-5. [PMID: 8653995]
  • G Lin, E M Hawes, G McKay, S F Cooper, E D Korchinski, K K Midha. The metabolism of piperidine-type phenothiazine antipsychotic agents. II. Sulforidazine in dog and human. Xenobiotica; the fate of foreign compounds in biological systems. 1993 Jan; 23(1):27-36. doi: 10.3109/00498259309059359. [PMID: 8097899]
  • G Lin, E M Hawes, G McKay, K K Midha. The metabolism of piperidine-type phenothiazine antipsychotic agents. I. Sulforidazine in the rat. Xenobiotica; the fate of foreign compounds in biological systems. 1992 Mar; 22(3):303-17. doi: 10.3109/00498259209046642. [PMID: 1353930]
  • C B Eap, A Souche, L Koeb, P Baumann. Light-induced racemization: artifacts in the analysis of the diastereoisomeric pairs of thioridazine 5-sulfoxide in the plasma and urine of patients treated with thioridazine. Therapeutic drug monitoring. 1991 Jul; 13(4):356-62. doi: . [PMID: 1780970]
  • C von Bahr, G Movin, C Nordin, A Lidén, M Hammarlund-Udenaes, A Hedberg, H Ring, F Sjöqvist. Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype. Clinical pharmacology and therapeutics. 1991 Mar; 49(3):234-40. doi: 10.1038/clpt.1991.22. [PMID: 2007317]
  • B S Chakraborty, K K Midha, G McKay, E M Hawes, J W Hubbard, E D Korchinski, M G Choc, W T Robinson. Single dose kinetics of thioridazine and its two psychoactive metabolites in healthy humans: a dose proportionality study. Journal of pharmaceutical sciences. 1989 Oct; 78(10):796-801. doi: 10.1002/jps.2600781003. [PMID: 2600782]
  • B S Chakraborty, E M Hawes, K K Midha. Development of a radioimmunoassay procedure for sulforidazine and its comparison with a high-performance liquid chromatographic method. Therapeutic drug monitoring. 1988; 10(2):205-14. doi: 10.1097/00007691-198802000-00016. [PMID: 3381240]
  • B S Chakraborty, E M Hawes, G McKay, J W Hubbard, E D Korchinski, K K Midha, M G Choc, W T Robinson. S-oxidation of thioridazine to psychoactive metabolites: an oral dose-proportionality study in healthy volunteers. Drug metabolism and drug interactions. 1988; 6(3-4):425-37. doi: 10.1515/dmdi.1988.6.3-4.425. [PMID: 3271648]
  • M L Rao, W A Brown, R Wagner. Radioreceptor assay and high-performance liquid chromatography yield similar results for serum thioridazine and its major metabolites. Therapeutic drug monitoring. 1988; 10(2):184-7. doi: 10.1097/00007691-198802000-00012. [PMID: 3381236]
  • D A Ganes, K K Midha. Sensitive and specific high-performance liquid chromatographic assay for the quantification of sulforidazine and two diastereomeric sulforidazine-5-sulfoxide metabolites in plasma. Journal of chromatography. 1987 Dec; 423(?):227-37. doi: 10.1016/0378-4347(87)80346-8. [PMID: 3443653]
  • B S Chakraborty, M S Sardessai, T J Jaworski, K K Midha, E M Hawes. Synthesis and properties of haptens for the development of radioimmunoassays for thioridazine, mesoridazine, and sulforidazine. Pharmaceutical research. 1987 Jun; 4(3):207-13. doi: 10.1023/a:1016451926984. [PMID: 3509283]
  • R M Greendyke, D R Kanter. Plasma propranolol levels and their effect on plasma thioridazine and haloperidol concentrations. Journal of clinical psychopharmacology. 1987 Jun; 7(3):178-82. doi: NULL. [PMID: 3597804]
  • A S Papadopoulos, J L Crammer. Sulphoxide metabolites of thioridazine in man. Xenobiotica; the fate of foreign compounds in biological systems. 1986 Dec; 16(12):1097-107. doi: 10.3109/00498258609038987. [PMID: 3798957]
  • A S Papadopoulos, J L Crammer, D A Cowan. Phenolic metabolites of thioridazine in man. Xenobiotica; the fate of foreign compounds in biological systems. 1985 Apr; 15(4):309-16. doi: 10.3109/00498258509045365. [PMID: 4024665]
  • E Friedman, F D Yocca, T B Cooper. Antidepressant drugs with varying pharmacological profiles alter rat pineal beta adrenergic-mediated function. The Journal of pharmacology and experimental therapeutics. 1984 Mar; 228(3):545-50. doi: . [PMID: 6323672]