6-[[3-Fluoro-5-(4-methoxyoxan-4-yl)phenoxy]methyl]-1-methylquinolin-2-one (BioDeep_00000179921)

   

human metabolite blood metabolite


代谢物信息卡片


6-((3-Fluoro-5-(4-methoxy-3,4,5,6-tetrahydro-2H-pyran-4-yl)phenoxy)methyl)-1-methylquinol-2-one

化学式: C23H24FNO4 (397.1689276)
中文名称: 6-[[3-氟-5-(3,4,5,6-四氢-4-甲氧基-2H-吡喃-4-基)苯氧基]甲基]-1-甲基-1H-喹啉-2-酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1C2=C(C=CC1=O)C=C(C=C2)COC3=CC(=CC(=C3)C4(CCOCC4)OC)F
InChI: InChI=1S/C23H24FNO4/c1-25-21-5-3-16(11-17(21)4-6-22(25)26)15-29-20-13-18(12-19(24)14-20)23(27-2)7-9-28-10-8-23/h3-6,11-14H,7-10,15H2,1-2H3

描述信息

同义名列表

3 个代谢物同义名

6-((3-Fluoro-5-(4-methoxy-3,4,5,6-tetrahydro-2H-pyran-4-yl)phenoxy)methyl)-1-methylquinol-2-one; 6-[[3-fluoro-5-(4-methoxyoxan-4-yl)phenoxy]methyl]-1-methylquinolin-2-one; ICI-D2138



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • M Yeadon, R C Price, A N Payne. Allergen-induced glycoconjugate secretion in guinea-pig trachea in vivo: modulation by indomethacin, BW B70C and ZD-2138. Pulmonary pharmacology. 1995 Feb; 8(1):53-63. doi: 10.1006/pulp.1995.1008. [PMID: 8535100]
  • S M Nasser, G S Bell, S Foster, K E Spruce, R MacMillan, A J Williams, T H Lee, J P Arm. Effect of the 5-lipoxygenase inhibitor ZD2138 on aspirin-induced asthma. Thorax. 1994 Aug; 49(8):749-56. doi: 10.1136/thx.49.8.749. [PMID: 8091318]
  • S M Nasser, G S Bell, R J Hawksworth, K E Spruce, R MacMillan, A J Williams, T H Lee, J P Arm. Effect of the 5-lipoxygenase inhibitor ZD2138 on allergen-induced early and late asthmatic responses. Thorax. 1994 Aug; 49(8):743-8. doi: 10.1136/thx.49.8.743. [PMID: 8091317]
  • C Lambert-van der Brempt, P Bruneau, M A Lamorlette, S J Foster. Conformational analysis of 5-lipoxygenase inhibitors: role of the substituents in chiral recognition and on the active conformations of the (methoxyalkyl)thiazole and methoxytetrahydropyran series. Journal of medicinal chemistry. 1994 Jan; 37(1):113-24. doi: 10.1021/jm00027a014. [PMID: 8289184]
  • G C Crawley, T G Bird, P Bruneau, R I Dowell, P N Edwards, S J Foster, J M Girodeau, R M McMillan, E R Walker, D Waterson. Structure and activity relationships leading to the discovery of ICI D2138, a selective, potent and orally active inhibitor of 5-lipoxygenase. Journal of lipid mediators. 1993 Mar; 6(1-3):249-57. doi: ". [PMID: 8395247]
  • R M McMillan, K E Spruce, G C Crawley, E R Walker, S J Foster. Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase. British journal of pharmacology. 1992 Dec; 107(4):1042-7. doi: 10.1111/j.1476-5381.1992.tb13404.x. [PMID: 1334748]
  • G C Crawley, R I Dowell, P N Edwards, S J Foster, R M McMillan, E R Walker, D Waterson, T G Bird, P Bruneau, J M Giroaeau. Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors. Journal of medicinal chemistry. 1992 Jul; 35(14):2600-9. doi: 10.1021/jm00092a010. [PMID: 1321908]