Duloxetine (BioDeep_00000017984)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
methyl[(3S)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl]amine
化学式: C18H19NOS (297.1187284)
中文名称: 度洛西汀
谱图信息:
最多检出来源 Homo sapiens(blood) 66.67%
Reviewed
Last reviewed on 2024-09-14.
Cite this Page
Duloxetine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/duloxetine (retrieved
2024-11-22) (BioDeep RN: BioDeep_00000017984). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32
InChI: InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1
描述信息
Duloxetine (brand names Cymbalta, Yentreve, and in parts of Europe, Xeristar or Ariclaim) is a drug which primarily targets major depressive disorder (MDD), generalized anxiety disorder (GAD), pain related to diabetic peripheral neuropathy and in some countries stress urinary incontinence (SUI). It is manufactured and marketed by Eli Lilly and Company. Duloxetine has not yet been FDA approved for stress urinary incontinence or for fibromyalgia. Duloxetine is a selective SNRI (selective serotonin-norepinephrine reuptake inhibitor). Duloxetine is a systemic drug therapy which affects the body as a whole. Known also under the code name LY248686, it is a potent dual reuptake inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), possessing comparable affinities in binding to NE- and 5-HT transporter sites. It is a less potent inhibitor of dopamine reuptake.
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D000068760 - Serotonin and Noradrenaline Reuptake Inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants
D002491 - Central Nervous System Agents > D000700 - Analgesics
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents
D049990 - Membrane Transport Modulators
同义名列表
15 个代谢物同义名
methyl[(3S)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl]amine; (3S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine; N-Methyl-3-(1-naphthalenyloxy)-3-(2-thiophene)propanamide; N-Methyl-3-(1-naphthalenyloxy)-2-thiophenepropanamine; Duloxetine ethanedioate (1:1), (+-)-isomer - T353987; Hydrochloride, duloxetine; Duloxetine hydrochloride; Duloxetine, (+)-isomer; HCL, Duloxetine; (+-)-Duloxetine; Duloxetine HCL; Duloxetine; LY 248686; Yentreve; Cymbalta
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:36795
- PubChem: 60835
- HMDB: HMDB0014619
- DrugBank: DB00476
- ChEMBL: CHEMBL1175
- Wikipedia: Duloxetine
- MeSH: Duloxetine Hydrochloride
- chemspider: 54822
- PMhub: MS000001539
- CAS: 136434-34-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Pu Yang, Haiyan Chen, Tian Wang, Ling Li, Hong Su, Jing Li, Yujun He, Shengyong Su. Electroacupuncture attenuates chronic inflammatory pain and depression comorbidity by inhibiting hippocampal neuronal apoptosis via the PI3K/Akt signaling pathway.
Neuroscience letters.
2023 Aug; 812(?):137411. doi:
10.1016/j.neulet.2023.137411. [PMID: 37516346] - Xuezhi Ma, Shijie Zhou, Wenyuan Sun, Jie Sun, Guangguang Li, Lining Wang, Yang Guo. Efficacy and safety of duloxetine in chronic musculoskeletal pain: a systematic review and meta-analysis.
BMC musculoskeletal disorders.
2023 May; 24(1):394. doi:
10.1186/s12891-023-06488-6. [PMID: 37198620] - Jia-Man Yang, Yi Wang, Jun-Yi Li, Cong-Cong Li, Zhen-Tao Wang, Zhen Shen, Liang Ou, Ze-Hua Chen. Duloxetine for rehabilitation after total knee arthroplasty: a systematic review and meta-analysis.
International journal of surgery (London, England).
2023 Apr; 109(4):913-924. doi:
10.1097/js9.0000000000000230. [PMID: 37097617] - Lu-Kai Zhang, Qiang Li, Yan-Fen Fang, Ji-Wei Qi. Effect of duloxetine on pain relief after total knee arthroplasty: A meta-analysis of randomized controlled trials.
Medicine.
2023 Mar; 102(10):e33101. doi:
10.1097/md.0000000000033101. [PMID: 36897714] - Mian Wang, Ziwen Pei, Alex Molassiotis. Recent advances in managing chemotherapy-induced peripheral neuropathy: A systematic review.
European journal of oncology nursing : the official journal of European Oncology Nursing Society.
2022 Jun; 58(?):102134. doi:
10.1016/j.ejon.2022.102134. [PMID: 35421796] - Tomoyuki Yamada, Satoru Mitsuboshi, Junko Makino, Kaoru Suzuki, Masami Nishihara, Masashi Neo. Risk of Pregabalin-Induced Hypoglycemia: Analysis of the Japanese Adverse Drug Event Report Database.
Journal of clinical pharmacology.
2022 06; 62(6):756-761. doi:
10.1002/jcph.2009. [PMID: 34817883] - Ali Bidari, Banafsheh Ghavidel-Parsa, Faeze Gharibpoor. Comparison of the serum brain-derived neurotrophic factor (BDNF) between fibromyalgia and nociceptive pain groups; and effect of duloxetine on the BDNF level.
BMC musculoskeletal disorders.
2022 May; 23(1):411. doi:
10.1186/s12891-022-05369-8. [PMID: 35501732] - Reina Taguchi, Takafumi Naito, Koji Suzuki, Yuko Kurosawa, Hiroaki Itoh, Junichi Kawakami. Maternal Plasma and Cord Blood Concentration Profiles of Duloxetine During the Peripartum Period and Their Associations With the Modified Finnegan Score.
Therapeutic drug monitoring.
2022 04; 44(2):351-352. doi:
10.1097/ftd.0000000000000943. [PMID: 34812767] - Mariko Nakamura, Akira Yoshimi, Akihiro Mouri, Tatsuya Tokura, Hiroyuki Kimura, Shinichi Kishi, Tomoya Miyauchi, Kunihiro Iwamoto, Mikiko Ito, Aiji Sato-Boku, Norio Ozaki, Toshitaka Nabeshima, Yukihiro Noda. Duloxetine attenuates pain in association with downregulation of platelet serotonin transporter in patients with burning mouth syndrome and atypical odontalgia.
Human psychopharmacology.
2022 03; 37(2):e2818. doi:
10.1002/hup.2818. [PMID: 34541697] - Peter Manu. Repurposing Drugs for Post-COVID-19 Fatigue Syndrome: Methylphenidate, Duloxetine, and Brexpiprazole.
American journal of therapeutics.
2022 01; 29(2):e229-e230. doi:
10.1097/mjt.0000000000001471. [PMID: 35389574] - Ke-Yu Chen, Ruo-Yang Li. Efficacy and safety of different antidepressants and anticonvulsants in central poststroke pain: A network meta-analysis and systematic review.
PloS one.
2022; 17(10):e0276012. doi:
10.1371/journal.pone.0276012. [PMID: 36227855] - Lanying Jiang, Yadan Xiong, Jinguo Cui. Comparison of the Efficacy and Safety of Duloxetine and Gabapentin in Diabetic Peripheral Neuropathic Pain: A Meta-Analysis.
Contrast media & molecular imaging.
2022; 2022(?):4084420. doi:
10.1155/2022/4084420. [PMID: 35299589] - Nahid Punjani, Caroline Kang, Ryan Flannigan, Phil Bach, Margaret Altemus, James H Kocsis, Alan Wu, Hudson Pierce, Peter N Schlegel. Impact of duloxetine on male fertility: A randomised controlled clinical trial.
Andrologia.
2021 Nov; 53(10):e14207. doi:
10.1111/and.14207. [PMID: 34374108] - Gabriel Onn Kit Loh, Emily Yii Ling Wong, Yvonne Tze Fung Tan, Yi Lin Lee, Chun Keat Chew, Nurul Diyana Mohd Sali, Damenthi Nair, Kok Khiang Peh. Simultaneous determination of duloxetine and 4-hydroxy duloxetine glucuronide in human plasma and back-conversion study.
Bioanalysis.
2021 Nov; 13(22):1681-1696. doi:
10.4155/bio-2021-0185. [PMID: 34743613] - Bo Chen, Jingrui Duan, Shengyue Wen, Jian Pang, Min Zhang, Hongsheng Zhan, Yuxin Zheng. An Updated Systematic Review and Meta-analysis of Duloxetine for Knee Osteoarthritis Pain.
The Clinical journal of pain.
2021 11; 37(11):852-862. doi:
10.1097/ajp.0000000000000975. [PMID: 34483232] - Rafaela F Rodrigues, Taila Kawano, Rodrigo V Placido, Lellis H Costa, Marcia H M C Podesta, Rafaela S Santos, Giovane Galdino, Carlos M Barros, Vanessa B Boralli. Investigation of the Combination of Pregabalin with Duloxetine or Amitriptyline on the Pharmacokinetics and Antiallodynic Effect During Neuropathic Pain in Rats.
Pain physician.
2021 07; 24(4):E511-E520. doi:
NULL. [PMID: 34213877] - Andy Kuo, Laura Corradini, Janet R Nicholson, Maree T Smith. Assessment of the Anti-Allodynic and Anti-Hyperalgesic Efficacy of a Glycine Transporter 2 Inhibitor Relative to Pregabalin, Duloxetine and Indomethacin in a Rat Model of Cisplatin-Induced Peripheral Neuropathy.
Biomolecules.
2021 06; 11(7):. doi:
10.3390/biom11070940. [PMID: 34202809] - Isela Álvarez-González, Scarlett Camacho-Cantera, Patricia Gómez-González, Michael J Rendón Barrón, José A Morales-González, Eduardo O Madrigal-Santillán, Rogelio Paniagua-Pérez, Eduardo Madrigal-Bujaidar. Genotoxic and oxidative effect of duloxetine on mouse brain and liver tissues.
Scientific reports.
2021 03; 11(1):6897. doi:
10.1038/s41598-021-86366-0. [PMID: 33767322] - Ichie Kajiwara, Makoto Sano, Yoshimi Ichimaru, Yukino Oshima, Osamu Kitajima, Hiroyuki Hao, Atsushi Masamune, Jinsuk Kim, Yukimoto Ishii, Hideaki Ijichi, Takahiro Suzuki. Duloxetine improves cancer-associated pain in a mouse model of pancreatic cancer through stimulation of noradrenaline pathway and its antitumor effects.
Pain.
2020 12; 161(12):2909-2919. doi:
10.1097/j.pain.0000000000001997. [PMID: 32694385] - Wanli Gao, Rui Chen, Nan Xie, Daolin Tang, Borong Zhou, Ding Wang. Duloxetine-Induced Neural Cell Death and Promoted Neurite Outgrowth in N2a Cells.
Neurotoxicity research.
2020 Dec; 38(4):859-870. doi:
10.1007/s12640-020-00216-x. [PMID: 32415528] - Junko Tachi, Haruhiko Tokuda, Takashi Onuma, Shinobu Yamaguchi, Woo Kim, Tomoyuki Hioki, Rie Matsushima-Nishiwaki, Kumiko Tanabe, Osamu Kozawa, Hiroki Iida. Duloxetine strengthens osteoblast activation by prostaglandin E1: Upregulation of p38 MAP kinase.
Prostaglandins & other lipid mediators.
2020 12; 151(?):106481. doi:
10.1016/j.prostaglandins.2020.106481. [PMID: 33002595] - Mohammad Zafar Imam, Andy Kuo, Janet R Nicholson, Laura Corradini, Maree T Smith. Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain.
Pharmacological reports : PR.
2020 Oct; 72(5):1418-1425. doi:
10.1007/s43440-020-00145-8. [PMID: 32715433] - Simona Rizea-Savu, Simona Nicoleta Duna, Adrian Ghita, Adriana Iordachescu, Marinela Chirila. The Effect of Food on the Single-Dose Bioavailability and Tolerability of the Highest Marketed Strength of Duloxetine.
Clinical pharmacology in drug development.
2020 10; 9(7):797-804. doi:
10.1002/cpdd.759. [PMID: 31793229] - Isra Rana, Namrah Khan, Muhammad Mohsin Ansari, Fawad Ali Shah, Fakhar Ud Din, Sadia Sarwar, Muhammad Imran, Omer Salman Qureshi, Ho-Ik Choi, Cheol-Ho Lee, Jin-Ki Kim, Alam Zeb. Solid lipid nanoparticles-mediated enhanced antidepressant activity of duloxetine in lipopolysaccharide-induced depressive model.
Colloids and surfaces. B, Biointerfaces.
2020 Oct; 194(?):111209. doi:
10.1016/j.colsurfb.2020.111209. [PMID: 32599505] - Zastrozhin, Petukhov, Pankratenko, Grishina, Ryzhikova, Skryabin, Koporov, Bryun, Sychev. Impact of Polymorphism of CYP2D6 on Equilibrium Concentration of Duloxetine in Patients Suffering from Major Depressive Disorder.
Psychopharmacology bulletin.
2020 07; 50(3):47-57. doi:
NULL. [PMID: 32733111] - Nadia Tancredi, Neha Kohli. Smoking cessation and duloxetine toxicity: A case report.
Journal of the American Pharmacists Association : JAPhA.
2020 Jul; 60(4):e117-e120. doi:
10.1016/j.japh.2020.01.003. [PMID: 32094037] - Thi Lien Ngo, Chung-Hee Lee, Nayoung Han, Hyun-Moon Back, Su-Jin Rhee, Keumhan Noh, Hwi-Yeol Yun, Wonku Kang, Jung-Woo Chae. Application of an Inter-Species Extrapolation Method for the Prediction of Drug Interactions between Propolis and Duloxetine in Humans.
International journal of molecular sciences.
2020 Mar; 21(5):. doi:
10.3390/ijms21051862. [PMID: 32182820] - Katherine Stockstill, Carrie Wahlman, Kathryn Braden, Zhoumou Chen, Gina L Yosten, Dilip K Tosh, Kenneth A Jacobson, Timothy M Doyle, Willis K Samson, Daniela Salvemini. Sexually dimorphic therapeutic response in bortezomib-induced neuropathic pain reveals altered pain physiology in female rodents.
Pain.
2020 01; 161(1):177-184. doi:
10.1097/j.pain.0000000000001697. [PMID: 31490328] - Fatma Mohamed Elsenosy, Ghada Ahmed Abdelbary, Ahmed Hassen Elshafeey, Ibrahim Elsayed, Ahmed Roshdy Fares. Brain Targeting of Duloxetine HCL via Intranasal Delivery of Loaded Cubosomal Gel: In vitro Characterization, ex vivo Permeation, and in vivo Biodistribution Studies.
International journal of nanomedicine.
2020; 15(?):9517-9537. doi:
10.2147/ijn.s277352. [PMID: 33324051] - Weipang Chang, Jianguo G Gu. Effects on tactile transmission by serotonin transporter inhibitors at Merkel discs of mouse whisker hair follicles.
Molecular pain.
2020 Jan; 16(?):1744806920938237. doi:
10.1177/1744806920938237. [PMID: 32600103] - Kosuke Yoshida, Yoko Aburakawa, Yasuhiro Suzuki, Kenji Kuroda, Takashi Kimura. Acute Hyponatremia Resulting from Duloxetine-induced Syndrome of Inappropriate Antidiuretic Hormone Secretion.
Internal medicine (Tokyo, Japan).
2019 Jul; 58(13):1939-1942. doi:
10.2169/internalmedicine.2346-18. [PMID: 30799365] - Timothy Nguyen, Ivan Shoukhardin, Afsha Gouse. Duloxetine Uses in Patients With Kidney Disease: Different Recommendations From the United States Versus Europe and Canada.
American journal of therapeutics.
2019 Jul; 26(4):e516-e519. doi:
10.1097/mjt.0000000000000737. [PMID: 29419534] - Atsushi Takayama, Takahiko Nagamine, Yoshinobu Matsumoto, Masaru Nakamura. Duloxetine and Angiotensin II Receptor Blocker Combination Potentially Induce Severe Hyponatremia in an Elderly Woman.
Internal medicine (Tokyo, Japan).
2019 Jun; 58(12):1791-1794. doi:
10.2169/internalmedicine.2059-18. [PMID: 30799349] - Domenico De Donatis, Vincenzo Florio, Stefano Porcelli, Alois Saria, Laura Mercolini, Alessandro Serretti, Andreas Conca. Duloxetine plasma level and antidepressant response.
Progress in neuro-psychopharmacology & biological psychiatry.
2019 06; 92(?):127-132. doi:
10.1016/j.pnpbp.2019.01.001. [PMID: 30611837] - Selin Aktürk Esen, Cuma Bülent Gül, Serdar Kahvecioğlu, Nimet Aktaş, İrfan Esen. Acute Urinary Retention and Acute Kidney Injury After Duloxetine Treatment: A Rare Case Report.
Journal of clinical psychopharmacology.
2019 May; 39(3):279-281. doi:
10.1097/jcp.0000000000001020. [PMID: 30908353] - Tao Luo, Qiao-Sheng Liu, Yuan-Jian Yang, Bo Wei. Aripiprazole for the treatment of duloxetine-induced hyperprolactinemia: A case report.
Journal of affective disorders.
2019 05; 250(?):330-332. doi:
10.1016/j.jad.2019.03.006. [PMID: 30875676] - Helena Kyunghee Kim, Kathrin Tyryshkin, Nika Elmi, Moyez Dharsee, Kenneth R Evans, Jennifer Good, Mojib Javadi, Stephanie McCormack, Anthony L Vaccarino, Xiao Zhang, Ana Cristina Andreazza, Harriet Feilotter. Plasma microRNA expression levels and their targeted pathways in patients with major depressive disorder who are responsive to duloxetine treatment.
Journal of psychiatric research.
2019 03; 110(?):38-44. doi:
10.1016/j.jpsychires.2018.12.007. [PMID: 30580082] - Lu Zhang, Yi-Xuan Liu, Zhe Wang, Xiao-Qi Wang, Jing-Jing Zhang, Rong-Huan Jiang, Xiang-Qun Wang, Shi-Wei Zhu, Kun Wang, Zuo-Jing Liu, Huai-Qiu Zhu, Li-Ping Duan. Clinical characteristic and fecal microbiota responses to probiotic or antidepressant in patients with diarrhea-predominant irritable bowel syndrome with depression comorbidity: a pilot study.
Chinese medical journal.
2019 Feb; 132(3):346-351. doi:
10.1097/cm9.0000000000000071. [PMID: 30681503] - Takahiro Toda, Shinichiro Yamamoto, Noriko Umehara, Yasuo Mori, Minoru Wakamori, Shunichi Shimizu. Protective Effects of Duloxetine against Cerebral Ischemia-Reperfusion Injury via Transient Receptor Potential Melastatin 2 Inhibition.
The Journal of pharmacology and experimental therapeutics.
2019 02; 368(2):246-254. doi:
10.1124/jpet.118.253922. [PMID: 30523061] - Xiujuan Chen, Chen Liang, Lijun Cui, Jian Le, Zheyuan Qian, Runsheng Zhang, Zhanying Hong, Yifeng Chai. A rapid LC-MS/MS method for simultaneous determination of quetiapine and duloxetine in rat plasma and its application to pharmacokinetic interaction study.
Journal of food and drug analysis.
2019 01; 27(1):323-331. doi:
10.1016/j.jfda.2018.07.003. [PMID: 30648587] - Mélanie Kremer, Ipek Yalcin, Yannick Goumon, Xavier Wurtz, Laurent Nexon, Dorothée Daniel, Salim Megat, Rhian A Ceredig, Carl Ernst, Gustavo Turecki, Virginie Chavant, Jean-François Théroux, Adrien Lacaud, Lauriane-Elisabeth Joganah, Vincent Lelievre, Dominique Massotte, Pierre-Eric Lutz, Ralf Gilsbach, Eric Salvat, Michel Barrot. A Dual Noradrenergic Mechanism for the Relief of Neuropathic Allodynia by the Antidepressant Drugs Duloxetine and Amitriptyline.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2018 11; 38(46):9934-9954. doi:
10.1523/jneurosci.1004-18.2018. [PMID: 30249798] - Dandan Wang, Jianbo Lai, Shaojia Lu, Manli Huang, Shaohua Hu, Yi Xu. Rapid-onset hyponatremia and delirium following duloxetine treatment for postherpetic neuralgia: Case report and literature review.
Medicine.
2018 Nov; 97(46):e13178. doi:
10.1097/md.0000000000013178. [PMID: 30431592] - Alain Braillon. Duloxetine in Patients With Kidney Disease: 'A Great Deal of Intelligence Can Be Invested in Ignorance When the Need for Illusion Is Deep': Saul Bellow.
American journal of therapeutics.
2018 Nov; 25(6):e760-e761. doi:
10.1097/mjt.0000000000000769. [PMID: 29782341] - Mary E Kelley, Boadie W Dunlop, Charles B Nemeroff, Adriana Lori, Tania Carrillo-Roa, Elisabeth B Binder, Michael H Kutner, Vivianne Aponte Rivera, W Edward Craighead, Helen S Mayberg. Response rate profiles for major depressive disorder: Characterizing early response and longitudinal nonresponse.
Depression and anxiety.
2018 10; 35(10):992-1000. doi:
10.1002/da.22832. [PMID: 30260539] - Wei-Tsung Kao, Chen-Lin Chang, For-Wey Lung. 5-HTT mRNA level as a potential biomarker of treatment response in patients with major depression in a clinical trial.
Journal of affective disorders.
2018 10; 238(?):597-608. doi:
10.1016/j.jad.2018.06.035. [PMID: 29957477] - Marc Augustin, Georgios Schoretsanitis, Christoph Hiemke, Gerhard Gründer, Ekkehard Haen, Michael Paulzen. Differences in Duloxetine Dosing Strategies in Smoking and Nonsmoking Patients: Therapeutic Drug Monitoring Uncovers the Impact on Drug Metabolism.
The Journal of clinical psychiatry.
2018 09; 79(5):. doi:
10.4088/jcp.17m12086. [PMID: 30192450] - Rhian Alice Ceredig, Florian Pierre, Stéphane Doridot, Unai Alduntzin, Eric Salvat, Ipek Yalcin, Claire Gaveriaux-Ruff, Michel Barrot, Dominique Massotte. Peripheral delta opioid receptors mediate duloxetine antiallodynic effect in a mouse model of neuropathic pain.
The European journal of neuroscience.
2018 09; 48(5):2231-2246. doi:
10.1111/ejn.14093. [PMID: 30059180] - Andrzej Wróbel, Ewa Rechberger, Tomasz Rechberger. The influence of duloxetine on detrusor overactivity in rats with depression induced by 13-cis-retinoic acid.
International urogynecology journal.
2018 07; 29(7):987-995. doi:
10.1007/s00192-017-3424-2. [PMID: 28762178] - Mahdi Ghorbani, Mahmoud Chamsaz, Mohsen Aghamohammadhasan, Alireza Shams. Ultrasonic assisted magnetic dispersive solid phase microextraction for pre concentration of serotonin-norepinephrine reuptake inhibitor drugs.
Analytical biochemistry.
2018 06; 551(?):7-18. doi:
10.1016/j.ab.2018.05.003. [PMID: 29750941] - Laurence Collin-Lévesque, Yosra El-Ghaddaf, Madeleine Genest, Martin Jutras, Grégoire Leclair, Etienne Weisskopf, Alice Panchaud, Ema Ferreira. Infant Exposure to Methylphenidate and Duloxetine During Lactation.
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine.
2018 04; 13(3):221-225. doi:
10.1089/bfm.2017.0126. [PMID: 29485905] - Michael Cronquist Christensen, Henrik Loft, Roger S McIntyre. Vortioxetine improves symptomatic and functional outcomes in major depressive disorder: A novel dual outcome measure in depressive disorders.
Journal of affective disorders.
2018 02; 227(?):787-794. doi:
10.1016/j.jad.2017.11.081. [PMID: 29689693] - Niels Klarskov, Dirk Cerneus, William Sawyer, Donald Newgreen, Olivier van Till, Gunnar Lose. The effect of single oral doses of duloxetine, reboxetine, and midodrine on the urethral pressure in healthy female subjects, using urethral pressure reflectometry.
Neurourology and urodynamics.
2018 01; 37(1):244-249. doi:
10.1002/nau.23282. [PMID: 28419624] - Satoru Esumi, Yoshihisa Kitamura, Hitomi Yokota-Kumasaki, Soichiro Ushio, Akane Yamada-Takemoto, Ryo Nagai, Atsushi Ogawa, Yoichi Kawasaki, Toshiaki Sendo. Effects of Magnesium Oxide on the Serum Duloxetine Concentration and Antidepressant-Like Effects of Duloxetine in Rats.
Biological & pharmaceutical bulletin.
2018; 41(11):1727-1731. doi:
10.1248/bpb.b18-00392. [PMID: 30381673] - Haitang Jiang, Suzhen Chen, Na Lu, Yingying Yue, Yingying Yin, Yuqun Zhang, Wenhao Jiang, Jinfeng Liang, Yonggui Yuan. Reduced serum VGF levels were reversed by antidepressant treatment in depressed patients.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2017 12; 18(8):586-591. doi:
10.1080/15622975.2016.1224923. [PMID: 28635540] - Sho Moriguchi, Harumasa Takano, Yasuyuki Kimura, Tomohisa Nagashima, Keisuke Takahata, Manabu Kubota, Soichiro Kitamura, Tatsuya Ishii, Masanori Ichise, Ming-Rong Zhang, Hitoshi Shimada, Masaru Mimura, Jeffrey H Meyer, Makoto Higuchi, Tetsuya Suhara. Occupancy of Norepinephrine Transporter by Duloxetine in Human Brains Measured by Positron Emission Tomography with (S,S)-[18F]FMeNER-D2.
The international journal of neuropsychopharmacology.
2017 12; 20(12):957-962. doi:
10.1093/ijnp/pyx069. [PMID: 29016875] - Nicolas Zdanowicz, Christine Reynaert, Denis Jacques, Brice Lepiece, Thomas Dubois. Selective Serotonergic (SSRI) Versus Noradrenergic (SNRI) Reuptake Inhibitors with and without Acetylsalicylic Acid in Major Depressive Disorder.
Psychiatria Danubina.
2017 Sep; 29(Suppl 3):270-273. doi:
NULL. [PMID: 28953776] - Yuka Kobayashi, Wataru Nagashima, Tatsuya Tokura, Keizo Yoshida, Eri Umemura, Tomoya Miyauchi, Munetaka Arao, Mikiko Ito, Hiroyuki Kimura, Kenichi Kurita, Norio Ozaki. Duloxetine Plasma Concentrations and Its Effectiveness in the Treatment of Nonorganic Chronic Pain in the Orofacial Region.
Clinical neuropharmacology.
2017 Jul; 40(4):163-168. doi:
10.1097/wnf.0000000000000225. [PMID: 28622208] - Rui Xue, Ying Li, Xin-Hua He, Zeng-Liang Jin, Shi-Yong Fan, Ting-Ting Zhang, Nuo-Min Li, Li Yuan, Ai-Ping Zheng, Bo-Hua Zhong, Yun-Feng Li, You-Zhi Zhang. Pharmacokinetic profiles contribute to the differences in behavioral pharmacology of 071031B enantiomers as novel serotonin and norepinephrine reuptake inhibitors.
Journal of psychopharmacology (Oxford, England).
2017 03; 31(3):377-386. doi:
10.1177/0269881116681456. [PMID: 28245750] - Renu Chadha, Alka Bali, Gulshan Bansal. Bioanalytical Method Validation for Dronedarone and Duloxetine in Blood Serum.
Journal of AOAC International.
2017 Jan; 100(1):45-50. doi:
10.5740/jaoacint.16-0204. [PMID: 27760589] - Tae-Kyeong Lee, Joon Ha Park, Ji Hyeon Ahn, Myoung Cheol Shin, Jun Hwi Cho, Eun Joo Bae, Young-Myeong Kim, Moo-Ho Won, Choong-Hyun Lee. Pretreated duloxetine protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury through decreases of glial activation and oxidative stress.
Journal of the neurological sciences.
2016 Nov; 370(?):229-236. doi:
10.1016/j.jns.2016.09.059. [PMID: 27772765] - Danielle Santana-Coelho, José Rogerio Souza-Monteiro, Ricardo S O Paraense, Guilherme L Busanello, Gabriela P F Arrifano, Jackson R Mendonça, Mauro E P Silveira-Junior, Luiz Fernando F Royes, Maria Elena Crespo-López. Antidepressant drugs in convulsive seizures: Pre-clinical evaluation of duloxetine in mice.
Neurochemistry international.
2016 10; 99(?):62-71. doi:
10.1016/j.neuint.2016.06.001. [PMID: 27288549] - Chiara Rovera, Massimo Carlo Mauri, Elena Bertin, Chiara Di Pace, Silvia Paletta, Alessandra Reggiori, Ilaria Francesca De Gaspari, Dario Cattaneo, Daniela Mari, Alfredo Carlo Altamura. Duloxetine in elderly major depression disorder: effectiveness and drug plasma level evaluation.
Human psychopharmacology.
2016 09; 31(5):349-55. doi:
10.1002/hup.2544. [PMID: 27400882] - Matthew J Snyder, Lawrence M Gibbs, Tammy J Lindsay. Treating Painful Diabetic Peripheral Neuropathy: An Update.
American family physician.
2016 Aug; 94(3):227-34. doi:
". [PMID: 27479625] - Katja Biering Leth-Møller, Annette Højmann Hansen, Maia Torstensson, Stig Ejdrup Andersen, Lars Ødum, Gunnar Gislasson, Christian Torp-Pedersen, Ellen Astrid Holm. Antidepressants and the risk of hyponatremia: a Danish register-based population study.
BMJ open.
2016 05; 6(5):e011200. doi:
10.1136/bmjopen-2016-011200. [PMID: 27194321] - John J Sramek, Larry W Hardy, Peter Bieck, Cynthia Zamora, Mark Versavel, Jahnavi Kharidia, Todd Grinnell, Yu-Luan Chen, Michael Sullivan, Hong Ding, Neal R Cutler. Exploratory Biomarker Study of the Triple Reuptake Inhibitor SEP-432 Compared to the Dual Reuptake Inhibitor Duloxetine in Healthy Normal Subjects.
CNS neuroscience & therapeutics.
2016 May; 22(5):404-12. doi:
10.1111/cns.12513. [PMID: 26849844] - Arthur J Siegel, Sophie S Forte, Nasir A Bhatti, Steven E Gelda. Drug-Related Hyponatremic Encephalopathy: Rapid Clinical Response Averts Life-Threatening Acute Cerebral Edema.
The American journal of case reports.
2016 Mar; 17(?):150-3. doi:
10.12659/ajcr.896572. [PMID: 26956638] - Kelly Ann Scanlon, Robert Stoppacher, Lee M Blum, Samantha J Starkey. Comprehensive Duloxetine Analysis in a Fatal Overdose.
Journal of analytical toxicology.
2016 Mar; 40(2):167-70. doi:
10.1093/jat/bkv134. [PMID: 26662354] - Wan-wen Ren, Zhi-ying Zhou, Mi-mi Xu, Sen Long, Guang-zheng Tang, Hong-jing Mao, Shu-lin Chen. [Treatment of Persistent Somatoform Pain Disorder by Floating Needle Therapy and Duloxetine].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2016 Feb; 36(2):166-71. doi:
". [PMID: 27078991] - Saori Nishijima, Kimio Sugaya, Katsumi Kadekawa, Katsuhiro Ashitomi, Tomoyuki Ueda, Hideyuki Yamamoto. Propiverine increases urethral wall catecholamine levels and bladder leak point pressure in rats.
International journal of urology : official journal of the Japanese Urological Association.
2016 Jan; 23(1):93-9. doi:
10.1111/iju.12991. [PMID: 26502799] - Michael Paulzen, Gerhard Gründer, Tanja Veselinovic, Bernhard Wolf, Christoph Hiemke, Sarah E Lammertz. Duloxetine enters the brain - But why is it not found in the cerebrospinal fluid.
Journal of affective disorders.
2016 Jan; 189(?):159-63. doi:
10.1016/j.jad.2015.08.073. [PMID: 26437230] - Hitoshi Yasuda, Nigishi Hotta, Masato Kasuga, Atsunori Kashiwagi, Ryuzo Kawamori, Tadaaki Yamada, Yuko Baba, Levent Alev, Ko Nakajo. Efficacy and safety of 40 mg or 60 mg duloxetine in Japanese adults with diabetic neuropathic pain: Results from a randomized, 52-week, open-label study.
Journal of diabetes investigation.
2016 Jan; 7(1):100-8. doi:
10.1111/jdi.12361. [PMID: 26816607] - William Kielbasa, Evelyn Lobo. Pharmacodynamics of norepinephrine reuptake inhibition: Modeling the peripheral and central effects of atomoxetine, duloxetine, and edivoxetine on the biomarker 3,4-dihydroxyphenylglycol in humans.
Journal of clinical pharmacology.
2015 Dec; 55(12):1422-31. doi:
10.1002/jcph.551. [PMID: 26011686] - Christel Renoux, Lisa M Lix, Valérie Patenaude, Lauren C Bresee, J Michael Paterson, Jean-Philippe Lafrance, Hala Tamim, Salaheddin M Mahmud, Mhd Wasem Alsabbagh, Brenda Hemmelgarn, Colin R Dormuth, Pierre Ernst. Serotonin-Norepinephrine Reuptake Inhibitors and the Risk of AKI: A Cohort Study of Eight Administrative Databases and Meta-Analysis.
Clinical journal of the American Society of Nephrology : CJASN.
2015 Oct; 10(10):1716-22. doi:
10.2215/cjn.11271114. [PMID: 26231193] - Atul R Mahableshwarkar, John Zajecka, William Jacobson, Yinzhong Chen, Richard S E Keefe. A Randomized, Placebo-Controlled, Active-Reference, Double-Blind, Flexible-Dose Study of the Efficacy of Vortioxetine on Cognitive Function in Major Depressive Disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2015 Jul; 40(8):2025-37. doi:
10.1038/npp.2015.52. [PMID: 25687662] - Nobuhito Murai, Nobuaki Takeshita, Fusako Nishigaki, Megumi Irie, Seiji Tamura, Toshiaki Aoki, Nobuya Matsuoka. AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in rat models of nociceptive pain.
Neurological research.
2015 Jun; 37(6):525-30. doi:
10.1179/1743132815y.0000000007. [PMID: 25591424] - Mehmet Agilli, Fevzi Nuri Aydin. Methodological approach to brain-derived neurotrophic factor plasma levels in major depressed patients receiving duloxetine.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2015 Jun; 36(6):1061-2. doi:
10.1007/s10072-015-2095-3. [PMID: 25637063] - Michele Fornaro, Andrea Escelsior, Giulio Rocchi, Benedetta Conio, Paola Magioncalda, Valentina Marozzi, Andrea Presta, Bruno Sterlini, Paola Contini, Mario Amore, Pantaleo Fornaro, Matteo Martino. BDNF plasma levels variations in major depressed patients receiving duloxetine.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2015 May; 36(5):729-34. doi:
10.1007/s10072-014-2027-7. [PMID: 25501804] - N Murai, H Fushiki, S Honda, Y Murakami, A Iwashita, M Irie, S Tamura, Y Nagakura, T Aoki. Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats.
Neuroscience.
2015 Mar; 289(?):262-9. doi:
10.1016/j.neuroscience.2014.12.065. [PMID: 25595980] - Thorsten Mikoteit, Ulrich Hemmeter, Anne Eckert, Serge Brand, Roland Bischof, Alexandra Delini-Stula, Edith Holsboer-Trachsler, Johannes Beck. Improved Alertness Is Associated with Early Increase in Serum Brain-Derived Neurotrophic Factor and Antidepressant Treatment Outcome in Major Depression.
Neuropsychobiology.
2015; 72(1):16-28. doi:
10.1159/000437439. [PMID: 26337518] - Olcay Sagirli, Sıdıka Erturk Toker, Armağan Önal. Development of sensitive spectrofluorimetric and spectrophotometric methods for the determination of duloxetine in capsule and spiked human plasma.
Luminescence : the journal of biological and chemical luminescence.
2014 Dec; 29(8):1014-8. doi:
10.1002/bio.2652. [PMID: 24619645] - Miyu Mori, Tetsuro Koide, Yoshinori Imanishi, Yuriyo Matsui, Toru Matsuda. Duloxetine-induced hyponatremia in an elderly patient treated with thiazide diuretics.
Indian journal of pharmacology.
2014 Nov; 46(6):657-9. doi:
10.4103/0253-7613.144947. [PMID: 25538343] - Minsoo Han, Chiman Song, Nakcheol Jeong, Hoh-Gyu Hahn. Exploration of 3-Aminoazetidines as Triple Reuptake Inhibitors by Bioisosteric Modification of 3-α-Oxyazetidine.
ACS medicinal chemistry letters.
2014 Sep; 5(9):999-1004. doi:
10.1021/ml500187a. [PMID: 25221656] - Michał Kaza, Edyta Gilant, Monika Filist, Iwona Szlaska, Tomasz Pawiński, Piotr J Rudzki. Determination of duloxetine in human plasma with proven lack of influence of the major metabolite 4-hydroxyduloxetine.
Clinical biochemistry.
2014 Sep; 47(13-14):1313-5. doi:
10.1016/j.clinbiochem.2014.05.059. [PMID: 24886771] - M Intakhab Alam, Sanjula Baboota, Alka Ahuja, Mushir Ali, Javed Ali, Jasjeet K Sahni, Aseem Bhatnagar. Pharmacoscintigraphic evaluation of potential of lipid nanocarriers for nose-to-brain delivery of antidepressant drug.
International journal of pharmaceutics.
2014 Aug; 470(1-2):99-106. doi:
10.1016/j.ijpharm.2014.05.004. [PMID: 24810241] - Evelyn D Lobo, Tonya Quinlan, Apurva Prakash. Pharmacokinetics of orally administered duloxetine in children and adolescents with major depressive disorder.
Clinical pharmacokinetics.
2014 Aug; 53(8):731-40. doi:
10.1007/s40262-014-0149-y. [PMID: 24989060] - Jun Yun, Minsoo Han, Chiman Song, Seung Hoon Cheon, Kihang Choi, Hoh-Gyu Hahn. Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors.
Bioorganic & medicinal chemistry letters.
2014 Aug; 24(15):3234-7. doi:
10.1016/j.bmcl.2014.06.026. [PMID: 24974340] - Thorsten Mikoteit, Johannes Beck, Anne Eckert, Ulrich Hemmeter, Serge Brand, Roland Bischof, Edith Holsboer-Trachsler, Alexandra Delini-Stula. High baseline BDNF serum levels and early psychopathological improvement are predictive of treatment outcome in major depression.
Psychopharmacology.
2014 Aug; 231(15):2955-65. doi:
10.1007/s00213-014-3475-8. [PMID: 24562062] - R Ian Storer, Paul E Brennan, Alan D Brown, Peter J Bungay, Kelly M Conlon, Matthew S Corbett, Robert P DePianta, Paul V Fish, Alexander Heifetz, Danny K H Ho, Alan S Jessiman, Gordon McMurray, Cesar Augusto F de Oliveira, Lee R Roberts, James A Root, Veerabahu Shanmugasundaram, Michael J Shapiro, Melanie Skerten, Dominique Westbrook, Simon Wheeler, Gavin A Whitlock, John Wright. Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors.
Journal of medicinal chemistry.
2014 Jun; 57(12):5258-69. doi:
10.1021/jm5003292. [PMID: 24878222] - Abdullah Akpinar, Abdülhadi Cihangir Uğuz, Mustafa Nazıroğlu. Agomelatine and duloxetine synergistically modulates apoptotic pathway by inhibiting oxidative stress triggered intracellular calcium entry in neuronal PC12 cells: role of TRPM2 and voltage-gated calcium channels.
The Journal of membrane biology.
2014 May; 247(5):451-9. doi:
10.1007/s00232-014-9652-1. [PMID: 24682240] - Nobuhito Murai, Toshiaki Aoki, Seiji Tamura, Hiroko Yamamoto, Nozomu Hamakawa, Nobuya Matsuoka. AS1069562, the (+)-isomer of indeloxazine, but not duloxetine has a curative-like analgesic effect in a rat model of streptozotocin-induced diabetic neuropathy.
Neuropharmacology.
2014 Apr; 79(?):10-6. doi:
10.1016/j.neuropharm.2013.10.030. [PMID: 24211301] - Nobuhito Murai, Toshiaki Aoki, Seiji Tamura, Toshihiro Sekizawa, Shuichiro Kakimoto, Mina Tsukamoto, Tomoya Oe, Ryugo Enomoto, Nozomu Hamakawa, Nobuya Matsuoka. AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in a rat model of neuropathic pain with unique characteristics in spinal monoamine turnover.
The Journal of pharmacology and experimental therapeutics.
2014 Mar; 348(3):372-82. doi:
10.1124/jpet.113.208686. [PMID: 24338505] - Jill C Chappell, Graeme Eisenhofer, Michael J Owens, Harry Haber, D Richard Lachno, Robert A Dean, Mary Pat Knadler, Charles B Nemeroff, Malcolm I Mitchell, Michael J Detke, Smriti Iyengar, Beth Pangallo, Evelyn D Lobo. Effects of duloxetine on norepinephrine and serotonin transporter activity in healthy subjects.
Journal of clinical psychopharmacology.
2014 Feb; 34(1):9-16. doi:
10.1097/jcp.0000000000000061. [PMID: 24346757] - Michele Fornaro, Giulio Rocchi, Andrea Escelsior, Paola Contini, Massimo Ghio, Salvatore Colicchio, Domenico De Berardis, Mario Amore, Pantaleo Fornaro, Matteo Martino. VEGF plasma level variations in duloxetine-treated patients with major depression.
Journal of affective disorders.
2013 Nov; 151(2):590-595. doi:
10.1016/j.jad.2013.06.055. [PMID: 23871390] - Fionn E O'Brien, Gerard Clarke, Timothy G Dinan, John F Cryan, Brendan T Griffin. Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability.
The international journal of neuropsychopharmacology.
2013 Nov; 16(10):2259-72. doi:
10.1017/s1461145713000692. [PMID: 23931269] - F Fischer, N Vonderlin, C Seyler, E Zitron, B Schernus, H Katus, E Scholz. Acute and subacute effects of the selective serotonin-noradrenaline reuptake inhibitor duloxetine on cardiac hERG channels.
Naunyn-Schmiedeberg's archives of pharmacology.
2013 Sep; 386(9):795-804. doi:
10.1007/s00210-013-0878-8. [PMID: 23666493] - Matteo Martino, Giulio Rocchi, Andrea Escelsior, Paola Contini, Salvatore Colicchio, Domenico de Berardis, Mario Amore, Pantaleo Fornaro, Michele Fornaro. NGF serum levels variations in major depressed patients receiving duloxetine.
Psychoneuroendocrinology.
2013 Sep; 38(9):1824-8. doi:
10.1016/j.psyneuen.2013.02.009. [PMID: 23507186] - James L Roerig, Kristine J Steffen, Cheryl Zimmerman, James E Mitchell, Ross D Crosby, Li Cao. A comparison of duloxetine plasma levels in postbariatric surgery patients versus matched nonsurgical control subjects.
Journal of clinical psychopharmacology.
2013 Aug; 33(4):479-84. doi:
10.1097/jcp.0b013e3182905ffb. [PMID: 23771193] - Jung-woo Chae, Hyun-moon Baek, Sang Kyum Kim, Ho-il Kang, Kwang-il Kwon. Quantitative determination of duloxetine and its metabolite in rat plasma by HPLC-MS/MS.
Biomedical chromatography : BMC.
2013 Aug; 27(8):953-5. doi:
10.1002/bmc.2895. [PMID: 23519740] - I-H Baek, B-Y Lee, W Kang, K-I Kwon. Pharmacokinetic analysis of two different doses of duloxetine following oral administration in dogs.
Drug research.
2013 Aug; 63(8):404-8. doi:
10.1055/s-0033-1341493. [PMID: 23599035]