Dipyridamole (BioDeep_00000017976)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin-1-yl)-[1,3]diazino[5,4-d]pyrimidin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol
化学式: C24H40N8O4 (504.31723600000004)
中文名称: 双嘧达莫
谱图信息:
最多检出来源 Homo sapiens(blood) 4.57%
分子结构信息
SMILES: C1CCN(CC1)c1c2c(c(nc(n2)N(CCO)CCO)N2CCCCC2)nc(n1)N(CCO)CCO
InChI: InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
描述信息
Dipyridamole is only found in individuals that have used or taken this drug. It is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation.
B - Blood and blood forming organs > B01 - Antithrombotic agents > B01A - Antithrombotic agents > B01AC - Platelet aggregation inhibitors excl. heparin
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
33 个代谢物同义名
2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin-1-yl)-[1,3]diazino[5,4-d]pyrimidin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol; Boehringer ingelheim brand OF dipyridamole; Berlin-chemie brand OF dipyridamole; Berlin chemie brand OF dipyridamole; Ashbourne brand OF dipyridamole; Novopharm brand OF dipyridamole; Apotex brand OF dipyridamole; Belmac brand OF dipyridamole; IPRAD brand OF dipyridamole; Apo dipyridamole; Apo-dipyridamole; Antistenocardin; Novo-dipiradol; Novo dipiradol; Cleridium 150; Dipyridamolum; dipyridamole; Dipyridamine; Dipyramidole; Dypyridamol; Dipiridamol; Cerebrovase; Dipyudamine; Dipyridamol; Persantine; Usaf ge-12; Cléridium; Persantin; Kurantil; Cardoxin; Curantil; Curantyl; Miosen
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:4653
- PubChem: 3108
- HMDB: HMDB0015110
- DrugBank: DB00975
- ChEMBL: CHEMBL932
- Wikipedia: Dipyridamole
- MeSH: Dipyridamole
- chemspider: 2997
- CAS: 58-32-2
- PMhub: MS000001524
- RefMet: Dipyridamole
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 99506 - Heracleum candicans: 10.1007/S11418-008-0266-8
- 9606 - Homo sapiens: -
- 489434 - Prangos ferulacea:
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rita Pepponi, Roberta De Simone, Chiara De Nuccio, Sergio Visentin, Andrea Matteucci, Antonietta Bernardo, Patrizia Popoli, Antonella Ferrante. Repurposing Dipyridamole in Niemann Pick Type C Disease: A Proof of Concept Study.
International journal of molecular sciences.
2022 Mar; 23(7):. doi:
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Medicine.
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2017; 44 Suppl 1(?):31-34. doi:
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Journal of vascular research.
2017; 54(5):309-319. doi:
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European journal of drug metabolism and pharmacokinetics.
2016 Dec; 41(6):733-741. doi:
10.1007/s13318-015-0302-5. [PMID: 26458556] - Annelaure Damont, Sébastien Goutal, Sylvain Auvity, Héric Valette, Bertrand Kuhnast, Wadad Saba, Nicolas Tournier. Imaging the impact of cyclosporin A and dipyridamole on P-glycoprotein (ABCB1) function at the blood-brain barrier: A [(11)C]-N-desmethyl-loperamide PET study in nonhuman primates.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2016 Aug; 91(?):98-104. doi:
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European journal of clinical pharmacology.
2016 Jun; 72(6):725-30. doi:
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Naunyn-Schmiedeberg's archives of pharmacology.
2016 Apr; 389(4):361-8. doi:
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Clinical pharmacology and therapeutics.
2016 Apr; 99(4):381-9. doi:
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International braz j urol : official journal of the Brazilian Society of Urology.
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Life sciences.
2015 Dec; 143(?):8-17. doi:
10.1016/j.lfs.2015.10.026. [PMID: 26596562] - Lei Hua, Gui Lai, Liu Zhenjun, Ma Guie. [The study of anticoagulants selection in platelet-rich plasma preparation].
Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery.
2015 Jul; 31(4):295-300. doi:
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Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2015 Mar; 26(2):363-5. doi:
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Peptides.
2015 Feb; 64(?):67-73. doi:
10.1016/j.peptides.2015.01.003. [PMID: 25613228] - Pitchai Balakumar, Rajavel Varatharajan, Ying Hui Nyo, Raja Renushia, Devarajan Raaginey, Ann Nah Oh, Shaikh Sohrab Akhtar, Mani Rupeshkumar, Karupiah Sundram, Sokkalingam A Dhanaraj. Fenofibrate and dipyridamole treatments in low-doses either alone or in combination blunted the development of nephropathy in diabetic rats.
Pharmacological research.
2014 Dec; 90(?):36-47. doi:
10.1016/j.phrs.2014.08.008. [PMID: 25263930] - Chi-Chih Hung, Mei-Li Yang, Ming-Yen Lin, Hugo You-Hsien Lin, Lee-Moay Lim, Hung-Tien Kuo, Shang-Jyh Hwang, Jer-Chia Tsai, Hung-Chun Chen. Dipyridamole treatment is associated with improved renal outcome and patient survival in advanced chronic kidney disease.
The Kaohsiung journal of medical sciences.
2014 Dec; 30(12):599-607. doi:
10.1016/j.kjms.2014.10.002. [PMID: 25476097] - Chia-Wen Hsu, Jinghua Zhao, Ruili Huang, Jui-Hua Hsieh, Jon Hamm, Xiaoqing Chang, Keith Houck, Menghang Xia. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor.
Scientific reports.
2014 Sep; 4(?):6437. doi:
10.1038/srep06437. [PMID: 25257666] - T Raczat, L Kraemer, C Gall, D R Weiss, R Eckstein, J Ringwald. The influence of four different anticoagulants on dynamic light scattering of platelets.
Vox sanguinis.
2014 Aug; 107(2):196-9. doi:
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Journal of neurology.
2014 Jul; 261(7):1405-12. doi:
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International journal of cardiology.
2014 Mar; 172(2):530-2. doi:
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Molecular pharmaceutics.
2014 Mar; 11(3):746-54. doi:
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Molecules (Basel, Switzerland).
2014 Jan; 19(1):686-98. doi:
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Biochemical pharmacology.
2013 Dec; 86(11):1531-40. doi:
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Current vascular pharmacology.
2013 Nov; 11(6):824-37. doi:
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Circulation.
2013 Sep; 128(12):1341-8. doi:
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2013 May; 28(5):1135-49. doi:
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Nephrology (Carlton, Vic.).
2013 May; 18(5):376-81. doi:
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American journal of cardiovascular drugs : drugs, devices, and other interventions.
2013 Apr; 13(2):113-20. doi:
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Journal of neurology.
2013 Feb; 260(2):590-6. doi:
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Drug metabolism and pharmacokinetics.
2013; 28(5):406-10. doi:
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Rheumatology international.
2013 Jan; 33(1):219-22. doi:
10.1007/s00296-010-1540-0. [PMID: 20532511] - Dimitrios Psachoulias, Maria Vertzoni, James Butler, David Busby, Moira Symillides, Jennifer Dressman, Christos Reppas. An in vitro methodology for forecasting luminal concentrations and precipitation of highly permeable lipophilic weak bases in the fasted upper small intestine.
Pharmaceutical research.
2012 Dec; 29(12):3486-98. doi:
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Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.
2012 Dec; 19(6):1182-9. doi:
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American journal of therapeutics.
2012 Nov; 19(6):407-12. doi:
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Journal of clinical ultrasound : JCU.
2012 Nov; 40(9):607-10. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2012 Oct; 129(2):346-62. doi:
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2012 Oct; 82(2):401-9. doi:
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International journal of pharmaceutics.
2012 Sep; 434(1-2):148-54. doi:
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The Biochemical journal.
2012 Sep; 446(2):179-90. doi:
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Thrombosis research.
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2012 Aug; 50(8):2622-8. doi:
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Biochemical pharmacology.
2012 Aug; 84(3):383-90. doi:
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The Lancet. Neurology.
2012 Jun; 11(6):512-20. doi:
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Archives of medical science : AMS.
2012 May; 8(2):375-88. doi:
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
2012 May; 59(5):682-8. doi:
10.1053/j.ajkd.2011.11.036. [PMID: 22281051] - Qiang Lin, Yue Min, Yanhong Li, Yun Zhu, Xiaoxiang Song, Qinying Xu, Lifeng Wang, Jiang Cheng, Qihua Feng, Xiaozhong Li. Henoch-Schönlein purpura with hypocomplementemia.
Pediatric nephrology (Berlin, Germany).
2012 May; 27(5):801-6. doi:
10.1007/s00467-011-2070-z. [PMID: 22271365] - Karthik Ananthasubramaniam, Robert Weiss, Bruce McNutt, Barbara Klauke, Kathleen Feaheny, Stan Bukofzer. A randomized, double-blind, placebo-controlled study of the safety and tolerance of regadenoson in subjects with stage 3 or 4 chronic kidney disease.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.
2012 Apr; 19(2):319-29. doi:
10.1007/s12350-011-9508-3. [PMID: 22259009] - Elena Guillén-Gómez, Itziar Pinilla-Macua, Sandra Pérez-Torras, Doo-Sup Choi, Yolanda Arce, José A Ballarín, Marçal Pastor-Anglada, Montserrat M Díaz-Encarnación. New role of the human equilibrative nucleoside transporter 1 (hENT1) in epithelial-to-mesenchymal transition in renal tubular cells.
Journal of cellular physiology.
2012 Apr; 227(4):1521-8. doi:
10.1002/jcp.22869. [PMID: 21678404] - Mona M Soliman, Maha M Arafah. Treatment with dipyridamole improves cardiac function and prevent injury in a rat model of hemorrhage.
European journal of pharmacology.
2012 Mar; 678(1-3):26-31. doi:
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The Journal of clinical investigation.
2012 Feb; 122(2):493-6. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2012 Feb; 27(2):475-7. doi:
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