Desoximetasone (BioDeep_00000017974)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-17-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one

化学式: C22H29FO4 (376.205)
中文名称: 地塞米松, 去氧肟酮
谱图信息: 最多检出来源 Homo sapiens(blood) 16.67%

分子结构信息

SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1C(=O)CO
InChI: InChI=1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3

描述信息

Desoximetasone is only found in individuals that have used or taken this drug. It is a topical anti-inflammatory glucocorticoid used in dermatoses, skin allergies, psoriasis, etc. [PubChem]The precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. This is achieved first by the drug binding to the glucocorticoid receptors which then translocates into the nucleus and binds to DNA causing various activations and repressions of genes. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07X - Corticosteroids, other combinations > D07XC - Corticosteroids, potent, other combinations
D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07A - Corticosteroids, plain > D07AC - Corticosteroids, potent (group iii)
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D000893 - Anti-Inflammatory Agents

同义名列表

32 个代谢物同义名

(1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-17-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one; (11beta,16alpha)-9-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione; (11b,16a)-9-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione; (11Β,16α)-9-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione; 9alpha-Fluoro-16alpha-methyl-Delta(1)-corticosterone; 9a-Fluoro-16a-methyl-delta(1)-corticosterone; 9a-Fluoro-16a-methyl-δ(1)-corticosterone; 9Α-fluoro-16α-methyl-δ(1)-corticosterone; Optipharma brand OF desoximetasone; Bipharma brand OF desoximetasone; Hoechst brand OF desoximetasone; Stiefel brand OF desoximetasone; Medicis brand OF desoximetasone; Aventis brand OF desoximetasone; Abbott brand OF desoximetasone; Dermik brand OF desoximetasone; 17-Desoxymethasone; Deoxydexamethasone; 17 Desoxymethasone; Desoximetasonum; Desoxymethasone; Desoxymetasone; Desoximetasona; Desoximetasone; Topisolon; Topicorte; Topicort; Flubason; Stiedex; Desoxi; Ibaril; Desoximetasone



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表


文献列表

  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • Marc Cherlet, Siegrid De Baere, Patrick De Backer. Quantitative determination of dexamethasone in bovine milk by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Jun; 805(1):57-65. doi: 10.1016/j.jchromb.2004.02.015. [PMID: 15113540]
  • J M Garden, R K Freinkel. Systemic absorption of topical steroids. Metabolic effects as an index of mild hypercortisolism. Archives of dermatology. 1986 Sep; 122(9):1007-10. doi: NULL. [PMID: 3527074]
  • F Schröpl. [Clinical studies with prednicarbate with special reference to double-blind comparisons with common therapeutic preparations]. Zeitschrift fur Hautkrankheiten. 1986; 61 Suppl 1(?):80-7. doi: NULL. [PMID: 3705676]
  • S Nolting. [Treatment with topical corticosteroids in severe or resistant dermatoses]. Dermatosen in Beruf und Umwelt. Occupation and environment. 1985; 33(4):140-4. doi: NULL. [PMID: 2931266]
  • G Kavli, K Midelfart, G Volden, H Krokan. Photochemical reactions of Heracleum laciniatum. Influence of dimethyl sulphoxide and corticosteroids. The British journal of dermatology. 1983 Jul; 109 Suppl 25(?):137-40. doi: 10.1111/j.1365-2133.1983.tb06826.x. [PMID: 6860581]
  • R C Cornell, R B Stoughton. Six-month controlled study of effect of desoximetasone and betamethasone 17-valerate on the pituitary-adrenal axis. The British journal of dermatology. 1981 Jul; 105(1):91-5. doi: 10.1111/j.1365-2133.1981.tb00888.x. [PMID: 7259982]
  • R Gratacos. [Parallel double-blind comparison of bazalin and desoximetasone 0.25 in neurodermatitis]. Medicina cutanea ibero-latino-americana. 1981; 9(5):383-8. doi: NULL. [PMID: 7038354]
  • F Hartmann, A Proppe, D Proppe. Circadian plasma cortisol levels during topical use of desoximetasone and triamcinolone acetonide in man. European journal of clinical pharmacology. 1980 May; 17(5):363-9. doi: 10.1007/bf00558449. [PMID: 6893435]
  • E N Ehrlich, W E Nolten, M D Lindheimer. Mineralocorticoids and the regulation of sodium metabolism in normal and hypertensive pregnancy: a review. Clinical and experimental hypertension. 1980; 2(5):803-19. doi: 10.3109/10641968009037143. [PMID: 6159142]
  • J E Nilsson, L J Gip. Systemic effects of local treatment with high doses of potent corticosteroids in psoriatics. Acta dermato-venereologica. 1979; 59(3):245-8. doi: NULL. [PMID: 87083]
  • P A Bromley, F O Müller, J Malan, J Torres, O Vanderbeke. Plasma cortisol levels in normal volunteers receiving either betamethasone valerate or desoximetasone by topical application. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 1978 Aug; 54(6):239-41. doi: NULL. [PMID: 362568]