Desonide (BioDeep_00000017973)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

(1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosa-14,17-dien-16-one

化学式: C24H32O6 (416.2198772)
中文名称: 地索奈德
谱图信息: 最多检出来源 Homo sapiens(blood) 1.03%

分子结构信息

SMILES: CC1(C)OC2CC3C4CCC5=CC(=O)C=CC5(C)C4C(O)CC3(C)C2(C(=O)CO)O1
InChI: InChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3

描述信息

Desonide is only found in individuals that have used or taken this drug. It is a nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses. [PubChem]Like other topical corticosteroids, desonide has anti-inflammatory, antipruritic and vasoconstrictive properties. The drug binds to cytosolic glucocorticoid receptors. This complex migrates to the nucleus and binds to genetic elements on the DNA. This activates and represses various genes. However corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07A - Corticosteroids, plain > D07AB - Corticosteroids, moderately potent (group ii)
S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BA - Corticosteroids, plain
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D000893 - Anti-Inflammatory Agents

同义名列表

40 个代谢物同义名

数据库引用编号

11 个数据库交叉引用编号

ChEBI: CHEBI:204734
PubChem: 5311066
PubChem: 578798
HMDB: HMDB0015389
DrugBank: DB01260
ChEMBL: CHEMBL1201109
Wikipedia: Desonide
MeSH: Desonide
chemspider: 4470603
CAS: 638-94-8
PMhub: MS000001509

分类词条

21-hydroxysteroids

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Zhen Xie, Yu-Xin Yang, Hao Zhang. Mask-induced contact dermatitis in handling COVID-19 outbreak. Contact dermatitis. 2020 08; 83(2):166-167. doi: 10.1111/cod.13599. [PMID: 32390190]
Priscila Rosa, Mariane Lago Friedrich, Juliana Dos Santos, Daniele Rubert Nogueira Librelotto, Luana Haselein Maurer, Tatiana Emanuelli, Cristiane de Bona da Silva, Andréa Inês Horn Adams. Desonide nanoencapsulation with açai oil as oil core: Physicochemical characterization, photostability study and in vitro phototoxicity evaluation. Journal of photochemistry and photobiology. B, Biology. 2019 Oct; 199(?):111606. doi: 10.1016/j.jphotobiol.2019.111606. [PMID: 31522112]
Aditya K Gupta, Sarah G Versteeg. Topical Treatment of Facial Seborrheic Dermatitis: A Systematic Review. American journal of clinical dermatology. 2017 Apr; 18(2):193-213. doi: 10.1007/s40257-016-0232-2. [PMID: 27804089]
Seul Ji Lee, Sung-il Woo, Soo Hyun Ahn, Dong Kyu Lim, Ji Yeon Hong, Jeong Hill Park, Johan Lim, Mi-kyeong Kim, Sung Won Kwon. Functional interpretation of metabolomics data as a new method for predicting long-term side effects: treatment of atopic dermatitis in infants. Scientific reports. 2014 Dec; 4(?):7408. doi: 10.1038/srep07408. [PMID: 25491116]
R J B Peters, J E Oosterink, A A M Stolker, C Georgakopoulos, M W F Nielen. Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories. Analytical and bioanalytical chemistry. 2010 Apr; 396(7):2583-98. doi: 10.1007/s00216-010-3484-3. [PMID: 20155493]
I Madhusudhana Reddy, Alka Beotra, S Jain, S Ahi. A simple and rapid ESI-LC-MS/MS method for simultaneous screening of doping agents in urine samples. Indian journal of pharmacology. 2009 Apr; 41(2):80-6. doi: 10.4103/0253-7613.51347. [PMID: 20336223]
A Vonaparti, E Lyris, I Panderi, M Koupparis, C Georgakopoulos. Direct injection LC/ESI-MS horse urine analysis for the quantification and identification of threshold substances for doping control. I. Determination of hydrocortisone. Journal of mass spectrometry : JMS. 2008 Sep; 43(9):1255-64. doi: 10.1002/jms.1401. [PMID: 18407581]
Kenji Ishikura, Masahiro Ikeda, Yuko Hamasaki, Hiroshi Hataya, Gen Nishimura, Ryugo Hiramoto, Masataka Honda. Nephrotic state as a risk factor for developing posterior reversible encephalopathy syndrome in paediatric patients with nephrotic syndrome. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2008 Aug; 23(8):2531-6. doi: 10.1093/ndt/gfn013. [PMID: 18258739]
C Piérard-Franchimont, V Vroome, G Cauwenbergh, G E Piérard. Corneofungimetry bioassay on Malassezia spp. under ketoconazole and desonide influences. Skin pharmacology and physiology. 2005 Mar; 18(2):98-102. doi: 10.1159/000083710. [PMID: 15767771]
E Pujos, M M Flament-Waton, O Paisse, M F Grenier-Loustalot. Comparison of the analysis of corticosteroids using different techniques. Analytical and bioanalytical chemistry. 2005 Jan; 381(1):244-54. doi: 10.1007/s00216-004-2890-9. [PMID: 15700162]
Halina Bartosik-Psujek, Zbigniew Stelmasiak. Steroid therapy altered serum levels of CCL2 and CCL5 chemokines in multiple sclerosis patients during relapse. European neurology. 2004; 52(4):237-41. doi: 10.1159/000082164. [PMID: 15550762]
B Lebrun-Vignes, V Legrain, J Amoric, A Taïeb. [Comparative study of efficacy and effect on plasma cortisol levels of micronised desonide cream 0.1 p. 100 versus betamethasone dipropionate cream 0.05 p. 100 In the treatment of childhood atopic dermatitis]. Annales de dermatologie et de venereologie. 2000 Jun; 127(6-7):590-5. doi: NULL. [PMID: 10930856]
C Queille, R Pommarede, J H Saurat. Efficacy versus systemic effects of six topical steroids in the treatment of atopic dermatitis of childhood. Pediatric dermatology. 1984 Jan; 1(3):246-53. doi: 10.1111/j.1525-1470.1984.tb01124.x. [PMID: 6494068]