Desloratadine (BioDeep_00000017938)

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite

代谢物信息卡片

13-chloro-2-(piperidin-4-ylidene)-4-azatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene

化学式: C19H19ClN2 (310.1236684)
中文名称: 脱羧氯雷他定
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 0.46%

分子结构信息

SMILES: C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4
InChI: InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2

描述信息

Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral H1-antagonist action. It is the active descarboethoxy metabolite of loratidine (a second generation histamine). Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].
Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].

同义名列表

12 个代谢物同义名

13-chloro-2-(piperidin-4-ylidene)-4-azatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene; 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine; 8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; Descarboethoxyloratadine acetate; Descarboethoxyloratadine; Descarboethoxyoratidine; Desloratidine; Desloratadine; Neoclarityn; Clarinex; Aerius; Sch34117

数据库引用编号

11 个数据库交叉引用编号

ChEBI: CHEBI:291342
PubChem: 124087
HMDB: HMDB0015102
DrugBank: DB00967
ChEMBL: CHEMBL1172
Wikipedia: Desloratadine
chemspider: 110575
CAS: 100643-71-8
PMhub: MS000001318
RefMet: Desloratadine
medchemexpress: HY-B0539

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Muhammad Jamil, Ijaz Malook, Shafiq Ur Rehman, Muhammad Mudasar Aslam, Muhammad Fayyaz, Gulmeena Shah, Alevcan Kaplan, Muhammad Nauman Khan, Baber Ali, Rana Roy, Sezai Ercisli, Steve Harakeh, Mohammed Moulay, Muhammad Ammar Javed, Amany H A Abeed. Inoculation of heavy metal resistant bacteria alleviated heavy metal-induced oxidative stress biomarkers in spinach (Spinacia oleracea L.). BMC plant biology. 2024 Mar; 24(1):221. doi: 10.1186/s12870-024-04757-7. [PMID: 38539080]
Tian Wang, Boya Hao, Shilin Xu, Jie Meng, Tao Wen, Jian Liu, Haiyan Xu. Effective RNAi in leukemia cells is enhanced by spermine-modified pullulan combined with desloratadine. Carbohydrate polymers. 2022 Sep; 292(?):119646. doi: 10.1016/j.carbpol.2022.119646. [PMID: 35725203]
Gang Wang, Aihua Ye, Xiangyu Xu, Chen Chen, Jiaoli Yang. Desloratadine citrate combined with compound glycyrrhizin in the treatment of subacute eczema: A randomized trial. Pakistan journal of pharmaceutical sciences. 2022 May; 35(3(Special)):919-922. doi: . [PMID: 35791588]
Yulong Wen, Yidan Tang, Miaoyue Li, Yu Lai. Efficiency and safety of desloratadine in combination with compound glycyrrhizin in the treatment of chronic urticaria: a meta-analysis and systematic review of randomised controlled trials. Pharmaceutical biology. 2021 Dec; 59(1):1276-1285. doi: 10.1080/13880209.2021.1973039. [PMID: 34517748]
Yajing Hou, Shuai Ge, Xiaowei Li, Cheng Wang, Huaizhen He, Langchong He. Testing of the inhibitory effects of loratadine and desloratadine on SARS-CoV-2 spike pseudotyped virus viropexis. Chemico-biological interactions. 2021 Apr; 338(?):109420. doi: 10.1016/j.cbi.2021.109420. [PMID: 33609497]
Yu Zhang, Jiaming Zhang, Qiuchi Xu, Yimeng Wang, Wenying Wu, Weiping Wang, Xiaoting Li, Tianhong Zhang. Simultaneous Determination of Loratadine and Its Metabolite Desloratadine in Beagle Plasma by LC-MS/MS and Application for Pharmacokinetics Study of Loratadine Tablets and Omeprazole‑Induced Drug-Drug Interaction. Drug design, development and therapy. 2021; 15(?):5109-5122. doi: 10.2147/dddt.s328106. [PMID: 34992347]
Ansumana Mohammed Keita, Mouna Zahlane, Laila Benjilali, Lamiaa Essaadouni. [Drug-induced toxidermia in a patient receiving hydroxychloroquine as systemic therapy for primary Gougerot-Sjögren syndrome: a case report]. The Pan African medical journal. 2021; 38(?):283. doi: 10.11604/pamj.2021.38.283.28478. [PMID: 34122710]
Maria Troyanova-Wood, Cassidy Gobbell, Zhaokai Meng, Olga Gasheva, Anatoliy Gashev, Vladislav V Yakovlev. Assessing the effect of prolonged use of desloratadine on adipose Brillouin shift and composition in rats. Journal of biophotonics. 2021 01; 14(1):e202000269. doi: 10.1002/jbio.202000269. [PMID: 32951319]
Xiaoling Liu, Xiaojia Liu, Yu Ren, Hongxin Yang, Xiaolei Sun, Haiyun Huang. Clinical Efficacy of Vitamin D3 Adjuvant Therapy in Allergic Rhinitis: A Randomized Controlled Trial. Iranian journal of immunology : IJI. 2020 12; 17(4):283-291. doi: 10.22034/iji.2020.84336.1652. [PMID: 33382385]
Yuxin Zhang, Yihua Lu, Lijuan Wang, Yuan Tian, Zunjian Zhang. Pharmacokinetics and Tissue Distribution of Loratadine, Desloratadine and Their Active Metabolites in Rat based on a Newly Developed LC-MS/MS Analytical Method. Drug research. 2020 Nov; 70(11):528-540. doi: 10.1055/a-1233-5575. [PMID: 32877950]
Huseyin Kocaturk, Fevzi Bedir, Mehmet Sefa Altay, Ebubekir Bakan, Bahadir Suleyman, Gulce Naz Yazici, Mukadder Sunar, Zeynep Suleyman, Halis Suleyman. The effect of desloratadine on ischemia reperfusion induced oxidative and inflammatory renal injury in rats. Renal failure. 2020 Nov; 42(1):531-538. doi: 10.1080/0886022x.2020.1769656. [PMID: 32524906]
Suguru Kato, Abhi Shah, Mihaela Plesescu, Yoshinari Miyata, Jayaprakasam Bolleddula, Swapan Chowdhury, Xiaochun Zhu. Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver. Drug metabolism and disposition: the biological fate of chemicals. 2020 10; 48(10):934-943. doi: 10.1124/dmd.120.000128. [PMID: 32665417]
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Shenling Li, Xiaotian Zhang, Zhiyuan Li, Xiaodan Jiang, Niankai Zhang, Jisheng Zhang, Yichuan Huang, Han Zhao, Yan Jiang, Na Li. Desloratadine Ameliorates Olfactory Disorder and Suppresses AMPA Receptor GluA1 Expression in Allergic Rhinitis Rat. Archivum immunologiae et therapiae experimentalis. 2020 Feb; 68(1):6. doi: 10.1007/s00005-020-00569-3. [PMID: 32076842]
Tadaho Nakamura, Kotaro Hiraoka, Ryuichi Harada, Takuro Matsuzawa, Yoichi Ishikawa, Yoshihito Funaki, Takeo Yoshikawa, Manabu Tashiro, Kazuhiko Yanai, Nobuyuki Okamura. Brain histamine H1 receptor occupancy after oral administration of desloratadine and loratadine. Pharmacology research & perspectives. 2019 08; 7(4):e00499. doi: 10.1002/prp2.499. [PMID: 31338198]
Matti K Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J Neuvonen, Mikko Niemi, Janne T Backman. Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans. Drug metabolism and disposition: the biological fate of chemicals. 2019 04; 47(4):377-385. doi: 10.1124/dmd.118.084665. [PMID: 30630815]
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Muhammed Sedat Sakat, Korhan Kilic, Fatih Mehmet Kandemir, Serkan Yildirim, Abdulkadir Sahin, Sefa Kucukler, Yavuz Selim Saglam. The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2018 Oct; 275(10):2495-2505. doi: 10.1007/s00405-018-5104-3. [PMID: 30159729]
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Attarat Pattanawongsa, Pramod C Nair, Andrew Rowland, John O Miners. Human UDP-Glucuronosyltransferase (UGT) 2B10: Validation of Cotinine as a Selective Probe Substrate, Inhibition by UGT Enzyme-Selective Inhibitors and Antidepressant and Antipsychotic Drugs, and Structural Determinants of Enzyme Inhibition. Drug metabolism and disposition: the biological fate of chemicals. 2016 Mar; 44(3):378-88. doi: 10.1124/dmd.115.068213. [PMID: 26669329]
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Arzu Tatar, Secil Nazife Parlak, Muhammet Yayla, Rustem Anil Ugan, Elif Polat, Zekai Halici. Effects of allergic rhinitis and desloratadine on the submandibular gland in a rat allergy model. International forum of allergy & rhinology. 2015 Dec; 5(12):1164-9. doi: 10.1002/alr.21589. [PMID: 26201305]
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