3-Methoxy-4-Hydroxyphenylglycol sulfate (BioDeep_00000017929)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


[2-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)ethoxy]sulphonic acid

化学式: C9H12O7S (264.0303722)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 93.55%

分子结构信息

SMILES: COC1=C(C=CC(=C1)C(CO)OS(=O)(=O)O)O
InChI: InChI=1S/C9H12O7S/c1-15-8-4-6(2-3-7(8)11)9(5-10)16-17(12,13)14/h2-4,9-11H,5H2,1H3,(H,12,13,14)

描述信息

3-Methoxy-4-Hydroxyphenylglycol sulfate, also known as (3-methoxy-4-sulfonyloxyphenyl)glycol or MHPG-sulfate, belongs to the class of organic compounds known as methoxyphenols. Methoxyphenols are compounds containing a methoxy group attached to the benzene ring of a phenol moiety. 3-Methoxy-4-Hydroxyphenylglycol sulfate is a member of phenols and an alcohol.
A sulfated metabolite of brain norepinephrine. It is formed by phenolsulphotransferase acting on 3-methoxy-4-hydroxphenylglycol (MHPG). [HMDB]

同义名列表

18 个代谢物同义名

[2-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)ethoxy]sulphonic acid; [2-hydroxy-1-(4-hydroxy-3-methoxyphenyl)ethoxy]sulfonic acid; [2-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)ethoxy]sulphonate; [2-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)ethoxy]sulfonate; 4-Hydroxy-3-methoxyphenylethylene glycol 4-sulfate; 3-Methoxy-4-hydroxyphenylglycol sulfate conjugate; 3-Methoxy-4--hydroxyphenylethyleneglycol sulfate; 3-Methoxy-4-hydroxyphenylglycol sulphuric acid; 3-Methoxy-4-hydroxyphenylglycol sulfuric acid; 3-Methoxy-4-hydroxyphenyl glycol sulfate; 4-Hydroxy-3-methoxyphenylglycol sulphate; 3-Methoxy-4-hydroxyphenylglycol sulphate; 4-Hydroxy-3-methoxyphenylglycol sulfate; 3-methoxy-4-hydroxyphenylglycol sulfate; (3-Methoxy-4-sulfonyloxyphenyl)glycol; MHPG-Sulphate; MHPG-Sulfate; MHPG-SO4



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hyo Young Jung, Dae Young Yoo, Woosuk Kim, Sung Min Nam, Jong Whi Kim, Jung Hoon Choi, Youn-Gil Kwak, Yeo Sung Yoon, In Koo Hwang. Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites. BMC complementary and alternative medicine. 2014 Dec; 14(?):476. doi: 10.1186/1472-6882-14-476. [PMID: 25495725]
  • Debra S Harris, Thomas Everhart, Peyton Jacob, Emil Lin, John E Mendelson, Reese T Jones. A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion. BMC clinical pharmacology. 2009 Aug; 9(?):13. doi: 10.1186/1472-6904-9-13. [PMID: 19646280]
  • Ikuko Kishida, Eleni Aklillu, Chiaki Kawanishi, Leif Bertilsson, Hans Agren. Monoamine metabolites level in CSF is related to the 5-HTT gene polymorphism in treatment-resistant depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2007 Oct; 32(10):2143-51. doi: 10.1038/sj.npp.1301336. [PMID: 17299512]
  • E Filaire, B Legrand, K Bret, M Sagnol, J M Cottet-Emard, J M Pequignot. Psychobiologic responses to 4 days of increased training and recovery in cyclists. International journal of sports medicine. 2002 Nov; 23(8):588-94. doi: 10.1055/s-2002-35531. [PMID: 12439775]
  • Peyton Jacob, Margaret Wilson, Lisa Yu, John Mendelson, Reese T Jones. Determination of 4-hydroxy-3-methoxyphenylethylene glycol 4-sulfate in human urine using liquid chromatography-tandem mass spectrometry. Analytical chemistry. 2002 Oct; 74(20):5290-6. doi: 10.1021/ac020101a. [PMID: 12403583]
  • R Bourdeaux, B Capolaghi, C Lacroix, C Younos, P R Lehr. Assay of urinary free and conjugated 3-methoxy-4-hydroxyphenylethyleneglycol by high-performance liquid chromatography with amperometric detection. Journal of chromatography. B, Biomedical applications. 1995 Mar; 665(1):45-51. doi: 10.1016/0378-4347(94)00516-8. [PMID: 7795800]
  • H Emoto, C Koga, H Ishii, H Yokoo, M Yoshida, M Tanaka. A CRF antagonist attenuates stress-induced increases in NA turnover in extended brain regions in rats. Brain research. 1993 Nov; 627(1):171-6. doi: 10.1016/0006-8993(93)90762-c. [PMID: 8293299]
  • K Mine, M Okada, N Mishima, M Fujiwara, T Nakagawa. Plasma-free and sulfoconjugated MHPG in major depressive disorders: differences between responders to treatment and nonresponders. Biological psychiatry. 1993 Nov; 34(9):654-60. doi: 10.1016/0006-3223(93)90159-b. [PMID: 8292695]
  • J N de Leeuwe, U Hentschel, R Tavenier, P Edelbroek. Prediction of endocrine stress reactions by means of personality variables. Psychological reports. 1992 Jun; 70(3 Pt 1):791-802. doi: 10.2466/pr0.1992.70.3.791. [PMID: 1620772]
  • G M Van Kempen, F G Zitman, A C Linssen, P M Edelbroek. Biochemical measures in patients with a somatoform pain disorder, before, during, and after treatment with amitriptyline with or without flupentixol. Biological psychiatry. 1992 Apr; 31(7):670-80. doi: 10.1016/0006-3223(92)90276-6. [PMID: 1599984]
  • F Meng. [Plasma norepinephrine concentration and 24 hour urinary 3-methoxy-4-hydroxyphenylglycol sulfate excretion in endogenous depressed patients]. Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry. 1992 Apr; 25(2):74-7, 125. doi: NULL. [PMID: 1499411]
  • W Li, Z Xin, D Pi. [Effect of qigong on sympathetico-adrenomedullary function in patients with liver yang exuberance hypertension]. Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine. 1990 May; 10(5):283-5, 261. doi: NULL. [PMID: 2168814]
  • J G Filser, S Koch, M Fischer, W E Müller. Determination of urinary 3-methoxy-4-hydroxyphenylethylene glycol and its conjugates by high-performance liquid chromatography with electrochemical and ultraviolet absorbance detection. Journal of chromatography. 1989 Sep; 493(2):275-86. doi: 10.1016/s0378-4347(00)82734-6. [PMID: 2584295]
  • W E Müller, K Bauer, W Rost, J G Filser, M Fischer, W F Gattaz. Urinary MHPG-sulfate and urinary MHPG-glucuronide, two possible markers of the central or peripheral norepinephrine metabolism in man. The effect of alprazolam treatment. Pharmacopsychiatry. 1988 Nov; 21(6):371-3. doi: 10.1055/s-2007-1017013. [PMID: 3244770]
  • W F Gattaz, K Bauer, W Rost, C K Hübner, W E Müller. Alprazolam response in major depression: relationship with urinary levels of MHPG-sulfate. Pharmacopsychiatry. 1988 Nov; 21(6):374-5. doi: 10.1055/s-2007-1017014. [PMID: 3244771]
  • J G Filser, J Spira, M Fischer, W F Gattaz, W E Müller. The evaluation of 4-hydroxy-3-methoxyphenylglycol sulfate as a possible marker of central norepinephrine turnover. Studies in healthy volunteers and depressed patients. Journal of psychiatric research. 1988; 22(3):171-81. doi: 10.1016/0022-3956(88)90003-9. [PMID: 2852249]
  • L D Zhang. [Traditional Chinese medicine typing of schizophrenia]. Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine. 1987 Sep; 7(9):526-8, 515. doi: ". [PMID: 2893668]
  • D F Zhou, Y C Shen, L N Shu, H C Lo. Dexamethasone suppression test and urinary MHPG X SO4 determination in depressive disorders. Biological psychiatry. 1987 Jul; 22(7):883-91. doi: 10.1016/0006-3223(87)90086-2. [PMID: 3607115]
  • H Yokogoshi. Effect of dietary level of protein or methionine and threonine on the amino acids and catecholamines in brain of rats fed a high tyrosine diet. Journal of nutritional science and vitaminology. 1985 Oct; 31(5):519-31. doi: 10.3177/jnsv.31.519. [PMID: 3935763]
  • D F Zhou. [DST urinary MHPG.SO4 excretion and platelet MAO activity in depression]. Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry. 1985 Oct; 18(5):274-8. doi: NULL. [PMID: 3833511]
  • G B Glavin. Selective noradrenaline depletion markedly alters stress responses in rats. Life sciences. 1985 Aug; 37(5):461-5. doi: 10.1016/0024-3205(85)90408-4. [PMID: 3848611]
  • S Murray, D S Davies. Quantitative analysis of (3-methoxy-4-sulphooxyphenyl)ethylene glycol (MHPG sulphate) in human urine. Journal of chromatography. 1985 Feb; 337(2):441-3. doi: 10.1016/0378-4347(85)80061-x. [PMID: 3988874]
  • Y F Wang. [Urinary 3-methoxy-4-hydroxyphenylglycol sulfate in school children with minimal brain dysfunction syndrome]. Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry. 1985 Feb; 18(1):45-9. doi: NULL. [PMID: 3987458]
  • L Peyrin, J M Pequignot, G Chauplannaz, B Laurent, J Moindrot, G Aimard. [Selective study of sulfate and glucuronide conjugates of urinary MHPG in nervous depression. Peripheral and central influences]. L'Encephale. 1985 Jan; 11(1):19-24. doi: . [PMID: 3996286]
  • L Peyrin, J M Pequignot, G Chauplannaz, B Laurent, G Aimard. Sulfate and glucuronide conjugates of 3-methoxy-4-hydroxyphenylglycol (MHPG) in urine of depressed patients: central and peripheral influences. Journal of neural transmission. 1985; 63(3-4):255-69. doi: 10.1007/bf01252030. [PMID: 4067598]
  • G F Temporin, M Billi. [Development of the sympatoadrenergic function in the fetus and the newborn infant]. La Pediatria medica e chirurgica : Medical and surgical pediatrics. 1984 Sep; 6(5):677-80. doi: NULL. [PMID: 6535132]
  • R A Lobo, D Shoupe, S Roy, W Paul. Central and peripheral metabolites of norepinephrine and dopamine in postmenopausal women. American journal of obstetrics and gynecology. 1984 Jul; 149(5):548-52. doi: 10.1016/0002-9378(84)90034-6. [PMID: 6742025]
  • Y C Shen, Y F Wang. Urinary 3-methoxy-4-hydroxyphenylglycol sulfate excretion in seventy-three schoolchildren with minimal brain dysfunction syndrome. Biological psychiatry. 1984 Jun; 19(6):861-70. doi: NULL. [PMID: 6743722]
  • M Strolin Benedetti, A Eschalier, A Lesage, G Dordain, V Rovei, E Zarifian, P Dostert. Effect of a reversible and selective MAO-A inhibitor (cimoxatone) on diurnal variation in plasma prolactin level in man. European journal of clinical pharmacology. 1984; 26(1):71-7. doi: 10.1007/bf00546712. [PMID: 6538844]
  • M F Poirier, J P Olié, H Lôo, P Deniker, M Strolin Benedetti, V Rovei, A Lesage. [Antidepressive action, pharmacokinetic characteristics and biochemical properties of cimoxatone, a new reversible MAO-A inhibitor]. L'Encephale. 1983; 9(4):331-43. doi: NULL. [PMID: 6368197]
  • L Peyrin, J M Pequignot. Free and conjugated 3-methoxy-4-hydroxyphenylglycol in human urine: peripheral origin of glucuronide. Psychopharmacology. 1983; 79(1):16-20. doi: 10.1007/bf00433009. [PMID: 6403958]
  • Y Hoaki, T Nishikawa, Y Ida, Y Kohno, M Tanaka. Effect of haloperidol administration on serum MHPG-SO4 levels in chronic schizophrenics. The Kurume medical journal. 1981; 28(3):197-200. doi: 10.2739/kurumemedj.28.197. [PMID: 7343757]