Foropafant (BioDeep_00000179198)

   

human metabolite blood metabolite


代谢物信息卡片


N-[2-(dimethylamino)ethyl]-N-[(pyridin-3-yl)methyl]-4-[2,4,6-tris(propan-2-yl)phenyl]-1,3-thiazol-2-amine

化学式: C28H40N4S (464.2974)
中文名称: N1,N1-二甲基-N2-(吡啶-3-基甲基)-N2-(4-(2,4,6-三异丙基苯基)噻唑-2-基)乙烷-1,2-二胺
谱图信息: 最多检出来源 Homo sapiens(blood) 96.61%

分子结构信息

SMILES: CC(C)C1=CC(=C(C(=C1)C(C)C)C2=CSC(=N2)N(CCN(C)C)CC3=CN=CC=C3)C(C)C
InChI: InChI=1S/C28H40N4S/c1-19(2)23-14-24(20(3)4)27(25(15-23)21(5)6)26-18-33-28(30-26)32(13-12-31(7)8)17-22-10-9-11-29-16-22/h9-11,14-16,18-21H,12-13,17H2,1-8H3

描述信息

C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors

同义名列表

4 个代谢物同义名

N-[2-(dimethylamino)ethyl]-N-[(pyridin-3-yl)methyl]-4-[2,4,6-tris(propan-2-yl)phenyl]-1,3-thiazol-2-amine; N-[2-(dimethylamino)ethyl]-N-(pyridin-3-ylmethyl)-4-(2,4,6-triisopropylphenyl)-1,3-thiazol-2-amine; N-(2-Dimethylaminoethyl)-N-(3-pyridinylmethyl)(4-(2,4,6-triisopropylphenyl)thiazol-2-yl)amine; Foropafant



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Caroline Bélanger, Hanan Elimam, Julie Lefebvre, Pierre Borgeat, Sylvie Marleau. Involvement of endogenous leukotriene B4 and platelet-activating factor in polymorphonuclear leucocyte recruitment to dermal inflammatory sites in rats. Immunology. 2008 Jul; 124(3):295-303. doi: 10.1111/j.1365-2567.2007.02767.x. [PMID: 18217950]
  • Iradj Sobhani, Sergio Canedo, Beatriz Alchepo, Christiane Vissuzaine, Catherine Chevalier, Marion Buyse, Laurent Moizo, J Pierre Laigneau, Michel Mignon, J Miguel Lewin, André Bado. Putative effect of Helicobacter pylori and gastritis on gastric acid secretion in cat. American journal of physiology. Gastrointestinal and liver physiology. 2002 Apr; 282(4):G727-34. doi: 10.1152/ajpgi.00282.2001. [PMID: 11897633]
  • Céline Cheminade, Véronique Gautier, Aziz Hichami, Patrick Allaume, Dominique Le Lannou, Alain B Legrand. 1-O-alkylglycerols improve boar sperm motility and fertility. Biology of reproduction. 2002 Feb; 66(2):421-8. doi: 10.1095/biolreprod66.2.421. [PMID: 11804958]
  • L Kotelevets, V Noë, E Bruyneel, E Myssiakine, E Chastre, M Mareel, C Gespach. Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion. The Journal of biological chemistry. 1998 Jun; 273(23):14138-45. doi: 10.1074/jbc.273.23.14138. [PMID: 9603913]
  • J M Herbert, H C Castro-Faria-Neto, J M Barbosa-Filho, R S Cordeiro, E Tibiriça. Pharmacological evidence for the putative existence of two different subtypes of PAF receptors on platelets and leukocytes; studies with yangambin. Journal of lipid mediators and cell signalling. 1997 Sep; 17(1):1-14. doi: 10.1016/s0929-7855(97)00011-4. [PMID: 9302650]
  • A Bernat, P Hoffmann, A Dumas, C Serradeil-le Gal, D Raufaste, J M Herbert. V2 receptor antagonism of DDAVP-induced release of hemostasis factors in conscious dogs. The Journal of pharmacology and experimental therapeutics. 1997 Aug; 282(2):597-602. doi: NULL. [PMID: 9262320]
  • D J Evans, P J Barnes, M Cluzel, B J O'Connor. Effects of a potent platelet-activating factor antagonist, SR27417A, on allergen-induced asthmatic responses. American journal of respiratory and critical care medicine. 1997 Jul; 156(1):11-6. doi: 10.1164/ajrccm.156.1.9611112. [PMID: 9230719]
  • P R Tiller, J Cunniff, A P Land, J Schwartz, I Jardine, M Wakefield, L Lopez, J F Newton, R D Burton, B M Folk, D L Buhrman, P Price, D Wu. Drug quantitation on a benchtop liquid chromatography-tandem mass spectrometry system. Journal of chromatography. A. 1997 May; 771(1-2):119-25. doi: 10.1016/s0021-9673(97)00147-7. [PMID: 9210315]
  • J M Herbert, A Bernat, E Tibiriça. Effect of SR 27417, a novel PAF antagonist on antigen-induced hypotension in the rat. Journal of lipid mediators and cell signalling. 1997 Jan; 15(2):115-23. doi: 10.1016/s0929-7855(96)00452-x. [PMID: 9034959]
  • J M Herbert, M C Laplace, A M Mares, F Dol. Platelet-activating factor (PAF) is not an essential component of the cascade leading to smooth muscle cell proliferation following vascular injury. Journal of lipid mediators and cell signalling. 1995 Jul; 12(1):49-57. doi: 10.1016/0929-7855(95)00007-d. [PMID: 7551689]
  • H C Castro-Faria-Neto, C V Araújo, S Moreira, P T Bozza, G Thomas, J M Barbosa-Filho, R S Cordeiro, E V Tibiriçá. Yangambin: a new naturally-occurring platelet-activating factor receptor antagonist: in vivo pharmacological studies. Planta medica. 1995 Apr; 61(2):106-12. doi: 10.1055/s-2006-958026. [PMID: 7753914]
  • M Fonteles, G Fang, N M Thielman, P S Yotseff, R L Guerrant. Role of platelet activating factor in the inflammatory and secretory effects of Clostridium difficile toxin A. Journal of lipid mediators and cell signalling. 1995 Mar; 11(2):133-43. doi: 10.1016/0929-7855(94)00033-9. [PMID: 7540097]
  • J M Herbert, M C Laplace, C Cailleau, J P Maffrand. Effect of SR 27417 on the binding of [3H]PAF to rabbit and human platelets and human polymorphonuclear leukocytes. Journal of lipid mediators. 1993 May; 7(1):57-78. doi: ". [PMID: 8395255]
  • J M Herbert, M C Laplace, A Bernat, V Salel, J P Maffrand. Effect of SR 27417 on oedema formation induced in rabbit skin by platelet-activating factor or antigen. European journal of pharmacology. 1992 Jun; 216(2):175-81. doi: 10.1016/0014-2999(92)90358-b. [PMID: 1397004]
  • J M Herbert, M C Laplace, J P Maffrand. Ex vivo effects of SR 27417, a novel PAF antagonist, on rabbit platelet aggregation and [3H]-PAF binding. Journal of lipid mediators. 1992 Feb; 5(1):1-12. doi: NULL. [PMID: 1327264]
  • A Bernat, J M Herbert, V Salel, L Lespy, J P Maffrand. Protective effect of SR 27417, a novel PAF antagonist, on PAF- or endotoxin-induced hypotension in the rat and the guinea-pig. Journal of lipid mediators. 1992 Feb; 5(1):41-8. doi: ". [PMID: 1391738]