Formamide, N-[(1Z)-2-(4-methoxyphenyl)ethenyl]- (BioDeep_00000179184)
human metabolite blood metabolite
代谢物信息卡片
Formamide, N-[(1Z)-2-(4-methoxyphenyl)ethenyl]-
化学式: C10H11NO2 (177.0789746)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 80%
分子结构信息
SMILES: COC1=CC=C(C=CNC=O)C=C1
InChI: InChI=1S/C10H11NO2/c1-13-10-4-2-9(3-5-10)6-7-11-8-12/h2-8H,1H3,(H,11,12)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Todd E Fox, Megan M Young, Michelle M Pedersen, Xianlin Han, Thomas W Gardner, Mark Kester. Diabetes diminishes phosphatidic acid in the retina: a putative mediator for reduced mTOR signaling and increased neuronal cell death.
Investigative ophthalmology & visual science.
2012 Oct; 53(11):7257-67. doi:
10.1167/iovs.11-7626. [PMID: 22952117] - Samy L Habib, Mukesh Yadav, Shaza Tizani, Basant Bhandari, Anthony J Valente. Tuberin inhibits production of the matrix protein fibronectin in diabetes.
Journal of the American Society of Nephrology : JASN.
2012 Oct; 23(10):1652-62. doi:
10.1681/asn.2012030285. [PMID: 22904348] - Brian J Siroky, Hong Yin, Justin T Babcock, Lu Lu, Anna R Hellmann, Bradley P Dixon, Lawrence A Quilliam, John J Bissler. Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress.
American journal of physiology. Renal physiology.
2012 Sep; 303(6):F831-44. doi:
10.1152/ajprenal.00441.2011. [PMID: 22791333] - Michael H Kohrman. Emerging treatments in the management of tuberous sclerosis complex.
Pediatric neurology.
2012 May; 46(5):267-75. doi:
10.1016/j.pediatrneurol.2012.02.015. [PMID: 22520346] - Ihor V Yosypiv. Congenital anomalies of the kidney and urinary tract: a genetic disorder?.
International journal of nephrology.
2012; 2012(?):909083. doi:
10.1155/2012/909083. [PMID: 22685656] - Nirmalya Dey, Falguni Das, Nandini Ghosh-Choudhury, Chandi Charan Mandal, Dipen J Parekh, Karen Block, Balakuntalam S Kasinath, Hanna E Abboud, Goutam Ghosh Choudhury. microRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasion.
PloS one.
2012; 7(6):e37366. doi:
10.1371/journal.pone.0037366. [PMID: 22685542] - Chaowen Yu, Yuan Yang, Lin Zou, Zhangxue Hu, Jing Li, Yunqiang Liu, Yongxin Ma, Mingyi Ma, Dan Su, Sizhong Zhang. Identification of novel mutations in Chinese Hans with autosomal dominant polycystic kidney disease.
BMC medical genetics.
2011 Dec; 12(?):164. doi:
10.1186/1471-2350-12-164. [PMID: 22185115] - Jennifer D Cohen, Jaime M C Gard, Raymond B Nagle, Justin D Dietrich, Terrence J Monks, Serrine S Lau. ERK crosstalks with 4EBP1 to activate cyclin D1 translation during quinol-thioether-induced tuberous sclerosis renal cell carcinoma.
Toxicological sciences : an official journal of the Society of Toxicology.
2011 Nov; 124(1):75-87. doi:
10.1093/toxsci/kfr203. [PMID: 21813464] - Samy L Habib, Anamika Yadav, Lenin Mahimainathan, Anthony J Valente. Regulation of PI 3-K, PTEN, p53, and mTOR in Malignant and Benign Tumors Deficient in Tuberin.
Genes & cancer.
2011 Nov; 2(11):1051-60. doi:
10.1177/1947601912445376. [PMID: 22737271] - Jennifer D Cohen, Kimberly Y Tham, Nicholas J Mastrandrea, Alfred C Gallegos, Terrence J Monks, Serrine S Lau. cAMP-dependent cytosolic mislocalization of p27(kip)-cyclin D1 during quinol-thioether-induced tuberous sclerosis renal cell carcinoma.
Toxicological sciences : an official journal of the Society of Toxicology.
2011 Aug; 122(2):361-71. doi:
10.1093/toxsci/kfr118. [PMID: 21693435] - Heidi L Kenerson, Matthew M Yeh, Raymond S Yeung. Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation.
PloS one.
2011 Mar; 6(3):e18075. doi:
10.1371/journal.pone.0018075. [PMID: 21479224] - Seok-Hyung Kim, Christina K Speirs, Lilianna Solnica-Krezel, Kevin C Ess. Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin.
Disease models & mechanisms.
2011 Mar; 4(2):255-67. doi:
10.1242/dmm.005587. [PMID: 20959633] - Chakradhar Velagapudi, Basant S Bhandari, Sherry Abboud-Werner, Simona Simone, Hanna E Abboud, Samy L Habib. The tuberin/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetes.
Journal of the American Society of Nephrology : JASN.
2011 Feb; 22(2):262-73. doi:
10.1681/asn.2010040352. [PMID: 21289215] - Sandra L Dabora, David Neal Franz, Stephen Ashwal, Arthur Sagalowsky, Francis J DiMario, Daniel Miles, Drew Cutler, Darcy Krueger, Raul N Uppot, Rahmin Rabenou, Susana Camposano, Jan Paolini, Fiona Fennessy, Nancy Lee, Chelsey Woodrum, Judith Manola, Judy Garber, Elizabeth A Thiele. Multicenter phase 2 trial of sirolimus for tuberous sclerosis: kidney angiomyolipomas and other tumors regress and VEGF- D levels decrease.
PloS one.
2011; 6(9):e23379. doi:
10.1371/journal.pone.0023379. [PMID: 21915260] - Todd W Miller, Brent N Rexer, Joan T Garrett, Carlos L Arteaga. Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer.
Breast cancer research : BCR.
2011; 13(6):224. doi:
10.1186/bcr3039. [PMID: 22114931] - Ramón Peces, Emilio Cuesta-López, Carlos Peces, Rafael Selgas. Giant bilateral renal angiomyolipomas and lymphangioleiomyomatosis presenting after two successive pregnancies successfully treated with surgery and rapamycin.
TheScientificWorldJournal.
2011; 11(?):2115-23. doi:
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Biotechnology research international.
2011; 2011(?):274693. doi:
10.4061/2011/274693. [PMID: 21350659] - Alex Martinez-Martí, Enriqueta Felip. PI3K Pathway in NSCLC.
Frontiers in oncology.
2011; 1(?):55. doi:
10.3389/fonc.2011.00055. [PMID: 22655251] - Chang Cheng, W Eugene Ho, Fera Y Goh, Shou Ping Guan, Li Ren Kong, Wen-Qi Lai, Bernard P Leung, W S Fred Wong. Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway.
PloS one.
2011; 6(6):e20932. doi:
10.1371/journal.pone.0020932. [PMID: 21695271] - Samy L Habib, Besant K Bhandari, Nahed Sadek, Sherry L Abboud-Werner, Hanna E Abboud. Novel mechanism of regulation of the DNA repair enzyme OGG1 in tuberin-deficient cells.
Carcinogenesis.
2010 Nov; 31(11):2022-30. doi:
10.1093/carcin/bgq189. [PMID: 20837600] - Elizabeth A Barnes, Heidi L Kenerson, Baldwin C Mak, Raymond S Yeung. The loss of tuberin promotes cell invasion through the ß-catenin pathway.
American journal of respiratory cell and molecular biology.
2010 Nov; 43(5):617-27. doi:
10.1165/rcmb.2008-0335oc. [PMID: 20042714] - Elizabeth A Barnes, Heidi L Kenerson, Xiuyun Jiang, Raymond S Yeung. Tuberin regulates E-cadherin localization: implications in epithelial-mesenchymal transition.
The American journal of pathology.
2010 Oct; 177(4):1765-78. doi:
10.2353/ajpath.2010.090233. [PMID: 20813961] - Andrew Schreiner, Siamak Daneshmand, Aaron Bayne, Gayle Countryman, Christopher L Corless, Megan L Troxell. Distinctive morphology of renal cell carcinomas in tuberous sclerosis.
International journal of surgical pathology.
2010 Oct; 18(5):409-18. doi:
10.1177/1066896909333510. [PMID: 19403547] - John J Bissler, Brian J Siroky, Hong Yin. Glomerulocystic kidney disease.
Pediatric nephrology (Berlin, Germany).
2010 Oct; 25(10):2049-56; quiz 2056. doi:
10.1007/s00467-009-1416-2. [PMID: 20091054] - Claas Wodarczyk, Gianfranco Distefano, Isaline Rowe, Massimiliano Gaetani, Barbara Bricoli, Mordi Muorah, Andrea Spitaleri, Valeria Mannella, Piero Ricchiuto, Monika Pema, Maddalena Castelli, Ariel E Casanova, Luca Mollica, Manuela Banzi, Manila Boca, Corinne Antignac, Sophie Saunier, Giovanna Musco, Alessandra Boletta. Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals.
PloS one.
2010 Sep; 5(9):e12719. doi:
10.1371/journal.pone.0012719. [PMID: 20856870] - Miroslav P Milev, Chris M Brown, Andrew J Mouland. Live cell visualization of the interactions between HIV-1 Gag and the cellular RNA-binding protein Staufen1.
Retrovirology.
2010 May; 7(?):41. doi:
10.1186/1742-4690-7-41. [PMID: 20459747] - John D Short, Ruhee Dere, Kevin D Houston, Sheng-Li Cai, Jinhee Kim, Judith M Bergeron, Jianjun Shen, Jiyong Liang, Mark T Bedford, Gordon B Mills, Cheryl Lyn Walker. AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability.
Molecular carcinogenesis.
2010 May; 49(5):429-39. doi:
10.1002/mc.20613. [PMID: 20146253] - Ruhee Dere, Patricia D Wilson, Richard N Sandford, Cheryl Lyn Walker. Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR.
PloS one.
2010 Feb; 5(2):e9239. doi:
10.1371/journal.pone.0009239. [PMID: 20169078] - Chelsey Woodrum, Alison Nobil, Sandra L Dabora. Comparison of three rapamycin dosing schedules in A/J Tsc2+/- mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors.
Journal of translational medicine.
2010 Feb; 8(?):14. doi:
10.1186/1479-5876-8-14. [PMID: 20146790] - Samy L Habib. Tuberous sclerosis complex and DNA repair.
Advances in experimental medicine and biology.
2010; 685(?):84-94. doi:
10.1007/978-1-4419-6448-9_8. [PMID: 20687497] - Shinong Wang, Mark C Wilkes, Edward B Leof, Raimund Hirschberg. Noncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesis.
American journal of physiology. Renal physiology.
2010 Jan; 298(1):F142-9. doi:
10.1152/ajprenal.00320.2009. [PMID: 19846571] - Sameshima Kiyoko, Osaka Hitoshi. [Care continuity for patients with tuberous sclerosis complex (TSC) during transition from childhood to adulthood].
Nihon rinsho. Japanese journal of clinical medicine.
2010 Jan; 68(1):136-40. doi:
NULL. [PMID: 20077806] - Wiesława Grajkowska, Katarzyna Kotulska, Elżbieta Jurkiewicz, Ewa Matyja. Brain lesions in tuberous sclerosis complex. Review.
Folia neuropathologica.
2010; 48(3):139-49. doi:
NULL. [PMID: 20924998] - Samy L Habib. Molecular mechanism of regulation of OGG1: tuberin deficiency results in cytoplasmic redistribution of transcriptional factor NF-YA.
Journal of molecular signaling.
2009 Dec; 4(?):8. doi:
10.1186/1750-2187-4-8. [PMID: 20040097] - Angelo M Taveira-Dasilva, Wendy K Steagall, Joel Moss. Therapeutic options for lymphangioleiomyomatosis (LAM): where we are and where we are going.
F1000 medicine reports.
2009 Dec; 1(?):. doi:
10.3410/m1-93. [PMID: 20948684] - A Tarasewicz, A Debska-Slizień, J Konopa, Z Zdrojewski, B Rutkowski. Rapamycin as a therapy of choice after renal transplantation in a patient with tuberous sclerosis complex.
Transplantation proceedings.
2009 Nov; 41(9):3677-82. doi:
10.1016/j.transproceed.2009.06.227. [PMID: 19917366] - Matthew M Grinsell, Victoria F Norwood. At the bottom of the differential diagnosis list: unusual causes of pediatric hypertension.
Pediatric nephrology (Berlin, Germany).
2009 Nov; 24(11):2137-46. doi:
10.1007/s00467-008-0744-y. [PMID: 18320238] - Alessandra Boletta. Emerging evidence of a link between the polycystins and the mTOR pathways.
PathoGenetics.
2009 Oct; 2(1):6. doi:
10.1186/1755-8417-2-6. [PMID: 19863783] - Claas Wodarczyk, Isaline Rowe, Marco Chiaravalli, Monika Pema, Feng Qian, Alessandra Boletta. A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus.
PloS one.
2009 Sep; 4(9):e7137. doi:
10.1371/journal.pone.0007137. [PMID: 19774080] - Kristen Pollizzi, Izabela Malinowska-Kolodziej, Cheryl Doughty, Charles Betz, Jian Ma, June Goto, David J Kwiatkowski. A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles.
Human molecular genetics.
2009 Jul; 18(13):2378-87. doi:
10.1093/hmg/ddp176. [PMID: 19357198] - Elena Lesma, Silvia Maria Sirchia, Silvia Ancona, Stephana Carelli, Silvano Bosari, Filippo Ghelma, Emanuele Montanari, Anna Maria Di Giulio, Alfredo Gorio. The methylation of the TSC2 promoter underlies the abnormal growth of TSC2 angiomyolipoma-derived smooth muscle cells.
The American journal of pathology.
2009 Jun; 174(6):2150-9. doi:
10.2353/ajpath.2009.080799. [PMID: 19443708] - Nancy Lee, Chelsey L Woodrum, Alison M Nobil, Aubrey E Rauktys, Michael P Messina, Sandra L Dabora. Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models.
BMC pharmacology.
2009 Apr; 9(?):8. doi:
10.1186/1471-2210-9-8. [PMID: 19368729] - Samy L Habib. Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patients.
Molecular cancer.
2009 Mar; 8(?):13. doi:
10.1186/1476-4598-8-13. [PMID: 19265534] - Tiffiney R Hartman, Dongyan Liu, Jack T Zilfou, Victoria Robb, Tasha Morrison, Terry Watnick, Elizabeth P Henske. The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway.
Human molecular genetics.
2009 Jan; 18(1):151-63. doi:
10.1093/hmg/ddn325. [PMID: 18845692] - Kit Sing Au, Catherine H Ward, Hope Northrup. Tuberous sclerosis complex: disease modifiers and treatments.
Current opinion in pediatrics.
2008 Dec; 20(6):628-33. doi:
10.1097/mop.0b013e328318c529. [PMID: 19005330] - Simona Simone, Yves Gorin, Chakradhar Velagapudi, Hanna E Abboud, Samy L Habib. Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase.
Diabetes.
2008 Oct; 57(10):2626-36. doi:
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Lancet (London, England).
2008 Aug; 372(9639):657-68. doi:
10.1016/s0140-6736(08)61279-9. [PMID: 18722871] - John D Short, Kevin D Houston, Ruhee Dere, Sheng-Li Cai, Jinhee Kim, Charles L Johnson, Russell R Broaddus, Jianjun Shen, Susie Miyamoto, Fuyuhiko Tamanoi, David Kwiatkowski, Gordon B Mills, Cheryl Lyn Walker. AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27.
Cancer research.
2008 Aug; 68(16):6496-506. doi:
10.1158/0008-5472.can-07-5756. [PMID: 18701472] - Margit Rosner, Michaela Hanneder, Nicol Siegel, Alessandro Valli, Markus Hengstschläger. The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners.
Mutation research.
2008 Mar; 658(3):234-46. doi:
10.1016/j.mrrev.2008.01.001. [PMID: 18291711] - O Ibraghimov-Beskrovnaya, N Bukanov. Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies.
Cellular and molecular life sciences : CMLS.
2008 Feb; 65(4):605-19. doi:
10.1007/s00018-007-7362-x. [PMID: 17975706] - Aubrey Rauktys, Nancy Lee, Laifong Lee, Sandra L Dabora. Topical rapamycin inhibits tuberous sclerosis tumor growth in a nude mouse model.
BMC dermatology.
2008 Jan; 8(?):1. doi:
10.1186/1471-5945-8-1. [PMID: 18226258] - Samy L Habib, Simona Simone, Jeff J Barnes, Hanna E Abboud. Tuberin haploinsufficiency is associated with the loss of OGG1 in rat kidney tumors.
Molecular cancer.
2008 Jan; 7(?):10. doi:
10.1186/1476-4598-7-10. [PMID: 18218111] - Samy L Habib, Daniel J Riley, Lenin Mahimainathan, Basant Bhandari, Goutam Ghosh Choudhury, Hanna E Abboud. Tuberin regulates the DNA repair enzyme OGG1.
American journal of physiology. Renal physiology.
2008 Jan; 294(1):F281-90. doi:
10.1152/ajprenal.00370.2007. [PMID: 17989114] - Maja Grabacka, Krzysztof Reiss. Anticancer Properties of PPARalpha-Effects on Cellular Metabolism and Inflammation.
PPAR research.
2008; 2008(?):930705. doi:
10.1155/2008/930705. [PMID: 18509489] - Michael P Messina, Aubrey Rauktys, Laifong Lee, Sandra L Dabora. Tuberous sclerosis preclinical studies: timing of treatment, combination of a rapamycin analog (CCI-779) and interferon-gamma, and comparison of rapamycin to CCI-779.
BMC pharmacology.
2007 Nov; 7(?):14. doi:
10.1186/1471-2210-7-14. [PMID: 17986349] - Geraldine A Finlay, Amy J Malhowski, Yingling Liu, Barry L Fanburg, David J Kwiatkowski, Deniz Toksoz. Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity.
Cancer research.
2007 Oct; 67(20):9878-86. doi:
10.1158/0008-5472.can-07-1394. [PMID: 17942919] - Shuji Momose, Toshiyuki Kobayashi, Norihiro Tada, Shinji Itoyama, Okio Hino. N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo.
Biochemical and biophysical research communications.
2007 May; 356(3):693-8. doi:
10.1016/j.bbrc.2007.03.036. [PMID: 17379185] - Thomas Weimbs. Regulation of mTOR by polycystin-1: is polycystic kidney disease a case of futile repair?.
Cell cycle (Georgetown, Tex.).
2006 Nov; 5(21):2425-9. doi:
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The FEBS journal.
2006 Jun; 273(11):2388-98. doi:
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Journal of neuroscience research.
2006 Feb; 83(2):222-32. doi:
10.1002/jnr.20723. [PMID: 16342205] - Sheng-Li Cai, Cheryl Lyn Walker. TSC2, a key player in tumor suppression and cystic kidney disease.
Nephrologie & therapeutique.
2006 Jan; 2 Suppl 2(?):S119-22. doi:
NULL. [PMID: 17373211] - Eric Thervet. Sirolimus therapy following early cyclosporine withdrawal in transplant patients: mechanisms of action and clinical results.
International journal of nanomedicine.
2006; 1(3):269-81. doi:
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Human gene therapy.
2005 Dec; 16(12):1367-76. doi:
10.1089/hum.2005.16.1367. [PMID: 16390268] - Geraldine A Finlay, Victor J Thannickal, Barry L Fanburg, David J Kwiatkowski. Platelet-derived growth factor-induced p42/44 mitogen-activated protein kinase activation and cellular growth is mediated by reactive oxygen species in the absence of TSC2/tuberin.
Cancer research.
2005 Dec; 65(23):10881-90. doi:
10.1158/0008-5472.can-05-1394. [PMID: 16322235] - Magdalena Karbowniczek, Elizabeth Petri Henske. The role of tuberin in cellular differentiation: are B-Raf and MAPK involved?.
Annals of the New York Academy of Sciences.
2005 Nov; 1059(?):168-73. doi:
10.1196/annals.1339.045. [PMID: 16382052] - Eddy H T Wu, Yung H Wong. Activation of delta-, kappa-, and mu-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells.
Biochemical and biophysical research communications.
2005 Sep; 334(3):838-44. doi:
10.1016/j.bbrc.2005.06.184. [PMID: 16053916] - Junji Tsurutani, S Sianna Castillo, John Brognard, Courtney A Granville, Chunyu Zhang, Joell J Gills, Jacqueline Sayyah, Phillip A Dennis. Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells.
Carcinogenesis.
2005 Jul; 26(7):1182-95. doi:
10.1093/carcin/bgi072. [PMID: 15790591] - Takuma Aoyama, Takashi Matsui, Mikhail Novikov, Jongsun Park, Brian Hemmings, Anthony Rosenzweig. Serum and glucocorticoid-responsive kinase-1 regulates cardiomyocyte survival and hypertrophic response.
Circulation.
2005 Apr; 111(13):1652-9. doi:
10.1161/01.cir.0000160352.58142.06. [PMID: 15795328] - Eddy H T Wu, Yung H Wong. Involvement of G i/o proteins in nerve growth factor-stimulated phosphorylation and degradation of tuberin in PC-12 cells and cortical neurons.
Molecular pharmacology.
2005 Apr; 67(4):1195-205. doi:
10.1124/mol.104.007237. [PMID: 15626752] - Baskaran Govindarajan, Daniel J Brat, Marie Csete, William D Martin, Emma Murad, Karin Litani, Cynthia Cohen, Francesca Cerimele, Matthew Nunnelley, Benjamin Lefkove, Toshiyuki Yamamoto, Chunsik Lee, Jack L Arbiser. Transgenic expression of dominant negative tuberin through a strong constitutive promoter results in a tissue-specific tuberous sclerosis phenotype in the skin and brain.
The Journal of biological chemistry.
2005 Feb; 280(7):5870-4. doi:
10.1074/jbc.m411768200. [PMID: 15576369] - J D Cook, C L Walker. The Eker rat: establishing a genetic paradigm linking renal cell carcinoma and uterine leiomyoma.
Current molecular medicine.
2004 Dec; 4(8):813-24. doi:
10.2174/1566524043359656. [PMID: 15579028] - Aristotelis Astrinidis, Elizabeth Petri Henske. Aberrant cellular differentiation and migration in renal and pulmonary tuberous sclerosis complex.
Journal of child neurology.
2004 Sep; 19(9):710-5. doi:
10.1177/08830738040190091201. [PMID: 15563018] - Magdalena Karbowniczek, Timothy Cash, Mitchell Cheung, Gavin P Robertson, Aristotelis Astrinidis, Elizabeth Petri Henske. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.
The Journal of biological chemistry.
2004 Jul; 279(29):29930-7. doi:
10.1074/jbc.m402591200. [PMID: 15150271] - Banalata Sen, Douglas C Wolf, Susan D Hester. The transcriptional profile of the kidney in Tsc2 heterozygous mutant Long Evans (Eker) rats compared to wild-type.
Mutation research.
2004 May; 549(1-2):213-24. doi:
10.1016/j.mrfmmm.2003.12.023. [PMID: 15120972] - Kathryn A Jones, Xiuyun Jiang, Yuji Yamamoto, Raymond S Yeung. Tuberin is a component of lipid rafts and mediates caveolin-1 localization: role of TSC2 in post-Golgi transport.
Experimental cell research.
2004 May; 295(2):512-24. doi:
10.1016/j.yexcr.2004.01.022. [PMID: 15093748] - Hiroyuki Adachi, Shuichi Majima, Shigeyuki Kon, Toshiyuki Kobayashi, Kazunori Kajino, Hiroaki Mitani, Youko Hirayama, Hiroaki Shiina, Mikio Igawa, Okio Hino. Niban gene is commonly expressed in the renal tumors: a new candidate marker for renal carcinogenesis.
Oncogene.
2004 Apr; 23(19):3495-500. doi:
10.1038/sj.onc.1207468. [PMID: 14990989] - Oxana M Tsygankova, Elena Feshchenko, Peter S Klein, Judy L Meinkoth. Thyroid-stimulating hormone/cAMP and glycogen synthase kinase 3beta elicit opposing effects on Rap1GAP stability.
The Journal of biological chemistry.
2004 Feb; 279(7):5501-7. doi:
10.1074/jbc.m305824200. [PMID: 14660640] - Baldwin C Mak, Raymond S Yeung. The tuberous sclerosis complex genes in tumor development.
Cancer investigation.
2004; 22(4):588-603. doi:
10.1081/cnv-200027144. [PMID: 15565817] - Marcelo J Surpili, Tatiana M Delben, Jörg Kobarg. Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1.
Biochemistry.
2003 Dec; 42(51):15369-76. doi:
10.1021/bi034575v. [PMID: 14690447] - Vinodh Narayanan. Tuberous sclerosis complex: genetics to pathogenesis.
Pediatric neurology.
2003 Nov; 29(5):404-9. doi:
10.1016/j.pediatrneurol.2003.09.002. [PMID: 14684235] - Jiyong Liang, Joyce M Slingerland. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression.
Cell cycle (Georgetown, Tex.).
2003 Jul; 2(4):339-45. doi:
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Molecular carcinogenesis.
2003 Jun; 37(2):98-109. doi:
10.1002/mc.10125. [PMID: 12766909] - Nisreen El-Hashemite, Hongbing Zhang, Elizabeth P Henske, David J Kwiatkowski. Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma.
Lancet (London, England).
2003 Apr; 361(9366):1348-9. doi:
10.1016/s0140-6736(03)13044-9. [PMID: 12711473] - Yong Li, Ken Inoki, Panayiotis Vacratsis, Kun-Liang Guan. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.
The Journal of biological chemistry.
2003 Apr; 278(16):13663-71. doi:
10.1074/jbc.m300862200. [PMID: 12582162] - Samy L Habib, Minh N Phan, Sonal K Patel, Donghui Li, Terrence J Monks, Serrine S Lau. Reduced constitutive 8-oxoguanine-DNA glycosylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker rat.
Carcinogenesis.
2003 Mar; 24(3):573-82. doi:
10.1093/carcin/24.3.573. [PMID: 12663520] - Shengli Cai, Jeffrey I Everitt, Hiroyuki Kugo, Jennifer Cook, Elena Kleymenova, Cheryl Lyn Walker. Polycystic kidney disease as a result of loss of the tuberous sclerosis 2 tumor suppressor gene during development.
The American journal of pathology.
2003 Feb; 162(2):457-68. doi:
10.1016/s0002-9440(10)63840-0. [PMID: 12547704] - David M Hockenbery. Nailing down a link between tuberin and renal cysts.
The American journal of pathology.
2003 Feb; 162(2):369-71. doi:
10.1016/s0002-9440(10)63831-x. [PMID: 12547695] - Aristotelis Astrinidis, Timothy P Cash, Deborah S Hunter, Cheryl L Walker, Jonathan Chernoff, Elizabeth P Henske. Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration.
Oncogene.
2002 Dec; 21(55):8470-6. doi:
10.1038/sj.onc.1205962. [PMID: 12466966] - Shuji Momose, Toshiyuki Kobayashi, Hiroaki Mitani, Masumi Hirabayashi, Kazumi Ito, Masatsugu Ueda, Yo-ichi Nabeshima, Okio Hino. Identification of the coding sequences responsible for Tsc2-mediated tumor suppression using a transgenic rat system.
Human molecular genetics.
2002 Nov; 11(24):2997-3006. doi:
10.1093/hmg/11.24.2997. [PMID: 12417521] - Matt Y Liu, Shengli Cai, Alexsandra Espejo, Mark T Bedford, Cheryl Lyn Walker. 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s).
Cancer research.
2002 Nov; 62(22):6475-80. doi:
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Cancer research.
2002 Oct; 62(20):5645-50. doi:
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Archives of biochemistry and biophysics.
2002 Aug; 404(2):210-7. doi:
10.1016/s0003-9861(02)00300-4. [PMID: 12147258] - Hae-Seong Yoon, Terrence J Monks, Jeffrey I Everitt, Cheryl L Walker, Serrine S Lau. Cell proliferation is insufficient, but loss of tuberin is necessary, for chemically induced nephrocarcinogenicity.
American journal of physiology. Renal physiology.
2002 Aug; 283(2):F262-70. doi:
10.1152/ajprenal.00261.2001. [PMID: 12110509] - S R Johnson, C A Clelland, J Ronan, A E Tattersfield, A J Knox. The TSC-2 product tuberin is expressed in lymphangioleiomyomatosis and angiomyolipoma.
Histopathology.
2002 May; 40(5):458-63. doi:
10.1046/j.1365-2559.2002.01394.x. [PMID: 12010366] - Ralf Wienecke, Eckart Klemm, Sarolta Karparti, Neil A Swanson, Andrew J Green, Jeffrey E DeClue. Reduction of expression of tuberin, the tuberous-sclerosis-complex-gene-2 product in tuberous sclerosis complex associated connective tissue nevi and sporadic squamous and basal cell carcinomas.
Journal of cutaneous pathology.
2002 May; 29(5):287-90. doi:
10.1034/j.1600-0560.2002.290505.x. [PMID: 12100629] - Carla Irani, Elena A Goncharova, Deborah S Hunter, Cheryl L Walker, Reynold A Panettieri, Vera P Krymskaya. Phosphatidylinositol 3-kinase but not tuberin is required for PDGF-induced cell migration.
American journal of physiology. Lung cellular and molecular physiology.
2002 Apr; 282(4):L854-62. doi:
10.1152/ajplung.00291.2001. [PMID: 11880313] - Hiroyuki Kugoh, Elena Kleymenova, Cheryl Lyn Walker. Retention of membrane-localized beta-catenin in cells lacking functional polycystin-1 and tuberin.
Molecular carcinogenesis.
2002 Mar; 33(3):131-6. doi:
10.1002/mc.10034. [PMID: 11870878] - M Hengstschläger, D M Rodman, A Miloloza, E Hengstschläger-Ottnad, M Rosner, M Kubista. Tuberous sclerosis gene products in proliferation control.
Mutation research.
2001 Jul; 488(3):233-9. doi:
10.1016/s1383-5742(01)00058-8. [PMID: 11397651] - M G Catania, P S Mischel, H V Vinters. Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B.
Journal of neuropathology and experimental neurology.
2001 Jul; 60(7):711-23. doi:
10.1093/jnen/60.7.711. [PMID: 11444800]