Flumecinol (BioDeep_00000179104)

   

human metabolite blood metabolite


代谢物信息卡片


1-phenyl-1-[3-(trifluoromethyl)phenyl]propan-1-ol

化学式: C16H15F3O (280.1074936)
中文名称: 氟美西诺
谱图信息: 最多检出来源 Mus musculus(blood) 50%

分子结构信息

SMILES: CCC(C1=CC=CC=C1)(C2=CC(=CC=C2)C(F)(F)F)O
InChI: InChI=1S/C16H15F3O/c1-2-15(20,12-7-4-3-5-8-12)13-9-6-10-14(11-13)16(17,18)19/h3-11,20H,2H2,1H3

描述信息

C26170 - Protective Agent > C2081 - Hepatoprotective Agent

同义名列表

9 个代谢物同义名

1-phenyl-1-[3-(trifluoromethyl)phenyl]propan-1-ol; 1-(3-Trifluoromethylphenyl)-1-phenylpropanol; m-Trifluoromethyl-alpha-ethylbenzhydrol; Flumatsynol; Flumacinol; flumecinol; Ziksorin; Zyxorin; Zixoryn



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • A S Saratikov, T P Novozheeva, R R Akhmedzhanov. Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis. Bulletin of experimental biology and medicine. 2002 Sep; 134(3):271-3. doi: 10.1023/a:1021563703378. [PMID: 12512000]
  • Iu I Detsyk, L V Iushchyk, Ia D Novyts'kyĭ. [The clinical picture and diagnosis of the Gilbert-Meylengraht syndrome]. Likars'ka sprava. 1997 Sep; ?(5):139-42. doi: NULL. [PMID: 9491723]
  • Z Z Khakimov, A Kh Rakhmanov. [A comparative study of the effect of hepatoprotectors and inducers on cardiogreen pharmacokinetics in acute toxic hepatitis in the prepuberty period]. Eksperimental'naia i klinicheskaia farmakologiia. 1994 Nov; 57(6):57-9. doi: ". [PMID: 7756967]
  • I B Turner, M D Rawlins, P Wood, O F James. Flumecinol for the treatment of pruritus associated with primary biliary cirrhosis. Alimentary pharmacology & therapeutics. 1994 Jun; 8(3):337-42. doi: 10.1111/j.1365-2036.1994.tb00297.x. [PMID: 7918930]
  • O V Lopatko, I R Mavlianov. [The lipid peroxidation processes and enzymatic activity of the antioxidant system in the lung tissue of premature rat pups and in the mother-placenta-fetus system during the antenatal use of phenobarbital and ziksorin]. Eksperimental'naia i klinicheskaia farmakologiia. 1993 Nov; 56(6):41-3. doi: ". [PMID: 8111298]
  • L A Sylvia, J T Gerig. Fluorine NMR studies of the metabolism of flumecinol (3-trifluoromethyl-alpha-ethylbenzhydrol). Drug metabolism and disposition: the biological fate of chemicals. 1993 Jan; 21(1):105-13. doi: NULL. [PMID: 8095202]
  • T G Khlopushina, A V Krinskaia, L P Kovalenko, V P Zherdev, A V Val'dman. [Effects of zixoryn on pharmacokinetics of antipyrine in intact and sensitized guinea pigs]. Biulleten' eksperimental'noi biologii i meditsiny. 1991 Jul; 112(7):67-9. doi: NULL. [PMID: 1793861]
  • G P Ul'ianov, V V Lampatov. [The effect of inducers of microsomal enzymes on glucose transport in the kidneys]. Farmakologiia i toksikologiia. 1990 Jan; 53(1):48-50. doi: NULL. [PMID: 2328799]
  • J Morvay, J Török. Effect of 3-trifluoromethyl-alpha-ethylbenzhydrol (flumecinol) on lipid peroxidation in early human placenta. Acta physiologica Hungarica. 1988; 71(2):207-11. doi: ". [PMID: 3389164]
  • E P Astaf'eva, E B Berkhin, G P Ul'ianov. [Effect of zixoryn on diuresis and renal transport of xenobiotics]. Biulleten' eksperimental'noi biologii i meditsiny. 1987 Nov; 104(11):602-3. doi: NULL. [PMID: 3676500]
  • I Klebovich, L Vereczkey, E Tóth, J Tamás, M Mák, G Jalsovszky, S Holly. Metabolism of flumecinol in humans. Xenobiotica; the fate of foreign compounds in biological systems. 1987 Oct; 17(10):1247-58. doi: 10.3109/00498258709167416. [PMID: 3424871]
  • I Klebovich, J Csetényi, S Kerpel-Fronius, L Vereczkey. Pharmacokinetic studies of [14C]-flumecinol in humans. Arzneimittel-Forschung. 1987 Mar; 37(3):368-71. doi: NULL. [PMID: 3593454]
  • A Szeitz, E Huszár, I Herjavecz, K Vértes, L A Debreczeni. Effect of enzyme inducer flumecinolum (Zixoryn) on aminophylline metabolism in rats. Acta physiologica Hungarica. 1987; 70(2-3):317-21. doi: NULL. [PMID: 3434310]
  • V P Lozovoĭ, N N Vol'skii, V M Nepomniashchikh, E M Tananko, T A Nosikova. [Effect of microsomal monooxygenase inductor zixoryn on clinico-immunologic indicators in allergologic patients]. Terapevticheskii arkhiv. 1987; 59(2):7-9. doi: NULL. [PMID: 3576481]
  • I Marosvári, K Neubauer. Treatment of neonatal hyperbilirubinaemia with flumecinolone, a new enzyme inducing drug. Acta paediatrica Hungarica. 1985; 26(4):297-302. doi: NULL. [PMID: 3938290]
  • B Gachályi, A Vas, A Káldor. Combined effect of alpha-methyldopa and a new enzyme inducer, Zixoryn, on the hepatic mixed-function monooxygenase system in humans. International journal of clinical pharmacology, therapy, and toxicology. 1983 Apr; 21(4):183-5. doi: NULL. [PMID: 6862721]
  • I Klebovich, M Kapás, L Vereczkey. Capillary gas chromatographic method for determination of flumecinol in plasma and saliva. Journal of chromatography. 1983 Mar; 273(1):207-12. doi: 10.1016/s0378-4347(00)80940-8. [PMID: 6853652]
  • Z Vezekenyi, J Ferenci, B Radnai, T Horvath, T Past, L Nagy, T Jávor. Human tolerance of flumecinol (Zixoryn, RGH-3332), its regime and dosage in healthy volunteers. International journal of clinical pharmacology research. 1983; 3(2):77-88. doi: NULL. [PMID: 6679516]
  • I Klebovich, L Vereczkey, S Kerpel-Fronius, G Ringwald, I Bodrogligeti. Pharmacokinetic studies of flumecinol in man and dog. European journal of drug metabolism and pharmacokinetics. 1982; 7(2):99-104. doi: 10.1007/bf03188725. [PMID: 7117300]