4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one (BioDeep_00000178940)

   

human metabolite blood metabolite


代谢物信息卡片


4-(ethoxymethylidene)-2-phenyl-4,5-dihydro-1,3-oxazol-5-one

化学式: C12H11NO3 (217.0738896)
中文名称: 4-乙氧基亚甲基-2-苯基恶唑啉-5-酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC=C1C(=O)OC(=N1)C2=CC=CC=C2
InChI: InChI=1S/C12H11NO3/c1-2-15-8-10-12(14)16-11(13-10)9-6-4-3-5-7-9/h3-8H,2H2,1H3

描述信息

D007155 - Immunologic Factors

同义名列表

18 个代谢物同义名

4-(ethoxymethylidene)-2-phenyl-4,5-dihydro-1,3-oxazol-5-one; 4-Ethoxymethylene-2-phenyl-4H-1,3-oxazol-5-one; 2-Phenyl-4-(ethoxymethylene)-5(4H)-oxazolone; 4-Ethoxymethylene-2-phenyl-2-oxazoline-5-one; 4-(Ethoxymethylene)-2-phenyloxazol-5(4H)-one; 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one; 2-Phenyl-4-ethoxymethylene-5(4H)-oxazolone; 2-Phenyl-4-(ethoxymethylene)oxazol-5-one; 2-Phenyl-4-ethoxymethylene-5-oxazolone; 4 Ethoxymethylene 2 phenyloxazolone; 4-Ethoxymethylene-2-phenyloxazolone; 2-Phenyl-oxazolone; Pxazolone; Oxazolone; Phenyl ox; PhOx; EtOX; OXA



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yunji Bae, Taeyoung Kim, Nojune Park, Sangho Choi, Dongkeun Yi, Silvia Soto, Nelson Zamora, Sunam Kim, Minhye Yang. Ameliorative Effects of Daphnopsis costaricensis Extract against Oxazolone-Induced Atopic Dermatitis-like Lesions in BALB/c Mice. Nutrients. 2022 Oct; 14(21):. doi: 10.3390/nu14214521. [PMID: 36364783]
  • Tae-Kyeong Lee, Dae Won Kim, Ji Hyeon Ahn, Choong-Hyun Lee, Jae-Chul Lee, Soon Sung Lim, Il Jun Kang, Seongkweon Hong, Soo Young Choi, Moo-Ho Won, Joon Ha Park. Protective Effects of Topical Administration of Laminarin in Oxazolone-Induced Atopic Dermatitis-like Skin Lesions. Marine drugs. 2022 Oct; 20(11):. doi: 10.3390/md20110669. [PMID: 36354992]
  • Hao Dong, Chenjie Feng, Xiyunyi Cai, Yuanyuan Hao, Xinyue Gu, Lei Cai, Shuting Wu, Jiamin Chen, Zhou Liu, Wen Xie, Xuanren Lu, Hongfa Qian, Yulin Liu, Yiming Cao, Junlin Zhu, Jiayi Xu, Yanjie Zhou, Shuangyu Ma, Sha Yang, Yufeng Shi, Haojiang Yu, Minjie Shi, Yurong Wang, Harvest F Gu, Lei Fan, Liang Wu. 7-Methoxyisoflavone ameliorates atopic dermatitis symptoms by regulating multiple signaling pathways and reducing chemokine production. Scientific reports. 2022 05; 12(1):8760. doi: 10.1038/s41598-022-12695-3. [PMID: 35610286]
  • Banzragch Dorjsembe, Chu Won Nho, Yongsoo Choi, Jin-Chul Kim. Extract from Black Soybean Cultivar A63 Extract Ameliorates Atopic Dermatitis-like Skin Inflammation in an Oxazolone-Induced Murine Model. Molecules (Basel, Switzerland). 2022 Apr; 27(9):. doi: 10.3390/molecules27092751. [PMID: 35566102]
  • Xiao Xiao Wu, Wing Sum Siu, Chi Ling Wat, Chung Lap Chan, Chi Man Koon, Xiang Li, Wen Cheng, Hui Ma, Miranda Sin Man Tsang, Christopher Wai-Kei Lam, Ping Chung Leung, Clara Bik San Lau, Chun-Kwok Wong. Effects of topical application of a tri-herb formula on inflammatory dry-skin condition in mice with oxazolone-induced atopic dermatitis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Oct; 91(?):153691. doi: 10.1016/j.phymed.2021.153691. [PMID: 34425472]
  • Yuying Guo, Cong Ding, Tao Chang, Weitang Yuan, Xin Liu. VISTA-Ig ameliorates OXA-induced allergic dermatitis symptoms in mice. Immunopharmacology and immunotoxicology. 2021 Jun; 43(3):380-385. doi: 10.1080/08923973.2021.1925907. [PMID: 34028330]
  • Nageh Ahmed El-Mahdy, Magda El-Sayed El-Sayad, Aya Hassan El-Kadem, Sally El-Sayed Abu-Risha. Metformin alleviates inflammation in oxazolone induced ulcerative colitis in rats: plausible role of sphingosine kinase 1/sphingosine 1 phosphate signaling pathway. Immunopharmacology and immunotoxicology. 2021 Apr; 43(2):192-202. doi: 10.1080/08923973.2021.1878214. [PMID: 33504231]
  • Erle Dang, George Man, Dale Lee, Debbie A Crumrine, Theodora M Mauro, Peter M Elias, Mao-Qiang Man. Mutations in 3β-hydroxysteroid-δ8, δ7-isomerase paradoxically benefit epidermal permeability barrier homeostasis in mice. Experimental dermatology. 2021 03; 30(3):384-389. doi: 10.1111/exd.14236. [PMID: 33205489]
  • Chin-Yu Lin, Yun-Ting Hsieh, Long Yi Chan, Ting-Ya Yang, Tomoji Maeda, Tsong-Min Chang, Huey-Chun Huang. Dictamnine delivered by PLGA nanocarriers ameliorated inflammation in an oxazolone-induced dermatitis mouse model. Journal of controlled release : official journal of the Controlled Release Society. 2021 01; 329(?):731-742. doi: 10.1016/j.jconrel.2020.10.007. [PMID: 33031879]
  • Noo Ri Lee, Beom Jun Kim, Chung Hyeok Lee, Young Bin Lee, Solam Lee, Hyun Jee Hwang, Eunjung Kim, Sung Hee Kim, Min-Geol Lee, Sang Eun Lee, Gareth G Lavery, Eung Ho Choi. Role of 11β-hydroxysteroid dehydrogenase type 1 in the development of atopic dermatitis. Scientific reports. 2020 11; 10(1):20237. doi: 10.1038/s41598-020-77281-x. [PMID: 33214595]
  • Evangelos Mavridis, Eleftherios Bermperoglou, Eleni Pontiki, Dimitra Hadjipavlou-Litina. 5-(4H)-Oxazolones and Their Benzamides as Potential Bioactive Small Molecules. Molecules (Basel, Switzerland). 2020 Jul; 25(14):. doi: 10.3390/molecules25143173. [PMID: 32664550]
  • Min-Jeong Heo, Soo Young Choi, Chanmi Lee, Yeong Min Choi, In-Sook An, Seunghee Bae, Sungkwan An, Jin Hyuk Jung. Perphenazine Attenuates the Pro-Inflammatory Responses in Mouse Models of Th2-Type Allergic Dermatitis. International journal of molecular sciences. 2020 May; 21(9):. doi: 10.3390/ijms21093241. [PMID: 32375285]
  • Min-Jeong Heo, Chanmi Lee, Soo Young Choi, Yeong Min Choi, In-Sook An, Seunghee Bae, Sungkwan An, Jin Hyuk Jung. Nintedanib ameliorates animal model of dermatitis. Scientific reports. 2020 03; 10(1):4493. doi: 10.1038/s41598-020-61424-1. [PMID: 32161331]
  • Luting Zeng, Yingqin Liu, Congcong Xing, Yijie Huang, Xin Sun, Guangchen Sun. Saponin from Periploca forrestii Schltr Mitigates Oxazolone-Induced Atopic Dermatitis via Modulating Macrophage Activation. Mediators of inflammation. 2020; 2020(?):4346367. doi: 10.1155/2020/4346367. [PMID: 33122966]
  • Sullim Lee, Hyun Jegal, Sim-Kyu Bong, Kyeong-No Yoon, No-June Park, Myoung-Sook Shin, Min Hye Yang, Yong Kee Kim, Su-Nam Kim. Anti-Atopic Effect of Acorn Shell Extract on Atopic Dermatitis-Like Lesions in Mice and Its Active Phytochemicals. Biomolecules. 2019 12; 10(1):. doi: 10.3390/biom10010057. [PMID: 31905797]
  • Liuhong Zhang, Ning Cao, Yuwen Wang, Youxu Wang, Chao Wu, Xuemei Cheng, Changhong Wang. Improvement of Oxazolone-Induced Ulcerative Colitis in Rats Using Andrographolide. Molecules (Basel, Switzerland). 2019 Dec; 25(1):. doi: 10.3390/molecules25010076. [PMID: 31878303]
  • Priscilla B Pail, Gabriela W Neculqueo, Giovana P Maccari, Pedro C Chagastelles, Raquel D S Freitas, Ana P A Dagnino, Maria M Campos. The role of kinin B1 and B2 receptors in the mouse model of oxazolone-induced atopic dermatitis. International immunopharmacology. 2019 Jul; 72(?):62-73. doi: 10.1016/j.intimp.2019.03.063. [PMID: 30959373]
  • Xuemei Sun, Xiukun Huang, Xunshuai Zhu, Lin Liu, Siyan Mo, Hongyuan Wang, Xiugui Wei, Shunyu Lu, Facheng Bai, Dandan Wang, Xing Lin, Jun Lin. HBOA ameliorates CCl4-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jul; 115(?):108901. doi: 10.1016/j.biopha.2019.108901. [PMID: 31079002]
  • Huan He, Xiaoxiao Gao, Xiaomin Wang, Xin Li, Xiaoxue Jiang, Zhehui Xie, Ke Ma, Jun Ma, Kazuo Umezawa, Yuyang Zhang. Comparison of anti-atopic dermatitis activities between DHMEQ and tacrolimus ointments in mouse model without stratum corneum. International immunopharmacology. 2019 Jun; 71(?):43-51. doi: 10.1016/j.intimp.2019.03.015. [PMID: 30877873]
  • Jonghwan Jegal, No-June Park, Tae-Young Kim, Sangho Choi, Sang Woo Lee, Jin Hang, Su-Nam Kim, Min Hye Yang. Effect of Topically Applied Wikstroemia dolichantha Diels on the Development of Atopic Dermatitis-Like Skin Symptoms in Mice. Nutrients. 2019 Apr; 11(4):. doi: 10.3390/nu11040914. [PMID: 31018627]
  • Malavattu G Prasad, Chapala V Lakshmi, Naresh K Katari, Krishnan Anand, Manojit Pal, Sreekantha B Jonnalagadda. Synthesis of 2-Substituted 4-Arylidene-5(4H)-oxazolones as Potential Cytotoxic Agents in the Presence of Lemon Juice as a Biocatalyst. Combinatorial chemistry & high throughput screening. 2019; 22(9):625-634. doi: 10.2174/1386207322666191024105150. [PMID: 31696809]
  • Verónica Moner, Estibalitz Fernández, Ana Cristina Calpena, Adriana Garcia-Herrera, Mercedes Cócera, Olga López. A lamellar body mimetic system for the treatment of oxazolone-induced atopic dermatitis in hairless mice. Journal of dermatological science. 2018 May; 90(2):172-179. doi: 10.1016/j.jdermsci.2018.01.010. [PMID: 29395580]
  • Sullim Lee, No-June Park, Sim-Kyu Bong, Jonghwan Jegal, Sang-A Park, Su-Nam Kim, Min Hye Yang. Ameliorative effects of Juniperus rigida fruit on oxazolone- and 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice. Journal of ethnopharmacology. 2018 Mar; 214(?):160-167. doi: 10.1016/j.jep.2017.12.022. [PMID: 29258854]
  • Jonghwan Jegal, No-June Park, Sang-A Park, Sim-Kyu Bong, Hyun Jegal, Su-Nam Kim, Min Hye Yang. Juniperus chinensis Fruits Attenuate Oxazolone- and 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis Symptoms in Mice. Biological & pharmaceutical bulletin. 2018; 41(2):259-265. doi: 10.1248/bpb.b17-00818. [PMID: 29386485]
  • Elisa Meroni, Nathalie Stakenborg, Pedro J Gomez-Pinilla, Gert De Hertogh, Gera Goverse, Gianluca Matteoli, Simon Verheijden, Guy E Boeckxstaens. Functional characterization of oxazolone-induced colitis and survival improvement by vagus nerve stimulation. PloS one. 2018; 13(5):e0197487. doi: 10.1371/journal.pone.0197487. [PMID: 29791477]
  • Jonghwan Jegal, No-June Park, Sim-Kyu Bong, Hyun Jegal, Su-Nam Kim, Min Hye Yang. Dioscorea quinqueloba Ameliorates Oxazolone- and 2,4-Dinitrochlorobenzene-induced Atopic Dermatitis Symptoms in Murine Models. Nutrients. 2017 Dec; 9(12):. doi: 10.3390/nu9121324. [PMID: 29206209]
  • Risa Yasuike, Risa Tamagawa-Mineoka, Mayumi Ueta, Naomi Nakamura, Shigeru Kinoshita, Norito Katoh. The role of toll-like receptor 3 in chronic contact hypersensitivity induced by repeated elicitation. Journal of dermatological science. 2017 Nov; 88(2):184-191. doi: 10.1016/j.jdermsci.2017.07.017. [PMID: 28807557]
  • Przemysław Krawczyk, Beata Jędrzejewska, Piotr Cysewski, Tomasz Janek. Synthesis, photophysical and biological properties of a new oxazolone fluorescent probe for bioimaging: an experimental and theoretical study. Organic & biomolecular chemistry. 2017 Oct; 15(42):8952-8966. doi: 10.1039/c7ob02439h. [PMID: 29043360]
  • Soichiro Adachi, Namiko Hoshi, Jun Inoue, Eiichiro Yasutomi, Takafumi Otsuka, Ramesh Dhakhwa, Zi Wang, Yuna Koo, Toshihiro Takamatsu, Yuriko Matsumura, Haruka Yamairi, Daisuke Watanabe, Makoto Ooi, Toshihito Tanahashi, Shin Nishiumi, Masaru Yoshida, Takeshi Azuma. Indigo Naturalis Ameliorates Oxazolone-Induced Dermatitis but Aggravates Colitis by Changing the Composition of Gut Microflora. International archives of allergy and immunology. 2017; 173(1):23-33. doi: 10.1159/000471923. [PMID: 28482341]
  • Tomonori Nakanishi, Yuzo Tokunaga, Masao Yamasaki, Laurie Erickson, Satoshi Kawahara. Orally administered conjugated linoleic acid ameliorates allergic dermatitis induced by repeated applications of oxazolone in mice. Animal science journal = Nihon chikusan Gakkaiho. 2016 Dec; 87(12):1554-1561. doi: 10.1111/asj.12603. [PMID: 26990926]
  • Bálint Botz, Susanne M Brunner, Ágnes Kemény, Erika Pintér, Jason J McDougall, Barbara Kofler, Zsuzsanna Helyes. Galanin 3 receptor-deficient mice show no alteration in the oxazolone-induced contact dermatitis phenotype. Experimental dermatology. 2016 09; 25(9):725-7. doi: 10.1111/exd.13059. [PMID: 27121264]
  • Xuewei Wang, Fugang Fan, Qin Cao. Modified Pulsatilla decoction attenuates oxazolone-induced colitis in mice through suppression of inflammation and epithelial barrier disruption. Molecular medicine reports. 2016 Aug; 14(2):1173-9. doi: 10.3892/mmr.2016.5358. [PMID: 27278299]
  • Miranda S M Tsang, Delong Jiao, Ben C L Chan, Kam-Lun Hon, Ping C Leung, Clara B S Lau, Eric C W Wong, Ling Cheng, Carmen K M Chan, Christopher W K Lam, Chun K Wong. Anti-Inflammatory Activities of Pentaherbs Formula, Berberine, Gallic Acid and Chlorogenic Acid in Atopic Dermatitis-Like Skin Inflammation. Molecules (Basel, Switzerland). 2016 Apr; 21(4):519. doi: 10.3390/molecules21040519. [PMID: 27104513]
  • Hong Ye, Yali Wang, A Bennett Jenson, Jun Yan. Identification of inflammatory factor TNFα inhibitor from medicinal herbs. Experimental and molecular pathology. 2016 Apr; 100(2):307-11. doi: 10.1016/j.yexmp.2015.12.014. [PMID: 26778692]
  • Sang Eun Lee, Min Kyung Jung, Seung Joon Oh, Se Kyoo Jeong, Seung Hun Lee. Pseudoceramide stimulates peroxisome proliferator-activated receptor-α expression in a murine model of atopic dermatitis: molecular basis underlying the anti-inflammatory effect and the preventive effect against steroid-induced barrier impairment. Archives of dermatological research. 2015 Nov; 307(9):781-92. doi: 10.1007/s00403-015-1584-9. [PMID: 26121942]
  • Jiaoyan Lv, Linlin Zou, Lina Zhao, Wei Yang, Yingluo Xiong, Bingji Li, Rui He. Leukotriene B₄-leukotriene B₄ receptor axis promotes oxazolone-induced contact dermatitis by directing skin homing of neutrophils and CD8⁺ T cells. Immunology. 2015 Sep; 146(1):50-8. doi: 10.1111/imm.12478. [PMID: 25959240]
  • Na Young Yoon, Min young Jung, Dong Hye Kim, Hae Jin Lee, Eung Ho Choi. Topical glucocorticoid or pimecrolimus treatment suppresses thymic stromal lymphopoietin-related allergic inflammatory mechanism in an oxazolone-induced atopic dermatitis murine model. Archives of dermatological research. 2015 Sep; 307(7):569-81. doi: 10.1007/s00403-015-1558-y. [PMID: 25786383]
  • Kyung-Min Lim, SeungJin Bae, Jung Eun Koo, Eun-Sun Kim, Ok-Nam Bae, Joo Young Lee. Suppression of skin inflammation in keratinocytes and acute/chronic disease models by caffeic acid phenethyl ester. Archives of dermatological research. 2015 Apr; 307(3):219-27. doi: 10.1007/s00403-014-1529-8. [PMID: 25501505]
  • Julia Homann, Jing Suo, Mike Schmidt, Natasja de Bruin, Klaus Scholich, Gerd Geisslinger, Nerea Ferreirós. In Vivo Availability of Pro-Resolving Lipid Mediators in Oxazolone Induced Dermal Inflammation in the Mouse. PloS one. 2015; 10(11):e0143141. doi: 10.1371/journal.pone.0143141. [PMID: 26599340]
  • Marion T Kasaian, Karen M Page, Susan Fish, Agnes Brennan, Timothy A Cook, Karen Moreira, Melvin Zhang, Michael Jesson, Kimberly Marquette, Rita Agostinelli, Julie Lee, Cara M M Williams, Lioudmila Tchistiakova, Paresh Thakker. Therapeutic activity of an interleukin-4/interleukin-13 dual antagonist on oxazolone-induced colitis in mice. Immunology. 2014 Nov; 143(3):416-27. doi: 10.1111/imm.12319. [PMID: 24831554]
  • Torsten Olszak, Joana F Neves, C Marie Dowds, Kristi Baker, Jonathan Glickman, Nicholas O Davidson, Chyuan-Sheng Lin, Christian Jobin, Stephan Brand, Karl Sotlar, Koichiro Wada, Kazufumi Katayama, Atsushi Nakajima, Hiroyuki Mizuguchi, Kunito Kawasaki, Kazuhiro Nagata, Werner Müller, Scott B Snapper, Stefan Schreiber, Arthur Kaser, Sebastian Zeissig, Richard S Blumberg. Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature. 2014 May; 509(7501):497-502. doi: 10.1038/nature13150. [PMID: 24717441]
  • Yunmin Lu, Meiying Zhu, Wei Chen, Li Yin, Jinshui Zhu, Niwei Chen, Weixiong Chen. Tetramethylpyrazine improves oxazolone-induced colitis by inhibiting the NF-κB pathway. Clinical and investigative medicine. Medecine clinique et experimentale. 2014 Feb; 37(1):E1-9. doi: 10.25011/cim.v37i1.20863. [PMID: 24502806]
  • Dingding An, Sungwhan F Oh, Torsten Olszak, Joana F Neves, Fikri Y Avci, Deniz Erturk-Hasdemir, Xi Lu, Sebastian Zeissig, Richard S Blumberg, Dennis L Kasper. Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells. Cell. 2014 Jan; 156(1-2):123-33. doi: 10.1016/j.cell.2013.11.042. [PMID: 24439373]
  • Mikhail Kalinichev, Mélanie Rouillier, Francoise Girard, Isabelle Royer-Urios, Bruno Bournique, Terry Finn, Delphine Charvin, Brice Campo, Emmanuel Le Poul, Vincent Mutel, Sonia Poli, Stuart A Neale, Thomas E Salt, Robert Lütjens. ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization. The Journal of pharmacology and experimental therapeutics. 2013 Mar; 344(3):624-36. doi: 10.1124/jpet.112.200915. [PMID: 23257312]
  • Lori A Coburn, Sara N Horst, Rupesh Chaturvedi, Caroline T Brown, Margaret M Allaman, Brooks P Scull, Kshipra Singh, M Blanca Piazuelo, Maithili V Chitnavis, Mallary E Hodges, Michael J Rosen, Christopher S Williams, James C Slaughter, Dawn B Beaulieu, David A Schwartz, Keith T Wilson. High-throughput multi-analyte Luminex profiling implicates eotaxin-1 in ulcerative colitis. PloS one. 2013; 8(12):e82300. doi: 10.1371/journal.pone.0082300. [PMID: 24367513]
  • Randi Lundberg, Susanne K Clausen, Wanyong Pang, Dennis S Nielsen, Kristian Möller, Knud E Josefsen, Axel K Hansen. Gastrointestinal microbiota and local inflammation during oxazolone-induced dermatitis in BALB/cA mice. Comparative medicine. 2012 Oct; 62(5):371-80. doi: NULL. [PMID: 23114040]
  • Keiichi Hiramoto, Yurika Yamate, Hiromi Kobayashi, Masamitsu Ishii, Takanori Miura, Eisuke F Sato, Masayasu Inoue. Effect of the smell of Seirogan, a wood creosote, on dermal and intestinal mucosal immunity and allergic inflammation. Journal of clinical biochemistry and nutrition. 2012 Sep; 51(2):91-5. doi: 10.3164/jcbn.11-82. [PMID: 22962524]
  • Do-Hoon Kim, Woo Ram Park, Jeong Hwan Kim, Eun Chul Cho, Eun Jung An, Jin-Woong Kim, Seong-Geun Oh. Fabrication of pseudo-ceramide-based lipid microparticles for recovery of skin barrier function. Colloids and surfaces. B, Biointerfaces. 2012 Jun; 94(?):236-41. doi: 10.1016/j.colsurfb.2012.01.049. [PMID: 22361356]
  • Tadafumi Tamura. Olopatadine ophthalmic solution suppresses substance P release in the conjunctivitis models. Asia Pacific allergy. 2012 Apr; 2(2):115-21. doi: 10.5415/apallergy.2012.2.2.115. [PMID: 22701861]
  • L Márquez, C Shen, I Cleynen, G De Hertogh, K Van Steen, K Machiels, C Perrier, V Ballet, S Organe, M Ferrante, L Henckaerts, G Galicia, P Rutgeerts, J L Ceuppens, S Vermeire. Effects of haptoglobin polymorphisms and deficiency on susceptibility to inflammatory bowel disease and on severity of murine colitis. Gut. 2012 Apr; 61(4):528-34. doi: 10.1136/gut.2011.240978. [PMID: 21708824]
  • Vanesa Ivetić Tkalčević, Snježana Cužić, Miroslava Dominis Kramarić, Michael J Parnham, Vesna Eraković Haber. Topical azithromycin and clarithromycin inhibit acute and chronic skin inflammation in sensitized mice, with apparent selectivity for Th2-mediated processes in delayed-type hypersensitivity. Inflammation. 2012 Feb; 35(1):192-205. doi: 10.1007/s10753-011-9305-9. [PMID: 21336676]
  • Josipa Grzetic, Jos Oomens. Spectroscopic evidence for an oxazolone structure in anionic b-type peptide fragments. Journal of the American Society for Mass Spectrometry. 2012 Feb; 23(2):290-300. doi: 10.1007/s13361-011-0297-3. [PMID: 22170467]
  • Einar J Stauber, Petrissa Kuczka, Maike van Ohlen, Birgit Vogt, Tim Janowitz, Markus Piotrowski, Till Beuerle, Ute Wittstock. Turning the 'mustard oil bomb' into a 'cyanide bomb': aromatic glucosinolate metabolism in a specialist insect herbivore. PloS one. 2012; 7(4):e35545. doi: 10.1371/journal.pone.0035545. [PMID: 22536404]
  • Takashi Mori, Yoshiharu Tanimoto, Mika Ota, Takaomi Masakado, Sachiko Kitamoto, Koichi Saito, Naohiko Isobe, Hideo Kaneko. Comparison of cytokine profiles in bronchoalveolar lavage fluid of mice exposed to respiratory and contact sensitizers. The Journal of toxicological sciences. 2012; 37(2):337-43. doi: 10.2131/jts.37.337. [PMID: 22467024]
  • Magdalena Zemelka-Wiącek, Monika Majewska-Szczepanik, Włodzimierz Ptak, Marian Szczepanik. Epicutaneous immunization with protein antigen induces antigen-non-specific suppression of CD8 T cell mediated contact sensitivity. Pharmacological reports : PR. 2012; 64(6):1485-96. doi: 10.1016/s1734-1140(12)70946-5. [PMID: 23406759]
  • Nandkishore S Thombare, Nisha Aggarwal, Rajesh Kumar, Madhuban Gopal. Synthesis of 2-furyl-4-arylidene-5(4H)-oxazolones as new potent antibacterial agents against phyto-pathogenic and nitrifying bacteria. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2012; 47(4):326-35. doi: 10.1080/03601234.2012.640916. [PMID: 22428894]
  • Van T Chu, Claudia Berek. Immunization induces activation of bone marrow eosinophils required for plasma cell survival. European journal of immunology. 2012 Jan; 42(1):130-7. doi: 10.1002/eji.201141953. [PMID: 22057654]
  • J R Goldsmith, Christian Jobin. Think small: zebrafish as a model system of human pathology. Journal of biomedicine & biotechnology. 2012; 2012(?):817341. doi: 10.1155/2012/817341. [PMID: 22701308]
  • Nicole Wittenbrink, Anke Klein, Armin A Weiser, Johannes Schuchhardt, Michal Or-Guil. Is there a typical germinal center? A large-scale immunohistological study on the cellular composition of germinal centers during the hapten-carrier-driven primary immune response in mice. Journal of immunology (Baltimore, Md. : 1950). 2011 Dec; 187(12):6185-96. doi: 10.4049/jimmunol.1101440. [PMID: 22102720]
  • C Frieke Kuper, Marijana Radonjic, Jos van Triel, Rob Stierum, Rianne J de Groot, Josje H E Arts. Oxazolone (OXA) is a respiratory allergen in Brown Norway rats. Toxicology. 2011 Nov; 290(1):59-68. doi: 10.1016/j.tox.2011.08.017. [PMID: 21893156]
  • Laryssa K Rauh, Cíntia D S Horinouchi, Alliete M V Loddi, Evelise F Pietrovski, Rosalina Neris, Fernando Souza-Fonseca-Guimarães, Dorly F Buchi, Maique W Biavatti, Michel F Otuki, Daniela A Cabrini. Effectiveness of Vernonia scorpioides ethanolic extract against skin inflammatory processes. Journal of ethnopharmacology. 2011 Nov; 138(2):390-7. doi: 10.1016/j.jep.2011.09.012. [PMID: 21959183]
  • Wenyan Man, Mona Man, Melanie Hupe, Gemma Martin-Ezquerra, Kenneth R Feingold, Peter M Elias, Mao-Qiang Man. Topical herbal extract (Huangdang mixture) exhibits both preventive and therapeutic effects in murine acute irritant contact dermatitis. International journal of dermatology. 2011 Nov; 50(11):1421-1427. doi: 10.1111/j.1365-4632.2011.04970.x. [PMID: 22004502]
  • Pawel Olszowy, Malgorzata Szultka, Boguslaw Buszewski. Poly(3-alkylthiophenes): new sorption materials for solid phase microextraction of drugs isolated from human plasma. Analytical and bioanalytical chemistry. 2011 Sep; 401(4):1377-84. doi: 10.1007/s00216-011-5159-0. [PMID: 21710286]
  • Young Bok Lee, Hyun Jung Park, Mi Jung Kwon, Se Kyoo Jeong, Sang Hyun Cho. Beneficial effects of pseudoceramide-containing physiologic lipid mixture as a vehicle for topical steroids. European journal of dermatology : EJD. 2011 Sep; 21(5):710-6. doi: 10.1684/ejd.2011.1447. [PMID: 21708519]
  • Tamas Varga, Zsolt Czimmerer, Laszlo Nagy. PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation. Biochimica et biophysica acta. 2011 Aug; 1812(8):1007-22. doi: 10.1016/j.bbadis.2011.02.014. [PMID: 21382489]
  • Tor Regberg, Charlotta Lindquist, Ake Pilotti, Christel Ellström, Lars Fägerstam, Ann Eckersten, Yasuro Shinohara, Steven L Gallion, Joseph C Hogan. Novel affinity ligands for chromatography using combinatorial chemistry. Combinatorial chemistry & high throughput screening. 2011 May; 14(4):267-78. doi: 10.2174/138620711795222482. [PMID: 21143179]
  • Jun-Won Yun, Jung A Seo, Yeon Su Jeong, Il-Hong Bae, Won-Hee Jang, Jihae Lee, Sun-Young Kim, Song-Seok Shin, Byoung-Young Woo, Ki-Wha Lee, Kyung-Min Lim, Young-Ho Park. TRPV1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery. Journal of dermatological science. 2011 Apr; 62(1):8-15. doi: 10.1016/j.jdermsci.2010.10.014. [PMID: 21345654]
  • Allisson Freire Bento, Rodrigo Marcon, Rafael Cypriano Dutra, Rafaela Franco Claudino, Maíra Cola, Daniela Ferraz Pereira Leite, João B Calixto. β-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARγ pathway. The American journal of pathology. 2011 Mar; 178(3):1153-66. doi: 10.1016/j.ajpath.2010.11.052. [PMID: 21356367]
  • Fatemeh Sabermahani, Mohammad Ali Taher, Habibe Bahrami, Samieh Fozooni. Alumina coated with oxazolone derivative for extraction of trace amounts of cadmium and copper from water and plant samples. Journal of hazardous materials. 2011 Jan; 185(2-3):945-50. doi: 10.1016/j.jhazmat.2010.09.111. [PMID: 21074321]
  • Chan Hum Park, Noriko Yamabe, Takuya Okamoto, Kazuo Toriizuka, Takako Yokozawa. Chinese prescription kangen-karyu ameliorates the development of diabetic hepatic damages via regulating oxidative stress and inflammation in the liver of db/db mice. Biological & pharmaceutical bulletin. 2011; 34(3):383-8. doi: 10.1248/bpb.34.383. [PMID: 21372389]
  • Zenro Ikezawa, Junko Komori, Yuko Ikezawa, Yusuke Inoue, Mio Kirino, Masako Katsuyama, Michiko Aihara. A Role of Staphyococcus aureus, Interleukin-18, Nerve Growth Factor and Semaphorin 3A, an Axon Guidance Molecule, in Pathogenesis and Treatment of Atopic Dermatitis. Allergy, asthma & immunology research. 2010 Oct; 2(4):235-46. doi: 10.4168/aair.2010.2.4.235. [PMID: 20885908]
  • Kyoji Yoshino, Katsuko Yamazaki, Mitsuaki Sano. Preventive effects of black tea theaflavins against mouse type IV allergy. Journal of the science of food and agriculture. 2010 Sep; 90(12):1983-7. doi: 10.1002/jsfa.4035. [PMID: 20597096]
  • V J Galani, B G Patel, N B Patel. Argyreia speciosa (Linn. f.) sweet: A comprehensive review. Pharmacognosy reviews. 2010 Jul; 4(8):172-8. doi: 10.4103/0973-7847.70913. [PMID: 22228958]
  • Yan Pan, Qin Ouyang. [Effects of Bawei Xilei San on mice with oxazolone-induced colitis and the mechanisms]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2010 Jun; 8(6):568-74. doi: 10.3736/jcim20100610. [PMID: 20550880]
  • Soon-Hee Lee, Yong Heo, Young-Chul Kim. Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice. Journal of veterinary science. 2010 Mar; 11(1):35-41. doi: 10.4142/jvs.2010.11.1.35. [PMID: 20195063]
  • Nicole Wittenbrink, Tom S Weber, Anke Klein, Armin A Weiser, Werner Zuschratter, Michael Sibila, Johannes Schuchhardt, Michal Or-Guil. Broad volume distributions indicate nonsynchronized growth and suggest sudden collapses of germinal center B cell populations. Journal of immunology (Baltimore, Md. : 1950). 2010 Feb; 184(3):1339-47. doi: 10.4049/jimmunol.0901040. [PMID: 20053939]
  • Yutaka Hatano, Mao-Qiang Man, Yoshikazu Uchida, Debra Crumrine, Theodora M Mauro, Kenneth R Feingold, Peter M Elias, Walter M Holleran. Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators. The Journal of allergy and clinical immunology. 2010 Jan; 125(1):160-9.e1. doi: 10.1016/j.jaci.2009.06.049. [PMID: 19818482]
  • Yi Zhou, He Wang, Yue-Shan Li, Yi-Wen Tao, Jian-Ye Zhang, Zhi-Qiang Zhang. [Paeoniflorin increases beta-defensin expression and attenuates lesion in the colonic mucosa from mice with oxazolone-induced colitis]. Yao xue xue bao = Acta pharmaceutica Sinica. 2010 Jan; 45(1):37-42. doi: ". [PMID: 21351447]
  • Nerida Cole, Paul W Sou, Alanna Ngo, Karen H Tsang, Joseph A J Severino, Sondur J Arun, Colin C Duke, Vivienne E Reeve. Topical 'Sydney' propolis protects against UV-radiation-induced inflammation, lipid peroxidation and immune suppression in mouse skin. International archives of allergy and immunology. 2010; 152(2):87-97. doi: 10.1159/000265530. [PMID: 20016191]
  • Toshiharu Hayashi. Therapeutic strategies for SLE involving cytokines: mechanism-oriented therapies especially IFN-gamma targeting gene therapy. Journal of biomedicine & biotechnology. 2010; 2010(?):. doi: 10.1155/2010/461641. [PMID: 20827419]
  • Tetsuo Watanabe, Takeshi Yamamoto, Minako Yoshida, Kanae Fujiwara, Natsuko Kageyama-Yahara, Hirofumi Kuramoto, Yutaka Shimada, Makoto Kadowaki. The traditional herbal medicine saireito exerts its inhibitory effect on murine oxazolone-induced colitis via the induction of Th1-polarized immune responses in the mucosal immune system of the colon. International archives of allergy and immunology. 2010; 151(2):98-106. doi: 10.1159/000235999. [PMID: 19752563]
  • Andrea Mencarelli, Barbara Renga, Giuseppe Palladino, Eleonora Distrutti, Stefano Fiorucci. The plant sterol guggulsterone attenuates inflammation and immune dysfunction in murine models of inflammatory bowel disease. Biochemical pharmacology. 2009 Nov; 78(9):1214-23. doi: 10.1016/j.bcp.2009.06.026. [PMID: 19555671]
  • Ji Hae Lee, Kyoung-Mi Jung, Il-Hong Bae, SiYoung Cho, Dae-Bang Seo, Sang-Jun Lee, Young-Ho Park, Kyung-Min Lim. Anti-inflammatory and barrier protecting effect of Lithospermum erythrorhizon extracts in chronic oxazolone-induced murine atopic dermatitis. Journal of dermatological science. 2009 Oct; 56(1):64-6. doi: 10.1016/j.jdermsci.2009.07.001. [PMID: 19651492]
  • Tiffany C Scharschmidt, Mao-Qiang Man, Yutaka Hatano, Debra Crumrine, Roshan Gunathilake, John P Sundberg, Kathleen A Silva, Theodora M Mauro, Melanie Hupe, Soyun Cho, Yan Wu, Anna Celli, Matthias Schmuth, Kenneth R Feingold, Peter M Elias. Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens. The Journal of allergy and clinical immunology. 2009 Sep; 124(3):496-506, 506.e1. doi: 10.1016/j.jaci.2009.06.046. [PMID: 19733297]
  • Yutaka Hatano, Mao-Qiang Man, Yoshikazu Uchida, Debra Crumrine, Tiffany C Scharschmidt, Esther G Kim, Theodora M Mauro, Kenneth R Feingold, Peter M Elias, Walter M Holleran. Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis. The Journal of investigative dermatology. 2009 Jul; 129(7):1824-35. doi: 10.1038/jid.2008.444. [PMID: 19177139]
  • T Morioka, K Yamanaka, H Mori, Y Omoto, K Tokime, M Kakeda, I Kurokawa, E C Gabazza, A Tsubura, Y Yasutomi, H Mizutani. IL-4/IL-13 antagonist DNA vaccination successfully suppresses Th2 type chronic dermatitis. The British journal of dermatology. 2009 Jun; 160(6):1172-9. doi: 10.1111/j.1365-2133.2009.09069.x. [PMID: 19416272]
  • Hai-Qiang Zhang, Tomas T Ding, Jun-Sheng Zhao, Xin Yang, Hai-Xia Zhang, Juan-Juan Zhang, Yun-Long Cui. Therapeutic effects of Clostridium butyricum on experimental colitis induced by oxazolone in rats. World journal of gastroenterology. 2009 Apr; 15(15):1821-8. doi: 10.3748/wjg.15.1821. [PMID: 19370778]
  • Jos Oomens, Sarah Young, Sam Molesworth, Michael van Stipdonk. Spectroscopic evidence for an oxazolone structure of the b(2) fragment ion from protonated tri-alanine. Journal of the American Society for Mass Spectrometry. 2009 Feb; 20(2):334-9. doi: 10.1016/j.jasms.2008.10.012. [PMID: 19013079]
  • J Faber, P Vos, D Kegler, K van Norren, J M Argilés, A Laviano, J Garssen, A van Helvoort. Beneficial immune modulatory effects of a specific nutritional combination in a murine model for cancer cachexia. British journal of cancer. 2008 Dec; 99(12):2029-36. doi: 10.1038/sj.bjc.6604785. [PMID: 19018259]
  • Yu Jin, Venkata S Kotakadi, Lei Ying, Anne B Hofseth, Xiangli Cui, Patricia A Wood, Anthony Windust, Lydia E Matesic, Edsel A Pena, Codruta Chiuzan, Narendra P Singh, Mitzi Nagarkatti, Prakash S Nagarkatti, Michael J Wargovich, Lorne J Hofseth. American ginseng suppresses inflammation and DNA damage associated with mouse colitis. Carcinogenesis. 2008 Dec; 29(12):2351-9. doi: 10.1093/carcin/bgn211. [PMID: 18802031]
  • Jonathan R Siscovick, Tamar Zapolanski, Cynthia Magro, Kristel Carrington, Shannon Prograis, Marnie Nussbaum, Salvador Gonzalez, Wanhong Ding, Richard D Granstein. Polypodium leucotomos inhibits ultraviolet B radiation-induced immunosuppression. Photodermatology, photoimmunology & photomedicine. 2008 Jun; 24(3):134-41. doi: 10.1111/j.1600-0781.2008.00352.x. [PMID: 18477132]
  • Shinji Kagami, Hidehisa Saeki, Yuichiro Tsunemi, Koichiro Nakamura, Yoshihiro Kuwano, Mayumi Komine, Takashi Nakayama, Osamu Yoshie, Kunihiko Tamaki. CCL27-transgenic mice show enhanced contact hypersensitivity to Th2, but not Th1 stimuli. European journal of immunology. 2008 Mar; 38(3):647-57. doi: 10.1002/eji.200737685. [PMID: 18266301]
  • J M Prieto, M C Recio, R M Giner, G R Schinella, S Máñez, J L Ríos. In vitro and in vivo effects of Ranunculus peltatus subsp. baudotii methanol extract on models of eicosanoid production and contact dermatitis. Phytotherapy research : PTR. 2008 Mar; 22(3):297-302. doi: 10.1002/ptr.2309. [PMID: 18058987]
  • Xun Sun, Shinichi Somada, Kensuke Shibata, Hiromi Muta, Hisakata Yamada, Hirofumi Yoshihara, Kuniomi Honda, Kazuhiko Nakamura, Ryhoichi Takayanagi, Kenzaburo Tani, Eckhard R Podack, Yasunobu Yoshikai. A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Gastroenterology. 2008 Feb; 134(2):447-58. doi: 10.1053/j.gastro.2007.11.004. [PMID: 18242212]
  • Mao-Qiang Man, Yutaka Hatano, Seung H Lee, Mona Man, Sandra Chang, Kenneth R Feingold, Donald Y M Leung, Walter Holleran, Yoshikazu Uchida, Peter M Elias. Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges. The Journal of investigative dermatology. 2008 Jan; 128(1):79-86. doi: 10.1038/sj.jid.5701011. [PMID: 17671515]
  • A Olmos, R M Giner, M C Recio, J L Rios, J M Cerdá-Nicolás, S Máñez. Effects of plant alkylphenols on cytokine production, tyrosine nitration and inflammatory damage in the efferent phase of contact hypersensitivity. British journal of pharmacology. 2007 Oct; 152(3):366-73. doi: 10.1038/sj.bjp.0707402. [PMID: 17660848]
  • Guangchen Sun, Yixiu Zhang, Daisuke Takuma, Masahide Onogawa, Junko Yokota, Atsuhide Hamada, Saburo Yoshioka, Masahiko Kusunose, Mitsuhiko Miyamura, Shojiro Kyotani, Yutaka Nishioka. Effect of orally administered Eriobotrya japonica seed extract on allergic contact dermatitis in rats. The Journal of pharmacy and pharmacology. 2007 Oct; 59(10):1405-12. doi: 10.1211/jpp.59.10.0011. [PMID: 17910816]
  • Bo Pang, Xinfeng Zhou, Hongbin Yu, Min Dong, Koli Taghizadeh, John S Wishnok, Steven R Tannenbaum, Peter C Dedon. Lipid peroxidation dominates the chemistry of DNA adduct formation in a mouse model of inflammation. Carcinogenesis. 2007 Aug; 28(8):1807-13. doi: 10.1093/carcin/bgm037. [PMID: 17347141]
  • Carolin Daniel, Nico A Sartory, Nadine Zahn, Ronald Schmidt, Gerd Geisslinger, Heinfried H Radeke, Jurgen M Stein. FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions. Molecular immunology. 2007 Jul; 44(13):3305-16. doi: 10.1016/j.molimm.2007.02.026. [PMID: 17475330]