Ethyl beta-carboline-3-carboxylate (BioDeep_00000178871)

   

human metabolite blood metabolite


代谢物信息卡片


Pyrido(3,4-b)indole-3-carboxylic acid ethyl ester

化学式: C14H12N2O2 (240.0898732)
中文名称: β-咔啉-3-羧酸乙酯(β-CCE)
谱图信息: 最多检出来源 Mus musculus(blood) 12.5%

分子结构信息

SMILES: CCOC(=O)C1=CC2=C(NC3=C2C=CC=C3)C=N1
InChI: InChI=1S/C14H12N2O2/c1-2-18-14(17)12-7-10-9-5-3-4-6-11(9)16-13(10)8-15-12/h3-8,16H,2H2,1H3

描述信息

同义名列表

13 个代谢物同义名

Pyrido(3,4-b)indole-3-carboxylic acid ethyl ester; beta-Carboline-3-carboxylic acid ethyl ester; ethyl 9H-pyrido[3,4-b]indole-3-carboxylate; Ethyl beta-carboline-3-carboxylic acid; Ethyl β-carboline-3-carboxylic acid; Ethyl b-carboline-3-carboxylic acid; Ethyl beta-carboline-3-carboxylate; Ethyl-beta-carboline-3-carboxylate; Ethyl b-carboline-3-carboxylate; Ethyl β-carboline-3-carboxylate; 3-Carboethoxy-beta carboline; BC-3-CAEE; beta-CCE



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jason M C Derry, Susan M J Dunn, Martin Davies. Identification of a residue in the gamma-aminobutyric acid type A receptor alpha subunit that differentially affects diazepam-sensitive and -insensitive benzodiazepine site binding. Journal of neurochemistry. 2004 Mar; 88(6):1431-8. doi: 10.1046/j.1471-4159.2003.02264.x. [PMID: 15009644]
  • R F Parrott, S V Vellucci, J A Goode. Behavioral effects of betacarbolines in pigs:. anxiety or aversion?. Pharmacology, biochemistry, and behavior. 2000 Aug; 66(4):713-9. doi: 10.1016/s0091-3057(00)00243-4. [PMID: 10973508]
  • R Chermat, D Brochet, F V DeFeudis, K Drieu. Interactions of Ginkgo biloba extract (EGb 761), diazepam and ethyl beta-carboline-3-carboxylate on social behavior of the rat. Pharmacology, biochemistry, and behavior. 1997 Feb; 56(2):333-9. doi: 10.1016/s0091-3057(96)00298-5. [PMID: 9050093]
  • N H Kalin, S E Shelton, J G Turner. Effects of beta-carboline on fear-related behavioral and neurohormonal responses in infant rhesus monkeys. Biological psychiatry. 1992 May; 31(10):1008-19. doi: 10.1016/0006-3223(92)90094-g. [PMID: 1324744]
  • B Elgoyhen, P S Lorenzo, M T Tellez-Iñón, E Adler-Graschinsky. Relaxant effects of beta-carbolines on rat aortic rings. The Journal of pharmacology and experimental therapeutics. 1992 May; 261(2):534-9. doi: ". [PMID: 1578370]
  • R M Eisenberg, C Johnson. Effects of beta-carboline-ethyl ester on plasma corticosterone--a parallel with antagonist-precipitated diazepam withdrawal. Life sciences. 1989; 44(20):1457-66. doi: 10.1016/0024-3205(89)90324-x. [PMID: 2725178]
  • T R Insel, J Scanlan, M Champoux, S J Suomi. Rearing paradigm in a nonhuman primate affects response to beta-CCE challenge. Psychopharmacology. 1988; 96(1):81-6. doi: 10.1007/bf02431537. [PMID: 3147480]
  • J R Hammond, I L Martin. Solubilization of the benzodiazepine/gamma-aminobutyric acid receptor complex: comparison of the detergents octylglucopyranoside and 3-[(3-cholamidopropyl)-dimethylammonio]1-propanesulfonate (CHAPS). Journal of neurochemistry. 1986 Oct; 47(4):1161-71. doi: 10.1111/j.1471-4159.1986.tb00735.x. [PMID: 3018163]
  • J R Glowa, P Skolnick, S M Paul. Effects of beta-carboline-3-carboxylic acid ethyl ester on suppressed and non-suppressed responding in the rhesus monkey. European journal of pharmacology. 1986 Sep; 129(1-2):39-47. doi: 10.1016/0014-2999(86)90334-1. [PMID: 3021479]
  • V Saano. Affinity of various compounds for benzodiazepine binding sites in rat brain, heart and kidneys in vitro. Acta pharmacologica et toxicologica. 1986 May; 58(5):333-8. doi: 10.1111/j.1600-0773.1986.tb00118.x. [PMID: 3017047]
  • H Havoundjian, R M Cohen, S M Paul, P Skolnick. Differential sensitivity of 'central' and 'peripheral' type benzodiazepine receptors to phospholipase A2. Journal of neurochemistry. 1986 Mar; 46(3):804-11. doi: 10.1111/j.1471-4159.1986.tb13043.x. [PMID: 3005493]
  • E Tamborska, P J Marangos. Brain benzodiazepine binding sites in ethanol dependent and withdrawal states. Life sciences. 1986 Feb; 38(5):465-72. doi: 10.1016/0024-3205(86)90072-x. [PMID: 3003481]
  • J N Crawley, P T Ninan, D Pickar, G P Chrousos, M Linnoila, P Skolnick, S M Paul. Neuropharmacological antagonism of the beta-carboline-induced 'anxiety' response in rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1985 Feb; 5(2):477-85. doi: 10.1523/jneurosci.05-02-00477.1985. [PMID: 2983041]
  • T R Insel, P T Ninan, J Aloi, D C Jimerson, P Skolnick, S M Paul. A benzodiazepine receptor-mediated model of anxiety. Studies in nonhuman primates and clinical implications. Archives of general psychiatry. 1984 Aug; 41(8):741-50. doi: 10.1001/archpsyc.1984.01790190015002. [PMID: 6331336]
  • P Skolnick, P Ninan, T Insel, J Crawley, S Paul. A novel chemically induced animal model of human anxiety. Psychopathology. 1984; 17 Suppl 1(?):25-36. doi: 10.1159/000284074. [PMID: 6143342]
  • E Costa, M G Corda, A Guidotti. On a brain polypeptide functioning as a putative effector for the recognition sites of benzodiazepine and beta-carboline derivatives. Neuropharmacology. 1983 Dec; 22(12B):1481-92. doi: 10.1016/0028-3908(83)90116-8. [PMID: 6322042]
  • M M Schweri, J V Martin, W B Mendelson, J E Barrett, S M Paul, P Skolnick. Pharmacokinetic and pharmacodynamic factors contributing to the convulsant action of beta-carboline-3-carboxylic acid esters. Life sciences. 1983 Oct; 33(15):1505-10. doi: 10.1016/0024-3205(83)90854-8. [PMID: 6621253]
  • S Mizuno, N Ogawa, A Mori. Differential effects of some transition metal cations on the binding of beta-carboline-3-carboxylate and diazepam. Neurochemical research. 1983 Jul; 8(7):873-80. doi: 10.1007/bf00964548. [PMID: 6312349]
  • P Skolnick, M M Schweri, S M Paul, J V Martin, R L Wagner, W B Mendelson. 3-carboethoxy-beta-carboline (beta-CCE) elicits electroencephalographic seizures in rats: reversal by the benzodiazepine antagonist CGS 8216. Life sciences. 1983 May; 32(21):2439-45. doi: 10.1016/0024-3205(83)90369-7. [PMID: 6855447]
  • P T Ninan, T M Insel, R M Cohen, J M Cook, P Skolnick, S M Paul. Benzodiazepine receptor-mediated experimental 'anxiety' in primates. Science (New York, N.Y.). 1982 Dec; 218(4579):1332-4. doi: 10.1126/science.6293059. [PMID: 6293059]
  • H Simonsen, M Nielsen, C Braestrup. Peripheral metabolism of beta-carboline-carboxylic acid esters. Acta pharmacologica et toxicologica. 1982 Feb; 50(2):89-92. doi: 10.1111/j.1600-0773.1982.tb00946.x. [PMID: 6280445]
  • P J Marangos, J Patel. Properties of [3H] beta-carboline-3-carboxylate ethyl ester binding to the benzodiazepine receptor. Life sciences. 1981 Oct; 29(16):1705-14. doi: 10.1016/0024-3205(81)90074-6. [PMID: 6273677]
  • P J Cowen, A R Green, D J Nutt. Ethyl beta-carboline carboxylate lowers seizure threshold and antagonizes flurazepam-induced sedation in rats. Nature. 1981 Mar; 290(5801):54-5. doi: 10.1038/290054a0. [PMID: 6259533]
  • S S Tenen, J D Hirsch. beta-Carboline-3-carboxylic acid ethyl ester antagonizes diazepam activity. Nature. 1980 Dec; 288(5791):609-10. doi: 10.1038/288609a0. [PMID: 6255340]
  • M Nielsen, C Braestrup. Ethyl beta-carboline-3-carboxylate shows differential benzodiazepine receptor interaction. Nature. 1980 Aug; 286(5773):606-7. doi: 10.1038/286606a0. [PMID: 6250077]
  • C Braestrup, M Nielsen, C E Olsen. Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors. Proceedings of the National Academy of Sciences of the United States of America. 1980 Apr; 77(4):2288-92. doi: 10.1073/pnas.77.4.2288. [PMID: 6246535]