Bempedoic acid (BioDeep_00000178834)
human metabolite blood metabolite
代谢物信息卡片
8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid
化学式: C19H36O5 (344.2562606)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 66.67%
分子结构信息
SMILES: CC(C)(CCCCCC(CCCCCC(C)(C)C(=O)O)O)C(=O)O
InChI: InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent > C80482 - Non-Statin Antilipidemic Agent
C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
D009676 - Noxae > D000963 - Antimetabolites
D007004 - Hypoglycemic Agents
D004791 - Enzyme Inhibitors
Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor[1]. Bempedoic acid (ETC-1002) activates AMPK[2].
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:149601
- PubChem: 10472693
- HMDB: HMDB0251991
- DrugBank: DB11936
- ChEMBL: CHEMBL3545313
- Wikipedia: Bempedoic_acid
- chemspider: 8648104
- CAS: 738606-46-7
- medchemexpress: HY-12357
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- David Fernandez-Vazquez, Sarah Weideman, Subhash Banerjee. Assessing the Role of Bempedoic Acid in Lipid-Lowering Therapy.
The American journal of cardiology.
2024 Apr; 216(?):93-94. doi:
10.1016/j.amjcard.2024.02.002. [PMID: 38369175] - Sining Xie, Federica Galimberti, Elena Olmastroni, Thomas F Luscher, Stefano Carugo, Alberico L Catapano, Manuela Casula. Effect of lipid-lowering therapies on C-reactive protein levels: a comprehensive meta-analysis of randomized controlled trials.
Cardiovascular research.
2024 Mar; 120(4):333-344. doi:
10.1093/cvr/cvae034. [PMID: 38373008] - Satyavir Yadav, Jitendra Pal Singh Sawhney. Treatment of dyslipidemia in acute coronary syndrome.
Indian heart journal.
2024 Mar; 76 Suppl 1(?):S51-S57. doi:
10.1016/j.ihj.2024.01.011. [PMID: 38307382] - P Barton Duell, Maciej Banach, Alberico L Catapano, Ulrich Laufs, G B John Mancini, Kausik K Ray, Christine Broestl, Yang Zhang, Lei Lei, Anne C Goldberg. Efficacy and safety of bempedoic acid in patients with heterozygous familial hypercholesterolemia: analysis of pooled patient-level data from phase 3 clinical trials.
Journal of clinical lipidology.
2024 Mar; 18(2):e153-e165. doi:
10.1016/j.jacl.2023.12.005. [PMID: 38341323] - Kristina Paponja, Ivan Pećin, Željko Reiner, Maciej Banach. Bempedoic acid: new evidence and recommendations on use.
Current opinion in lipidology.
2024 Feb; 35(1):41-50. doi:
10.1097/mol.0000000000000911. [PMID: 38085172] - Cristian Del Carpio-Tenorio, Jordan Llerena-Velastegui, Cecibel Villacis-Lopez, Marcela Placencia-Silva, Carolina Santander-Fuentes, Karen Benitez-Acosta, Cristian Sanahuja-Montiel, Daniel Dominguez-Gavilanes, Paul Carrasco-Perez, Carlos Calderon-Lopez. Impact of Bempedoic acid on LDL-C reduction and cardiovascular outcomes: A comprehensive meta-analysis of randomized controlled trials.
Current problems in cardiology.
2024 Feb; 49(2):102191. doi:
10.1016/j.cpcardiol.2023.102191. [PMID: 37981266] - Aman Goyal, Mah I Kan Changez, Muhammad Daoud Tariq, Fiza Mushtaq, Urooj Shamim, Amir Humza Sohail, Gauranga Mahalwar. Efficacy and outcomes of Bempedoic acid versus placebo in patients with statin-intolerance: A pilot systematic review and meta-analysis of randomized controlled trials.
Current problems in cardiology.
2024 Feb; 49(2):102236. doi:
10.1016/j.cpcardiol.2023.102236. [PMID: 38043880] - Julius L Katzmann, Paulina E Stürzebecher, Silvia Kruppert, Ulrich Laufs. LDL cholesterol target attainment in cardiovascular high- and very-high-risk patients with statin intolerance: a simulation study.
Scientific reports.
2024 01; 14(1):474. doi:
10.1038/s41598-023-50847-1. [PMID: 38172531] - Heinz Drexel, Arthur Mader. Bempedoic Acid: How Will It Shape the Future Lipid-Lowering Landscape? Mode of Action, Evidence, and Clinical Use.
Cardiology.
2024; 149(1):71-77. doi:
10.1159/000535372. [PMID: 37989119] - Yi Li, Hongyu Gao, Jinghui Zhao, Liqing Ma, Dan Hu. Safety and efficacy of bempedoic acid among patients with statin intolerance and those without: A meta-analysis and a systematic randomized controlled trial review.
PloS one.
2024; 19(1):e0297854. doi:
10.1371/journal.pone.0297854. [PMID: 38277431] - Naseer Uddin, Abdul Ahad Syed, Syed Muhammad Ismail, Muhammad Talal Ashraf, Muhammad Khuzzaim Khan, Affan Sohail. Clinical Efficacy and Safety of Bempedoic Acid in High Cardiovascular Risk Patients: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Current problems in cardiology.
2023 Dec; 48(12):102003. doi:
10.1016/j.cpcardiol.2023.102003. [PMID: 37516330] - Ovidio De Filippo, Fabrizio D'Ascenzo, Mario Iannaccone, Maurizio Bertaina, Attilio Leone, Irene Borzillo, Emanuele Ravetti, Andrea Solano, Ilaria Pagliassotto, Marco Nebiolo, Francesco Bruno, Federico Giacobbe, Saverio Muscoli, Silvia Monticone, Maria Felice Brizzi, Giuseppe Biondi Zoccai, Gaetano Maria De Ferrari. Safety and efficacy of bempedoic acid: a systematic review and meta-analysis of randomised controlled trials.
Cardiovascular diabetology.
2023 11; 22(1):324. doi:
10.1186/s12933-023-02022-z. [PMID: 38017541] - Shravan Venkatraman, Saibal Das, Madhavi Eerike, Jerin Jose Cherian, Bhavani Shankara Bagepally. Efficacy and safety of bempedoic acid lipid-lowering therapy: a systematic review and meta-analysis of randomized controlled trials.
European journal of clinical pharmacology.
2023 Nov; 79(11):1453-1463. doi:
10.1007/s00228-023-03555-8. [PMID: 37672112] - Anne C Goldberg, Maciej Banach, Alberico L Catapano, P Barton Duell, Lawrence A Leiter, Jeffrey C Hanselman, Lei Lei, G B John Mancini. Evaluation of the efficacy and safety of bempedoic acid in women and men: Pooled analyses from phase 3 trials.
Atherosclerosis.
2023 11; 384(?):117192. doi:
10.1016/j.atherosclerosis.2023.117192. [PMID: 37648637] - David Mutschlechner, Maximilian Tscharre, Kurt Huber, Thomas Gremmel. Cardiovascular events in patients treated with bempedoic acid vs. placebo: systematic review and meta-analysis.
European heart journal. Cardiovascular pharmacotherapy.
2023 09; 9(6):583-591. doi:
10.1093/ehjcvp/pvad052. [PMID: 37463824] - Nicola Ferri, Massimiliano Ruscica, Raul D Santos, Alberto Corsini. Fixed Combination for the Treatment of Dyslipidaemia.
Current atherosclerosis reports.
2023 Sep; ?(?):. doi:
10.1007/s11883-023-01142-x. [PMID: 37715044] - Qiushuang Sun, Yating Guo, Wenjun Hu, Mengdi Zhang, Shijiao Wang, Yuanyuan Lei, Haitao Meng, Ning Li, Pengfei Xu, Zhiyu Li, Haishu Lin, Fang Huang, Zhixia Qiu. Bempedoic acid unveils therapeutic potential in non-alcoholic fatty liver disease: suppression of the hepatic PXR-SLC13A5/ACLY signaling axis.
Drug metabolism and disposition: the biological fate of chemicals.
2023 Sep; ?(?):. doi:
10.1124/dmd.123.001449. [PMID: 37684055] - Umidakhon Makhmudova, Beasat Samadifar, Aurel Maloku, Pellumb Haxhikadrija, Jens-Arndt Geiling, Robert Römer, Bernward Lauer, Sven Möbius-Winkler, Sylvia Otto, P Christian Schulze, Oliver Weingärtner. Intensive lipid-lowering therapy for early achievement of guideline-recommended LDL-cholesterol levels in patients with ST-elevation myocardial infarction ('Jena auf Ziel').
Clinical research in cardiology : official journal of the German Cardiac Society.
2023 Sep; 112(9):1212-1219. doi:
10.1007/s00392-022-02147-3. [PMID: 36602598] - Freddy Duarte Lau, Robert P Giugliano. Adenosine Triphosphate Citrate Lyase and Fatty Acid Synthesis Inhibition: A Narrative Review.
JAMA cardiology.
2023 09; 8(9):879-887. doi:
10.1001/jamacardio.2023.2402. [PMID: 37585218] - Sheila A Doggrell. Bempedoic acid as treatment for subjects at cardiovascular risk who are statin-intolerant.
Expert opinion on pharmacotherapy.
2023 Sep; 24(15):1673-1677. doi:
10.1080/14656566.2023.2242259. [PMID: 37496276] - Jong Kun Park, Noah Balarbar, Anandita Agarwala. Bempedoic Acid: A Contemporary Review of Its Pharmacology, Efficacy, and Safety Profile, Including Recent Data from the CLEAR Outcomes Clinical Trial.
Current cardiology reports.
2023 09; 25(9):969-978. doi:
10.1007/s11886-023-01911-9. [PMID: 37405598] - Michael D Shapiro, Pam R Taub, Michael J Louie, Lei Lei, Christie M Ballantyne. Efficacy and safety of bempedoic acid in patients with and without metabolic syndrome: Pooled analysis of data from four phase 3 clinical trials.
Atherosclerosis.
2023 08; 378(?):117182. doi:
10.1016/j.atherosclerosis.2023.06.973. [PMID: 37517922] - Li'ao Zhang, Wenjun Hu, Zhixia Qiu, Zhiyu Li, Jinlei Bian. Opportunities and Challenges for Inhibitors Targeting Citrate Transport and Metabolism in Drug Discovery.
Journal of medicinal chemistry.
2023 07; 66(14):9229-9250. doi:
10.1021/acs.jmedchem.3c00179. [PMID: 37428122] - Daniel Tobias Michaeli, Julia Caroline Michaeli, Sebastian Albers, Tobias Boch, Thomas Michaeli. Established and Emerging Lipid-Lowering Drugs for Primary and Secondary Cardiovascular Prevention.
American journal of cardiovascular drugs : drugs, devices, and other interventions.
2023 Jul; ?(?):. doi:
10.1007/s40256-023-00594-5. [PMID: 37486464] - Hermann Toplak, Aikaterini Bilitou, Hannes Alber, Johann Auer, Martin Clodi, Christoph Ebenbichler, Evelyn Fließer-Görzer, Carmen Gelsinger, Ursula Hanusch, Bernhard Ludvik, Thomas Maca, Andreas Schober, Reinhard Sock, Walter S Speidl, Thomas M Stulnig, Raimund Weitgasser, Andreas Zirlik, Marina Koch, Sebastian Wienerroither, Sorrel E Wolowacz, Françoise Diamand, Alberico L Catapano. Simulation of bempedoic acid and ezetimibe in the lipid-lowering treatment pathway in Austria using the contemporary SANTORINI cohort of high and very high risk patients.
Wiener klinische Wochenschrift.
2023 Jul; 135(13-14):364-374. doi:
10.1007/s00508-023-02221-4. [PMID: 37286910] - Maciej Banach, Peter E Penson, Michel Farnier, Zlatko Fras, Gustavs Latkovskis, Ulrich Laufs, Francesco Paneni, Paolo Parini, Matteo Pirro, Željko Reiner, Michal Vrablik, Carlos Escobar. Bempedoic acid in the management of lipid disorders and cardiovascular risk. 2023 position paper of the International Lipid Expert Panel (ILEP).
Progress in cardiovascular diseases.
2023 Mar; ?(?):. doi:
10.1016/j.pcad.2023.03.001. [PMID: 36889490] - Paul M Ridker, Lei Lei, Kausik K Ray, Christie M Ballantyne, Gary Bradwin, Nader Rifai. Effects of bempedoic acid on CRP, IL-6, fibrinogen and lipoprotein(a) in patients with residual inflammatory risk: A secondary analysis of the CLEAR harmony trial.
Journal of clinical lipidology.
2023 Feb; ?(?):. doi:
10.1016/j.jacl.2023.02.002. [PMID: 36813656] - Salil Deo, Peter Ueda, Adil Muhammad Sheikh, Salah Altarabsheh, Yakov Elgudin, Joseph Rubelowsky, Brian Cmolik, Neil Hawkins, David McAllister, Marc Ruel, Naveed Sattar, Jill Pell. Lipid Lowering in 'Very High Risk' Patients Undergoing Coronary Artery Bypass Surgery and Its Projected Reduction in Risk for Recurrent Vascular Events: A Monte Carlo Stepwise Simulation Approach.
Journal of cardiovascular pharmacology.
2023 02; 81(2):120-128. doi:
10.1097/fjc.0000000000001374. [PMID: 36315474] - Giuseppe Patti, Ilaria Cavallari, Arturo Cesaro, Felice Gragnano, Letizia Riva, Fabio Fimiani, Claudio Cuccia, Claudio Fresco, Paolo Calabrò, Sergio Leonardi, Rossella Marcucci, Andrea Rubboli. Use of bempedoic acid for LDL cholesterol lowering and cardiovascular risk reduction: a consensus document from the Italian study group on atherosclerosis, thrombosis and vascular biology.
Vascular pharmacology.
2023 02; 148(?):107137. doi:
10.1016/j.vph.2022.107137. [PMID: 36464086] - Tamás G Gergely, Gábor B Brenner, Regina N Nagy, Nabil V Sayour, András Makkos, Csenger Kovácsházi, Huimin Tian, Rainer Schulz, Zoltán Giricz, Anikó Görbe, Péter Ferdinandy. Effects of Bempedoic Acid in Acute Myocardial Infarction in Rats: No Cardioprotection and No Hidden Cardiotoxicity.
International journal of molecular sciences.
2023 Jan; 24(2):. doi:
10.3390/ijms24021585. [PMID: 36675100] - Toufik Abdul-Rahman, Syed Muhammad Awais Bukhari, Emiliano Cantu Herrera, Wireko Andrew Awuah, Jannel Lawrence, Heloisa de Andrade, Neal Patel, Rohan Shah, Raheel Shaikh, Camilo Andrés Avendaño Capriles, Sebahat Ulusan, Shahzaib Ahmad, Anna Chiara Corriero, Adriana C Mares, Akshay Goel, Adrija Hajra, Dhrubajyoti Bandyopadhyay, Rahul Gupta. Lipid Lowering Therapy: An Era Beyond Statins.
Current problems in cardiology.
2022 Dec; 47(12):101342. doi:
10.1016/j.cpcardiol.2022.101342. [PMID: 35918009] - Jing Gu, Robert J Sanchez, Ankita Chauhan, Sergio Fazio, Robert S Rosenson. Simulation of lipid-lowering therapy (LLT) intensification in very high-risk patients with atherosclerotic cardiovascular disease.
Journal of clinical lipidology.
2022 Nov; 16(6):901-905. doi:
10.1016/j.jacl.2022.10.001. [PMID: 36319536] - Mahmood Salim Yaseen, Nidhal Mohammed Ali. The effect of bempedoic acid an ATP-citrate lyase inhibitor on cardiovascular risk factors in rats with experimentally induced myocardial infarction and hyperlipidemia.
Cellular and molecular biology (Noisy-le-Grand, France).
2022 Sep; 68(10):94-99. doi:
10.14715/cmb/2022.68.10.15. [PMID: 37114265] - Peter P Toth, Sarah Bray, Guillermo Villa, Tamara Palagashvili, Naveed Sattar, Erik S G Stroes, Gavin M Worth. Network Meta-Analysis of Randomized Trials Evaluating the Comparative Efficacy of Lipid-Lowering Therapies Added to Maximally Tolerated Statins for the Reduction of Low-Density Lipoprotein Cholesterol.
Journal of the American Heart Association.
2022 09; 11(18):e025551. doi:
10.1161/jaha.122.025551. [PMID: 36073669] - Jichang Luo, Tianze Huang, Ran Xu, Xue Wang, Yutong Yang, Long Li, Xiao Zhang, Yinhang Zhang, Renjie Yang, Jie Wang, Hai Yang, Yan Ma, Bin Yang, Tao Wang, Liqun Jiao. Impact of conventional lipid-lowering therapy on circulating levels of PCSK9: protocol for a systematic review and meta-analysis of randomised controlled trials.
BMJ open.
2022 Sep; 12(9):e061884. doi:
10.1136/bmjopen-2022-061884. [PMID: 36691198] - Satyawan B Jadhav, Ryan L Crass, Sunny Chapel, Michael Kerschnitzki, William J Sasiela, Maurice G Emery, Benny M Amore, P Hugh R Barrett, Gerald F Watts, Alberico L Catapano. Pharmacodynamic effect of bempedoic acid and statin combinations: predictions from a dose-response model.
European heart journal. Cardiovascular pharmacotherapy.
2022 Sep; 8(6):578-586. doi:
10.1093/ehjcvp/pvab064. [PMID: 34448822] - Vimal Mehta, Raman Puri, P Barton Duell, S S Iyengar, Nathan D Wong, Jamal Yusuf, Saibal Mukhopadhyay, Akshaya Pradhan, Arumugam Muruganathan, S K Wangnoo, Dheeraj Kapoor, Ashu Rastogi, Mangesh H Tiwaskar, Kunal Mahajan, S N Narasingan, Rajeev Agarwala, Neil Bordoloi, Kumar Soumitra, Rabin Chakraborty, Sadanand Shetty, Bansi Saboo, Aziz Khan, D Prabhakar, Narendra Nath Khanna, Ashwani Mehta, Manish Bansal, Ravi Kasliwal, Rahul Mehrotra, Milan Chag, Altamesh Sheikh, Gururaj Balvantrao Sattur, P C Manoria, K K Pareek, A K Pancholia, Rashida Patanwala Melinker, Rashmi Nanda, Dinesh Kalra. Unmet Need for Further LDL-C Lowering in India despite Statin Therapy: Lipid Association of India Recommendations for the Use of Bempedoic Acid.
The Journal of the Association of Physicians of India.
2022 Sep; 70(9):11-12. doi:
10.5005/japi-11001-0099. [PMID: 36082889] - Christie M Ballantyne, Harold E Bays, Michael J Louie, Jeremy Smart, Yang Zhang, Kausik K Ray. Factors Associated With Enhanced Low-Density Lipoprotein Cholesterol Lowering With Bempedoic Acid.
Journal of the American Heart Association.
2022 08; 11(15):e024531. doi:
10.1161/jaha.121.024531. [PMID: 35916348] - Johnathon Seth Parham, Anne Carol Goldberg. Major Concepts in Treatment with Bempedoic Acid and Inclisiran that Clinicians Need To Know.
Current atherosclerosis reports.
2022 08; 24(8):619-625. doi:
10.1007/s11883-022-01036-4. [PMID: 35666408] - Christie M Ballantyne, Maciej Banach, Harold E Bays, Alberico L Catapano, Ulrich Laufs, Erik S G Stroes, Paula Robinson, Lei Lei, Kausik K Ray. Long-Term Safety and Efficacy of Bempedoic Acid in Patients With Atherosclerotic Cardiovascular Disease and/or Heterozygous Familial Hypercholesterolemia (from the CLEAR Harmony Open-Label Extension Study).
The American journal of cardiology.
2022 07; 174(?):1-11. doi:
10.1016/j.amjcard.2022.03.020. [PMID: 35483979] - Andrea Baessler, Marcus Fischer. [Novel options to maximize oral lipid lowering treatment : Role of bempedoic acid in combination treatment].
Herz.
2022 Jun; 47(3):212-219. doi:
10.1007/s00059-022-05111-z. [PMID: 35486131] - Lawrence A Leiter, Maciej Banach, Alberico L Catapano, P Barton Duell, Antonio M Gotto, Ulrich Laufs, G B John Mancini, Kausik K Ray, Jeffrey C Hanselman, Zhan Ye, Harold E Bays. Bempedoic acid in patients with type 2 diabetes mellitus, prediabetes, and normoglycaemia: A post hoc analysis of efficacy and glycaemic control using pooled data from phase 3 clinical trials.
Diabetes, obesity & metabolism.
2022 05; 24(5):868-880. doi:
10.1111/dom.14645. [PMID: 34981622] - Benny M Amore, William J Sasiela, Daniel K Ries, Perry Tresh, Maurice G Emery. Pharmacokinetics of bempedoic acid in patients with renal impairment.
Clinical and translational science.
2022 03; 15(3):789-798. doi:
10.1111/cts.13202. [PMID: 34800002] - Maurizio Averna, Claudio Bilato, Giorgio Sesti. Clinical evaluation of bempedoic acid for the treatment of hyperlipidaemia.
Nutrition, metabolism, and cardiovascular diseases : NMCD.
2022 01; 32(1):17-20. doi:
10.1016/j.numecd.2021.09.023. [PMID: 34802854] - Bruce A Warden, Bcps-Aq Cardiology, Jonathan Q Purnell, P Barton Duell, Sergio Fazio. Real-world utilization of bempedoic acid in an academic preventive cardiology practice.
Journal of clinical lipidology.
2022 Jan; 16(1):94-103. doi:
10.1016/j.jacl.2021.11.013. [PMID: 34924351] - Julius L Katzmann, Christian Becker, Aikaterini Bilitou, Ulrich Laufs. Simulation study on LDL cholesterol target attainment, treatment costs, and ASCVD events with bempedoic acid in patients at high and very-high cardiovascular risk.
PloS one.
2022; 17(10):e0276898. doi:
10.1371/journal.pone.0276898. [PMID: 36301892] - Kami R Whitney. Bempedoic acid: LDL-C lowering without adverse reactions.
JAAPA : official journal of the American Academy of Physician Assistants.
2021 Dec; 34(12):8-10. doi:
10.1097/01.jaa.0000795036.55877.c8. [PMID: 34813529] - Rebecca Linnenberger, Jessica Hoppstädter, Selina Wrublewsky, Emmanuel Ampofo, Alexandra K Kiemer. Statins and Bempedoic Acid: Different Actions of Cholesterol Inhibitors on Macrophage Activation.
International journal of molecular sciences.
2021 Nov; 22(22):. doi:
10.3390/ijms222212480. [PMID: 34830364] - Surasak Wichaiyo, Wasu Supharattanasitthi. Bempedoic Acid: A New Non-statin Drug for the Treatment of Dyslipidemia.
Clinical drug investigation.
2021 Oct; 41(10):843-851. doi:
10.1007/s40261-021-01075-w. [PMID: 34435333] - Ali M Agha, Peter H Jones, Christie M Ballantyne, Salim S Virani, Vijay Nambi. Greater than expected reduction in low-density lipoprotein-cholesterol (LDL-C) with bempedoic acid in a patient with heterozygous familial hypercholesterolemia (HeFH).
Journal of clinical lipidology.
2021 Sep; 15(5):649-652. doi:
10.1016/j.jacl.2021.07.002. [PMID: 34393074] - William Smith, Angela Cheng-Lai, James Nawarskas. Bempedoic Acid: A New Avenue for the Treatment of Dyslipidemia.
Cardiology in review.
2021 Sep; 29(5):274-280. doi:
10.1097/crd.0000000000000401. [PMID: 34132656] - Christopher Blaum, Fabian J Brunner, Alina Goßling, Friederike Kröger, Benjamin Bay, Thiess Lorenz, Annika Graef, Tanja Zeller, Renate Schnabel, Peter Clemmensen, Dirk Westermann, Stefan Blankenberg, Moritz Seiffert, Christoph Waldeyer. Target Populations and Treatment Cost for Bempedoic Acid and PCSK9 Inhibitors: A Simulation Study in a Contemporary CAD Cohort.
Clinical therapeutics.
2021 09; 43(9):1583-1600. doi:
10.1016/j.clinthera.2021.07.019. [PMID: 34462126] - Caroline Marie Wallemacq, Jenny Claire De Flines, Frédéric Daniel Mathieu. [Bempedoic acid and inclisiran : two new drugs to treat hypercholesterolemia].
Revue medicale suisse.
2021 Aug; 17(747):1411-1417. doi:
". [PMID: 34431634] - Christie M Ballantyne, Harold Bays, Alberico L Catapano, Anne Goldberg, Kausik K Ray, Joseph J Saseen. Role of Bempedoic Acid in Clinical Practice.
Cardiovascular drugs and therapy.
2021 08; 35(4):853-864. doi:
10.1007/s10557-021-07147-5. [PMID: 33818688] - Andrey V Susekov, Ludmila A Korol, Gerald F Watts. Bempedoic Acid in the Treatment of Patients with Dyslipidemias and Statin Intolerance.
Cardiovascular drugs and therapy.
2021 08; 35(4):841-852. doi:
10.1007/s10557-020-07139-x. [PMID: 33502687] - Lei Dai, Yuyue Zuo, Qiqi You, Hesong Zeng, Shiyi Cao. Efficacy and safety of bempedoic acid in patients with hypercholesterolemia: A systematic review and meta-analysis of randomized controlled trials.
European journal of preventive cardiology.
2021 07; 28(8):825-833. doi:
10.1177/2047487320930585. [PMID: 34298558] - Rai Ajit K Srivastava, Timothy R Hurley, Daniela Oniciu, Khosrow Adeli, Roger S Newton. Discovery of analogues of non-β oxidizable long-chain dicarboxylic fatty acids as dual inhibitors of fatty acids and cholesterol synthesis: Efficacy of lead compound in hyperlipidemic hamsters reveals novel mechanism.
Nutrition, metabolism, and cardiovascular diseases : NMCD.
2021 07; 31(8):2490-2506. doi:
10.1016/j.numecd.2021.05.024. [PMID: 34172319] - John T Wilkins, Donald M Lloyd-Jones. Novel Lipid-Lowering Therapies to Reduce Cardiovascular Risk.
JAMA.
2021 Jul; 326(3):266-267. doi:
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