Etamucine (BioDeep_00000178830)
human metabolite blood metabolite
代谢物信息卡片
化学式: C33H54N2O23 (846.3117214)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 90.91%
分子结构信息
SMILES: CC(=O)NC1C(C(C(OC1COCC2C(OC(C(C2O)(C)O)OCC3C(C(OC(C3O)CO)O)NC(=O)C)C(=O)O)CO)O)COC4C(C(C(C(O4)C(=O)O)O)O)O
InChI: InChI=1S/C33H54N2O23/c1-10(38)34-18-12(7-53-31-24(44)22(42)23(43)26(57-31)29(48)49)20(40)15(4-36)55-17(18)9-52-6-14-25(28(46)47)58-32(33(3,51)27(14)45)54-8-13-19(35-11(2)39)30(50)56-16(5-37)21(13)41/h12-27,30-32,36-37,40-45,50-51H,4-9H2,1-3H3,(H,34,38)(H,35,39)(H,46,47)(H,48,49)
描述信息
D055682 - Viscoelastic Substances > D055675 - Viscosupplements
D007155 - Immunologic Factors
D020011 - Protective Agents
D054327 - Lubricants
同义名列表
3 个代谢物同义名
3-{[(4-{[(6-carboxy-3,4,5-trihydroxyoxan-2-yl)oxy]methyl}-5-hydroxy-3-[(1-hydroxyethylidene)amino]-6-(hydroxymethyl)oxan-2-yl)methoxy]methyl}-6-({2,5-dihydroxy-3-[(1-hydroxyethylidene)amino]-6-(hydroxymethyl)oxan-4-yl}methoxy)-4,5-dihydroxy-5-methyloxane-2-carboxylate; 3-{[(4-{[(6-carboxy-3,4,5-trihydroxyoxan-2-yl)oxy]methyl}-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl)methoxy]methyl}-6-{[3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]methoxy}-4,5-dihydroxy-5-methyloxane-2-carboxylic acid; Etamucine
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Junrong Wang, Zhifang Wang, Lei Li, Man Wang, Jiaying Chang, Minghong Gao, Dongmei Wang, Chunxia Li. Ultra-small Janus nanoparticle-induced activation of ferroptosis for synergistic tumor immunotherapy.
Acta biomaterialia.
2024 Jun; 181(?):362-374. doi:
10.1016/j.actbio.2024.04.032
. [PMID: 38663684] - Zhigui He, Qiao Chen, Xinmei Duan, Yuan Zhong, Li Zhu, Nianlian Mou, Xu Yang, Yu Cao, Zhiqiang Han, Houhua He, Shuai Wu, Guixue Wang, Xian Qin, Kai Qu, Kun Zhang, Jie Liu, Wei Wu. Reactive oxygen species-responsive nano-platform with dual-targeting and fluorescent lipid-specific imaging capabilities for the management of atherosclerotic plaques.
Acta biomaterialia.
2024 Jun; 181(?):375-390. doi:
10.1016/j.actbio.2024.05.011
. [PMID: 38734284] - Shaojing He, Hui Li, Qianjie Zhang, Weimin Zhao, Wei Li, Chaohui Dai, Bixia Li, Jinhua Cheng, Shuang Wu, Zhongming Zhou, Jing Yang, Saijiao Li. Berberine alleviates inflammation in polycystic ovary syndrome by inhibiting hyaluronan synthase 2 expression.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155456. doi:
10.1016/j.phymed.2024.155456
. [PMID: 38537446] - Yinsheng Wu, Yong Wang, Fengyan Chen, Bingzhang Wang. Loading rutin on surfaces by the layer-by-layer assembly technique to improve the oxidation resistance and osteogenesis of titanium implants in osteoporotic rats.
Biomedical materials (Bristol, England).
2024 May; 19(4):. doi:
10.1088/1748-605x/ad4aa8
. [PMID: 38740037] - Wenzuo Luo, Xingui Zhang, Yingying Chu, Tiantian Chen, Huixuan Sun, Jiadong Liu, Guoxing Zhang, Lihong Fan, Haixing Xu, Yue Zhang, Ming Yang. Incorporation of Finasteride-Loaded Microspheres into Personalized Microneedle for Sustained Transdermal Delivery.
Langmuir : the ACS journal of surfaces and colloids.
2024 May; 40(20):10551-10560. doi:
10.1021/acs.langmuir.4c00280
. [PMID: 38710593] - Jing Li, Xiang Lu, Mengjia Weng, Yiru Wang, Jun Tang, Qian Xu, Lei Zhang, Jiaojiao Bai. Promoting tissue repair using deferoxamine nanoparticles loaded biomimetic gelatin/HA composite hydrogel.
Biomedical materials (Bristol, England).
2024 May; 19(4):. doi:
10.1088/1748-605x/ad46ba
. [PMID: 38697149] - Shengyang Zhang, Jianmo Chen, Hualiang Zhang, Songfeng Hu, Peijian Tong, Jianzeng Shen. Multiple intra-articular injections of autologous stromal vascular fractions for the treatment of multicompartmental osteoarthritis in both the tibiofemoral and patellofemoral joint: a single-blind randomized controlled study.
Postgraduate medical journal.
2024 May; 100(1184):399-406. doi:
10.1093/postmj/qgae009
. [PMID: 38311348] - Xing Yang, Chunsheng Li, Shuang Liu, Yunlong Li, Xinyu Zhang, Qiang Wang, Jin Ye, Yong Lu, Yujie Fu, Jiating Xu. Gallic acid-loaded HFZIF-8 for tumor-targeted delivery and thermal-catalytic therapy.
Nanoscale.
2024 May; 16(19):9496-9508. doi:
10.1039/d4nr01102c
. [PMID: 38651386] - Yufan Guo, Xiuru Yang, Yihong Zhang, Fazhen Luo, Juan Yang, Xupeng Zhang, Jinxia Mi, Yan Xie. Hyaluronic acid/dextran-based polymeric micelles co-delivering ursolic acid and doxorubicin to mitochondria for potentiating chemotherapy in MDR cancer.
Carbohydrate polymers.
2024 May; 332(?):121897. doi:
10.1016/j.carbpol.2024.121897
. [PMID: 38431408] - Gang Tan, Guanghui Hou, Junmin Qian, Yaping Wang, Weijun Xu, Wenjuan Luo, Xiaobing Chen, Aili Suo. Hyaluronan-decorated copper-doxorubicin-anlotinib nanoconjugate for targeted synergistic chemo/chemodynamic/antiangiogenic tritherapy against hepatocellular carcinoma.
Journal of colloid and interface science.
2024 May; 662(?):857-869. doi:
10.1016/j.jcis.2024.02.085
. [PMID: 38382370] - Chaewon Bae, Rodrigo Hernández Millares, Suhyun Ryu, Hyowon Moon, Dongwoo Kim, Gyubok Lee, Zhuomin Jiang, Min Hee Park, Kyung Hwan Kim, Woong Sub Koom, Sung-Joon Ye, Kangwon Lee. Synergistic Effect of Ferroptosis-Inducing Nanoparticles and X-Ray Irradiation Combination Therapy.
Small (Weinheim an der Bergstrasse, Germany).
2024 May; 20(19):e2310873. doi:
10.1002/smll.202310873
. [PMID: 38279618] - Krzysztof Drygalski, Romane Higos, Fatiha Merabtene, Patrycja Mojsak, Kamil Grubczak, Michal Ciborowski, Hady Razak, Karine Clément, Isabelle Dugail. Extracellular matrix hyaluronan modulates fat cell differentiation and primary cilia dynamics.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2024 May; 1869(4):159470. doi:
10.1016/j.bbalip.2024.159470
. [PMID: 38423452] - Ke Ding, Hailong Tian, Lei Li, Zhihan Wang, Shanshan Liu, Ning Ding, Edouard C Nice, Canhua Huang, Jinku Bao, Wei Gao, Zheng Shi. Drug repurposing-based nanoplatform via modulating autophagy to enhance chemo-phototherapy against colorectal cancer.
Journal of nanobiotechnology.
2024 Apr; 22(1):202. doi:
10.1186/s12951-024-02416-5
. [PMID: 38658952] - Andreia Marinho, Catarina Leal Seabra, Sofia A C Lima, Alexandre Lobo-da-Cunha, Salette Reis, Cláudia Nunes. Empowering Naringin's Anti-Inflammatory Effects through Nanoencapsulation.
International journal of molecular sciences.
2024 Apr; 25(8):. doi:
10.3390/ijms25084152
. [PMID: 38673736] - Rong Wang, Yukun Li, Zhaoxin Li, Haifeng Yao, Zhaohui Zhai. Hyaluronic acid filler-induced vascular occlusion-Three case reports and overview of prevention and treatment.
Journal of cosmetic dermatology.
2024 Apr; 23(4):1217-1223. doi:
10.1111/jocd.16147
. [PMID: 38131127] - Zhou Mingwang, Dong Zhuanli, Wei Changhao, Feng Lufang, Wang Xiaoping, Liu Haiping, J I Xing, Yang Kehu, L I Shenghua. Efficacy and safety of extracorporeal shock wave therapy combined with sodium hyaluronate in treatment of knee osteoarthritis: a systematic review and Meta-analysis.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2024 Apr; 44(2):243-250. doi:
10.19852/j.cnki.jtcm.20231226.002
. [PMID: 38504530] - Wei Li, Jie Lin, Jie Zhou, Siqi He, Anqi Wang, Yingfan Hu, Hanmei Li, Liang Zou, Ya Liu. Hyaluronic acid-functionalized DDAB/PLGA nanoparticles for improved oral delivery of magnolol in the treatment of ulcerative colitis.
International journal of pharmaceutics.
2024 Mar; 653(?):123878. doi:
10.1016/j.ijpharm.2024.123878
. [PMID: 38325622] - Hee Won Park, Wonjeong Lee, Sungjun Kim, Ashok Kumar Jangid, Jaewon Park, Chae Eun Lee, Kyobum Kim. Optimized Design of Hyaluronic Acid-Lipid Conjugate Biomaterial for Augmenting CD44 Recognition of Surface-Engineered NK Cells.
Biomacromolecules.
2024 Mar; 25(3):1959-1971. doi:
10.1021/acs.biomac.3c01373
. [PMID: 38379131] - Ning Wang, Bo Hong, Yingchun Zhao, Chuanbo Ding, Guodong Chai, Yue Wang, Jiali Yang, Lifeng Zhang, Weimin Yu, Yang Lu, Shuang Ma, Shuai Zhang, Xinglong Liu. Dopamine-grafted oxidized hyaluronic acid/gelatin/cordycepin nanofiber membranes modulate the TLR4/NF-kB signaling pathway to promote diabetic wound healing.
International journal of biological macromolecules.
2024 Mar; 262(Pt 1):130079. doi:
10.1016/j.ijbiomac.2024.130079
. [PMID: 38340939] - Soraiya Ebrahimpour-Koujan, Amir Ali Sohrabpour, Edward Giovannucci, Akram Vatannejad, Ahmad Esmaillzadeh. Effects of vitamin D supplementation on liver fibrogenic factors, vitamin D receptor and liver fibrogenic microRNAs in metabolic dysfunction-associated steatotic liver disease (MASLD) patients: an exploratory randomized clinical trial.
Nutrition journal.
2024 Feb; 23(1):24. doi:
10.1186/s12937-024-00911-x
. [PMID: 38413933] - Y R Hao, S Y Li, J Y Bao, J Y Wang, A Li, L Tian, Y Jie. [Efficacy of 0.05\% cyclosporine A combined with vitamin A palmitate in the treatment of meibomian gland dysfunction-related dry eye].
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology.
2024 Feb; 60(2):127-136. doi:
10.3760/cma.j.cn112142-20231109-00221
. [PMID: 38296318] - Noreen Halimani, Mikhail Nesterchuk, Alexandra A Tsitrina, Marat Sabirov, Irina N Andreichenko, Nataliya O Dashenkova, Elizaveta Petrova, Alexey M Kulikov, Timofei S Zatsepin, Roman A Romanov, Arsen S Mikaelyan, Yuri V Kotelevtsev. Knockdown of Hyaluronan synthase 2 suppresses liver fibrosis in mice via induction of transcriptomic changes similar to 4MU treatment.
Scientific reports.
2024 02; 14(1):2797. doi:
10.1038/s41598-024-53089-x
. [PMID: 38307876] - Yang Zhang, Huajiang Zhao, Jing Zhang. Hyaluronidase inhibitor sHA2.75 alleviates ischemia-reperfusion-induced acute kidney injury.
Cell cycle (Georgetown, Tex.).
2024 Feb; 23(3):248-261. doi:
10.1080/15384101.2024.2309019
. [PMID: 38526145] - Li Cui, Shuting Zou, Jing Liu, Huixia Lv, Hui Li, Zhenhai Zhang. Potential effects of sodium hyaluronate on constipation-predominant irritable bowel syndrome.
International immunopharmacology.
2024 Jan; 127(?):111404. doi:
10.1016/j.intimp.2023.111404
. [PMID: 38128311] - Shungo Iwamoto, Takashi Kobayashi, Hisatoshi Hanamatsu, Ikuko Yokota, Yukiko Teranishi, Akiho Iwamoto, Miyu Kitagawa, Sawako Ashida, Ayane Sakurai, Suguru Matsuo, Yuma Myokan, Aiyu Sugimoto, Ryo Ushioda, Kazuhiro Nagata, Noriko Gotoh, Kazuki Nakajima, Takashi Nishikaze, Jun-Ichi Furukawa, Naoki Itano. Tolerable glycometabolic stress boosts cancer cell resilience through altered N-glycosylation and Notch signaling activation.
Cell death & disease.
2024 01; 15(1):53. doi:
10.1038/s41419-024-06432-z
. [PMID: 38225221] - Li Cui, Yongzhi Hua, Shuting Zou, Chao Gu, Hui Li. Combination of fenchone and sodium hyaluronate ameliorated constipation-predominant irritable bowel syndrome and underlying mechanisms.
Chemical biology & drug design.
2024 Jan; 103(1):e14397. doi:
10.1111/cbdd.14397
. [PMID: 38030381] - Shiyi Zhao, Junbo Zhang, Mengyu Qiu, Yusen Hou, Xuebo Li, Guofeng Zhong, Kaijun Gou, Jingjing Li, Chen Zhang, Yan Qu, Xiao Wang. Mucoadhesive and thermosensitive Bletilla striata polysaccharide/chitosan hydrogel loaded nanoparticles for rectal drug delivery in ulcerative colitis.
International journal of biological macromolecules.
2024 Jan; 254(Pt 1):127761. doi:
10.1016/j.ijbiomac.2023.127761
. [PMID: 38287598] - Yingxue Yue, FanLi Shi, Jing Wang, Qing Ning, Zhenhai Zhang, Huixia Lv. Sulfated hyaluronic acid gel for the treatment of rheumatoid arthritis in rats.
International journal of biological macromolecules.
2024 Jan; 256(Pt 2):128537. doi:
10.1016/j.ijbiomac.2023.128537
. [PMID: 38043665] - Guanghui Li, Junle Li, Yee-Ying Lee, Chaoying Qiu, Xiaofang Zeng, Yong Wang. Pickering emulsions stabilized by chitosan-flaxseed gum-hyaluronic acid nanoparticles for controlled topical release of ferulic acid.
International journal of biological macromolecules.
2024 Jan; 255(?):128086. doi:
10.1016/j.ijbiomac.2023.128086
. [PMID: 37981278] - Jiaqi Liu, Hualei Xu, Haiyan Liang, Jiachan Zhang, Huanxiang Yuan, Dan Zhao, Changtao Wang. An antioxidative, green and safe nanofibers-based film containing pullulan, sodium hyaluronate and Ganoderma lucidum fermentation for enhanced skincare.
International journal of biological macromolecules.
2023 Dec; 253(Pt 4):127047. doi:
10.1016/j.ijbiomac.2023.127047
. [PMID: 37742895] - Shaohua Zhao, Xiaoliang Hao, Yanpeng Jian, Yigong Wang, Weijie Liu, Xinwei Shao, Jun Fan, Songshan Xu. [A dual-crosslinked injectable hydrogel derived from muscular decellularized matrix promoting myoblasts proliferation and myogenic differentiation].
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery.
2023 Dec; 37(12):1514-1522. doi:
10.7507/1002-1892.202306054
. [PMID: 38130196] - Ningzhe Wang, Kaida Zhang, Yurou Chen, Jie Hu, Yunqing Jiang, Xibo Wang, Qingfeng Ban. Tuning whey protein isolate/hyaluronic acid emulsion gel structure to enhance quercetin bioaccessibility and in vitro digestive characteristics.
Food chemistry.
2023 Dec; 429(?):136910. doi:
10.1016/j.foodchem.2023.136910
. [PMID: 37478604] - Jiayan Chen, Yimeng Chen, Guanghao Qin, Liangzhe Li, Mingze Li, Yuan Cheng, Shuting Zhuang, Zhihui Li, Qing Zhang, Yi Wu, Lanting Yang, Salissou Moutari, Jonathan E Moore, Ling Xu, Wei He, Sile Yu, Emmanuel Eric Pazo, Xingru He. A protocol for a single center, randomized, controlled trial comparing the clinical efficacy of 3\% diquafosol and 0.1\% hyaluronic acid in diabetic patients with dry eye disease.
Trials.
2023 Dec; 24(1):803. doi:
10.1186/s13063-023-07818-8
. [PMID: 38087329] - Simeng Xiao, Siying Huang, Xiaojing Yang, Yujie Lei, Mingxiang Chang, Junjie Hu, Yan Meng, Guohua Zheng, Xinyan Chen. The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery.
Drug delivery.
2023 Dec; 30(1):2162156. doi:
10.1080/10717544.2022.2162156
. [PMID: 36600637] - Nabil A Shoman, Rana M Gebreel, Mohamed A El-Nabarawi, Alshaimaa Attia. Optimization of hyaluronan-enriched cubosomes for bromfenac delivery enhancing corneal permeation: characterization, ex vivo, and in vivo evaluation.
Drug delivery.
2023 Dec; 30(1):2162162. doi:
10.1080/10717544.2022.2162162
. [PMID: 36587627] - Chunjing Guo, Wei Zhang, Qiaoyun Zhang, Yanguo Su, Xiaoya Hou, Qiang Chen, Huimin Guo, Ming Kong, Daquan Chen. Novel dual CAFs and tumour cell targeting pH and ROS dual sensitive micelles for targeting delivery of paclitaxel to liver cancer.
Artificial cells, nanomedicine, and biotechnology.
2023 Dec; 51(1):170-179. doi:
10.1080/21691401.2023.2193221
. [PMID: 37014123] - Amal M Sindi, Khaled M Hosny, Waleed Y Rizg, Fahad Y Sabei, Osama A Madkhali, Mohammed Ali Bakkari, Eman Alfayez, Hanaa Alkharobi, Samar A Alghamdi, Arwa A Banjar, Mohammed Majrashi, Mohammed Alissa. Utilization of experimental design in the formulation and optimization of hyaluronic acid-based nanoemulgel loaded with a turmeric-curry leaf oil nanoemulsion for gingivitis.
Drug delivery.
2023 Dec; 30(1):2184311. doi:
10.1080/10717544.2023.2184311
. [PMID: 36846914] - Jin Xie, Qi Huang, Huijuan Xie, Jun Liu, Shimin Tian, Ruiyi Cao, Ming Yang, Junzhi Lin, Li Han, Dingkun Zhang. Hyaluronic acid/inulin-based nanocrystals with an optimized ratio of indigo and indirubin for combined ulcerative colitis therapy via immune and intestinal flora regulation.
International journal of biological macromolecules.
2023 Dec; 252(?):126502. doi:
10.1016/j.ijbiomac.2023.126502
. [PMID: 37625742] - Mengjie Zeng, Zhiquan Wu, Jinying Liang, Aimin Gong. Efficacy and safety of Sodium hyaluronate combined with Celecoxib for Knee osteoarthritis: A systematic review and meta-analysis.
Asian journal of surgery.
2023 Nov; ?(?):. doi:
10.1016/j.asjsur.2023.11.077
. [PMID: 38008631] - Sudhir Verma, Isabel Y Moreno, Mingxia Sun, Tarsis Ferreira Gesteira, Vivien Coulson- Thomas. Age Related Changes in Hyaluronan Expression leads to Meibomian Gland Dysfunction.
Matrix biology : journal of the International Society for Matrix Biology.
2023 Nov; ?(?):. doi:
10.1016/j.matbio.2023.11.002
. [PMID: 37949327] - Mengru Yang, Ying Zhang, Zheming Hu, Haonan Xie, Wenli Tian, Zhidong Liu. Application of hyaluronic acid-based nanoparticles for cancer combination therapy.
International journal of pharmaceutics.
2023 Nov; 646(?):123459. doi:
10.1016/j.ijpharm.2023.123459
. [PMID: 37778513] - Nam Gyoung Ha, Sang Lim Kim, Seon Hwa Lee, Weon Ju Lee. A novel hydrogel-based moisturizing cream composed of hyaluronic acid for patients with xerosis: An intraindividual comparative analysis.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI).
2023 Nov; 29(11):e13499. doi:
10.1111/srt.13499
. [PMID: 38009036] - Xiaoying Zhao, Qianwei Jia, Juexiu Fu. Effectiveness of rb-bFGF Eye Drops for Post-Cataract Surgery Dry Eye and Observation of Changes in Tear Secretion and Corneal Damage in Patients.
Alternative therapies in health and medicine.
2023 Nov; 29(8):489-495. doi:
"
. [PMID: 37652420] - Baiqi Yang, Jinye Ma. Meta-analysis of the efficacy and safety of arthroscopic surgery associated with platelet-rich plasma infusion when treating knee osteoarthritis.
International journal of rheumatic diseases.
2023 Nov; 26(11):2248-2257. doi:
10.1111/1756-185x.14921
. [PMID: 37715357] - Jovânia Alves Oliveira, Marcela Iunes da Silveira, Roberta de Oliveira Alves, Fábio José Barbosa Bezerra, Guilherme José Pimentel Lopes de Oliveira, Suzane Cristina Pigossi. Effect of a gel containing green tea extract and hyaluronic acid on palate pain scores and wound healing after free gingival graft: a quasi-randomized controlled clinical trial.
Clinical oral investigations.
2023 Nov; 27(11):6735-6746. doi:
10.1007/s00784-023-05282-x
. [PMID: 37775584] - Shilong Wu, Qin Zhang, Qiyao Zhao, Yu Jiang, Xiaomeng Qu, Yifan Zhou, Tingting Zhao, Feng Cang, Yanyan Li. Cobalt-doped hollow polydopamine for oxygen generation and GSH consumption enhanced chemo-PTT combined cancer therapy.
Biomaterials advances.
2023 Nov; 154(?):213593. doi:
10.1016/j.bioadv.2023.213593
. [PMID: 37657278] - Qijiang Mao, Zhengze Huang, Yiyin Zhang, Qi Chen, Kexin Jiang, Yi Hong, Hongwei Ouyang, Yuelong Liang. A Strong Adhesive Biological Hydrogel for Colon Leakage Repair and Abdominal Adhesion Prevention.
Advanced healthcare materials.
2023 11; 12(28):e2301379. doi:
10.1002/adhm.202301379
. [PMID: 37531241] - Victor Passos Gibson, Houda Tahiri, Chun Yang, Quoc Thang Phan, Xavier Banquy, Pierre Hardy. Hyaluronan decorated layer-by-layer assembled lipid nanoparticles for miR-181a delivery in glioblastoma treatment.
Biomaterials.
2023 11; 302(?):122341. doi:
10.1016/j.biomaterials.2023.122341
. [PMID: 37778056] - Felicitas Schwörer, Marcus Trapp, Luca Silvi, Philipp Gutfreund, Roland Steitz, Reiner Dahint. Location of Polyelectrolytes in Swollen Lipid Oligobilayers.
Langmuir : the ACS journal of surfaces and colloids.
2023 10; 39(42):14958-14968. doi:
10.1021/acs.langmuir.3c01792
. [PMID: 37815275] - Ali Abusharha, E Ian Pearce, Tayyaba Afsar, Suhail Razak. Protecting Tear-Film Stability under Adverse Environmental Conditions Using a Mucomimetic with a Non-Newtonian Viscosity Agent.
Medicina (Kaunas, Lithuania).
2023 Oct; 59(10):. doi:
10.3390/medicina59101862
. [PMID: 37893580] - Xuelian Wang, Hongye Cai, Xinyu Huang, Zhuhang Lu, Luxi Zhang, Junjie Hu, Daizhi Tian, Jiyu Fu, Guizhi Zhang, Yan Meng, Guohua Zheng, Cong Chang. Formulation and evaluation of a two-stage targeted liposome coated with hyaluronic acid for improving lung cancer chemotherapy and overcoming multidrug resistance.
Journal of biomaterials science. Polymer edition.
2023 10; 34(14):1928-1951. doi:
10.1080/09205063.2023.2201815
. [PMID: 37060335] - Jianfeng Zhang, Fan Xu, Haiyue Lin, Yuxiao Ma, Yi Hu, Qifeng Meng, Peng Lin, Yu Zhang. Efficacy of fractional CO2 laser therapy combined with hyaluronic acid dressing for treating facial atrophic acne scars: a systematic review and meta-analysis of randomized controlled trials.
Lasers in medical science.
2023 Sep; 38(1):214. doi:
10.1007/s10103-023-03879-y
. [PMID: 37723352] - Qinglin Wu, Zuqing Wu, Zhifu Lu. Efficacy of acupotomy combined with sodium hyaluronate versus sodium hyaluronate alone in the treatment of knee osteoarthritis: A meta-analysis.
Medicine.
2023 Sep; 102(37):e34930. doi:
10.1097/md.0000000000034930
. [PMID: 37713816] - Qun-Fa Huang, Yan-Hong Li, Zeng-Jin Huang, Mei Jun, Wei Wang, Xiao-Li Chen, Guan-Hai Wang. Artesunate carriers induced ferroptosis to overcome biological barriers for anti-cancer.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2023 Sep; 190(?):284-293. doi:
10.1016/j.ejpb.2023.07.014
. [PMID: 37532638] - Joong Hyun Shim. Anti-aging Effect of Allium pseudojaponicum in UVA-irradiated Human Epidermal Keratinocytes.
Cellular and molecular biology (Noisy-le-Grand, France).
2023 Aug; 69(8):137-143. doi:
10.14715/cmb/2023.69.8.21
. [PMID: 37715405] - Xinyan Tao, Yuan Liu, Zhenhua Ding, Shuang Xie, Wenxiong Cao, Xiaohong Li. Injectable cell-targeting fiber rods to promote lipolysis and regulate inflammation for obesity treatment.
Biomaterials science.
2023 Aug; 11(16):5663-5673. doi:
10.1039/d3bm00619k
. [PMID: 37432672] - Ge Feng, Tong Peng, Wei-Jin Hong, You-Liang Zhang, Guo Li, Wei Zheng, Hang Wang, Sheng-Kang Luo. A Two-Center, Prospective, Randomized Controlled Trial to Evaluate the Efficacy and Safety of and Satisfaction with Different Methods of ART FILLER® UNIVERSAL Injection for Correcting Moderate to Severe Nasolabial Folds in Chinese Individuals.
Aesthetic plastic surgery.
2023 08; 47(4):1550-1559. doi:
10.1007/s00266-023-03278-2
. [PMID: 36810835] - Kunal Sarkar, Sarbashri Bank, Arindam Chatterjee, Koushik Dutta, Anwesha Das, Santanu Chakraborty, Nirvika Paul, Jit Sarkar, Sriparna De, Sudakshina Ghosh, Krishnendu Acharyya, Dipankar Chattopadhyay, Madhusudan Das. Hyaluronic acid-graphene oxide quantum dots nanoconjugate as dual purpose drug delivery and therapeutic agent in meta-inflammation.
Journal of nanobiotechnology.
2023 Aug; 21(1):246. doi:
10.1186/s12951-023-02015-w
. [PMID: 37528408] - Di Chu, Junjun Chen, Xingmei Liu, Anqi Liao, Xiaohuan Song, Yutong Li, Leilei Yang, Zheng Chen, Zhuo Yu, Jianfeng Guo. A tetramethylpyrazine-loaded hyaluronic acid-based hydrogel modulates macrophage polarization for promoting wound recovery in diabetic mice.
International journal of biological macromolecules.
2023 Aug; 245(?):125495. doi:
10.1016/j.ijbiomac.2023.125495
. [PMID: 37353128] - Xiang Luo, Sha Ao, Hongze Wu, David Julian McClements, Likun Fang, Mengyu Huang, Yanyan Zhou, Xuguang Yin, Meiyang Xi, Tao Cai, Kewu Zhu. Hyaluronic Acid Poly(glyceryl)10-Stearate Derivatives: Novel Emulsifiers for Improving the Gastrointestinal Stability and Bioaccessibility of Coenzyme Q10 Nanoemulsions.
Journal of agricultural and food chemistry.
2023 Jul; 71(29):11180-11194. doi:
10.1021/acs.jafc.3c02322
. [PMID: 37436914] - Jin-Shuai Lan, Rui-Feng Zeng, Zhe Li, Ya Wu, Li Liu, Li-Xia Chen, Yun Liu, Yi-Tian He, Tong Zhang, Yue Ding. CD44-Targeted Photoactivatable Polymeric Nanosystem with On-Demand Drug Release as a "Photoactivatable Bomb" for Combined Photodynamic Therapy-Chemotherapy of Cancer.
ACS applied materials & interfaces.
2023 Jul; 15(29):34554-34569. doi:
10.1021/acsami.3c05645
. [PMID: 37462246] - Wei Liu, Yuan-Yuan Liu, Meng-Qiu Zhang, Miao-Zhen Qin, Yuan-Yuan Yang, Bi-Wen Liu, Dong-Jian Zhang, Cui-Hua Jiang, Zhi-Qi Yin, Min Lu, Jian-Ping Shen, Jian Zhang. A comparative study of the ameliorative effects of hyaluronic acid oligosaccharides and hyaluronic acid on DSS-induced colitis in mice and research on relevant mechanisms.
Food & function.
2023 Jul; 14(14):6482-6495. doi:
10.1039/d2fo03644d
. [PMID: 37366083] - Xuan Yue, Shiyi Zhao, Mengyu Qiu, Junbo Zhang, Guofeng Zhong, Chi Huang, Xuebo Li, Chen Zhang, Yan Qu. Physical dual-network photothermal antibacterial multifunctional hydrogel adhesive for wound healing of drug-resistant bacterial infections synthesized from natural polysaccharides.
Carbohydrate polymers.
2023 Jul; 312(?):120831. doi:
10.1016/j.carbpol.2023.120831
. [PMID: 37059558] - Lin Li, Chang Liu, Jing Fu, Yan Wang, Danyang Yang, Bing Peng, Xin Liu, Xuyang Han, Yujiao Meng, Fang Feng, Xueqing Hu, Cong Qi, Yazhuo Wang, Ying Zheng, Ping Li. CD44 targeted indirubin nanocrystal-loaded hyaluronic acid hydrogel for the treatment of psoriasis.
International journal of biological macromolecules.
2023 Jul; 243(?):125239. doi:
10.1016/j.ijbiomac.2023.125239
. [PMID: 37295696] - Ying Cao, Jieren Luo, Shun Han, Zewei Li, Tianxiang Fan, Muhui Zeng, Xin Wen, Yongzheng Peng, Li Jiang, Weiyu Han, Lijun Lin, Siu Ngor Fu, David J Hunter, Changhai Ding, Lujin Li, Zhaohua Zhu. A model-based quantitative analysis of efficacy and associated factors of platelet rich plasma treatment for osteoarthritis.
International journal of surgery (London, England).
2023 06; 109(6):1742-1752. doi:
10.1097/js9.0000000000000337
. [PMID: 36999827] - Yu-Hui Zhang, Chen-Shuang Liu, Ye Tian, Jie Wang, Siqintana Xin, Xianliang Sheng. An eco-friendly photo-responsive hyaluronic acid-based supramolecular polysaccharide hybrid hydrogels for plant growth regulation and heavy metal ions adsorption.
International journal of biological macromolecules.
2023 Jun; ?(?):125194. doi:
10.1016/j.ijbiomac.2023.125194
. [PMID: 37270137] - Yan Guo, Yanglei Cheng, Hai Li, Hongyu Guan, Haipeng Xiao, Yanbing Li. The Potential of Artemisinins as Novel Treatment for Thyroid Eye Disease by Inhibiting Adipogenesis in Orbital Fibroblasts.
Investigative ophthalmology & visual science.
2023 Jun; 64(7):28. doi:
10.1167/iovs.64.7.28
. [PMID: 37326592] - Tushit Sharma, Shubham Thakur, Manjot Kaur, Amrinder Singh, Subheet Kumar Jain. Novel Hyaluronic Acid ethosomes based gel formulation for topical use with reduced toxicity, better skin permeation, deposition, and improved pharmacodynamics.
Journal of liposome research.
2023 Jun; 33(2):129-143. doi:
10.1080/08982104.2022.2087675
. [PMID: 35730480] - Chen He, YingXue Yue, Ruilong Li, Yiping Huang, Luan Shu, Huixia Lv, Jing Wang, Zhenhai Zhang. Sodium hyaluronates applied in the face affects the diversity of skin microbiota in healthy people.
International journal of cosmetic science.
2023 Jun; 45(3):373-386. doi:
10.1111/ics.12845
. [PMID: 36710533] - Hanieh Karimi, Shahram Rabbani, Delaram Babadi, Simin Dadashzadeh, Azadeh Haeri. Piperine liposome-embedded in hyaluronan hydrogel as an effective platform for prevention of postoperative peritoneal adhesion.
Journal of microencapsulation.
2023 Jun; 40(4):279-301. doi:
10.1080/02652048.2023.2194415
. [PMID: 36948888] - Kamila Bohne Japiassu, Francois Fay, Alessandro Marengo, Sebastião A Mendanha, Catherine Cailleau, Younès Louaguenouni, Qinglin Wang, Stéphanie Denis, Nicolas Tsapis, Thais Leite Nascimento, Eliana Martins Lima, Elias Fattal. Hyaluronic acid-conjugated liposomes loaded with dexamethasone: A promising approach for the treatment of inflammatory diseases.
International journal of pharmaceutics.
2023 May; 639(?):122946. doi:
10.1016/j.ijpharm.2023.122946
. [PMID: 37044230] - Sarah A Altalhi, Serag Eldin I Elbehairi, Mohammad Y Alfaifi, Fawziah A Al-Salmi, Ali A Shati, Leena S Alqahtani, Eman Fayad, Reda F M Elshaarawy, Ali M Nasr. Therapeutic potential and protection enhancement of mesenchymal stem cell against cisplatin-induced nephrotoxicity using hyaluronic acid-chitosan nanoparticles as an adjuvant.
International journal of pharmaceutics.
2023 May; ?(?):123023. doi:
10.1016/j.ijpharm.2023.123023
. [PMID: 37150270] - Chang Ni, Zijun Zhang, Yuling Wang, Zhenhai Zhang, Xueping Guo, Huixia Lv. Hyaluronic acid and HA-modified cationic liposomes for promoting skin penetration and retention.
Journal of controlled release : official journal of the Controlled Release Society.
2023 05; 357(?):432-443. doi:
10.1016/j.jconrel.2023.03.049
. [PMID: 37004799] - Gi-Beum Kim, Kwansung Seo, Jong-Ung Youn, Il Keun Kwon, Jinny Park, Kwang-Hyun Park, Jong-Suk Kim. Unsaturated Fatty Acids Complex Regulates Inflammatory Cytokine Production through the Hyaluronic Acid Pathway.
Molecules (Basel, Switzerland).
2023 Apr; 28(8):. doi:
10.3390/molecules28083554
. [PMID: 37110788] - Amira E El-Nahas, Heba M Elbedaiwy, Inas M Masoud, Rania G Aly, Maged W Helmy, Amal H El-Kamel. Berberine-loaded zein/hyaluronic acid composite nanoparticles for efficient brain uptake to alleviate neuro-degeneration in the pilocarpine model of epilepsy.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2023 Apr; ?(?):. doi:
10.1016/j.ejpb.2023.04.008
. [PMID: 37068561] - Kangdi Sun, Tooba Shoaib, Mark W Rutland, Joseph Beller, Changwoo Do, Rosa M Espinosa-Marzal. Insight into the assembly of lipid-hyaluronan complexes in osteoarthritic conditions.
Biointerphases.
2023 04; 18(2):021005. doi:
10.1116/6.0002502
. [PMID: 37041102] - Haixuan Yuan, Bowen Liu, Fulei Liu, Cong Li, Lingfei Han, Xiaoxian Huang, Jingwei Xue, Wei Qu, Jian Xu, Wenyuan Liu, Feng Feng, Lei Wang. Enhanced anti-rheumatoid arthritis activity of total alkaloids from Picrasma quassioides in collagen-induced arthritis rats by a targeted drug delivery system.
Journal of pharmaceutical sciences.
2023 Apr; ?(?):. doi:
10.1016/j.xphs.2023.03.024
. [PMID: 37023852] - Fan Xu, Minghua Li, Zujun Que, Mingliang Su, Wang Yao, Yu Zhang, Bin Luo, Yan Li, Zhanxia Zhang, Jianhui Tian. Combined chemo-immuno-photothermal therapy based on ursolic acid/astragaloside IV-loaded hyaluronic acid-modified polydopamine nanomedicine inhibiting the growth and metastasis of non-small cell lung cancer.
Journal of materials chemistry. B.
2023 Apr; ?(?):. doi:
10.1039/d2tb02328h
. [PMID: 37009696] - Kai Wu, Wei Zhang, Hao Chen, Jie Wu, Xiaotong Wang, Xinjian Yang, Xing-Jie Liang, Jinchao Zhang, Dandan Liu. An iron oxyhydroxide-based nanosystem sensitizes ferroptosis by a 'Three-Pronged' strategy in breast cancer stem cells.
Acta biomaterialia.
2023 04; 160(?):281-296. doi:
10.1016/j.actbio.2023.02.015
. [PMID: 36822484] - Dan Jiang, Xiaoyang Xia, Zhixiong He, Yanan Xue, Xia Xiang. Hyaluronic acid-functionalized redox-responsive organosilica nanoparticles for targeted resveratrol delivery to attenuate acrylamide-induced toxicity.
International journal of biological macromolecules.
2023 Mar; 232(?):123463. doi:
10.1016/j.ijbiomac.2023.123463
. [PMID: 36716846] - Toan V Phan, Yamin Oo, Teerapat Rodboon, Truc T Nguyen, Ladawan Sariya, Risa Chaisuparat, Waranyoo Phoolcharoen, Supansa Yodmuang, Joao N Ferreira. Plant molecular farming-derived epidermal growth factor revolutionizes hydrogels for improving glandular epithelial organoid biofabrication.
SLAS technology.
2023 Mar; ?(?):. doi:
10.1016/j.slast.2023.03.002
. [PMID: 36966988] - Li Li, Xiaoju Shen, Xiaoxiang Mo, Zhiquan Chen, Fei Yu, Xiaocheng Mo, Jinjing Song, Guolin Huang, Kai Liang, Zhuo Luo, Naiquan Mao, Jie Yang. CEMIP-mediated hyaluronan metabolism facilitates SCLC metastasis by activating TLR2/c-Src/ERK1/2 axis.
Biochimica et biophysica acta. Molecular cell research.
2023 Mar; 1870(5):119451. doi:
10.1016/j.bbamcr.2023.119451
. [PMID: 36931608] - Sadhana Raut, Nupur Gargate, Sharddha Ugale, K N Gujar, Harshad Kapare. Formulation and Development of Hyaluronic Acid based gel with Ketoconazole -Loaded Nanostructured Lipid Carriers in Fungal Infection.
Pharmaceutical nanotechnology.
2023 Mar; ?(?):. doi:
10.2174/2211738511666230310103017
. [PMID: 36896905] - Ahmet Alp Bilgic, Huri Sabur, Mutlu Acar, Filiz Canpolat. Effects of lipid-containing eye drops on the ocular surface and in vivo confocal microscopy findings in patients using systemic isotretinoin.
Cutaneous and ocular toxicology.
2023 Mar; 42(1):25-31. doi:
10.1080/15569527.2023.2166523
. [PMID: 36635986] - Yiqin Zhou, Haobo Li, Shiqi Cao, Yaguang Han, Jiahua Shao, Qiwei Fu, Bo Wang, Jun Wu, Dong Xiang, Ziye Liu, Huang Wang, Jun Zhu, Qirong Qian, Xiaolei Yang, Song Wang. Clinical Efficacy of Intra-Articular Injection with P-PRP Versus that of L-PRP in Treating Knee Cartilage Lesion: A Randomized Controlled Trial.
Orthopaedic surgery.
2023 Mar; 15(3):740-749. doi:
10.1111/os.13643
. [PMID: 36647244] - Li-Hua Yan, Yu-Jie Zhang, Hai-Jie Hu, Chuan Zhang, Yue Wang, Xue-Tian Xu, Tong-Cun Zhang, Rui Su, Xue-Gang Luo. Enhanced Transdermal Absorption of Hyaluronic Acid via Fusion with Pep-1 and a Hyaluronic Acid Binding Peptide.
Macromolecular bioscience.
2023 03; 23(3):e2200173. doi:
10.1002/mabi.202200173
. [PMID: 36448643] - Ningzhe Wang, Jianjun Cheng, Yunqing Jiang, Yao Meng, Kaida Zhang, Qingfeng Ban, Xibo Wang. Emulsions stabilised by casein and hyaluronic acid: Effects of high intensity ultrasound on the stability and vitamin E digestive characteristics.
Ultrasonics sonochemistry.
2023 Mar; 94(?):106314. doi:
10.1016/j.ultsonch.2023.106314
. [PMID: 36724648] - Dong Dong, Zihao Cheng, Tongyao Wang, Xingyu Wu, Chang Ding, Yong Chen, Huayu Xiong, Jichao Liang. Acid-degradable nanocomposite hydrogel and glucose oxidase combination for killing bacterial with photothermal augmented chemodynamic therapy.
International journal of biological macromolecules.
2023 Feb; ?(?):123745. doi:
10.1016/j.ijbiomac.2023.123745
. [PMID: 36806779] - Roger Mariné-Casadó, Joan Teichenné, Yaiza Tobajas, Antoni Caimari, Agustí Villar, Andrea Zangara, Anna Mulà, Josep Maria Del Bas. Pomegranate natural extract Pomanox® positively modulates skin health-related parameters in normal and UV-induced photoaging conditions in Hs68 human fibroblast cells.
International journal of food sciences and nutrition.
2023 Feb; 74(1):51-63. doi:
10.1080/09637486.2022.2152189
. [PMID: 36457282] - Xiaofeng Ding, Shiyan Li, Meng Tian, Ping Yang, Youjun Ding, Yiwei Wang, Guomei Duan, Daihui Zhang, Bin Chen, Qian Tan. Facile preparation of a novel nanoemulsion based hyaluronic acid hydrogel loading with Poria cocos triterpenoids extract for wound dressing.
International journal of biological macromolecules.
2023 Jan; 226(?):1490-1499. doi:
10.1016/j.ijbiomac.2022.11.261
. [PMID: 36442559] - Felipe Silva de França, Denise V Tambourgi. Hyaluronan breakdown by snake venom hyaluronidases: From toxins delivery to immunopathology.
Frontiers in immunology.
2023; 14(?):1125899. doi:
10.3389/fimmu.2023.1125899
. [PMID: 37006255] - S N Sakhnov, S V Yanchenko, A V Malyshev, G Yu Karapetov, T G Katkhanov, L M Petrosyan, O A Baskakov, Yu A Dobronosova, G L Kolomiets, T I Lepa, E E Lysov, A R Tseeva. [Therapeutic hygiene of eyelids in dry eye disease prior to cataract phacoemulsification].
Vestnik oftalmologii.
2023; 139(1):46-54. doi:
10.17116/oftalma202313901146
. [PMID: 36924514] - Li Shao, Sujing Jiang, Yan Li, Ling Yu, Hui Liu, Laiji Ma, Suzhen Yang. Aqueous extract of Cordyceps cicadae (Miq.) promotes hyaluronan synthesis in human skin fibroblasts: A potential moisturizing and anti-aging ingredient.
PloS one.
2023; 18(7):e0274479. doi:
10.1371/journal.pone.0274479
. [PMID: 37418356] - Wantong Zhao, Lin Ma, Changxiu Lin, Jingshu Piao, Mingguan Piao. Intestinal transport mechanism of HA-LOR microspheres with different molecular weights in the MDCK cell model.
Pakistan journal of pharmaceutical sciences.
2023 Jan; 36(1):171-180. doi:
"
. [PMID: 36967509] - Xiaojia Liu, Caiyan Lin, Wenfei Zhong, Zhongwen Yuan, Pengke Yan, Shixia Guan. Effective Attenuation of Arteriosclerosis Following Lymphatic-Targeted Delivery of Hyaluronic Acid-Decorated Rapamycin Liposomes.
International journal of nanomedicine.
2023; 18(?):4403-4419. doi:
10.2147/ijn.s410653
. [PMID: 37551276] - Chavee Laomeephol, Sudartip Areecheewakul, Supannikar Tawinwung, Koramit Suppipat, Preedakorn Chunhacha, Nuno M Neves, Jittima Amie Luckanagul. Potential roles of hyaluronic acid in in vivo CAR T cell reprogramming for cancer immunotherapy.
Nanoscale.
2022 Dec; 14(48):17821-17840. doi:
10.1039/d2nr05949e
. [PMID: 36472072] - Arindam Pramanik, Zexi Xu, Nicola Ingram, Patricia Louise Coletta, Paul A Millner, Arwen I I Tyler, Thomas A Hughes. Hyaluronic-Acid-Tagged Cubosomes Deliver Cytotoxics Specifically to CD44-Positive Cancer Cells.
Molecular pharmaceutics.
2022 12; 19(12):4601-4611. doi:
10.1021/acs.molpharmaceut.2c00439
. [PMID: 35938983] - Tommaso Cai, Luca Gallelli, Erika Cione, Paolo Verze, Alessandro Palmieri, Vincenzo Mirone, Gernot Bonkat, Florian M Wagenlehner, Truls E Bjerklund Johansen. The efficacy and tolerability of pollen extract in combination with hyaluronic acid and vitamins in the management of patients affected by chronic prostatitis/chronic pelvic pain syndrome: a 26 weeks, randomized, controlled, single-blinded, phase III study.
Minerva urology and nephrology.
2022 Dec; 74(6):780-788. doi:
10.23736/s2724-6051.21.04141-2
. [PMID: 33781014] - Ali Ozcan, Mustafa Germec, Irfan Turhan. Optimization and kinetic modeling of media composition for hyaluronic acid production from carob extract with Streptococcus zooepidemicus.
Bioprocess and biosystems engineering.
2022 Dec; 45(12):2019-2029. doi:
10.1007/s00449-022-02806-9
. [PMID: 36329267]