Emapunil (BioDeep_00000178674)
human metabolite blood metabolite
代谢物信息卡片
化学式: C23H23N5O2 (401.1852)
中文名称: 依马普尼
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: CCN(CC1=CC=CC=C1)C(=O)CN1C(=O)N(C)C2=CN=C(N=C12)C1=CC=CC=C1
InChI: InChI=1S/C23H23N5O2/c1-3-27(15-17-10-6-4-7-11-17)20(29)16-28-22-19(26(2)23(28)30)14-24-21(25-22)18-12-8-5-9-13-18/h4-14H,3,15-16H2,1-2H3
描述信息
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- PubChem: 6433109
- HMDB: HMDB0251766
- DrugBank: DB12666
- ChEMBL: CHEMBL513922
- Wikipedia: Emapunil
- chemspider: 4938297
- CAS: 226954-04-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Gabrielle K Crombie, Hannah K Palliser, Julia C Shaw, Deborah M Hodgson, David W Walker, Jonathan J Hirst. Neurosteroid-based intervention using Ganaxolone and Emapunil for improving stress-induced myelination deficits and neurobehavioural disorders.
Psychoneuroendocrinology.
2021 11; 133(?):105423. doi:
10.1016/j.psyneuen.2021.105423. [PMID: 34601389] - Sujata Sridharan, Joel Raffel, Ashwini Nandoskar, Chris Record, David J Brooks, David Owen, David Sharp, Paolo A Muraro, Roger Gunn, Richard Nicholas. Confirmation of Specific Binding of the 18-kDa Translocator Protein (TSPO) Radioligand [18F]GE-180: a Blocking Study Using XBD173 in Multiple Sclerosis Normal Appearing White and Grey Matter.
Molecular imaging and biology.
2019 10; 21(5):935-944. doi:
10.1007/s11307-019-01323-8. [PMID: 30796709] - Kristin Mages, Felix Grassmann, Herbert Jägle, Rainer Rupprecht, Bernhard H F Weber, Stefanie M Hauck, Antje Grosche. The agonistic TSPO ligand XBD173 attenuates the glial response thereby protecting inner retinal neurons in a murine model of retinal ischemia.
Journal of neuroinflammation.
2019 Feb; 16(1):43. doi:
10.1186/s12974-019-1424-5. [PMID: 30777091] - Géraldine Leva, Christian Klein, Jérémie Benyounes, François Hallé, Frédéric Bihel, Nicolas Collongues, Jérôme De Seze, Ayikoe-Guy Mensah-Nyagan, Christine Patte-Mensah. The translocator protein ligand XBD173 improves clinical symptoms and neuropathological markers in the SJL/J mouse model of multiple sclerosis.
Biochimica et biophysica acta. Molecular basis of disease.
2017 12; 1863(12):3016-3027. doi:
10.1016/j.bbadis.2017.09.007. [PMID: 28899788] - Lincoln Biswas, Xinzhi Zhou, Baljean Dhillon, Annette Graham, Xinhua Shu. Retinal pigment epithelium cholesterol efflux mediated by the 18 kDa translocator protein, TSPO, a potential target for treating age-related macular degeneration.
Human molecular genetics.
2017 11; 26(22):4327-4339. doi:
10.1093/hmg/ddx319. [PMID: 28973423] - Renee Sokias, Eryn L Werry, Sook W Chua, Tristan A Reekie, Lenka Munoz, Erick C N Wong, Lars M Ittner, Michael Kassiou. Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination.
MedChemComm.
2017 Jan; 8(1):202-210. doi:
10.1039/c6md00523c. [PMID: 30108706] - Zhi-Kun Qiu, Jia-Li He, Xu Liu, Guan-Hua Zhang, Jia Zeng, Hong Nie, Yong-Gang Shen, Ji-Sheng Chen. The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus.
Scientific reports.
2016 11; 6(?):37345. doi:
10.1038/srep37345. [PMID: 27886206] - Barbara Costa, Eleonora Da Pozzo, Chiara Cavallini, Sabrina Taliani, Federico Da Settimo, Claudia Martini. Long Residence Time at the Neurosteroidogenic 18 kDa Translocator Protein Characterizes the Anxiolytic Ligand XBD173.
ACS chemical neuroscience.
2016 08; 7(8):1041-6. doi:
10.1021/acschemneuro.6b00149. [PMID: 27385308] - Li-Ming Zhang, Zhi-Kun Qiu, Xiao-Fei Chen, Nan Zhao, Hong-Xia Chen, Rui- Xue, You-Zhi Zhang, Ri-Fang Yang, Yun-Feng Li. Involvement of allopregnanolone in the anti-PTSD-like effects of AC-5216.
Journal of psychopharmacology (Oxford, England).
2016 05; 30(5):474-81. doi:
10.1177/0269881115625115. [PMID: 26783231] - Katsushi Kumata, Joji Yui, Akiko Hatori, Masayuki Fujinaga, Kazuhiko Yanamoto, Tomoteru Yamasaki, Kazunori Kawamura, Hidekatsu Wakizaka, Nobuki Nengaki, Yuichiro Yoshida, Masanao Ogawa, Toshimitsu Fukumura, Ming-Rong Zhang. Synthesis and evaluation of novel carbon-11 labeled oxopurine analogues for positron emission tomography imaging of translocator protein (18 kDa) in peripheral organs.
Journal of medicinal chemistry.
2011 Sep; 54(17):6040-9. doi:
10.1021/jm200516a. [PMID: 21790126] - Ryuji Nakao, Takehito Ito, Kazutaka Hayashi, Toshimitsu Fukumura, Kazutoshi Suzuki. Ultrafast LC method for purification and metabolite analysis of PET probes.
Nuclear medicine and biology.
2010 Jan; 37(1):67-72. doi:
10.1016/j.nucmedbio.2009.08.002. [PMID: 20122670] - Kazuhiko Yanamoto, Tomoteru Yamasaki, Katsushi Kumata, Joji Yui, Chika Odawara, Kazunori Kawamura, Akiko Hatori, Osamu Inoue, Masatoshi Yamaguchi, Kazutoshi Suzuki, Ming-Rong Zhang. Evaluation of N-benzyl-N-[11C]methyl-2- (7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ([11C]DAC) as a novel translocator protein (18 kDa) radioligand in kainic acid-lesioned rat.
Synapse (New York, N.Y.).
2009 Nov; 63(11):961-71. doi:
10.1002/syn.20678. [PMID: 19593823] - Ming-Rong Zhang, Katsushi Kumata, Jun Maeda, Kazuhiko Yanamoto, Akiko Hatori, Maki Okada, Makoto Higuchi, Shigeru Obayashi, Tetsuya Suhara, Kazutoshi Suzuki. 11C-AC-5216: a novel PET ligand for peripheral benzodiazepine receptors in the primate brain.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2007 Nov; 48(11):1853-61. doi:
10.2967/jnumed.107.043505. [PMID: 17978354] - Misato Amitani, Ming-Rong Zhang, Junko Noguchi, Katsushi Kumata, Takehito Ito, Nobuhiko Takai, Kazutoshi Suzuki, Rie Hosoi, Osamu Inoue. Blood flow dependence of the intratumoral distribution of peripheral benzodiazepine receptor binding in intact mouse fibrosarcoma.
Nuclear medicine and biology.
2006 Nov; 33(8):971-5. doi:
10.1016/j.nucmedbio.2006.08.004. [PMID: 17127169]
