Ellagitannin (BioDeep_00000178661)
human metabolite blood metabolite
代谢物信息卡片
2,3,14,15,16,19,20,21,36,37-decahydroxy-6,11,24,32,35-pentaoxo-36-(2-oxopropyl)-7,10,25,28,31,40-hexaoxaoctacyclo[35.2.1.0^{5,39}.0^{8,27}.0^{9,30}.0^{12,17}.0^{18,23}.0^{33,38}]tetraconta-1(39),2,4,12,14,16,18,20,22,33-decaen-29-yl 3,4,5-trihydroxybenzoate
化学式: C44H32O27 (992.1130922)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)CC1(C(=O)C=C2C3C1(OC4=C3C(=CC(=C4O)O)C(=O)OC5C6COC(=O)C7=CC(=C(C(=C7C8=C(C(=C(C=C8C(=O)OC5C(C(O6)OC(=O)C9=CC(=C(C(=C9)O)O)O)OC2=O)O)O)O)O)O)O)O)O
InChI: InChI=1S/C44H32O27/c1-10(45)8-43(63)22(51)7-15-26-25-14(6-20(50)30(55)34(25)71-44(26,43)64)40(61)67-33-21-9-65-38(59)12-4-18(48)28(53)31(56)23(12)24-13(5-19(49)29(54)32(24)57)39(60)68-35(33)36(69-41(15)62)42(66-21)70-37(58)11-2-16(46)27(52)17(47)3-11/h2-7,21,26,33,35-36,42,46-50,52-57,63-64H,8-9H2,1H3
描述信息
同义名列表
3 个代谢物同义名
2,3,14,15,16,19,20,21,36,37-decahydroxy-6,11,24,32,35-pentaoxo-36-(2-oxopropyl)-7,10,25,28,31,40-hexaoxaoctacyclo[35.2.1.0^{5,39}.0^{8,27}.0^{9,30}.0^{12,17}.0^{18,23}.0^{33,38}]tetraconta-1(39),2,4,12,14,16,18,20,22,33-decaen-29-yl 3,4,5-trihydroxybenzoate; [2,3,14,15,16,19,20,21,36,37-Decahydroxy-6,11,24,32,35-pentaoxo-36-(2-oxopropyl)-7,10,25,28,31,40-hexaoxaoctacyclo[35.2.1.05,39.08,27.09,30.012,17.018,23.033,38]tetraconta-1(39),2,4,12,14,16,18,20,22,33-decaen-29-yl] 3,4,5-trihydroxybenzoate; Ellagitannin
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Stefano Piazza, Giulia Martinelli, Nicole Maranta, Carola Pozzoli, Marco Fumagalli, Vincenzo Nicolaci, Elisa Sonzogni, Luca Colombo, Enrico Sangiovanni, Mario Dell'Agli. Investigation into the Anti-Acne Effects of Castanea sativa Mill Leaf and Its Pure Ellagitannin Castalagin in HaCaT Cells Infected with Cutibacterium acnes.
International journal of molecular sciences.
2024 Apr; 25(9):. doi:
10.3390/ijms25094764. [PMID: 38731983] - Gopalsamy Rajiv Gandhi, Poovathumkal James Antony, Stanislaus Antony Ceasar, Alan Bruno Silva Vasconcelos, Monalisa Martins Montalvão, Mariana Nobre Farias de Franca, Ayane de Sá Resende, Chelankara Suresh Sharanya, Yi Liu, Govindasamy Hariharan, Ren-You Gan. Health functions and related molecular mechanisms of ellagitannin-derived urolithins.
Critical reviews in food science and nutrition.
2024; 64(2):280-310. doi:
10.1080/10408398.2022.2106179. [PMID: 35959701] - Yunyun Tan, Shuming Tan, Tingyuan Ren, Lu Yu, Pei Li, Guofang Xie, Chao Chen, Meng Yuan, Qing Xu, Zhen Chen. Transcriptomics Reveals the Mechanism of Rosa roxburghii Tratt Ellagitannin in Improving Hepatic Lipid Metabolism Disorder in db/db Mice.
Nutrients.
2023 Sep; 15(19):. doi:
10.3390/nu15194187. [PMID: 37836471] - Mohamed A A Orabi, Esam A Orabi, El-Shaymaa Abdel-Sattar, Ann M English, Tsutomu Hatano, Hanan Elimam. Structural determination and anticholinesterase assay of C-glycosidic ellagitannins from Lawsonia inermis leaves: A study supported by DFT calculations and molecular docking.
Fitoterapia.
2023 Jan; 164(?):105360. doi:
10.1016/j.fitote.2022.105360. [PMID: 36423882] - Keiichiro Sugimoto, Midori Amako, Hiroaki Takeuchi, Kazuya Nakagawa, Morio Yoshimura, Yoshiaki Amakura, Tomoyuki Fujita, Shigeo Takenaka, Hiroshi Inui. Oenothein B in Eucalyptus Leaf Extract Suppresses Fructose Absorption in Caco-2 Cells.
Molecules (Basel, Switzerland).
2021 Dec; 27(1):. doi:
10.3390/molecules27010122. [PMID: 35011353] - Ines Castangia, Maria Letizia Manca, Mohamad Allaw, Jarkko Hellström, Daniel Granato, Maria Manconi. Jabuticaba (Myrciaria jaboticaba) Peel as a Sustainable Source of Anthocyanins and Ellagitannins Delivered by Phospholipid Vesicles for Alleviating Oxidative Stress in Human Keratinocytes.
Molecules (Basel, Switzerland).
2021 Nov; 26(21):. doi:
10.3390/molecules26216697. [PMID: 34771107] - Mohamed A A Orabi, Hiroshi Sakagami, Naoki Umemura, Hamad S Alyami, Tsutomu Hatano. Two new C-glycosidic ellagitannins and accompanying tannins from Lawsonia inermis leaves and their cytotoxic effects.
Fitoterapia.
2021 Sep; 153(?):104925. doi:
10.1016/j.fitote.2021.104925. [PMID: 33984438] - Juri Takayoshi, Yong-Lin Huang, Yosuke Matsuo, Yoshinori Saito, Dian-Peng Li, Takashi Tanaka. Ellagitannin Digestion in Moth Larvae and a New Dimeric Ellagitannin from the Leaves of Platycarya strobilacea.
Molecules (Basel, Switzerland).
2021 Jul; 26(14):. doi:
10.3390/molecules26144134. [PMID: 34299409] - Ewa Żary-Sikorska, Bartosz Fotschki, Krzysztof Kołodziejczyk, Adam Jurgoński, Monika Kosmala, Joanna Milala, Michał Majewski, Katarzyna Ognik, Jerzy Juśkiewicz. Strawberry phenolic extracts effectively mitigated metabolic disturbances associated with high-fat ingestion in rats depending on the ellagitannin polymerization degree.
Food & function.
2021 Jul; 12(13):5779-5792. doi:
10.1039/d1fo00894c. [PMID: 34038498] - Shinji Yoshikawa, Lih-Geeng Chen, Morio Yoshimura, Yoshiaki Amakura, Tsutomu Hatano, Shoko Taniguchi. Barricyclin D1-a dimeric ellagitannin with a macrocyclic structure-and accompanying tannins from Barringtonia racemosa.
Bioscience, biotechnology, and biochemistry.
2021 Jun; 85(7):1609-1620. doi:
10.1093/bbb/zbab073. [PMID: 33890626] - Deming Looi, Boon H Goh, Shafi U Khan, Nafees Ahemad, Uma D Palanisamy. Metabolites of the ellagitannin, geraniin inhibit human ACE; in vitro and in silico evidence.
International journal of food sciences and nutrition.
2021 Jun; 72(4):470-477. doi:
10.1080/09637486.2020.1830263. [PMID: 33032478] - Valtteri Virtanen, Susanna Räikkönen, Elina Puljula, Maarit Karonen. Ellagitannin-Lipid Interaction by HR-MAS NMR Spectroscopy.
Molecules (Basel, Switzerland).
2021 Jan; 26(2):. doi:
10.3390/molecules26020373. [PMID: 33445813] - Ewa Żary-Sikorska, Bartosz Fotschki, Adam Jurgoński, Monika Kosmala, Joanna Milala, Krzysztof Kołodziejczyk, Michał Majewski, Katarzyna Ognik, Jerzy Juśkiewicz. Protective Effects of a Strawberry Ellagitannin-Rich Extract against Pro-Oxidative and Pro-Inflammatory Dysfunctions Induced by a High-Fat Diet in a Rat Model.
Molecules (Basel, Switzerland).
2020 Dec; 25(24):. doi:
10.3390/molecules25245874. [PMID: 33322602] - Asiri Perera, So Ha Ton, Mohanambal Moorthy, Uma Devi Palanisamy. The insulin-sensitising properties of the ellagitannin geraniin and its metabolites from Nephelium lappaceum rind in 3T3-L1 cells.
International journal of food sciences and nutrition.
2020 Dec; 71(8):940-953. doi:
10.1080/09637486.2020.1754348. [PMID: 32319838] - Dominika Przybylska, Alicja Z Kucharska, Iwona Cybulska, Tomasz Sozański, Narcyz Piórecki, Izabela Fecka. Cornus mas L. Stones: A Valuable By-Product as an Ellagitannin Source with High Antioxidant Potential.
Molecules (Basel, Switzerland).
2020 Oct; 25(20):. doi:
10.3390/molecules25204646. [PMID: 33053845] - Eman Al-Sayed, Michal Korinek, Ahmed Esmat, Guan-Yu Chen, Yuan-Bin Cheng, Pei-Wen Hsieh, Bing-Hung Chen, Tsong-Long Hwang. Anti-inflammatory, hepatoprotective and antioxidant activity of ellagitannin isolated from Melaleuca styphelioides.
Phytochemistry.
2020 Sep; 177(?):112429. doi:
10.1016/j.phytochem.2020.112429. [PMID: 32559488] - Michał Majewski, Ewa Kucharczyk, Roman Kaliszan, Michał Markuszewski, Bartosz Fotschki, Jerzy Juśkiewicz, Małgorzata Borkowska-Sztachańska, Katarzyna Ognik. The Characterization of Ground Raspberry Seeds and the Physiological Response to Supplementation in Hypertensive and Normotensive Rats.
Nutrients.
2020 Jun; 12(6):. doi:
10.3390/nu12061630. [PMID: 32492905] - Kristen M Roberts, Elizabeth M Grainger, Jennifer M Thomas-Ahner, Alice Hinton, Junnan Gu, Ken Riedl, Yael Vodovotz, Ronney Abaza, Steven J Schwartz, Steven K Clinton. Dose-Dependent Increases in Ellagitannin Metabolites as Biomarkers of Intake in Humans Consuming Standardized Black Raspberry Food Products Designed for Clinical Trials.
Molecular nutrition & food research.
2020 05; 64(10):e1900800. doi:
10.1002/mnfr.201900800. [PMID: 32112501] - Maarit Karonen, Jeffrey R Ahern, Lucie Legroux, Jussi Suvanto, Marica T Engström, Jari Sinkkonen, Juha-Pekka Salminen, Hervé Hoste. Ellagitannins Inhibit the Exsheathment of Haemonchus contortus and Trichostrongylus colubriformis Larvae: The Efficiency Increases Together with the Molecular Size.
Journal of agricultural and food chemistry.
2020 Apr; 68(14):4176-4186. doi:
10.1021/acs.jafc.9b06774. [PMID: 32181655] - Manami Era, Yosuke Matsuo, Yoshinori Saito, Takashi Tanaka. Production of Ellagitannin Hexahydroxydiphenoyl Ester by Spontaneous Reduction of Dehydrohexa-hydroxydiphenoyl Ester.
Molecules (Basel, Switzerland).
2020 Feb; 25(5):. doi:
10.3390/molecules25051051. [PMID: 32110993] - Maarit Karonen, Marianne Oraviita, Irene Mueller-Harvey, Juha-Pekka Salminen, Rebecca J Green. Ellagitannins with Glucopyranose Cores Have Higher Affinities to Proteins than Acyclic Ellagitannins by Isothermal Titration Calorimetry.
Journal of agricultural and food chemistry.
2019 Nov; 67(46):12730-12740. doi:
10.1021/acs.jafc.9b04353. [PMID: 31650840] - Elżbieta Karlińska, Łukasz Pecio, Jakub Macierzyński, Anna Stochmal, Monika Kosmala. Structural elucidation of the ellagitannin with a molecular weight of 2038 isolated from strawberry fruit (Fragaria ananassa Duch.) and named fragariin A.
Food chemistry.
2019 Oct; 296(?):109-115. doi:
10.1016/j.foodchem.2019.05.191. [PMID: 31202294] - Caroline Fabri Bittencourt Rodrigues, Marcelo José Pena Ferreira, Mariana Novo Belchor, Caroline R C Costa, Danielle P Novaes, Adeilso Bispo Dos Santos Junior, Cinthia I Tamayose, Marcus Vinícius Terashima Pinho, Marcos Antonio de Oliveira, Marcos Hikari Toyama. Evaluation of the Inhibitory Potential of Casuarictin, an Ellagitannin Isolated from White Mangrove (Laguncularia racemosa) Leaves, on Snake Venom Secretory Phospholipase A2.
Marine drugs.
2019 Jul; 17(7):. doi:
10.3390/md17070403. [PMID: 31288445] - Yoko Nitta, Hideyuki Ito, Hirohumi Komori, Hiroshi Ueno, Daiki Takeshima, Mikiko Ito, Motoyoshi Sakaue, Hiroe Kikuzaki. The ellagitannin trimer rugosin G inhibits recombinant human histidine decarboxylase.
Bioscience, biotechnology, and biochemistry.
2019 Jul; 83(7):1315-1318. doi:
10.1080/09168451.2019.1606695. [PMID: 30995171] - El Hadji Assane Diop, Emerson Ferreira Queiroz, Laurence Marcourt, Sébastien Kicka, Serge Rudaz, Tahir Diop, Thierry Soldati, Jean-Luc Wolfender. Antimycobacterial activity in a single-cell infection assay of ellagitannins from Combretum aculeatum and their bioavailable metabolites.
Journal of ethnopharmacology.
2019 Jun; 238(?):111832. doi:
10.1016/j.jep.2019.111832. [PMID: 30914349] - Yue Chen, Zhongqin Chen, Qingwen Guo, Xudong Gao, Qiqi Ma, Zihan Xue, Nicola Ferri, Min Zhang, Haixia Chen. Identification of Ellagitannins in the Unripe Fruit of Rubus Chingii Hu and Evaluation of its Potential Antidiabetic Activity.
Journal of agricultural and food chemistry.
2019 Jun; 67(25):7025-7039. doi:
10.1021/acs.jafc.9b02293. [PMID: 31240933] - Bartosz Fotschki, Jerzy Juśkiewicz, Adam Jurgoński, Monika Kosmala, Joanna Milala, Zenon Zduńczyk, Jarosław Markowski. Grinding levels of raspberry pomace affect intestinal microbial activity, lipid and glucose metabolism in Wistar rats.
Food research international (Ottawa, Ont.).
2019 06; 120(?):399-406. doi:
10.1016/j.foodres.2019.03.014. [PMID: 31000255] - Douglas Costa Gontijo, Pablo Costa Gontijo, Geraldo Célio Brandão, Marisa Alves Nogueira Diaz, Alaíde Braga de Oliveira, Luciano Gomes Fietto, João Paulo Viana Leite. Antioxidant study indicative of antibacterial and antimutagenic activities of an ellagitannin-rich aqueous extract from the leaves of Miconia latecrenata.
Journal of ethnopharmacology.
2019 May; 236(?):114-123. doi:
10.1016/j.jep.2019.03.007. [PMID: 30853643] - Xiao Yang, Francisco A Tomás-Barberán. Tea Is a Significant Dietary Source of Ellagitannins and Ellagic Acid.
Journal of agricultural and food chemistry.
2019 May; 67(19):5394-5404. doi:
10.1021/acs.jafc.8b05010. [PMID: 30339026] - Nicholas A DaSilva, Pragati P Nahar, Hang Ma, Aseel Eid, Zhengxi Wei, Susan Meschwitz, Nasser H Zawia, Angela L Slitt, Navindra P Seeram. Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation in vitro.
Nutritional neuroscience.
2019 Mar; 22(3):185-195. doi:
10.1080/1028415x.2017.1360558. [PMID: 28784051] - María Romo-Vaquero, Adrián Cortés-Martín, Viviana Loria-Kohen, Ana Ramírez-de-Molina, Izaskun García-Mantrana, María Carmen Collado, Juan Carlos Espín, María Victoria Selma. Deciphering the Human Gut Microbiome of Urolithin Metabotypes: Association with Enterotypes and Potential Cardiometabolic Health Implications.
Molecular nutrition & food research.
2019 02; 63(4):e1800958. doi:
10.1002/mnfr.201800958. [PMID: 30471188] - Eman Al-Sayed, Mohamed M Abdel-Daim, Mohamed Abdelrazik Khattab. Hepatoprotective activity of praecoxin A isolated from Melaleuca ericifolia against carbon tetrachloride-induced hepatotoxicity in mice. Impact on oxidative stress, inflammation, and apoptosis.
Phytotherapy research : PTR.
2019 Feb; 33(2):461-470. doi:
10.1002/ptr.6242. [PMID: 30506741] - Manami Era, Yosuke Matsuo, Yoshinori Saito, Koyo Nishida, Zhi-Hong Jiang, Takashi Tanaka. Ellagitannins and Related Compounds from Penthorum chinense.
Journal of natural products.
2019 01; 82(1):129-135. doi:
10.1021/acs.jnatprod.8b00838. [PMID: 30576141] - Zhaohe Yuan, Yanming Fang, Taikui Zhang, Zhangjun Fei, Fengming Han, Cuiyu Liu, Min Liu, Wei Xiao, Wenjing Zhang, Shan Wu, Mengwei Zhang, Youhui Ju, Huili Xu, He Dai, Yujun Liu, Yanhui Chen, Lili Wang, Jianqing Zhou, Dian Guan, Ming Yan, Yanhua Xia, Xianbin Huang, Dongyuan Liu, Hongmin Wei, Hongkun Zheng. The pomegranate (Punica granatum L.) genome provides insights into fruit quality and ovule developmental biology.
Plant biotechnology journal.
2018 07; 16(7):1363-1374. doi:
10.1111/pbi.12875. [PMID: 29271050] - María V Selma, Antonio González-Sarrías, Jordi Salas-Salvadó, Cristina Andrés-Lacueva, Cesarettin Alasalvar, Asım Örem, Francisco A Tomás-Barberán, Juan C Espín. The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome.
Clinical nutrition (Edinburgh, Scotland).
2018 06; 37(3):897-905. doi:
10.1016/j.clnu.2017.03.012. [PMID: 28347564] - Bartosz Fotschki, Jerzy Juśkiewicz, Krzysztof Kołodziejczyk, Adam Jurgoński, Monika Kosmala, Joanna Milala, Katarzyna Ognik, Zenon Zduńczyk. Protective Effects of Ellagitannin-Rich Strawberry Extracts on Biochemical and Metabolic Disturbances in Rats Fed a Diet High in Fructose.
Nutrients.
2018 Apr; 10(4):. doi:
10.3390/nu10040445. [PMID: 29617310] - Takashi Yoshida, Morio Yoshimura, Yoshiaki Amakura. Chemical and Biological Significance of Oenothein B and Related Ellagitannin Oligomers with Macrocyclic Structure.
Molecules (Basel, Switzerland).
2018 Mar; 23(3):. doi:
10.3390/molecules23030552. [PMID: 29498647] - María-Teresa García-Conesa, Karen Chambers, Emilie Combet, Paula Pinto, Mar Garcia-Aloy, Cristina Andrés-Lacueva, Sonia de Pascual-Teresa, Pedro Mena, Alekxandra Konic Ristic, Wendy J Hollands, Paul A Kroon, Ana Rodríguez-Mateos, Geoffrey Istas, Christos A Kontogiorgis, Dilip K Rai, Eileen R Gibney, Christine Morand, Juan Carlos Espín, Antonio González-Sarrías. Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses.
International journal of molecular sciences.
2018 Feb; 19(3):. doi:
10.3390/ijms19030694. [PMID: 29495642] - Gustavo Gabriel Martos, Alicia Mamaní, María Paula Filippone, Atilio Pedro Castagnaro, Juan Carlos Díaz Ricci. The ellagitannin HeT induces electrolyte leakage, calcium influx and the accumulation of nitric oxide and hydrogen peroxide in strawberry.
Plant physiology and biochemistry : PPB.
2018 Feb; 123(?):400-405. doi:
10.1016/j.plaphy.2017.12.035. [PMID: 29306187] - Jussi Suvanto, Petri Tähtinen, Saku Valkamaa, Marica T Engström, Maarit Karonen, Juha-Pekka Salminen. Variability in Foliar Ellagitannins of Hippophaë rhamnoides L. and Identification of a New Ellagitannin, Hippophaenin C.
Journal of agricultural and food chemistry.
2018 Jan; 66(3):613-620. doi:
10.1021/acs.jafc.7b04834. [PMID: 29262676] - Takashi Tanaka, Yosuke Matsuo, Yoshinori Saito. Solubility of Tannins and Preparation of Oil-Soluble Derivatives.
Journal of oleo science.
2018; 67(10):1179-1187. doi:
10.5650/jos.ess18164. [PMID: 30305552] - Stefanie Quosdorf, Anja Schuetz, Herbert Kolodziej. Different Inhibitory Potencies of Oseltamivir Carboxylate, Zanamivir, and Several Tannins on Bacterial and Viral Neuraminidases as Assessed in a Cell-Free Fluorescence-Based Enzyme Inhibition Assay.
Molecules (Basel, Switzerland).
2017 Nov; 22(11):. doi:
10.3390/molecules22111989. [PMID: 29149072] - Yuuki Shimozu, Teruo Kuroda, Tomofusa Tsuchiya, Tsutomu Hatano. Structures and Antibacterial Properties of Isorugosins H-J, Oligomeric Ellagitannins from Liquidambar formosana with Characteristic Bridging Groups between Sugar Moieties.
Journal of natural products.
2017 10; 80(10):2723-2733. doi:
10.1021/acs.jnatprod.7b00496. [PMID: 29019685] - Lydia Ninan Lestario, Luke R Howard, Cindi Brownmiller, Nathan B Stebbins, Rohana Liyanage, Jackson O Lay. Changes in polyphenolics during maturation of Java plum (Syzygium cumini Lam.).
Food research international (Ottawa, Ont.).
2017 10; 100(Pt 3):385-391. doi:
10.1016/j.foodres.2017.04.023. [PMID: 28964361] - Jakub P Piwowarski, Barbara Bobrowska-Korczak, Iwona Stanisławska, Wojciech Bielecki, Robert Wrzesien, Sebastian Granica, Katarzyna Krupa, Anna K Kiss. Evaluation of the Effect of Epilobium angustifolium Aqueous Extract on LNCaP Cell Proliferation in In Vitro and In Vivo Models.
Planta medica.
2017 Oct; 83(14-15):1159-1168. doi:
10.1055/s-0043-109372. [PMID: 28454190] - Sheng Wu, Li Tian. Diverse Phytochemicals and Bioactivities in the Ancient Fruit and Modern Functional Food Pomegranate (Punica granatum).
Molecules (Basel, Switzerland).
2017 Sep; 22(10):. doi:
10.3390/molecules22101606. [PMID: 28946708] - José Pinela, M A Prieto, Amilcar L Antonio, Ana Maria Carvalho, M Beatriz P P Oliveira, Lillian Barros, Isabel C F R Ferreira. Ellagitannin-rich bioactive extracts of Tuberaria lignosa: insights into the radiation-induced effects in the recovery of high added-value compounds.
Food & function.
2017 Jul; 8(7):2485-2499. doi:
10.1039/c7fo00500h. [PMID: 28640298] - Yi Gong, Ronald B Pegg. Separation of Ellagitannin-Rich Phenolics from U.S. Pecans and Chinese Hickory Nuts Using Fused-Core HPLC Columns and Their Characterization.
Journal of agricultural and food chemistry.
2017 Jul; 65(28):5810-5820. doi:
10.1021/acs.jafc.7b01597. [PMID: 28648053] - Rocío García-Villalba, Hanne Vissenaekens, Judit Pitart, María Romo-Vaquero, Juan C Espín, Charlotte Grootaert, María V Selma, Katleen Raes, Guy Smagghe, Sam Possemiers, John Van Camp, Francisco A Tomas-Barberan. Gastrointestinal Simulation Model TWIN-SHIME Shows Differences between Human Urolithin-Metabotypes in Gut Microbiota Composition, Pomegranate Polyphenol Metabolism, and Transport along the Intestinal Tract.
Journal of agricultural and food chemistry.
2017 Jul; 65(27):5480-5493. doi:
10.1021/acs.jafc.7b02049. [PMID: 28616977] - Duc Hung Nguyen, U Min Seo, Bing Tian Zhao, Duc Dat Le, Su Hui Seong, Jae Sue Choi, Byung Sun Min, Mi Hee Woo. Ellagitannin and flavonoid constituents from Agrimonia pilosa Ledeb. with their protein tyrosine phosphatase and acetylcholinesterase inhibitory activities.
Bioorganic chemistry.
2017 06; 72(?):293-300. doi:
10.1016/j.bioorg.2017.04.017. [PMID: 28499190] - María A Nuñez-Sánchez, Antonio González-Sarrías, Rocío García-Villalba, Tamara Monedero-Saiz, Noelia V García-Talavera, María B Gómez-Sánchez, Carmen Sánchez-Álvarez, Ana M García-Albert, Francisco J Rodríguez-Gil, Miguel Ruiz-Marín, Francisco A Pastor-Quirante, Francisco Martínez-Díaz, Francisco A Tomás-Barberán, Juan Carlos Espín, María-Teresa García-Conesa. Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial.
The Journal of nutritional biochemistry.
2017 04; 42(?):126-133. doi:
10.1016/j.jnutbio.2017.01.014. [PMID: 28183047] - Yuuki Shimozu, Yuriko Kimura, Akari Esumi, Hiroe Aoyama, Teruo Kuroda, Hiroshi Sakagami, Tsutomu Hatano. Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas.
Molecules (Basel, Switzerland).
2017 Mar; 22(3):. doi:
10.3390/molecules22030470. [PMID: 28294988] - Kristen M Roberts, Elizabeth M Grainger, Jennifer M Thomas-Ahner, Alice Hinton, Junnan Gu, Kenneth M Riedl, Yael Vodovotz, Ronney Abaza, Steven J Schwartz, Steven K Clinton. Application of a low polyphenol or low ellagitannin dietary intervention and its impact on ellagitannin metabolism in men.
Molecular nutrition & food research.
2017 03; 61(3):. doi:
10.1002/mnfr.201600224. [PMID: 27813248] - Susanne M Henning, Paula H Summanen, Ru-Po Lee, Jieping Yang, Sydney M Finegold, David Heber, Zhaoping Li. Pomegranate ellagitannins stimulate the growth of Akkermansia muciniphila in vivo.
Anaerobe.
2017 Feb; 43(?):56-60. doi:
10.1016/j.anaerobe.2016.12.003. [PMID: 27940244] - Estelle Loing, Elisabeth Lamarque, Magali Borel. New targets in the battle against dandruff.
Journal of cosmetic science.
2017 Jan; 68(1):107-113. doi:
". [PMID: 29465391] - Eman Al-Sayed, Ahmed Esmat. Hepatoprotective and antioxidant effect of ellagitannins and galloyl esters isolated from Melaleuca styphelioides on carbon tetrachloride-induced hepatotoxicity in HepG2 cells.
Pharmaceutical biology.
2016 Sep; 54(9):1727-35. doi:
10.3109/13880209.2015.1125933. [PMID: 26731241] - Jing-Yi Ma, Xuelin Zhou, Jie Fu, Chi-Yu He, Ru Feng, Min Huang, Jia-Wen Shou, Zhen-Xiong Zhao, Xiao-Yang Li, Luye Zhang, Yang-Chao Chen, Yan Wang. In Vivo Metabolite Profiling of a Purified Ellagitannin Isolated from Polygonum capitatum in Rats.
Molecules (Basel, Switzerland).
2016 Aug; 21(9):. doi:
10.3390/molecules21091110. [PMID: 27563862] - Pilar Gaya, Margarita Medina, Abel Sánchez-Jiménez, José Mᵃ Landete. Phytoestrogen Metabolism by Adult Human Gut Microbiota.
Molecules (Basel, Switzerland).
2016 Aug; 21(8):. doi:
10.3390/molecules21081034. [PMID: 27517891] - Ben-Hong Zhou, Zhen-Peng Qiu, Hui-Lan Yi, Ding-Shan Zhou, Jing Wang, Yue Wu. [Research progress of ellagitannin intestinal metabolite urolithins].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2016 Aug; 41(16):2968-2974. doi:
10.4268/cjcmm20161604. [PMID: 28920333] - Elżbieta Klewicka, Michał Sójka, Robert Klewicki, Krzysztof Kołodziejczyk, Lidia Lipińska, Adriana Nowak. Ellagitannins from Raspberry (Rubus idaeus L.) Fruit as Natural Inhibitors of Geotrichum candidum.
Molecules (Basel, Switzerland).
2016 Jul; 21(7):. doi:
10.3390/molecules21070908. [PMID: 27420041] - Anne-Maria Pajari, Essi Päivärinta, Lassi Paavolainen, Elina Vaara, Tuuli Koivumäki, Ritu Garg, Anu Heiman-Lindh, Marja Mutanen, Varpu Marjomäki, Anne J Ridley. Ellagitannin-rich cloudberry inhibits hepatocyte growth factor induced cell migration and phosphatidylinositol 3-kinase/AKT activation in colon carcinoma cells and tumors in Min mice.
Oncotarget.
2016 Jul; 7(28):43907-43923. doi:
10.18632/oncotarget.9724. [PMID: 27270323] - María Ángeles Núñez-Sánchez, Ankur Karmokar, Antonio González-Sarrías, Rocío García-Villalba, Francisco A Tomás-Barberán, María Teresa García-Conesa, Karen Brown, Juan Carlos Espín. In vivo relevant mixed urolithins and ellagic acid inhibit phenotypic and molecular colon cancer stem cell features: A new potentiality for ellagitannin metabolites against cancer.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2016 Jun; 92(?):8-16. doi:
10.1016/j.fct.2016.03.011. [PMID: 26995228] - Mohamed A A Orabi, Shoko Taniguchi, Hiroshi Sakagami, Morio Yoshimura, Yoshiaki Amakura, Tsutomu Hatano. Hydrolyzable Tannins of Tamaricaceous Plants. 7.1 Structures and Cytotoxic Properties of Oligomeric Ellagitannins from Leaves of Tamarix nilotica and Cultured Tissues of Tamarix tetrandra.
Journal of natural products.
2016 Apr; 79(4):984-95. doi:
10.1021/acs.jnatprod.5b01065. [PMID: 26938659] - Juan A Ascacio-Valdés, Antonio F Aguilera-Carbó, José J Buenrostro, Arely Prado-Barragán, Raúl Rodríguez-Herrera, Cristóbal N Aguilar. The complete biodegradation pathway of ellagitannins by Aspergillus niger in solid-state fermentation.
Journal of basic microbiology.
2016 Apr; 56(4):329-36. doi:
10.1002/jobm.201500557. [PMID: 26915983] - Jieping Yang, Rupo Lee, Susanne M Henning, Gail Thames, Mark Hsu, Hei ManLam, David Heber, Zhaoping Li. Soy protein isolate does not affect ellagitannin bioavailability and urolithin formation when mixed with pomegranate juice in humans.
Food chemistry.
2016 Mar; 194(?):1300-3. doi:
10.1016/j.foodchem.2015.08.099. [PMID: 26471685] - Rocío García-Villalba, Juan Carlos Espín, Francisco A Tomás-Barberán. Chromatographic and spectroscopic characterization of urolithins for their determination in biological samples after the intake of foods containing ellagitannins and ellagic acid.
Journal of chromatography. A.
2016 Jan; 1428(?):162-75. doi:
10.1016/j.chroma.2015.08.044. [PMID: 26341594] - Manh Heun Kim, Kwan Hee Park, So Ra Kim, Kwang Jun Park, Myeong Hwan Oh, Jun Hyeok Heo, Ki Hoon Yoon, Jun Yin, Kyu Hyung Yoon, Min Won Lee. Two new phenolic compounds from the leaves of Alnus sibirica Fisch. ex Turcz.
Natural product research.
2016; 30(2):206-13. doi:
10.1080/14786419.2015.1053087. [PMID: 26211877] - Maarit Karonen, Marianne Oraviita, Irene Mueller-Harvey, Juha-Pekka Salminen, Rebecca J Green. Binding of an Oligomeric Ellagitannin Series to Bovine Serum Albumin (BSA): Analysis by Isothermal Titration Calorimetry (ITC).
Journal of agricultural and food chemistry.
2015 Dec; 63(49):10647-54. doi:
10.1021/acs.jafc.5b04843. [PMID: 26608224] - Sebastian Granica, Jakub P Piwowarski, Anna K Kiss. Ellagitannins modulate the inflammatory response of human neutrophils ex vivo.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2015 Dec; 22(14):1215-22. doi:
10.1016/j.phymed.2015.10.004. [PMID: 26655403] - Jakub P Piwowarski, Anna K Kiss, Sebastian Granica, Thomas Moeslinger. Urolithins, gut microbiota-derived metabolites of ellagitannins, inhibit LPS-induced inflammation in RAW 264.7 murine macrophages.
Molecular nutrition & food research.
2015 Nov; 59(11):2168-77. doi:
10.1002/mnfr.201500264. [PMID: 26202092] - Manami Era, Yosuke Matsuo, Takuya Shii, Yoshinori Saito, Takashi Tanaka, Zhi-Hong Jiang. Diastereomeric Ellagitannin Isomers from Penthorum chinense.
Journal of natural products.
2015 Aug; 78(8):2104-9. doi:
10.1021/acs.jnatprod.5b00439. [PMID: 26218585] - Zhaoping Li, Susanne M Henning, Ru-Po Lee, Qing-Yi Lu, Paula H Summanen, Gail Thames, Karen Corbett, Julia Downes, Chi-Hong Tseng, Sydney M Finegold, David Heber. Pomegranate extract induces ellagitannin metabolite formation and changes stool microbiota in healthy volunteers.
Food & function.
2015 Aug; 6(8):2487-95. doi:
10.1039/c5fo00669d. [PMID: 26189645] - Johanna Moilanen, Piia Koskinen, Juha-Pekka Salminen. Distribution and content of ellagitannins in Finnish plant species.
Phytochemistry.
2015 Aug; 116(?):188-197. doi:
10.1016/j.phytochem.2015.03.002. [PMID: 25819000] - Mohamed A A Orabi, Morio Yoshimura, Yoshiaki Amakura, Tsutomu Hatano. Ellagitannins, gallotannins, and gallo-ellagitannins from the galls of Tamarix aphylla.
Fitoterapia.
2015 Jul; 104(?):55-63. doi:
10.1016/j.fitote.2015.05.008. [PMID: 25987319] - Luciane de Lira Teixeira, Fabiano Cleber Bertoldi, Franco Maria Lajolo, Neuza Mariko Aymoto Hassimotto. Identification of Ellagitannins and Flavonoids from Eugenia brasilienses Lam. (Grumixama) by HPLC-ESI-MS/MS.
Journal of agricultural and food chemistry.
2015 Jun; 63(22):5417-27. doi:
10.1021/acs.jafc.5b01195. [PMID: 25990484] - Andrew G Ramstead, Igor A Schepetkin, Kimberly Todd, James Loeffelholz, James G Berardinelli, Mark T Quinn, Mark A Jutila. Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B.
International immunopharmacology.
2015 Jun; 26(2):367-77. doi:
10.1016/j.intimp.2015.04.008. [PMID: 25887271] - Hyunnho Cho, Hana Jung, Heejae Lee, Hae Chang Yi, Ho-kyung Kwak, Keum Taek Hwang. Chemopreventive activity of ellagitannins and their derivatives from black raspberry seeds on HT-29 colon cancer cells.
Food & function.
2015 May; 6(5):1675-83. doi:
10.1039/c5fo00274e. [PMID: 25906041] - Saeed Akhtar, Tariq Ismail, Daniele Fraternale, Piero Sestili. Pomegranate peel and peel extracts: chemistry and food features.
Food chemistry.
2015 May; 174(?):417-25. doi:
10.1016/j.foodchem.2014.11.035. [PMID: 25529700] - Andrea Bellesia, Elena Verzelloni, Davide Tagliazucchi. Pomegranate ellagitannins inhibit α-glucosidase activity in vitro and reduce starch digestibility under simulated gastro-intestinal conditions.
International journal of food sciences and nutrition.
2015 Feb; 66(1):85-92. doi:
10.3109/09637486.2014.953455. [PMID: 25519249] - Harry Martin, Elaine J Burgess, Wendy A Smith, Tony K McGhie, Janine M Cooney, Rona C M Lunken, Erika de Guzman, Tania Trower, Nigel B Perry. JAK2 and AMP-kinase inhibition in vitro by food extracts, fractions and purified phytochemicals.
Food & function.
2015 Jan; 6(1):305-12. doi:
10.1039/c4fo00626g. [PMID: 25463744] - María Eva González-Trujano, Francisco Pellicer, Pedro Mena, Diego A Moreno, Cristina García-Viguera. Antinociceptive and anti-inflammatory activities of a pomegranate (Punica granatum L.) extract rich in ellagitannins.
International journal of food sciences and nutrition.
2015; 66(4):395-9. doi:
10.3109/09637486.2015.1024208. [PMID: 25822007] - Jing-Yi Ma, Xuelin Zhou, Jie Fu, Tao Hu, Penelope M Y Or, Ru Feng, Chi-Yu He, Wen-Jing Chen, Xianfeng Zhang, Yangchao Chen, Yan Wang, John H K Yeung. Metabolite profiling analysis of FR429, an ellagitannin purified from Polygonum capitatum, in rat and human liver microsomes, cytosol and rat primary hepatocytes in vitro.
Chemico-biological interactions.
2014 Sep; 220(?):33-40. doi:
10.1016/j.cbi.2014.06.002. [PMID: 24928742] - Jakub P Piwowarski, Sebastian Granica, Marta Zwierzyńska, Joanna Stefańska, Patrick Schopohl, Matthias F Melzig, Anna K Kiss. Role of human gut microbiota metabolism in the anti-inflammatory effect of traditionally used ellagitannin-rich plant materials.
Journal of ethnopharmacology.
2014 Aug; 155(1):801-9. doi:
10.1016/j.jep.2014.06.032. [PMID: 24969824] - Francesca Giampieri, José M Alvarez-Suarez, Luca Mazzoni, Tamara Y Forbes-Hernandez, Massimiliano Gasparrini, Ana M Gonzàlez-Paramàs, Celestino Santos-Buelga, Josè L Quiles, Stefano Bompadre, Bruno Mezzetti, Maurizio Battino. An anthocyanin-rich strawberry extract protects against oxidative stress damage and improves mitochondrial functionality in human dermal fibroblasts exposed to an oxidizing agent.
Food & function.
2014 Aug; 5(8):1939-48. doi:
10.1039/c4fo00048j. [PMID: 24956972] - María V Selma, David Beltrán, Rocío García-Villalba, Juan C Espín, Francisco A Tomás-Barberán. Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species.
Food & function.
2014 Aug; 5(8):1779-84. doi:
10.1039/c4fo00092g. [PMID: 24909569] - Gordon J McDougall, Sean Conner, Gema Pereira-Caro, Rocio Gonzalez-Barrio, Emma M Brown, Susan Verrall, Derek Stewart, Tanya Moffet, Maria Ibars, Roger Lawther, Gloria O'Connor, Ian Rowland, Alan Crozier, Chris I R Gill. Tracking (Poly)phenol components from raspberries in ileal fluid.
Journal of agricultural and food chemistry.
2014 Jul; 62(30):7631-41. doi:
10.1021/jf502259j. [PMID: 24998385] - Jakub P Piwowarski, Sebastian Granica, Anna K Kiss. Influence of gut microbiota-derived ellagitannins' metabolites urolithins on pro-inflammatory activities of human neutrophils.
Planta medica.
2014 Jul; 80(11):887-95. doi:
10.1055/s-0034-1368615. [PMID: 24995502] - Bartosz Fotschki, Joanna Milala, Adam Jurgoński, Elżbieta Karlińska, Zenon Zduńczyk, Jerzy Juśkiewicz. Strawberry ellagitannins thwarted the positive effects of dietary fructooligosaccharides in rat cecum.
Journal of agricultural and food chemistry.
2014 Jun; 62(25):5871-80. doi:
10.1021/jf405612a. [PMID: 24894695] - Bei Wang, Tuuli Koivumäki, Petri Kylli, Marina Heinonen, Marjo Poutanen. Protein-phenolic interaction of tryptic digests of β-lactoglobulin and cloudberry ellagitannin.
Journal of agricultural and food chemistry.
2014 Jun; 62(22):5028-37. doi:
10.1021/jf501190x. [PMID: 24828893] - Lina Raudone, Ramune Bobinaite, Valdimaras Janulis, Pranas Viskelis, Sonata Trumbeckaite. Effects of raspberry fruit extracts and ellagic acid on respiratory burst in murine macrophages.
Food & function.
2014 Jun; 5(6):1167-74. doi:
10.1039/c3fo60593k. [PMID: 24699912] - Salud Vegara, Nuria Martí, José Lorente, Luís Coll, Sergio Streitenberger, Manuel Valero, Domingo Saura. Chemical guide parameters for Punica granatum cv. 'Mollar' fruit juices processed at industrial scale.
Food chemistry.
2014 Mar; 147(?):203-8. doi:
10.1016/j.foodchem.2013.09.122. [PMID: 24206706] - Vy Le, Debora Esposito, Mary H Grace, Danny Ha, Anh Pham, Anthony Bortolazzo, Zackery Bevens, John Kim, Roy Okuda, Slavko Komarnytsky, Mary Ann Lila, Joseph Brandon White. Cytotoxic effects of ellagitannins isolated from walnuts in human cancer cells.
Nutrition and cancer.
2014; 66(8):1304-14. doi:
10.1080/01635581.2014.956246. [PMID: 25264855] - Hideyuki Ito, Peng Li, Mayuko Koreishi, Akifumi Nagatomo, Norihisa Nishida, Takashi Yoshida. Ellagitannin oligomers and a neolignan from pomegranate arils and their inhibitory effects on the formation of advanced glycation end products.
Food chemistry.
2014; 152(?):323-30. doi:
10.1016/j.foodchem.2013.11.160. [PMID: 24444944] - Riitta Puupponen-Pimiä, Tuulikki Seppänen-Laakso, Matti Kankainen, Johanna Maukonen, Riitta Törrönen, Marjukka Kolehmainen, Tiina Leppänen, Eeva Moilanen, Liisa Nohynek, Anna-Marja Aura, Kaisa Poutanen, Francisco A Tómas-Barberán, Juan C Espín, Kirsi-Marja Oksman-Caldentey. Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome.
Molecular nutrition & food research.
2013 Dec; 57(12):2258-63. doi:
10.1002/mnfr.201300280. [PMID: 23934737] - Luca Dellafiora, Pedro Mena, Pietro Cozzini, Furio Brighenti, Daniele Del Rio. Modelling the possible bioactivity of ellagitannin-derived metabolites. In silico tools to evaluate their potential xenoestrogenic behavior.
Food & function.
2013 Oct; 4(10):1442-51. doi:
10.1039/c3fo60117j. [PMID: 23955176] - Wardah Mustafa Din, Khoo Teng Jin, Ramliza Ramli, Tzar Mohd Nizam Khaithir, Christophe Wiart. Antibacterial effects of ellagitannins from Acalypha wilkesiana var. macafeana hort.: surface morphology analysis with environmental scanning electron microscopy and synergy with antibiotics.
Phytotherapy research : PTR.
2013 Sep; 27(9):1313-20. doi:
10.1002/ptr.4876. [PMID: 23109276] - Agnieszka Bazylko, Jakub P Piwowarski, Agnieszka Filipek, Jessica Bonarewicz, Michał Tomczyk. In vitro antioxidant and anti-inflammatory activities of extracts from Potentilla recta and its main ellagitannin, agrimoniin.
Journal of ethnopharmacology.
2013 Aug; 149(1):222-7. doi:
10.1016/j.jep.2013.06.026. [PMID: 23811215] - Ricardo da Fontoura Sprenger, Quezia Bezerra Cass. Characterization of four Phyllanthus species using liquid chromatography coupled to tandem mass spectrometry.
Journal of chromatography. A.
2013 May; 1291(?):97-103. doi:
10.1016/j.chroma.2013.03.030. [PMID: 23611623] - Sebastian Granica, Monika E Czerwińska, Jakub P Piwowarski, Maria Ziaja, Anna K Kiss. Chemical composition, antioxidative and anti-inflammatory activity of extracts prepared from aerial parts of Oenothera biennis L. and Oenothera paradoxa Hudziok obtained after seeds cultivation.
Journal of agricultural and food chemistry.
2013 Jan; 61(4):801-10. doi:
10.1021/jf304002h. [PMID: 23311638]