Fluoxymesterone (BioDeep_00000017845)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(1R,2S,10S,11S,14S,15S,17S)-1-fluoro-14,17-dihydroxy-2,14,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one

化学式: C20H29FO3 (336.2100616)
中文名称: 氟甲睾酮
谱图信息: 最多检出来源 Homo sapiens(blood) 92.31%

分子结构信息

SMILES: CC1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3(F)C(O)CC21C
InChI: InChI=1S/C20H29FO3/c1-17-8-6-13(22)10-12(17)4-5-15-14-7-9-19(3,24)18(14,2)11-16(23)20(15,17)21/h10,14-16,23-24H,4-9,11H2,1-3H3

描述信息

Fluoxymesterone is only found in individuals that have used or taken this drug. It is an anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. [PubChem]Fluoxymesterone is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone. Like testosterone and other androgenic hormones, fluoxymesterone binds to the androgen receptor. It produces retention of nitrogen, sodium, potassium, and phosphorus; increases protein anabolism; decreases amino acid catabolism and decreased urinary excretion of calcium. The antitumour activity of fluoxymesterone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03B - Androgens > G03BA - 3-oxoandrosten (4) derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D045930 - Anabolic Agents
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C2360 - Anabolic Steroid

同义名列表

31 个代谢物同义名

(1R,2S,10S,11S,14S,15S,17S)-1-fluoro-14,17-dihydroxy-2,14,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one; 9-fluoro-11,17-dihydroxy-10,13,17-trimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one; 11beta,17beta-Dihydroxy-9alpha-fluoro-17alpha-methyl-4-androster-3-one; 9-Fluoro-11beta,17beta-dihydroxy-17-methylandrost-4-en-3-one; 11b,17b-Dihydroxy-9a-fluoro-17a-methyl-4-androster-3-one; 11Β,17β-dihydroxy-9α-fluoro-17α-methyl-4-androster-3-one; 9-Fluoro-11β,17β-dihydroxy-17-methylandrost-4-en-3-one; 9-Fluoro-11b,17b-dihydroxy-17-methylandrost-4-en-3-one; 17alpha-Methyl-9alpha-fluoro-11beta-hydroxytesterone; 9alpha-Fluoro-11beta-hydroxy-17-methyltestosterone; 9a-Fluoro-11b-hydroxy-17-methyltestosterone; 9Α-fluoro-11β-hydroxy-17-methyltestosterone; 17a-Methyl-9a-fluoro-11b-hydroxytesterone; 17Α-methyl-9α-fluoro-11β-hydroxytesterone; Pharmacia brand OF fluoxymesterone; Atlantis brand OF fluoxymesterone; Fluossimesterone; Fluoximesteronum; Fluoxymesteronum; Fluoxymesterone; Fluoximesterone; Fluoximesterona; Fluoximesteron; Fluoxymestrone; Androfluorone; Androfluorene; Halotestin; Android F; Android-F; Androxy; Stenox



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Jianghai Lu, Genye He, Xiaobing Wang, Youxuan Xu, Yun Wu, Ying Dong, Xin Liu, Zhenwen He, Jian Zhao, Hong Yuan. Mass spectrometric identification and characterization of new fluoxymesterone metabolites in human urine by liquid chromatography time-of-flight tandem mass spectrometry. Steroids. 2012 Jul; 77(8-9):871-7. doi: 10.1016/j.steroids.2012.04.003. [PMID: 22521423]
  • Cornelia Fürstenberger, Anna Vuorinen, Thierry Da Cunha, Denise V Kratschmar, Martial Saugy, Daniela Schuster, Alex Odermatt. The anabolic androgenic steroid fluoxymesterone inhibits 11β-hydroxysteroid dehydrogenase 2-dependent glucocorticoid inactivation. Toxicological sciences : an official journal of the Society of Toxicology. 2012 Apr; 126(2):353-61. doi: 10.1093/toxsci/kfs022. [PMID: 22273746]
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