Stallimycin (BioDeep_00000178439)

   

human metabolite blood metabolite


代谢物信息卡片


1H-Pyrrole-2-carboxamide,N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-

化学式: C22H27N9O4 (481.21859020000005)
中文名称: 司他霉素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1C=C(C=C1C(=O)NC2=CN(C(=C2)C(=O)NC3=CN(C(=C3)C(=O)NCCC(=N)N)C)C)NC=O
InChI: InChI=1S/C22H27N9O4/c1-29-9-13(26-12-32)6-17(29)21(34)28-15-8-18(31(3)11-15)22(35)27-14-7-16(30(2)10-14)20(33)25-5-4-19(23)24/h6-12H,4-5H2,1-3H3,(H3,23,24)(H,25,33)(H,26,32)(H,27,35)(H,28,34)

描述信息

C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D004214 - Distamycins
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents

同义名列表

8 个代谢物同义名

1H-Pyrrole-2-carboxamide,N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-; N-(5-{[5-({5-[(2-carbamimidoylethyl)carbamoyl]-1-methyl-1H-pyrrol-3-yl}carbamoyl)-1-methyl-1H-pyrrol-3-yl]carbamoyl}-1-methyl-1H-pyrrol-3-yl)carboximidic acid; N-(5-{[5-({5-[(2-carbamimidoylethyl)carbamoyl]-1-methyl-1H-pyrrol-3-yl}carbamoyl)-1-methyl-1H-pyrrol-3-yl]carbamoyl}-1-methyl-1H-pyrrol-3-yl)carboximidate; N-(5-{[5-({5-[(2-carbamimidoylethyl)carbamoyl]-1-methylpyrrol-3-yl}carbamoyl)-1-methylpyrrol-3-yl]carbamoyl}-1-methylpyrrol-3-yl)carboximidic acid; Stallimycin monohydrochloride; distamycin a; Stallimycin; Distamycin



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Mateus Mondin, Margarida L R Aguiar-Perecin. Heterochromatin patterns and ribosomal DNA loci distribution in diploid and polyploid Crotalaria species (Leguminosae, Papilionoideae), and inferences on karyotype evolution. Genome. 2011 Sep; 54(9):718-26. doi: 10.1139/g11-034. [PMID: 21864195]
  • Adriana Buarque Marcon, Iva Carneiro Leão Barros, Marcelo Guerra. Variation in chromosome numbers, CMA bands and 45S rDNA sites in species of Selaginella (Pteridophyta). Annals of botany. 2005 Jan; 95(2):271-6. doi: 10.1093/aob/mci022. [PMID: 15567808]
  • Keren Cooper, Jill M Farrant. Recovery of the resurrection plant Craterostigma wilmsii from desiccation: protection versus repair. Journal of experimental botany. 2002 Aug; 53(375):1805-13. doi: 10.1093/jxb/erf028. [PMID: 12147731]
  • J Lichota, K D Grasser. Differential chromatin association and nucleosome binding of the maize HMGA, HMGB, and SSRP1 proteins. Biochemistry. 2001 Jul; 40(26):7860-7. doi: 10.1021/bi010548y. [PMID: 11425313]
  • R V Fishleigh, K R Fox, A I Khalaf, A R Pitt, M Scobie, C J Suckling, J Urwin, R D Waigh, S C Young. DNA binding, solubility, and partitioning characteristics of extended lexitropsins. Journal of medicinal chemistry. 2000 Aug; 43(17):3257-66. doi: 10.1021/jm990620e. [PMID: 10966744]
  • L Feng, B Wang, B Driscoll, A Jong. Identification and characterization of Saccharomyces cerevisiae Cdc6 DNA-binding properties. Molecular biology of the cell. 2000 May; 11(5):1673-85. doi: 10.1091/mbc.11.5.1673. [PMID: 10793143]
  • E O Punina, Iu A Miakoshina, A M Efimov, A V Rodionov. [Chromosome maps of the plant family Trilliaceae: nucleotide composition of heterochromatin an localization of 18S-26S rRNA-genes of four-leafed paris (Paris quadrifolia L.)]. Genetika. 2000 May; 36(5):673-7. doi: ". [PMID: 10867884]
  • C I Webster, L C Packman, K H Pwee, J C Gray. High mobility group proteins HMG-1 and HMG-I/Y bind to a positive regulatory region of the pea plastocyanin gene promoter. The Plant journal : for cell and molecular biology. 1997 Apr; 11(4):703-15. doi: 10.1046/j.1365-313x.1997.11040703.x. [PMID: 9161031]
  • R Matyásek, J Fulnecek, J Fajkus, M Bezdĕk. Evidence for a sequence-directed conformation periodicity in the genomic highly repetitive DNA detectable with single-strand-specific chemical probe potassium permanganate. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 1996 Aug; 4(5):340-9. doi: 10.1007/bf02257269. [PMID: 8871822]
  • E Frigerio, N Magi, A Benecchi, E Pianezzola, M Strolin Benedetti. Determination of FCE 26644, a new polysulphonated derivative of distamycin A, in monkey plasma by reversed-phase ion-pair high-performance liquid chromatography with ultraviolet detection. Journal of chromatography. A. 1996 Apr; 729(1-2):237-42. doi: 10.1016/0021-9673(95)00976-0. [PMID: 9004945]
  • F B Howard, H T Miles, K Liu, J Frazier, G Raghunathan, V Sasisekharan. Structure of d(T)n.d(A)n.d(T)n: the DNA triple helix has B-form geometry with C2'-endo sugar pucker. Biochemistry. 1992 Nov; 31(44):10671-7. doi: 10.1021/bi00159a005. [PMID: 1420182]
  • J W Lown, K Krowicki, J Balzarini, R A Newman, E De Clercq. Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation. Journal of medicinal chemistry. 1989 Oct; 32(10):2368-75. doi: 10.1021/jm00130a024. [PMID: 2552118]
  • G De Fazio, M Kudamatsu. Inhibitory effect of Distamycin-A and a pyrazino-pyrazine derivative on tomato spotted wilt virus. Antiviral research. 1983 Aug; 3(2):109-13. doi: 10.1016/0166-3542(83)90032-3. [PMID: 6625560]
  • L Grehn, U Ragnarsson, B Eriksson, B Oberg. Synthesis and antiviral activity of distamycin A analogues: substitutions on the different pyrrole nitrogens and in the amidine function. Journal of medicinal chemistry. 1983 Jul; 26(7):1042-9. doi: 10.1021/jm00361a018. [PMID: 6306237]
  • M Bialer, B Yagen, R Mechoulam, Y Becker. Structure--activity relationships of pyrrole amidine antiviral antibiotics. 1. Modifications of the alkylamidine side chain. Journal of medicinal chemistry. 1979 Nov; 22(11):1296-301. doi: 10.1021/jm00197a004. [PMID: 230350]