Diphenylmethane (BioDeep_00000178416)
human metabolite blood metabolite Volatile Flavor Compounds
代谢物信息卡片
化学式: C13H12 (168.0938952)
中文名称: 二苯甲烷, 二苯基甲烷
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: C(C1=CC=CC=C1)C1=CC=CC=C1
InChI: InChI=1S/C13H12/c1-3-7-12(8-4-1)11-13-9-5-2-6-10-13/h1-10H,11H2
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:38884
- PubChem: 7580
- HMDB: HMDB0251459
- ChEMBL: CHEMBL1796022
- Wikipedia: Diphenylmethane
- CAS: 101-81-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Kristen Stout, Marketa Bernaskova, Gary W Miller, Antje Hufner, Wolfgang Schuehly. Bioinspired Honokiol Analogs and Their Evaluation for Activity on the Norepinephrine Transporter.
Molecules (Basel, Switzerland).
2018 Oct; 23(10):. doi:
10.3390/molecules23102536
. [PMID: 30287800] - Masakazu Nambo, Daisuke Kurihara, Tomomi Yamada, Taeko Nishiwaki-Ohkawa, Naoya Kadofusa, Yusuke Kimata, Keiko Kuwata, Masaaki Umeda, Minako Ueda. Combination of Synthetic Chemistry and Live-Cell Imaging Identified a Rapid Cell Division Inhibitor in Tobacco and Arabidopsis thaliana.
Plant & cell physiology.
2016 Nov; 57(11):2255-2268. doi:
10.1093/pcp/pcw140
. [PMID: 27519314] - Ji-Cheng Shu, Gui-Xin Chou, Zheng-Tao Wang. One new diphenylmethane glycoside from the leaves of Psidium guajava L.
Natural product research.
2012 Nov; 26(21):1971-5. doi:
10.1080/14786419.2011.633081
. [PMID: 22085357] - Jie Liu, Zhongyan Wang, Chao Liu, Honglei Xi, Chunmei Li, Yang Chen, Lin Sun, Liwei Mu, Liang Fang. Silicone adhesive, a better matrix for tolterodine patches-a research based on in vitro/in vivo studies.
Drug development and industrial pharmacy.
2012 Aug; 38(8):1008-14. doi:
10.3109/03639045.2011.637049
. [PMID: 22126709] - G Luippold, T Klein, M Mark, R Grempler. Empagliflozin, a novel potent and selective SGLT-2 inhibitor, improves glycaemic control alone and in combination with insulin in streptozotocin-induced diabetic rats, a model of type 1 diabetes mellitus.
Diabetes, obesity & metabolism.
2012 Jul; 14(7):601-7. doi:
10.1111/j.1463-1326.2012.01569.x
. [PMID: 22268612] - Masayuki Suzuki, Kiyofumi Honda, Masanori Fukazawa, Kazuharu Ozawa, Hitoshi Hagita, Takahiro Kawai, Minako Takeda, Tatsuo Yata, Mio Kawai, Taku Fukuzawa, Takamitsu Kobayashi, Tsutomu Sato, Yoshiki Kawabe, Sachiya Ikeda. Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice.
The Journal of pharmacology and experimental therapeutics.
2012 Jun; 341(3):692-701. doi:
10.1124/jpet.112.191593
. [PMID: 22410641] - Sung-Ho Kim, Gil-Soon Choi, Young-Hee Nam, Joo-Hee Kim, Gyu-Young Hur, Seung-Hyun Kim, Sang Myun Park, Hae-Sim Park. Role of vitamin D-binding protein in isocyanate-induced occupational asthma.
Experimental & molecular medicine.
2012 May; 44(5):319-29. doi:
10.3858/emm.2012.44.5.036
. [PMID: 22314196] - Gábor Simonyi. [New possibility in the oral glucose lowering treatment of type 2 diabetes mellitus: sodium-glucose co-transporter-2 inhibitors].
Orvosi hetilap.
2012 May; 153(18):695-701. doi:
10.1556/oh.2012.29351
. [PMID: 22547464] - Jara J Brunt, Saad Khan, John J Heikkila. Sodium arsenite and cadmium chloride induction of proteasomal inhibition and HSP accumulation in Xenopus laevis A6 kidney epithelial cells.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2012 Mar; 155(2):307-17. doi:
10.1016/j.cbpc.2011.09.011
. [PMID: 21983225] - Yi-Liang' Chen, Wei-Ju Feng, Xiao-Li Zhang. [Parkinson's disease combined with overactive bladder syndrome treated with acupuncture and medication].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2012 Mar; 32(3):215-8. doi:
NULL
. [PMID: 22471132] - Alessandro Gozzi, Valeria Colavito, Paul F Seke Etet, Dino Montanari, Silvia Fiorini, Stefano Tambalo, Angelo Bifone, Gigliola Grassi Zucconi, Marina Bentivoglio. Modulation of fronto-cortical activity by modafinil: a functional imaging and fos study in the rat.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2012 Feb; 37(3):822-37. doi:
10.1038/npp.2011.260
. [PMID: 22048464] - Nobuaki Mizutani, Hirofumi Goshima, Takeshi Nabe, Shin Yoshino. Establishment and characterization of a murine model for allergic asthma using allergen-specific IgE monoclonal antibody to study pathological roles of IgE.
Immunology letters.
2012 Jan; 141(2):235-45. doi:
10.1016/j.imlet.2011.10.010
. [PMID: 22037571] - Ann L Anderson, Shou-Hua Li, Kousick Biswas, Frances McSherry, Tyson Holmes, Erin Iturriaga, Roberta Kahn, Nora Chiang, Thomas Beresford, Jan Campbell, William Haning, Joseph Mawhinney, Michael McCann, Richard Rawson, Christopher Stock, Dennis Weis, Elmer Yu, Ahmed M Elkashef. Modafinil for the treatment of methamphetamine dependence.
Drug and alcohol dependence.
2012 Jan; 120(1-3):135-41. doi:
10.1016/j.drugalcdep.2011.07.007
. [PMID: 21840138] - R Grempler, L Thomas, M Eckhardt, F Himmelsbach, A Sauer, D E Sharp, R A Bakker, M Mark, T Klein, P Eickelmann. Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors.
Diabetes, obesity & metabolism.
2012 Jan; 14(1):83-90. doi:
10.1111/j.1463-1326.2011.01517.x
. [PMID: 21985634] - A Bahi. The pre-synaptic metabotropic glutamate receptor 7 "mGluR7" is a critical modulator of ethanol sensitivity in mice.
Neuroscience.
2011 Dec; 199(?):13-23. doi:
10.1016/j.neuroscience.2011.10.029
. [PMID: 22056957] - Kok-Yong Seng, Lu Fan, How Sung Lee, Wei Peng Yong, Boon Cher Goh, Lawrence Soon-U Lee. Population pharmacokinetics of modafinil and its acid and sulfone metabolites in Chinese males.
Therapeutic drug monitoring.
2011 Dec; 33(6):719-29. doi:
10.1097/ftd.0b013e318237a9e9
. [PMID: 22105589] - Eliseu O De Oliveira, Kan Wang, Hye-Sik Kong, Suhyon Kim, Matthew Miessau, Robert J Snelgrove, Y Michael Shim, Mikell Paige. Effect of the leukotriene A4 hydrolase aminopeptidase augmentor 4-methoxydiphenylmethane in a pre-clinical model of pulmonary emphysema.
Bioorganic & medicinal chemistry letters.
2011 Nov; 21(22):6746-50. doi:
10.1016/j.bmcl.2011.09.048
. [PMID: 21983441] - Sun-Ouck Kim, Eu Chang Hwang, Kyung Jin Oh, Dongdeuk Kwon, Kwangsung Park, Soo Bang Ryu. Efficacy and safety of combined therapy with tamsulosin and tolterodine in female patients with a maximal flow rate less than 12 ml/s.
International urogynecology journal.
2011 Oct; 22(10):1287-91. doi:
10.1007/s00192-011-1453-9
. [PMID: 21617983] - Masanori Ichikawa, Aki Yokomizo, Masao Itoh, Noriyasu Haginoya, Kazuyuki Sugita, Hiroyuki Usui, Koji Terayama, Akira Kanda. Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: novel, highly potent and orally efficacious squalene synthase inhibitors.
Bioorganic & medicinal chemistry.
2011 Sep; 19(17):5207-24. doi:
10.1016/j.bmc.2011.07.007
. [PMID: 21802309] - Ernesto Callegari, Bimal Malhotra, Peter J Bungay, Rob Webster, Katherine S Fenner, Sarah Kempshall, Jennifer L LaPerle, Martin C Michel, Gary G Kay. A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder.
British journal of clinical pharmacology.
2011 Aug; 72(2):235-46. doi:
10.1111/j.1365-2125.2011.03961.x
. [PMID: 21392072] - David C Henderson, Oliver Freudenreich, Christina P C Borba, Xingyue Wang, Paul M Copeland, Eric Macklin, Xiaoduo Fan, Corinne Cather, Donald C Goff. Effects of modafinil on weight, glucose and lipid metabolism in clozapine-treated patients with schizophrenia.
Schizophrenia research.
2011 Aug; 130(1-3):53-6. doi:
10.1016/j.schres.2011.04.009
. [PMID: 21565464] - Bimal Malhotra, Christine Alvey, Jason Gong, Xiaoxi Li, Gregory Duczynski, Kuan Gandelman. Effects of fesoterodine on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers.
British journal of clinical pharmacology.
2011 Aug; 72(2):257-62. doi:
10.1111/j.1365-2125.2011.03989.x
. [PMID: 21496065] - Bimal Malhotra, Maurice Dickins, Christine Alvey, Zhanna Jumadilova, Xiaoxi Li, Gregory Duczynski, Kuan Gandelman. Effects of the moderate CYP3A4 inhibitor, fluconazole, on the pharmacokinetics of fesoterodine in healthy subjects.
British journal of clinical pharmacology.
2011 Aug; 72(2):263-9. doi:
10.1111/j.1365-2125.2011.04007.x
. [PMID: 21545485] - Thi-Lien Nguyen, Yu-Hua Tian, In-Jee You, Seok-Yong Lee, Choon-Gon Jang. Modafinil-induced conditioned place preference via dopaminergic system in mice.
Synapse (New York, N.Y.).
2011 Aug; 65(8):733-41. doi:
10.1002/syn.20892
. [PMID: 21157933] - Hiroshi Nagabukuro, Katherine L Villa, L Alexandra Wickham, Alison A Kulick, Loise Gichuru, Marcie J Donnelly, Gregory O Voronin, Tony Pereira, Xinchun Tong, Andrew Nichols, Stephen E Alves, Gary P O'Neill, Christopher V Johnson, Emily J Hickey. Comparative analysis of the effects of antimuscarinic agents on bladder functions in both nonhuman primates and rodents.
The Journal of pharmacology and experimental therapeutics.
2011 Jul; 338(1):220-7. doi:
10.1124/jpet.111.179747
. [PMID: 21459965] - Stacey J Sukoff Rizzo, Sarah K Leonard, Adam Gilbert, Paul Dollings, Deborah L Smith, Mei-Yi Zhang, Li Di, Brian J Platt, Sarah Neal, Jason M Dwyer, Corey N Bender, Jean Zhang, Tim Lock, Dianne Kowal, Angela Kramer, Andrew Randall, Christine Huselton, Karthick Vishwanathan, Susanna Y Tse, John Butera, Robert H Ring, Sharon Rosenzweig-Lipson, Zoë A Hughes, John Dunlop. The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise?.
The Journal of pharmacology and experimental therapeutics.
2011 Jul; 338(1):345-52. doi:
10.1124/jpet.110.177378
. [PMID: 21508084] - U D Palanisamy, L T Ling, T Manaharan, V Sivapalan, T Subramaniam, M H Helme, T Masilamani. Standardized extract of Syzygium aqueum: a safe cosmetic ingredient.
International journal of cosmetic science.
2011 Jun; 33(3):269-75. doi:
10.1111/j.1468-2494.2010.00637.x
. [PMID: 21284663] - Wen-Yih Wu, Sheng-Mou Hsiao, Ting-Chen Chang, Ho-Hsiung Lin. Changes in urodynamic parameters after tolterodine treatment for female overactive bladder syndrome with or without voiding dysfunction.
The journal of obstetrics and gynaecology research.
2011 May; 37(5):436-41. doi:
10.1111/j.1447-0756.2010.01370.x
. [PMID: 21272154] - Wei Gan, Shao-Feng Zhang, Hong-Tao Jia, Sheng Xie, Mao-Hua Luo, Yun-Fei Li. [Tolterodine tartrate combined with alpha-receptor blocker for benign prostatic hyperplasia with detrusor overactivity].
Zhonghua nan ke xue = National journal of andrology.
2011 Apr; 17(4):348-50. doi:
. [PMID: 21548214]
- E Claire Dees, Jeffrey R Infante, Roger B Cohen, Bert H O'Neil, Suzanne Jones, Margaret von Mehren, Hadi Danaee, Yih Lee, Jeffrey Ecsedy, Mark Manfredi, Katherine Galvin, Bradley Stringer, Hua Liu, Omar Eton, Howard Fingert, Howard Burris. Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors.
Cancer chemotherapy and pharmacology.
2011 Apr; 67(4):945-54. doi:
10.1007/s00280-010-1377-y
. [PMID: 20607239] - Lygia T Budnik, Dennis Nowak, Rolf Merget, Catherine Lemiere, Xaver Baur. Elimination kinetics of diisocyanates after specific inhalative challenges in humans: mass spectrometry analysis, as a basis for biomonitoring strategies.
Journal of occupational medicine and toxicology (London, England).
2011 Mar; 6(1):9. doi:
10.1186/1745-6673-6-9
. [PMID: 21447151] - Adam V Wisnewski, Lan Xu, Eve Robinson, Jian Liu, Carrie A Redlich, Christina A Herrick. Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responses.
Journal of occupational medicine and toxicology (London, England).
2011 Mar; 6(?):6. doi:
10.1186/1745-6673-6-6
. [PMID: 21414210] - Christian de Mey, Lyudmila Mateva, Zahariy Krastev, Richard Sachse, Nolan Wood, Bimal Malhotra. Effects of hepatic dysfunction on the single-dose pharmacokinetics of fesoterodine.
Journal of clinical pharmacology.
2011 Mar; 51(3):397-405. doi:
10.1177/0091270010365547
. [PMID: 20371737] - Stine Mjåvatn Jakobsen, Hege Kersten, Espen Molden. Evaluation of brain anticholinergic activities of urinary spasmolytic drugs using a high-throughput radio receptor bioassay.
Journal of the American Geriatrics Society.
2011 Mar; 59(3):501-5. doi:
10.1111/j.1532-5415.2010.03307.x
. [PMID: 21391941] - Akihiro Tai, Takeshi Sawano, Futoshi Yazama, Hideyuki Ito. Evaluation of antioxidant activity of vanillin by using multiple antioxidant assays.
Biochimica et biophysica acta.
2011 Feb; 1810(2):170-7. doi:
10.1016/j.bbagen.2010.11.004
. [PMID: 21095222] - Howard B Goldman, Jon D Morrow, Jason Gong, Li-Jung Tseng, Tim Schneider. Early onset of fesoterodine efficacy in subjects with overactive bladder.
BJU international.
2011 Feb; 107(4):598-602. doi:
10.1111/j.1464-410x.2010.09586.x
. [PMID: 20868387] - Mona Darwish, Mary Kirby, Edward T Hellriegel, Ronghua Yang, Philmore Robertson. Systemic exposure to armodafinil and its tolerability in healthy elderly versus young men: an open-label, multiple-dose, parallel-group study.
Drugs & aging.
2011 Feb; 28(2):139-50. doi:
10.2165/11586370-000000000-00000
. [PMID: 21275439] - Kyle C Schmitt, Maarten E A Reith. The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors.
PloS one.
2011; 6(10):e25790. doi:
10.1371/journal.pone.0025790
. [PMID: 22043293] - Nami Shrestha Palikhe, Joo-Hee Kim, Hae-Sim Park. Biomarkers predicting isocyanate-induced asthma.
Allergy, asthma & immunology research.
2011 Jan; 3(1):21-6. doi:
10.4168/aair.2011.3.1.21
. [PMID: 21217921] - Takehiko Shiraishi, Peter E Nielsen. Improved cellular uptake of antisense peptide nucleic acids by conjugation to a cell-penetrating peptide and a lipid domain.
Methods in molecular biology (Clifton, N.J.).
2011; 751(?):209-21. doi:
10.1007/978-1-61779-151-2_13
. [PMID: 21674333] - Katarzyna Kulig, Krzysztof Więckowski, Anna Więckowska, Justyna Gajda, Bartłomiej Pochwat, Georg C Höfner, Klaus T Wanner, Barbara Malawska. Synthesis and biological evaluation of new derivatives of 2-substituted 4-hydroxybutanamides as GABA uptake inhibitors.
European journal of medicinal chemistry.
2011 Jan; 46(1):183-90. doi:
10.1016/j.ejmech.2010.11.001
. [PMID: 21111516] - Zhihui Dou, Ray Y Chen, Jiahong Xu, Ye Ma, Jin Hua Jiao, Stephen Durako, Yan Zhao, Decai Zhao, Hua Fang, Fujie Zhang. Changing baseline characteristics among patients in the China National Free Antiretroviral Treatment Program, 2002-09.
International journal of epidemiology.
2010 Dec; 39 Suppl 2(?):ii56-64. doi:
10.1093/ije/dyq215
. [PMID: 21113038] - Thomas J Spencer, Bertha K Madras, Ali A Bonab, Darin D Dougherty, Allison Clarke, Tara Mirto, Jessica Martin, Alan J Fischman. A positron emission tomography study examining the dopaminergic activity of armodafinil in adults using [¹¹C]altropane and [¹¹C]raclopride.
Biological psychiatry.
2010 Nov; 68(10):964-70. doi:
10.1016/j.biopsych.2010.08.026
. [PMID: 21035624] - Vera Peuckmann, Frank Elsner, Norbert Krumm, Peter Trottenberg, Lukas Radbruch. Pharmacological treatments for fatigue associated with palliative care.
The Cochrane database of systematic reviews.
2010 Nov; ?(11):CD006788. doi:
10.1002/14651858.cd006788.pub2
. [PMID: 21069692] - Christopher R Chapple, Sender Herschorn, Paul Abrams, Joseph T Wang, Marina Brodsky, Zhonghong Guan. Efficacy and safety of tolterodine extended-release in men with overactive bladder symptoms treated with an α-blocker: effect of baseline prostate-specific antigen concentration.
BJU international.
2010 Nov; 106(9):1332-8. doi:
10.1111/j.1464-410x.2010.09359.x
. [PMID: 20497416] - Mona Darwish, Mary Kirby, Denise M D'Andrea, Ronghua Yang, Edward T Hellriegel, Philmore Robertson. Pharmacokinetics of armodafinil and modafinil after single and multiple doses in patients with excessive sleepiness associated with treated obstructive sleep apnea: a randomized, open-label, crossover study.
Clinical therapeutics.
2010 Nov; 32(12):2074-87. doi:
10.1016/j.clinthera.2010.11.009
. [PMID: 21118743] - Zhihui Dou, Ray Y Chen, Zhe Wang, Guoping Ji, Guoping Peng, Xiaochun Qiao, Jihua Fu, Xiangdong Meng, Marc Bulterys, Ye Ma, Yan Zhao, Ning Wang, Fujie Zhang. HIV-infected former plasma donors in rural Central China: from infection to survival outcomes, 1985-2008.
PloS one.
2010 Oct; 5(10):e13737. doi:
10.1371/journal.pone.0013737
. [PMID: 21060835] - Wen-Feng Cai, Xiao-Wei Zhang, Hui-Min Yan, Yong-Gang Ma, Xiao-Xing Wang, Jun Yan, Bing-Mu Xin, Xiao-Xi Lv, Qing-Qing Wang, Zi-Yan Wang, Hong-Zhen Yang, Zhuo-Wei Hu. Intracellular or extracellular heat shock protein 70 differentially regulates cardiac remodelling in pressure overload mice.
Cardiovascular research.
2010 Oct; 88(1):140-9. doi:
10.1093/cvr/cvq182
. [PMID: 20542874] - Fengying Sun, Cheng Sui, Lesheng Teng, Ximing Liu, Lirong Teng, Qingfan Meng, Youxin Li. Studies on the preparation, characterization and pharmacological evaluation of tolterodine PLGA microspheres.
International journal of pharmaceutics.
2010 Sep; 397(1-2):44-9. doi:
10.1016/j.ijpharm.2010.06.042
. [PMID: 20600717] - Linda Cardozo, Vik Khullar, Ahmed El-Tahtawy, Zhonghong Guan, Bimal Malhotra, David Staskin. Modeling dose-response relationships of the effects of fesoterodine in patients with overactive bladder.
BMC urology.
2010 Aug; 10(?):14. doi:
10.1186/1471-2490-10-14
. [PMID: 20723260] - Kathrin Finke, Chris M Dodds, Peter Bublak, Ralf Regenthal, Frank Baumann, Tom Manly, Ulrich Müller. Effects of modafinil and methylphenidate on visual attention capacity: a TVA-based study.
Psychopharmacology.
2010 Jun; 210(3):317-29. doi:
10.1007/s00213-010-1823-x
. [PMID: 20352415] - Elizabeth K Hussey, Robert L Dobbins, Randall R Stoltz, Nancy L Stockman, Robin L O'Connor-Semmes, Anita Kapur, Sharon C Murray, Debbi Layko, Derek J R Nunez. Multiple-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy overweight and obese subjects: a randomized double-blind study.
Journal of clinical pharmacology.
2010 Jun; 50(6):636-46. doi:
10.1177/0091270009352185
. [PMID: 20200268] - Monica L Andersen, Eileen Kessler, Kevin S Murnane, Jessica C McClung, Sergio Tufik, Leonard L Howell. Dopamine transporter-related effects of modafinil in rhesus monkeys.
Psychopharmacology.
2010 Jun; 210(3):439-48. doi:
10.1007/s00213-010-1839-2
. [PMID: 20386883] - Elizabeth K Hussey, Richard V Clark, Dipti M Amin, Mark S Kipnes, Robin L O'Connor-Semmes, Eilis C O'Driscoll, Jenny Leong, Sharon C Murray, Robert L Dobbins, Debbi Layko, Derek J R Nunez. Single-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy volunteers and patients with type 2 diabetes mellitus.
Journal of clinical pharmacology.
2010 Jun; 50(6):623-35. doi:
10.1177/0091270009351879
. [PMID: 20056803] - Neil E Paterson, Allison Fedolak, Berend Olivier, Taleen Hanania, Afshin Ghavami, Barbara Caldarone. Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents.
Pharmacology, biochemistry, and behavior.
2010 Jun; 95(4):449-56. doi:
10.1016/j.pbb.2010.03.006
. [PMID: 20346966] - Zrinka Rajić, Dimitra Hadjipavlou-Litina, Eleni Pontiki, Marijeta Kralj, Lidija Suman, Branka Zorc. The novel ketoprofen amides--synthesis and biological evaluation as antioxidants, lipoxygenase inhibitors and cytostatic agents.
Chemical biology & drug design.
2010 Jun; 75(6):641-52. doi:
10.1111/j.1747-0285.2010.00963.x
. [PMID: 20337784] - Keith G Heinzerling, Aimee-Noelle Swanson, Soeun Kim, Lisa Cederblom, Ardis Moe, Walter Ling, Steven Shoptaw. Randomized, double-blind, placebo-controlled trial of modafinil for the treatment of methamphetamine dependence.
Drug and alcohol dependence.
2010 Jun; 109(1-3):20-9. doi:
10.1016/j.drugalcdep.2009.11.023
. [PMID: 20092966] - Philippe Zimmern, Heather J Litman, Elizabeth Mueller, Peggy Norton, Patricia Goode. Effect of fluid management on fluid intake and urge incontinence in a trial for overactive bladder in women.
BJU international.
2010 Jun; 105(12):1680-5. doi:
10.1111/j.1464-410x.2009.09055.x
. [PMID: 19912207] - Daniel A Shoskes, J Curtis Nickel, Michael W Kattan. Phenotypically directed multimodal therapy for chronic prostatitis/chronic pelvic pain syndrome: a prospective study using UPOINT.
Urology.
2010 Jun; 75(6):1249-53. doi:
10.1016/j.urology.2010.01.021
. [PMID: 20363491] - Shantel E Walcott, John J Heikkila. Celastrol can inhibit proteasome activity and upregulate the expression of heat shock protein genes, hsp30 and hsp70, in Xenopus laevis A6 cells.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2010 Jun; 156(2):285-93. doi:
10.1016/j.cbpa.2010.02.015
. [PMID: 20188206] - M Julio-Pieper, N P Hyland, J A Bravo, T G Dinan, J F Cryan. A novel role for the metabotropic glutamate receptor-7: modulation of faecal water content and colonic electrolyte transport in the mouse.
British journal of pharmacology.
2010 May; 160(2):367-75. doi:
10.1111/j.1476-5381.2010.00713.x
. [PMID: 20423346] - Jared W Young, Mark A Geyer. Action of modafinil--increased motivation via the dopamine transporter inhibition and D1 receptors?.
Biological psychiatry.
2010 Apr; 67(8):784-7. doi:
10.1016/j.biopsych.2009.12.015
. [PMID: 20132929] - Yuan Cao, Ji-Jun Chen, Ning-Hua Tan, Lukas Oberer, Trixie Wagner, Yong-Ping Wu, Guang-Zhi Zeng, He Yan, Qiang Wang. Antimicrobial selaginellin derivatives from Selaginella pulvinata.
Bioorganic & medicinal chemistry letters.
2010 Apr; 20(8):2456-60. doi:
10.1016/j.bmcl.2010.03.016
. [PMID: 20335035] - Mohammed T A Salim, Mika Okamoto, Shinnosuke Hosoda, Hiroshi Aoyama, Yuichi Hashimoto, Masanori Baba. Anti-bovine viral diarrhoea virus activity of novel diphenylmethane derivatives.
Antiviral chemistry & chemotherapy.
2010 Apr; 20(5):193-200. doi:
10.3851/imp1528
. [PMID: 20413826] - Guo Tao, Zhao Longshan, Wu Kehua, Xia Dongya, Lu Wei, Guan Zheng, Deng Chenhui. Population pharmacokinetics of modafinil in Chinese Han, Mongolian, Korean, Uygur, and Hui healthy subjects determined by nonlinear mixed-effects modeling.
Therapeutic drug monitoring.
2010 Apr; 32(2):189-93. doi:
10.1097/ftd.0b013e3181cf27d3
. [PMID: 20216121] - Ulrich Mehnert, André Reitz, Sumaya Abo Youssef, Brigitte Schurch. Proof of principle: The effect of antimuscarinics on bladder filling sensations in healthy subjects--a placebo controlled double blind investigation using 4 and 8 mg tolterodine extended release.
Neurourology and urodynamics.
2010 Mar; 29(3):464-9. doi:
10.1002/nau.20743
. [PMID: 19637377] - Bimal K Malhotra, Penelope H Crownover, Robert LaBadie, Paul Glue, Scott A MacDiarmid. The pharmacokinetic profile of fesoterodine 8 mg with daytime or nighttime dosing.
European journal of clinical pharmacology.
2010 Feb; 66(2):171-6. doi:
10.1007/s00228-009-0748-y
. [PMID: 19915829] - Jean-Jacques Wyndaele. Pediatrics: combining antimuscarinics shows promise for overactive bladder.
Nature reviews. Urology.
2010 Feb; 7(2):66-8. doi:
10.1038/nrurol.2010.1
. [PMID: 20145662] - Suzanne K Vosburg, Carl L Hart, Margaret Haney, Eric Rubin, Richard W Foltin. Modafinil does not serve as a reinforcer in cocaine abusers.
Drug and alcohol dependence.
2010 Jan; 106(2-3):233-6. doi:
10.1016/j.drugalcdep.2009.09.002
. [PMID: 19783386] - Tao Guo, Long-shan Zhao, Dong-Ya Xia. Pharmacokinetic study of modafinil in relation to gender and ethnicity in healthy young Chinese volunteers.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2010; 13(3):443-9. doi:
10.18433/j3fk5r
. [PMID: 21092715] - Beatriz S Amorim, Cintia B Ueta, Beatriz C G Freitas, Renata J Nassif, Cecília Helena de Azevedo Gouveia, Marcelo A Christoffolete, Anselmo S Moriscot, Carmen Lucia Lancelloti, Flávia Llimona, Hermes Vieira Barbeiro, Heraldo Possolo de Souza, Sergio Catanozi, Marisa Passarelli, Marcelo S Aoki, Antonio C Bianco, Miriam O Ribeiro. A TRbeta-selective agonist confers resistance to diet-induced obesity.
The Journal of endocrinology.
2009 Nov; 203(2):291-9. doi:
10.1677/joe-08-0539
. [PMID: 19713219] - Akira Tsujimura, Tetsuya Takao, Kinya Uchida, Keisuke Yamamoto, Shinichiro Fukuhara, Jiro Nakayama, Tomohiro Ueda, Toshiaki Hirai, Hiroshi Kiuchi, Yasushi Miyagawa, Toru Takahashi, Yasuyuki Kojimaan, Akihiko Okuyama. [Clinical efficacy of tolterodine for patients with overactive bladder after insufficient efficacy by monotherapy with alpha1-adrenoceptor antagonist].
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.
2009 Nov; 100(7):686-92. doi:
10.5980/jpnjurol.100.686
. [PMID: 19999133] - Qiang Zhang, Elbert J C van der Klift, Hans-Gerd Janssen, Teris A van Beek. An on-line normal-phase high performance liquid chromatography method for the rapid detection of radical scavengers in non-polar food matrixes.
Journal of chromatography. A.
2009 Oct; 1216(43):7268-74. doi:
10.1016/j.chroma.2009.08.043
. [PMID: 19726044] - Janette McGaugh, Michael J Mancino, Zachary Feldman, Mohit P Chopra, W Brooks Gentry, Christopher Cargile, Alison Oliveto. Open-label pilot study of modafinil for methamphetamine dependence.
Journal of clinical psychopharmacology.
2009 Oct; 29(5):488-91. doi:
10.1097/jcp.0b013e3181b591e0
. [PMID: 19745650] - Stéphane Bolduc, Katherine Moore, Sylvie Lebel, Pascale Lamontagne, Micheline Hamel. Double anticholinergic therapy for refractory overactive bladder.
The Journal of urology.
2009 Oct; 182(4 Suppl):2033-8. doi:
10.1016/j.juro.2009.05.099
. [PMID: 19695628] - Kenji Katsuno, Yoshikazu Fujimori, Yukiko Ishikawa-Takemura, Masayuki Isaji. Long-term treatment with sergliflozin etabonate improves disturbed glucose metabolism in KK-A(y) mice.
European journal of pharmacology.
2009 Sep; 618(1-3):98-104. doi:
10.1016/j.ejphar.2009.07.001
. [PMID: 19615995] - B K Malhotra, N Wood, R Sachse. Influence of age, gender, and race on pharmacokinetics, pharmacodynamics, and safety of fesoterodine.
International journal of clinical pharmacology and therapeutics.
2009 Sep; 47(9):570-8. doi:
10.5414/cpp47570
. [PMID: 19761716] - Ann L Anderson, Malcolm S Reid, Shou-Hua Li, Tyson Holmes, Lynn Shemanski, April Slee, Edwina V Smith, Roberta Kahn, Nora Chiang, Frank Vocci, Domenic Ciraulo, Charles Dackis, John D Roache, Ihsan M Salloum, Eugene Somoza, Harold C Urschel, Ahmed M Elkashef. Modafinil for the treatment of cocaine dependence.
Drug and alcohol dependence.
2009 Sep; 104(1-2):133-9. doi:
10.1016/j.drugalcdep.2009.04.015
. [PMID: 19560290] - Gal Neuman, Naim Shehadeh, Giora Pillar. Unsuccessful suicide attempt of a 15 year old adolescent with ingestion of 5000 mg modafinil.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.
2009 Aug; 5(4):372-3. doi:
10.5664/jcsm.27550
. [PMID: 19968017] - R Nageswara Rao, Dhananjay D Shinde. Enantioselective separation and determination of adrafinil and modafinil on Chiralcel OJ-H column in rat serum and urine using solid-phase extraction followed by HPLC.
Biomedical chromatography : BMC.
2009 Aug; 23(8):811-6. doi:
10.1002/bmc.1190
. [PMID: 19353685] - Prashant S Kharkar, Angela M Batman, Juan Zhen, Patrick M Beardsley, Maarten E A Reith, Aloke K Dutta. Synthesis and biological characterization of (3R,4R)-4-(2-(benzhydryloxy)ethyl)-1-((R)-2-hydroxy-2-phenylethyl)-piperidin-3-ol and its stereoisomers for activity toward monoamine transporters.
ChemMedChem.
2009 Jul; 4(7):1075-85. doi:
10.1002/cmdc.200900085
. [PMID: 19449323] - Ralf Regenthal, Holger Koch, Christian Köhler, Rainer Preiss, Ute Krügel. Depression-like deficits in rats improved by subchronic modafinil.
Psychopharmacology.
2009 Jul; 204(4):627-39. doi:
10.1007/s00213-009-1493-8
. [PMID: 19255746] - Shinnosuke Hosoda, Hiroshi Aoyama, Yukinori Goto, Mohammed T A Salim, Mika Okamoto, Mariko Hashimoto, Masanori Baba, Yuichi Hashimoto. Discovery of diphenylmethane analogs as anti-bovine diarrhea viral agents.
Bioorganic & medicinal chemistry letters.
2009 Jun; 19(12):3157-61. doi:
10.1016/j.bmcl.2009.04.137
. [PMID: 19447037] - Ligang Zhao, Yan Li, Liang Fang, Zhonggui He, Xuntao Liu, Lin Wang, Yongnan Xu, Changshu Ren. Transdermal delivery of tolterodine by O-acylmenthol: In vitro/in vivo correlation.
International journal of pharmaceutics.
2009 Jun; 374(1-2):73-81. doi:
10.1016/j.ijpharm.2009.03.005
. [PMID: 19446762] - Bimal Malhotra, Richard Sachse, Nolan Wood. Evaluation of drug-drug interactions with fesoterodine.
European journal of clinical pharmacology.
2009 Jun; 65(6):551-60. doi:
10.1007/s00228-009-0648-1
. [PMID: 19347334] - B Malhotra, R Sachse, N Wood. Influence of food on the pharmacokinetic profile of fesoterodine.
International journal of clinical pharmacology and therapeutics.
2009 Jun; 47(6):384-90. doi:
10.5414/cpp47384
. [PMID: 19473600] - Hsin-Tzu Liu, Michael B Chancellor, Hann-Chorng Kuo. Decrease of urinary nerve growth factor levels after antimuscarinic therapy in patients with overactive bladder.
BJU international.
2009 Jun; 103(12):1668-72. doi:
10.1111/j.1464-410x.2009.08380.x
. [PMID: 19220267] - Dorota Zolkowska, Raka Jain, Richard B Rothman, John S Partilla, Bryan L Roth, Vincent Setola, Thomas E Prisinzano, Michael H Baumann. Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil.
The Journal of pharmacology and experimental therapeutics.
2009 May; 329(2):738-46. doi:
10.1124/jpet.108.146142
. [PMID: 19197004] - Kei Shimoda, Hatsuyuki Hamada, Hiroki Hamada. Phytoremediation of benzophenone and bisphenol a by glycosylation with immobilized plant cells.
Environmental health insights.
2009 04; 3(?):19-25. doi:
10.4137/ehi.s897
. [PMID: 20508754] - Bimal Malhotra, Kuan Gandelman, Richard Sachse, Nolan Wood. Assessment of the effects of renal impairment on the pharmacokinetic profile of fesoterodine.
Journal of clinical pharmacology.
2009 Apr; 49(4):477-82. doi:
10.1177/0091270009332434
. [PMID: 19246724] - Jan Macek, Pavel Ptácek, Josef Klíma. Determination of tolterodine and its 5-hydroxymethyl metabolite in human plasma by hydrophilic interaction liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Apr; 877(10):968-74. doi:
10.1016/j.jchromb.2009.02.036
. [PMID: 19269904] - Nora D Volkow, Joanna S Fowler, Jean Logan, David Alexoff, Wei Zhu, Frank Telang, Gene-Jack Wang, Millard Jayne, Jacob M Hooker, Christopher Wong, Barbara Hubbard, Pauline Carter, Donald Warner, Payton King, Colleen Shea, Youwen Xu, Lisa Muench, Karen Apelskog-Torres. Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications.
JAMA.
2009 Mar; 301(11):1148-54. doi:
10.1001/jama.2009.351
. [PMID: 19293415] - Hans-Uwe Simon, Bimal Malhotra. The pharmacokinetic profile of fesoterodine: similarities and differences to tolterodine.
Swiss medical weekly.
2009 Mar; 139(9-10):146-51. doi:
smw-12542
. [PMID: 19145494] - Brianne E Akins, Estuardo Miranda, J Matthew Lacy, Barry K Logan. A multi-drug intoxication fatality involving Xyrem (GHB).
Journal of forensic sciences.
2009 Mar; 54(2):495-6. doi:
10.1111/j.1556-4029.2008.00965.x
. [PMID: 19187456] - Suling Feng, Jingjing Liu, Xiangming Han, Jing Fan. Resonance light scattering study on the interaction of benproperine phosphate with eriochrome blue black R in the presence of sodium dodecylbenzene sulphonate and its analytical application.
Luminescence : the journal of biological and chemical luminescence.
2009 Mar; 24(2):67-72. doi:
10.1002/bio.1064
. [PMID: 18800357] - Ziyong Tang, Bao Lu, Ellen Hatch, Steven H Sacks, Neil S Sheerin. C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy.
Journal of the American Society of Nephrology : JASN.
2009 Mar; 20(3):593-603. doi:
10.1681/asn.2008040434
. [PMID: 19158354] - James Shearer, Shane Darke, Craig Rodgers, Tim Slade, Ingrid van Beek, John Lewis, Donna Brady, Rebecca McKetin, Richard P Mattick, Alex Wodak. A double-blind, placebo-controlled trial of modafinil (200 mg/day) for methamphetamine dependence.
Addiction (Abingdon, England).
2009 Feb; 104(2):224-33. doi:
10.1111/j.1360-0443.2008.02437.x
. [PMID: 19149817] - Nicolas Cabaton, Coralie Dumont, Isabelle Severin, Elisabeth Perdu, Daniel Zalko, Mustapha Cherkaoui-Malki, Marie-Christine Chagnon. Genotoxic and endocrine activities of bis(hydroxyphenyl)methane (bisphenol F) and its derivatives in the HepG2 cell line.
Toxicology.
2009 Jan; 255(1-2):15-24. doi:
10.1016/j.tox.2008.09.024
. [PMID: 18973785] - Mona Darwish, Mary Kirby, Edward T Hellriegel, Ronghua Yang, Philmore Robertson. Pharmacokinetic profile of armodafinil in healthy subjects: pooled analysis of data from three randomized studies.
Clinical drug investigation.
2009; 29(2):87-100. doi:
10.2165/0044011-200929020-00003
. [PMID: 19133704]