Diphenylmethane (BioDeep_00000178416)
human metabolite blood metabolite
代谢物信息卡片
1,1-Dimethylenebis(benzene)
化学式: C13H12 (168.0938952)
中文名称: 二苯甲烷
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: C(C1=CC=CC=C1)C1=CC=CC=C1
InChI: InChI=1S/C13H12/c1-3-7-12(8-4-1)11-13-9-5-2-6-10-13/h1-10H,11H2
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:38884
- PubChem: 7580
- HMDB: HMDB0251459
- ChEMBL: CHEMBL1796022
- Wikipedia: Diphenylmethane
- CAS: 101-81-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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2016 Nov; 57(11):2255-2268. doi:
10.1093/pcp/pcw140. [PMID: 27519314] - Ji-Cheng Shu, Gui-Xin Chou, Zheng-Tao Wang. One new diphenylmethane glycoside from the leaves of Psidium guajava L.
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Antiviral chemistry & chemotherapy.
2010 Apr; 20(5):193-200. doi:
10.3851/imp1528. [PMID: 20413826] - Guo Tao, Zhao Longshan, Wu Kehua, Xia Dongya, Lu Wei, Guan Zheng, Deng Chenhui. Population pharmacokinetics of modafinil in Chinese Han, Mongolian, Korean, Uygur, and Hui healthy subjects determined by nonlinear mixed-effects modeling.
Therapeutic drug monitoring.
2010 Apr; 32(2):189-93. doi:
10.1097/ftd.0b013e3181cf27d3. [PMID: 20216121] - Ulrich Mehnert, André Reitz, Sumaya Abo Youssef, Brigitte Schurch. Proof of principle: The effect of antimuscarinics on bladder filling sensations in healthy subjects--a placebo controlled double blind investigation using 4 and 8 mg tolterodine extended release.
Neurourology and urodynamics.
2010 Mar; 29(3):464-9. doi:
10.1002/nau.20743. [PMID: 19637377] - Bimal K Malhotra, Penelope H Crownover, Robert LaBadie, Paul Glue, Scott A MacDiarmid. The pharmacokinetic profile of fesoterodine 8 mg with daytime or nighttime dosing.
European journal of clinical pharmacology.
2010 Feb; 66(2):171-6. doi:
10.1007/s00228-009-0748-y. [PMID: 19915829] - Jean-Jacques Wyndaele. Pediatrics: combining antimuscarinics shows promise for overactive bladder.
Nature reviews. Urology.
2010 Feb; 7(2):66-8. doi:
10.1038/nrurol.2010.1. [PMID: 20145662] - Suzanne K Vosburg, Carl L Hart, Margaret Haney, Eric Rubin, Richard W Foltin. Modafinil does not serve as a reinforcer in cocaine abusers.
Drug and alcohol dependence.
2010 Jan; 106(2-3):233-6. doi:
10.1016/j.drugalcdep.2009.09.002. [PMID: 19783386] - Tao Guo, Long-shan Zhao, Dong-Ya Xia. Pharmacokinetic study of modafinil in relation to gender and ethnicity in healthy young Chinese volunteers.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2010; 13(3):443-9. doi:
10.18433/j3fk5r. [PMID: 21092715] - Beatriz S Amorim, Cintia B Ueta, Beatriz C G Freitas, Renata J Nassif, Cecília Helena de Azevedo Gouveia, Marcelo A Christoffolete, Anselmo S Moriscot, Carmen Lucia Lancelloti, Flávia Llimona, Hermes Vieira Barbeiro, Heraldo Possolo de Souza, Sergio Catanozi, Marisa Passarelli, Marcelo S Aoki, Antonio C Bianco, Miriam O Ribeiro. A TRbeta-selective agonist confers resistance to diet-induced obesity.
The Journal of endocrinology.
2009 Nov; 203(2):291-9. doi:
10.1677/joe-08-0539. [PMID: 19713219] - Akira Tsujimura, Tetsuya Takao, Kinya Uchida, Keisuke Yamamoto, Shinichiro Fukuhara, Jiro Nakayama, Tomohiro Ueda, Toshiaki Hirai, Hiroshi Kiuchi, Yasushi Miyagawa, Toru Takahashi, Yasuyuki Kojimaan, Akihiko Okuyama. [Clinical efficacy of tolterodine for patients with overactive bladder after insufficient efficacy by monotherapy with alpha1-adrenoceptor antagonist].
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.
2009 Nov; 100(7):686-92. doi:
10.5980/jpnjurol.100.686. [PMID: 19999133] - Qiang Zhang, Elbert J C van der Klift, Hans-Gerd Janssen, Teris A van Beek. An on-line normal-phase high performance liquid chromatography method for the rapid detection of radical scavengers in non-polar food matrixes.
Journal of chromatography. A.
2009 Oct; 1216(43):7268-74. doi:
10.1016/j.chroma.2009.08.043. [PMID: 19726044] - Janette McGaugh, Michael J Mancino, Zachary Feldman, Mohit P Chopra, W Brooks Gentry, Christopher Cargile, Alison Oliveto. Open-label pilot study of modafinil for methamphetamine dependence.
Journal of clinical psychopharmacology.
2009 Oct; 29(5):488-91. doi:
10.1097/jcp.0b013e3181b591e0. [PMID: 19745650] - Stéphane Bolduc, Katherine Moore, Sylvie Lebel, Pascale Lamontagne, Micheline Hamel. Double anticholinergic therapy for refractory overactive bladder.
The Journal of urology.
2009 Oct; 182(4 Suppl):2033-8. doi:
10.1016/j.juro.2009.05.099. [PMID: 19695628] - Kenji Katsuno, Yoshikazu Fujimori, Yukiko Ishikawa-Takemura, Masayuki Isaji. Long-term treatment with sergliflozin etabonate improves disturbed glucose metabolism in KK-A(y) mice.
European journal of pharmacology.
2009 Sep; 618(1-3):98-104. doi:
10.1016/j.ejphar.2009.07.001. [PMID: 19615995] - B K Malhotra, N Wood, R Sachse. Influence of age, gender, and race on pharmacokinetics, pharmacodynamics, and safety of fesoterodine.
International journal of clinical pharmacology and therapeutics.
2009 Sep; 47(9):570-8. doi:
10.5414/cpp47570. [PMID: 19761716] - Ann L Anderson, Malcolm S Reid, Shou-Hua Li, Tyson Holmes, Lynn Shemanski, April Slee, Edwina V Smith, Roberta Kahn, Nora Chiang, Frank Vocci, Domenic Ciraulo, Charles Dackis, John D Roache, Ihsan M Salloum, Eugene Somoza, Harold C Urschel, Ahmed M Elkashef. Modafinil for the treatment of cocaine dependence.
Drug and alcohol dependence.
2009 Sep; 104(1-2):133-9. doi:
10.1016/j.drugalcdep.2009.04.015. [PMID: 19560290] - Gal Neuman, Naim Shehadeh, Giora Pillar. Unsuccessful suicide attempt of a 15 year old adolescent with ingestion of 5000 mg modafinil.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.
2009 Aug; 5(4):372-3. doi:
10.5664/jcsm.27550. [PMID: 19968017] - R Nageswara Rao, Dhananjay D Shinde. Enantioselective separation and determination of adrafinil and modafinil on Chiralcel OJ-H column in rat serum and urine using solid-phase extraction followed by HPLC.
Biomedical chromatography : BMC.
2009 Aug; 23(8):811-6. doi:
10.1002/bmc.1190. [PMID: 19353685] - Prashant S Kharkar, Angela M Batman, Juan Zhen, Patrick M Beardsley, Maarten E A Reith, Aloke K Dutta. Synthesis and biological characterization of (3R,4R)-4-(2-(benzhydryloxy)ethyl)-1-((R)-2-hydroxy-2-phenylethyl)-piperidin-3-ol and its stereoisomers for activity toward monoamine transporters.
ChemMedChem.
2009 Jul; 4(7):1075-85. doi:
10.1002/cmdc.200900085. [PMID: 19449323] - Ralf Regenthal, Holger Koch, Christian Köhler, Rainer Preiss, Ute Krügel. Depression-like deficits in rats improved by subchronic modafinil.
Psychopharmacology.
2009 Jul; 204(4):627-39. doi:
10.1007/s00213-009-1493-8. [PMID: 19255746] - Shinnosuke Hosoda, Hiroshi Aoyama, Yukinori Goto, Mohammed T A Salim, Mika Okamoto, Mariko Hashimoto, Masanori Baba, Yuichi Hashimoto. Discovery of diphenylmethane analogs as anti-bovine diarrhea viral agents.
Bioorganic & medicinal chemistry letters.
2009 Jun; 19(12):3157-61. doi:
10.1016/j.bmcl.2009.04.137. [PMID: 19447037] - Ligang Zhao, Yan Li, Liang Fang, Zhonggui He, Xuntao Liu, Lin Wang, Yongnan Xu, Changshu Ren. Transdermal delivery of tolterodine by O-acylmenthol: In vitro/in vivo correlation.
International journal of pharmaceutics.
2009 Jun; 374(1-2):73-81. doi:
10.1016/j.ijpharm.2009.03.005. [PMID: 19446762] - Bimal Malhotra, Richard Sachse, Nolan Wood. Evaluation of drug-drug interactions with fesoterodine.
European journal of clinical pharmacology.
2009 Jun; 65(6):551-60. doi:
10.1007/s00228-009-0648-1. [PMID: 19347334] - B Malhotra, R Sachse, N Wood. Influence of food on the pharmacokinetic profile of fesoterodine.
International journal of clinical pharmacology and therapeutics.
2009 Jun; 47(6):384-90. doi:
10.5414/cpp47384. [PMID: 19473600] - Hsin-Tzu Liu, Michael B Chancellor, Hann-Chorng Kuo. Decrease of urinary nerve growth factor levels after antimuscarinic therapy in patients with overactive bladder.
BJU international.
2009 Jun; 103(12):1668-72. doi:
10.1111/j.1464-410x.2009.08380.x. [PMID: 19220267] - Dorota Zolkowska, Raka Jain, Richard B Rothman, John S Partilla, Bryan L Roth, Vincent Setola, Thomas E Prisinzano, Michael H Baumann. Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil.
The Journal of pharmacology and experimental therapeutics.
2009 May; 329(2):738-46. doi:
10.1124/jpet.108.146142. [PMID: 19197004] - Kei Shimoda, Hatsuyuki Hamada, Hiroki Hamada. Phytoremediation of benzophenone and bisphenol a by glycosylation with immobilized plant cells.
Environmental health insights.
2009 04; 3(?):19-25. doi:
10.4137/ehi.s897. [PMID: 20508754] - Bimal Malhotra, Kuan Gandelman, Richard Sachse, Nolan Wood. Assessment of the effects of renal impairment on the pharmacokinetic profile of fesoterodine.
Journal of clinical pharmacology.
2009 Apr; 49(4):477-82. doi:
10.1177/0091270009332434. [PMID: 19246724] - Jan Macek, Pavel Ptácek, Josef Klíma. Determination of tolterodine and its 5-hydroxymethyl metabolite in human plasma by hydrophilic interaction liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Apr; 877(10):968-74. doi:
10.1016/j.jchromb.2009.02.036. [PMID: 19269904] - Nora D Volkow, Joanna S Fowler, Jean Logan, David Alexoff, Wei Zhu, Frank Telang, Gene-Jack Wang, Millard Jayne, Jacob M Hooker, Christopher Wong, Barbara Hubbard, Pauline Carter, Donald Warner, Payton King, Colleen Shea, Youwen Xu, Lisa Muench, Karen Apelskog-Torres. Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications.
JAMA.
2009 Mar; 301(11):1148-54. doi:
10.1001/jama.2009.351. [PMID: 19293415] - Hans-Uwe Simon, Bimal Malhotra. The pharmacokinetic profile of fesoterodine: similarities and differences to tolterodine.
Swiss medical weekly.
2009 Mar; 139(9-10):146-51. doi:
smw-12542. [PMID: 19145494] - Brianne E Akins, Estuardo Miranda, J Matthew Lacy, Barry K Logan. A multi-drug intoxication fatality involving Xyrem (GHB).
Journal of forensic sciences.
2009 Mar; 54(2):495-6. doi:
10.1111/j.1556-4029.2008.00965.x. [PMID: 19187456] - Suling Feng, Jingjing Liu, Xiangming Han, Jing Fan. Resonance light scattering study on the interaction of benproperine phosphate with eriochrome blue black R in the presence of sodium dodecylbenzene sulphonate and its analytical application.
Luminescence : the journal of biological and chemical luminescence.
2009 Mar; 24(2):67-72. doi:
10.1002/bio.1064. [PMID: 18800357] - Ziyong Tang, Bao Lu, Ellen Hatch, Steven H Sacks, Neil S Sheerin. C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy.
Journal of the American Society of Nephrology : JASN.
2009 Mar; 20(3):593-603. doi:
10.1681/asn.2008040434. [PMID: 19158354] - James Shearer, Shane Darke, Craig Rodgers, Tim Slade, Ingrid van Beek, John Lewis, Donna Brady, Rebecca McKetin, Richard P Mattick, Alex Wodak. A double-blind, placebo-controlled trial of modafinil (200 mg/day) for methamphetamine dependence.
Addiction (Abingdon, England).
2009 Feb; 104(2):224-33. doi:
10.1111/j.1360-0443.2008.02437.x. [PMID: 19149817] - Nicolas Cabaton, Coralie Dumont, Isabelle Severin, Elisabeth Perdu, Daniel Zalko, Mustapha Cherkaoui-Malki, Marie-Christine Chagnon. Genotoxic and endocrine activities of bis(hydroxyphenyl)methane (bisphenol F) and its derivatives in the HepG2 cell line.
Toxicology.
2009 Jan; 255(1-2):15-24. doi:
10.1016/j.tox.2008.09.024. [PMID: 18973785] - Mona Darwish, Mary Kirby, Edward T Hellriegel, Ronghua Yang, Philmore Robertson. Pharmacokinetic profile of armodafinil in healthy subjects: pooled analysis of data from three randomized studies.
Clinical drug investigation.
2009; 29(2):87-100. doi:
10.2165/0044011-200929020-00003. [PMID: 19133704]