[Diisocyanato(phenyl)methyl]benzene (BioDeep_00000178403)
human metabolite blood metabolite
代谢物信息卡片
[Diisocyanato(phenyl)methyl]benzene
化学式: C15H10N2O2 (250.07422400000002)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(N=C=O)N=C=O
InChI: InChI=1S/C15H10N2O2/c18-11-16-15(17-12-19,13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sung-Ho Kim, Gil-Soon Choi, Young-Hee Nam, Joo-Hee Kim, Gyu-Young Hur, Seung-Hyun Kim, Sang Myun Park, Hae-Sim Park. Role of vitamin D-binding protein in isocyanate-induced occupational asthma.
Experimental & molecular medicine.
2012 May; 44(5):319-29. doi:
10.3858/emm.2012.44.5.036. [PMID: 22314196] - Kirsi Säkkinen, Jarkko Tornaeus, Antti Hesso, Ari Hirvonen, Harri Vainio, Hannu Norppa, Christina Rosenberg. Protein adducts as biomarkers of exposure to aromatic diisocyanates in workers manufacturing polyurethane (PUR) foam.
Journal of environmental monitoring : JEM.
2011 Apr; 13(4):957-65. doi:
10.1039/c0em00595a. [PMID: 21344094] - Lygia T Budnik, Dennis Nowak, Rolf Merget, Catherine Lemiere, Xaver Baur. Elimination kinetics of diisocyanates after specific inhalative challenges in humans: mass spectrometry analysis, as a basis for biomonitoring strategies.
Journal of occupational medicine and toxicology (London, England).
2011 Mar; 6(1):9. doi:
10.1186/1745-6673-6-9. [PMID: 21447151] - Nami Shrestha Palikhe, Joo-Hee Kim, Hae-Sim Park. Biomarkers predicting isocyanate-induced asthma.
Allergy, asthma & immunology research.
2011 Jan; 3(1):21-6. doi:
10.4168/aair.2011.3.1.21. [PMID: 21217921] - S-H Kim, G-S Choi, Y-M Ye, I Jou, H-S Park, S M Park. Toluene diisocyanate (TDI) regulates haem oxygenase-1/ferritin expression: implications for toluene diisocyanate-induced asthma.
Clinical and experimental immunology.
2010 Jun; 160(3):489-97. doi:
10.1111/j.1365-2249.2010.04118.x. [PMID: 20345975] - Adam V Wisnewski, Jian Liu, Carrie A Redlich. Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate.
Analytical biochemistry.
2010 May; 400(2):251-8. doi:
10.1016/j.ab.2010.01.037. [PMID: 20123080] - Anoop Kumar, Nagaraju Dongari, Gabriele Sabbioni. New isocyanate-specific albumin adducts of 4,4'-methylenediphenyl diisocyanate (MDI) in rats.
Chemical research in toxicology.
2009 Dec; 22(12):1975-83. doi:
10.1021/tx900270z. [PMID: 19928878] - J Schreiber, J Knolle, J Sennekamp, K T Schulz, J U Hahn, K G Hering, M Raulf-Heimsoth, R Merget. Sub-acute occupational hypersensitivity pneumonitis due to low-level exposure to diisocyanates in a secretary.
The European respiratory journal.
2008 Sep; 32(3):807-11. doi:
10.1183/09031936.00060507. [PMID: 18757705] - Margareta Littorin, Saimei Hou, Karin Broberg, Jonas Björk, Susanne Fält, Galbani Abdoulaye, Malgorzata Kalemba, Charlotta Ryk, Staffan Skerfving. Influence of polymorphic metabolic enzymes on biotransformation and effects of diphenylmethane diisocyanate.
International archives of occupational and environmental health.
2008 Feb; 81(4):429-41. doi:
10.1007/s00420-007-0232-x. [PMID: 17676332] - Jürgen Pauluhn. Brown Norway rat asthma model of diphenylmethane-4,4'-diisocyanate (MDI): impact of vehicle for topical induction.
Regulatory toxicology and pharmacology : RTP.
2008 Feb; 50(1):144-54. doi:
10.1016/j.yrtph.2007.09.003. [PMID: 17964702] - Xiaohua Kong, Suresh S Narine. Physical properties of polyurethane plastic sheets produced from polyols from canola oil.
Biomacromolecules.
2007 Jul; 8(7):2203-9. doi:
10.1021/bm070016i. [PMID: 17550287] - A Robert, P Ducos, J M Francin, P Marsan. Biological monitoring of workers exposed to 4,4'-methylenediphenyl diisocyanate (MDI) in 19 French polyurethane industries.
International archives of occupational and environmental health.
2007 Apr; 80(5):412-22. doi:
10.1007/s00420-006-0150-3. [PMID: 17061110] - P D'Arrigo, C Giordano, P Macchi, L Malpezzi, G Pedrocchi-Fantoni, S Servi. Synthesis, platelet adhesion and cytotoxicity studies of new glycerophosphoryl-containing polyurethanes.
The International journal of artificial organs.
2007 Feb; 30(2):133-43. doi:
10.1177/039139880703000208. [PMID: 17377908] - C J Sennbro, C H Lindh, C Mattsson, B A G Jönsson, H Tinnerberg. Biological monitoring of exposure to 1,5-naphthalene diisocyanate and 4,4'-methylenediphenyl diisocyanate.
International archives of occupational and environmental health.
2006 Sep; 79(8):647-53. doi:
10.1007/s00420-006-0096-5. [PMID: 16506043] - Masanori Ogawa, Tsunehiro Oyama, Toyohi Isse, Tetsunosuke Yamaguchi, Tomoe Murakami, Yoko Endo, Toshihiro Kawamoto. Hemoglobin adducts as a marker of exposure to chemical substances, especially PRTR class I designated chemical substances.
Journal of occupational health.
2006 Sep; 48(5):314-28. doi:
10.1539/joh.48.314. [PMID: 17053297] - David I Bernstein, M Gerald Ott, Michael Woolhiser, Zana Lummus, Cynthia Graham. Evaluation of antibody binding to diisocyanate protein conjugates in a general population.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2006 Sep; 97(3):357-64. doi:
10.1016/s1081-1206(10)60801-0. [PMID: 17042142] - Jürgen Pauluhn. Brown Norway rat asthma model of diphenylmethane 4,4'-diisocyanate.
Inhalation toxicology.
2005 Dec; 17(13):729-39. doi:
10.1080/08958370500224631. [PMID: 16195208] - Carl Johan Sennbro, Margareta Littorin, Håkan Tinnerberg, Bo A G Jönsson. Upper reference limits for biomarkers of exposure to aromatic diisocyanates.
International archives of occupational and environmental health.
2005 Aug; 78(7):541-6. doi:
10.1007/s00420-005-0619-5. [PMID: 15995877] - G Johannesson, C J Sennbro, P Willix, C H Lindh, B A G Jönsson. Identification and characterisation of adducts between serum albumin and 4,4'-methylenediphenyl diisocyanate (MDI) in human plasma.
Archives of toxicology.
2004 Jul; 78(7):378-83. doi:
10.1007/s00204-004-0555-2. [PMID: 15007542] - Yoshitaka Morimatsu, Hiroya Akiyoshi, Morihiro Tajiri, Ryo Hirai, Hisamichi Aizawa. [A case of hypersensitivity pneumonitis showing acute respiratory distress syndrome due to exposure to dust containing diphenylmethane diisocyanate].
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society.
2004 Jun; 42(6):502-8. doi:
. [PMID: 15228137] - Carl Johan Sennbro, Christian H Lindh, Håkan Tinnerberg, Cecilia Gustavsson, Margareta Littorin, Hans Welinder, Bo A G Jönsson. Development, validation and characterization of an analytical method for the quantification of hydrolysable urinary metabolites and plasma protein adducts of 2,4- and 2,6-toluene diisocyanate, 1,5-naphthalene diisocyanate and 4,4'-methylenediphenyl diisocyanate.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2003 May; 8(3-4):204-17. doi:
10.1080/1354750031000090660. [PMID: 12944173] - Dong-an Wang, Jian Ji, Yong-hong Sun, Jia-cong Shen, Lin-xian Feng, Jennifer H Elisseeff. In situ immobilization of proteins and RGD peptide on polyurethane surfaces via poly(ethylene oxide) coupling polymers for human endothelial cell growth.
Biomacromolecules.
2002 Nov; 3(6):1286-95. doi:
10.1021/bm0255950. [PMID: 12425667] - Arata Korematsu, Yoshiaki Takemoto, Tadao Nakaya, Hideo Inoue. Synthesis, characterization and platelet adhesion of segmented polyurethanes grafted phospholipid analogous vinyl monomer on surface.
Biomaterials.
2002 Jan; 23(1):263-71. doi:
10.1016/s0142-9612(01)00104-1. [PMID: 11762845] - R Lemus, L Lukinskeine, M E Bier, A V Wisnewski, C A Redlich, M H Karol. Development of immunoassays for biomonitoring of hexamethylene diisocyanate exposure.
Environmental health perspectives.
2001 Nov; 109(11):1103-8. doi:
10.1289/ehp.011091103. [PMID: 11712993] - K Kääriä, A Hirvonen, H Norppa, P Piirilä, H Vainio, C Rosenberg. Exposure to 4,4'-methylenediphenyl diisocyanate (MDI) during moulding of rigid polyurethane foam: determination of airborne MDI and urinary 4,4'-methylenedianiline (MDA).
The Analyst.
2001 Apr; 126(4):476-9. doi:
10.1039/b009549o. [PMID: 11340982]