Salicylamide (BioDeep_00000017834)

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs BioNovoGene_Lab2019

代谢物信息卡片

Salicylamide, calcium (2:1) salt

化学式: C7H7NO2 (137.0476762)
中文名称: 水杨酰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C(=C1)C(=O)N)O
InChI: InChI=1S/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10)

描述信息

Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties. Its medicinal uses are similar to those of aspirin. Salicylamide is used in combination with both aspirin and caffeine in the over-the-counter pain remedies
N - Nervous system > N02 - Analgesics > N02B - Other analgesics and antipyretics > N02BA - Salicylic acid and derivatives
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
COVID info from PDB, Protein Data Bank
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Salicylamide is an inhibitor of microsomal UDP-glucuronosyltransferase. Salicylamide is an analgesic and anti-pyretic agent.

同义名列表

16 个代谢物同义名

Salicylamide, calcium (2:1) salt; Salicylamide, monosodium salt; Salicylamide, 3H-labeled; Salicylic acid amide; Salicylamide sulfate; 2-Carboxamidophenol; Salicylamide sodium; O-Hydroxybenzamide; 2-Hydroxybenzamide; 2-Carbamoylphenol; Salicylate amide; Salicylamidum; salicylamide; Salicilamida; OHB; Salicylamide

数据库引用编号

12 个数据库交叉引用编号

ChEBI: CHEBI:32114
PubChem: 5147
HMDB: HMDB0015687
DrugBank: DB08797
ChEMBL: CHEMBL27577
Wikipedia: Salicylamide
chemspider: 4963
CAS: 65-45-2
PMhub: MS000000495
RefMet: Salicylamide
medchemexpress: HY-B0811
BioNovoGene_Lab2019: BioNovoGene_Lab2019-507

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Qing Song, Yan Li, Zhongcheng Cao, Xiaoming Qiang, Zhenghuai Tan, Yong Deng. Novel salicylamide derivatives as potent multifunctional agents for the treatment of Alzheimer's disease: Design, synthesis and biological evaluation. Bioorganic chemistry. 2019 03; 84(?):137-149. doi: 10.1016/j.bioorg.2018.11.022. [PMID: 30500523]
Prabodh Chander Sharma, Mona Piplani, Harish Rajak. Synthesis, Characterization and Antimicrobial Evaluation of Lipid Based Norfloxacin Prodrug. Current drug delivery. 2018 Feb; 15(2):219-226. doi: 10.2174/1567201813666161018153852. [PMID: 27758690]
Kuo-Liang Wei, Fei-Yun Chen, Chih-Yi Lin, Guan-Lun Gao, Wen-Ya Kao, Chi-Hui Yeh, Chang-Rong Chen, Hao-Chun Huang, Wei-Ren Tsai, Koa-Jen Jong, Wan-Jung Li, Jyan-Gwo Joseph Su. Activation of aryl hydrocarbon receptor reduces carbendazim-induced cell death. Toxicology and applied pharmacology. 2016 09; 306(?):86-97. doi: 10.1016/j.taap.2016.06.004. [PMID: 27286660]
Sandra Halwachs, Louise Wassermann, Walther Honscha. A novel MDCKII in vitro model for assessing ABCG2-drug interactions and regulation of ABCG2 transport activity in the caprine mammary gland by environmental pollutants and pesticides. Toxicology in vitro : an international journal published in association with BIBRA. 2014 Apr; 28(3):432-41. doi: 10.1016/j.tiv.2013.12.015. [PMID: 24389113]
Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
Sebastian Polak, Kamil Fijorek. Inter-individual variability in the pre-clinical drug cardiotoxic safety assessment--analysis of the age-cardiomyocytes electric capacitance dependence. Journal of cardiovascular translational research. 2012 Jun; 5(3):321-32. doi: 10.1007/s12265-012-9357-8. [PMID: 22411323]
Silvia Wein, Rainer Cermak, Siegfried Wolffram, Peter Langguth. Chronic quercetin feeding decreases plasma concentrations of salicylamide phase II metabolites in pigs following oral administration. Xenobiotica; the fate of foreign compounds in biological systems. 2012 May; 42(5):477-82. doi: 10.3109/00498254.2011.641607. [PMID: 22188411]
Yasemin Dündar, Yasemin Özatik, Orhan Özatik, Volkan Ergin, Tijen Önkol, Adnan Menevşe, Kevser Erol, M Fethi Sahin. Synthesis and biological evaluation of the salicylamide and salicylic acid derivatives as anti-estrogen agents. Medicinal chemistry (Shariqah (United Arab Emirates)). 2012 May; 8(3):481-90. doi: 10.2174/1573406411208030481. [PMID: 22530891]
J A Murillo Pulgarín, A Alañón Molina, I Sánchez-Ferrer Robles. Simultaneous determination of salicylic acid and salicylamide in biological fluids. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2011 Sep; 79(5):909-14. doi: 10.1016/j.saa.2011.03.047. [PMID: 21561802]
Gero P Hooff, Nick A van Huizen, Roland J W Meesters, Eduard E Zijlstra, Mohamed Abdelraheem, Waleed Abdelraheem, Mohamed Hamdouk, Jan Lindemans, Theo M Luider. Analytical investigations of toxic p-phenylenediamine (PPD) levels in clinical urine samples with special focus on MALDI-MS/MS. PloS one. 2011; 6(8):e22191. doi: 10.1371/journal.pone.0022191. [PMID: 21829608]
Jean Matthieu Prot, Anne-Sophie Briffaut, Franck Letourneur, Philippe Chafey, Franck Merlier, Yves Grandvalet, Cécile Legallais, Eric Leclerc. Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip. PloS one. 2011; 6(8):e21268. doi: 10.1371/journal.pone.0021268. [PMID: 21857903]
Yoshio Nakagawa, Toshinari Suzuki, Kazuo Nakajima, Hidemi Ishii, Akio Ogata. Biotransformation and cytotoxic effects of hydroxychavicol, an intermediate of safrole metabolism, in isolated rat hepatocytes. Chemico-biological interactions. 2009 Jun; 180(1):89-97. doi: 10.1016/j.cbi.2009.02.003. [PMID: 19428348]
Heather A Hostetler, Lindsay R Syler, Lindy N Hall, Guan Zhu, Friedhelm Schroeder, Ann B Kier. A novel high-throughput screening assay for putative antidiabetic agents through PPARalpha interactions. Journal of biomolecular screening. 2008 Oct; 13(9):855-61. doi: 10.1177/1087057108323127. [PMID: 18812576]
E Ono, M Taniguchi, H Mita, K Akiyama. Salicylamide-induced anaphylaxis: increased urinary leukotriene E4 and prostaglandin D2 metabolite. Allergy. 2008 Apr; 63(4):480-2. doi: 10.1111/j.1398-9995.2007.01616.x. [PMID: 18315738]
Zhaohua Huang, Joshua I Park, Douglas S Watson, Peter Hwang, Francis C Szoka. Facile synthesis of multivalent nitrilotriacetic acid (NTA) and NTA conjugates for analytical and drug delivery applications. Bioconjugate chemistry. 2006 Nov; 17(6):1592-600. doi: 10.1021/bc0602228. [PMID: 17105240]
Ali Reza Zarei, Abbas Afkhami, Nahid Sarlak. Simultaneous spectrophotometric determination of paracetamol and salicylamide in human serum and pharmaceutical formulations by a differential kinetic method. Journal of AOAC International. 2005 Nov; 88(6):1695-701. doi: 10.1093/jaoac/88.6.1695. [PMID: 16526453]
Milena Jadrijević-Mladar Takac, Drazen Vikić Topić, Tihana Govorcinović. FT-IR and NMR spectroscopic studies of salicylic acid derivatives. I. Gentisamide -- a metabolite of salicylamide. Acta pharmaceutica (Zagreb, Croatia). 2004 Sep; 54(3):163-76. doi: NULL. [PMID: 15610614]
Marica Medić-Sarić, Ana Mornar, Ivona Jasprica. Lipophilicity study of salicylamide. Acta pharmaceutica (Zagreb, Croatia). 2004 Jun; 54(2):91-101. doi: ". [PMID: 15274753]
Zenei Taira, Kazunori Yabe, Yuka Hamaguchi, Kensuke Hirayama, Makoto Kishimoto, Shiro Ishida, Yukari Ueda. Effects of Sho-saiko-to extract and its components, Baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, on pharmacokinetic behavior of salicylamide in carbon tetrachloride intoxicated rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2004 May; 42(5):803-7. doi: 10.1016/j.fct.2003.12.017. [PMID: 15046826]
J A Murillo Pulgarín, A Alañón Molina. Direct determination of salicylamide in serum by matrix isopotential synchronous fluorimetry. Talanta. 2002 Mar; 56(3):557-64. doi: 10.1016/s0039-9140(01)00574-4. [PMID: 18968528]
A Li, H Seipelt, C Müller, Y Shi, M Artmann. Effects of salicylic acid derivatives on red blood cell membranes. Pharmacology & toxicology. 1999 Nov; 85(5):206-11. doi: 10.1111/j.1600-0773.1999.tb02010.x. [PMID: 10608482]
J A Pulgarín, L F Bermejo. Simultaneous determination of salicylamide and salsalate in serum and urine by first derivative variable-angle synchronous fluorescence spectrometry. Analytical biochemistry. 1998 Dec; 265(2):331-9. doi: 10.1006/abio.1998.2936. [PMID: 9882411]
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K S Pang, F Barker, A J Schwab, C A Goresky. Demonstration of rapid entry and a cellular binding space for salicylamide in perfused rat liver: a multiple indicator dilution study. The Journal of pharmacology and experimental therapeutics. 1994 Jul; 270(1):285-95. doi: NULL. [PMID: 8035326]
M S Abdel-Rahman, A S Reddi, F A Curro, R M Turkall, A M Kadry, J A Hansrote. Bioavailability of aspirin and salicylamide following oral co-administration in human volunteers. Canadian journal of physiology and pharmacology. 1991 Oct; 69(10):1436-42. doi: 10.1139/y91-215. [PMID: 1777842]
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A H Kahns, H Bundgaard. Hydrolysis kinetics of 1,3-benzoxazine-2,4-dione (a potential salicylamide prodrug) and various N-substituted derivatives. Acta pharmaceutica Nordica. 1991; 3(1):45-50. doi: NULL. [PMID: 1854435]
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