salicylamide (BioDeep_00000412992)

 

Secondary id: BioDeep_00000017834

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


salicylamide

化学式: C7H7NO2 (137.0476762)
中文名称: 水杨酰胺
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 2.4%

分子结构信息

SMILES: C1=CC=C(C(=C1)C(=O)N)O
InChI: InChI=1S/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10)

描述信息

N - Nervous system > N02 - Analgesics > N02B - Other analgesics and antipyretics > N02BA - Salicylic acid and derivatives
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
COVID info from PDB, Protein Data Bank
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; INTERNAL_ID 546; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3013; ORIGINAL_PRECURSOR_SCAN_NO 3010
CONFIDENCE standard compound; INTERNAL_ID 546; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3029; ORIGINAL_PRECURSOR_SCAN_NO 3027
CONFIDENCE standard compound; INTERNAL_ID 546; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2989; ORIGINAL_PRECURSOR_SCAN_NO 2987
CONFIDENCE standard compound; INTERNAL_ID 546; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3014; ORIGINAL_PRECURSOR_SCAN_NO 3012
CONFIDENCE standard compound; INTERNAL_ID 546; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3005; ORIGINAL_PRECURSOR_SCAN_NO 3002
CONFIDENCE standard compound; INTERNAL_ID 546; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3004; ORIGINAL_PRECURSOR_SCAN_NO 3001
Salicylamide is an inhibitor of microsomal UDP-glucuronosyltransferase. Salicylamide is an analgesic and anti-pyretic agent.

同义名列表

2 个代谢物同义名

salicylamide; 2-Hydroxybenzamide



数据库引用编号

55 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Qing Song, Yan Li, Zhongcheng Cao, Xiaoming Qiang, Zhenghuai Tan, Yong Deng. Novel salicylamide derivatives as potent multifunctional agents for the treatment of Alzheimer's disease: Design, synthesis and biological evaluation. Bioorganic chemistry. 2019 03; 84(?):137-149. doi: 10.1016/j.bioorg.2018.11.022. [PMID: 30500523]
  • Prabodh Chander Sharma, Mona Piplani, Harish Rajak. Synthesis, Characterization and Antimicrobial Evaluation of Lipid Based Norfloxacin Prodrug. Current drug delivery. 2018 Feb; 15(2):219-226. doi: 10.2174/1567201813666161018153852. [PMID: 27758690]
  • Kuo-Liang Wei, Fei-Yun Chen, Chih-Yi Lin, Guan-Lun Gao, Wen-Ya Kao, Chi-Hui Yeh, Chang-Rong Chen, Hao-Chun Huang, Wei-Ren Tsai, Koa-Jen Jong, Wan-Jung Li, Jyan-Gwo Joseph Su. Activation of aryl hydrocarbon receptor reduces carbendazim-induced cell death. Toxicology and applied pharmacology. 2016 09; 306(?):86-97. doi: 10.1016/j.taap.2016.06.004. [PMID: 27286660]
  • Sandra Halwachs, Louise Wassermann, Walther Honscha. A novel MDCKII in vitro model for assessing ABCG2-drug interactions and regulation of ABCG2 transport activity in the caprine mammary gland by environmental pollutants and pesticides. Toxicology in vitro : an international journal published in association with BIBRA. 2014 Apr; 28(3):432-41. doi: 10.1016/j.tiv.2013.12.015. [PMID: 24389113]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Sebastian Polak, Kamil Fijorek. Inter-individual variability in the pre-clinical drug cardiotoxic safety assessment--analysis of the age-cardiomyocytes electric capacitance dependence. Journal of cardiovascular translational research. 2012 Jun; 5(3):321-32. doi: 10.1007/s12265-012-9357-8. [PMID: 22411323]
  • Silvia Wein, Rainer Cermak, Siegfried Wolffram, Peter Langguth. Chronic quercetin feeding decreases plasma concentrations of salicylamide phase II metabolites in pigs following oral administration. Xenobiotica; the fate of foreign compounds in biological systems. 2012 May; 42(5):477-82. doi: 10.3109/00498254.2011.641607. [PMID: 22188411]
  • Yasemin Dündar, Yasemin Özatik, Orhan Özatik, Volkan Ergin, Tijen Önkol, Adnan Menevşe, Kevser Erol, M Fethi Sahin. Synthesis and biological evaluation of the salicylamide and salicylic acid derivatives as anti-estrogen agents. Medicinal chemistry (Shariqah (United Arab Emirates)). 2012 May; 8(3):481-90. doi: 10.2174/1573406411208030481. [PMID: 22530891]
  • J A Murillo Pulgarín, A Alañón Molina, I Sánchez-Ferrer Robles. Simultaneous determination of salicylic acid and salicylamide in biological fluids. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2011 Sep; 79(5):909-14. doi: 10.1016/j.saa.2011.03.047. [PMID: 21561802]
  • Gero P Hooff, Nick A van Huizen, Roland J W Meesters, Eduard E Zijlstra, Mohamed Abdelraheem, Waleed Abdelraheem, Mohamed Hamdouk, Jan Lindemans, Theo M Luider. Analytical investigations of toxic p-phenylenediamine (PPD) levels in clinical urine samples with special focus on MALDI-MS/MS. PloS one. 2011; 6(8):e22191. doi: 10.1371/journal.pone.0022191. [PMID: 21829608]
  • Jean Matthieu Prot, Anne-Sophie Briffaut, Franck Letourneur, Philippe Chafey, Franck Merlier, Yves Grandvalet, Cécile Legallais, Eric Leclerc. Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip. PloS one. 2011; 6(8):e21268. doi: 10.1371/journal.pone.0021268. [PMID: 21857903]
  • Yoshio Nakagawa, Toshinari Suzuki, Kazuo Nakajima, Hidemi Ishii, Akio Ogata. Biotransformation and cytotoxic effects of hydroxychavicol, an intermediate of safrole metabolism, in isolated rat hepatocytes. Chemico-biological interactions. 2009 Jun; 180(1):89-97. doi: 10.1016/j.cbi.2009.02.003. [PMID: 19428348]
  • Heather A Hostetler, Lindsay R Syler, Lindy N Hall, Guan Zhu, Friedhelm Schroeder, Ann B Kier. A novel high-throughput screening assay for putative antidiabetic agents through PPARalpha interactions. Journal of biomolecular screening. 2008 Oct; 13(9):855-61. doi: 10.1177/1087057108323127. [PMID: 18812576]
  • E Ono, M Taniguchi, H Mita, K Akiyama. Salicylamide-induced anaphylaxis: increased urinary leukotriene E4 and prostaglandin D2 metabolite. Allergy. 2008 Apr; 63(4):480-2. doi: 10.1111/j.1398-9995.2007.01616.x. [PMID: 18315738]
  • Zhaohua Huang, Joshua I Park, Douglas S Watson, Peter Hwang, Francis C Szoka. Facile synthesis of multivalent nitrilotriacetic acid (NTA) and NTA conjugates for analytical and drug delivery applications. Bioconjugate chemistry. 2006 Nov; 17(6):1592-600. doi: 10.1021/bc0602228. [PMID: 17105240]
  • Ali Reza Zarei, Abbas Afkhami, Nahid Sarlak. Simultaneous spectrophotometric determination of paracetamol and salicylamide in human serum and pharmaceutical formulations by a differential kinetic method. Journal of AOAC International. 2005 Nov; 88(6):1695-701. doi: 10.1093/jaoac/88.6.1695. [PMID: 16526453]
  • Milena Jadrijević-Mladar Takac, Drazen Vikić Topić, Tihana Govorcinović. FT-IR and NMR spectroscopic studies of salicylic acid derivatives. I. Gentisamide -- a metabolite of salicylamide. Acta pharmaceutica (Zagreb, Croatia). 2004 Sep; 54(3):163-76. doi: NULL. [PMID: 15610614]
  • Marica Medić-Sarić, Ana Mornar, Ivona Jasprica. Lipophilicity study of salicylamide. Acta pharmaceutica (Zagreb, Croatia). 2004 Jun; 54(2):91-101. doi: ". [PMID: 15274753]
  • Zenei Taira, Kazunori Yabe, Yuka Hamaguchi, Kensuke Hirayama, Makoto Kishimoto, Shiro Ishida, Yukari Ueda. Effects of Sho-saiko-to extract and its components, Baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, on pharmacokinetic behavior of salicylamide in carbon tetrachloride intoxicated rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2004 May; 42(5):803-7. doi: 10.1016/j.fct.2003.12.017. [PMID: 15046826]
  • J A Murillo Pulgarín, A Alañón Molina. Direct determination of salicylamide in serum by matrix isopotential synchronous fluorimetry. Talanta. 2002 Mar; 56(3):557-64. doi: 10.1016/s0039-9140(01)00574-4. [PMID: 18968528]
  • A Li, H Seipelt, C Müller, Y Shi, M Artmann. Effects of salicylic acid derivatives on red blood cell membranes. Pharmacology & toxicology. 1999 Nov; 85(5):206-11. doi: 10.1111/j.1600-0773.1999.tb02010.x. [PMID: 10608482]
  • J A Pulgarín, L F Bermejo. Simultaneous determination of salicylamide and salsalate in serum and urine by first derivative variable-angle synchronous fluorescence spectrometry. Analytical biochemistry. 1998 Dec; 265(2):331-9. doi: 10.1006/abio.1998.2936. [PMID: 9882411]
  • H J Kim, J H Cho, C D Klaassen. Depletion of hepatic 3'-phosphoadenosine 5'-phosphosulfate (PAPS) and sulfate in rats by xenobiotics that are sulfated. The Journal of pharmacology and experimental therapeutics. 1995 Nov; 275(2):654-8. doi: NULL. [PMID: 7473151]
  • K S Pang, F Barker, A J Schwab, C A Goresky. Demonstration of rapid entry and a cellular binding space for salicylamide in perfused rat liver: a multiple indicator dilution study. The Journal of pharmacology and experimental therapeutics. 1994 Jul; 270(1):285-95. doi: NULL. [PMID: 8035326]
  • M S Abdel-Rahman, A S Reddi, F A Curro, R M Turkall, A M Kadry, J A Hansrote. Bioavailability of aspirin and salicylamide following oral co-administration in human volunteers. Canadian journal of physiology and pharmacology. 1991 Oct; 69(10):1436-42. doi: 10.1139/y91-215. [PMID: 1777842]
  • D Loew, O Schuster, G Menke, J Biehl. Pharmacokinetics of the analgesic o-carbamoylphenoxyacetic acid. International journal of clinical pharmacology, therapy, and toxicology. 1991 Mar; 29(3):124-9. doi: NULL. [PMID: 2071259]
  • A H Kahns, H Bundgaard. Hydrolysis kinetics of 1,3-benzoxazine-2,4-dione (a potential salicylamide prodrug) and various N-substituted derivatives. Acta pharmaceutica Nordica. 1991; 3(1):45-50. doi: NULL. [PMID: 1854435]
  • I Braakman, G M Groothuis, D K Meijer. Zonal compartmentation of perfused rat liver: plasma reappearance of rhodamine B explained. The Journal of pharmacology and experimental therapeutics. 1989 Jun; 249(3):869-73. doi: NULL. [PMID: 2732948]
  • R M Millis, M C Ewii, G U Offiah, B P Hyde, E M Knight. The effects of aspirin-like drugs on the nutritional status of pregnant rats and offspring. Journal of the National Medical Association. 1988 May; 80(5):545-52. doi: NULL. [PMID: 3418736]
  • X Xu, K S Pang. High-performance liquid chromatographic method for the quantitation of salicylamide and its metabolites in biological fluids. Journal of chromatography. 1987 Sep; 420(2):313-27. doi: 10.1016/0378-4347(87)80187-1. [PMID: 3693503]
  • G Levy. Sulfate conjugation in drug metabolism: role of inorganic sulfate. Federation proceedings. 1986 Jul; 45(8):2235-40. doi: NULL. [PMID: 3459670]
  • J A Waschek, R M Fielding, T N Tozer, D J Effeney, S M Pond. Availability of plasma sulfate for conjugation of salicylamide in dogs. Biochemical pharmacology. 1986 Feb; 35(3):544-6. doi: 10.1016/0006-2952(86)90235-2. [PMID: 3947388]
  • R M Fielding, J A Waschek, D J Effeney, A C Pogany, S M Pond, T N Tozer. Extrahepatic extraction of salicylamide in dogs. The Journal of pharmacology and experimental therapeutics. 1986 Jan; 236(1):97-102. doi: NULL. [PMID: 3941404]
  • H A el-Sourady, F S Habib, S I Mohamed. Availability studies on acetylsalicylic acid, salicylamide and phenacetin at different pH values. Die Pharmazie. 1985 Sep; 40(9):639-41. doi: NULL. [PMID: 4070347]
  • J A Waschek, R M Fielding, S M Pond, G M Rubin, D J Effeney, T N Tozer. Dose-dependent sulfoconjugation of salicylamide in dogs: effect of sulfate depletion or administration. The Journal of pharmacology and experimental therapeutics. 1985 Aug; 234(2):431-4. doi: NULL. [PMID: 4020679]
  • M E Morris, G Levy. Pharmacodynamics of the hypnotic effect of salicylamide in rats. Journal of pharmaceutical sciences. 1985 Jun; 74(6):599-602. doi: 10.1002/jps.2600740603. [PMID: 4020644]
  • J A Waschek, G M Rubin, T N Tozer, R M Fielding, W R Couet, D J Effeney, S M Pond. Dose-dependent bioavailability and metabolism of salicylamide in dogs. The Journal of pharmacology and experimental therapeutics. 1984 Jul; 230(1):89-93. doi: NULL. [PMID: 6747835]
  • J H Lin, Y Sugiyama, M Hanano, S Awazu. Effect of product inhibition on elimination kinetics of ethoxybenzamide in rabbits. Analysis by physiological pharmacokinetic model. Drug metabolism and disposition: the biological fate of chemicals. 1984 Mar; 12(2):253-6. doi: NULL. [PMID: 6144493]
  • A G de Boer, D D Breimer, J M Gubbens-Stibbe, A Bosma. First-pass elimination of salicylamide in man following oral and rectal administration. Biopharmaceutics & drug disposition. 1983 Oct; 4(4):321-30. doi: 10.1002/bdd.2510040404. [PMID: 6689276]
  • M E Morris, G Levy. Determination of salicylamide and five metabolites in biological fluids by high-performance liquid chromatography. Journal of pharmaceutical sciences. 1983 Jun; 72(6):612-7. doi: 10.1002/jps.2600720609. [PMID: 6875820]
  • E M Knight, G Nzelibe, W Criss. Effect of salicylamide on the growth of a Morris hepatoma in rats fed 8\% and 25\% casein diets. Drug-nutrient interactions. 1983; 2(2):87-94. doi: NULL. [PMID: 6678754]
  • A R Morad. Salicylamide pharmacokinetics in healthy males: dietary effect. Biopharmaceutics & drug disposition. 1982 Apr; 3(2):175-83. doi: 10.1002/bdd.2510030208. [PMID: 7104464]
  • J Säwe, G M Pacifici, L Kager, C von Bahr, A Rane. Glucuronidation of morphine in human liver and interaction with oxazepam. Acta anaesthesiologica Scandinavica. Supplementum. 1982; 74(?):47-51. doi: 10.1111/j.1399-6576.1982.tb01845.x. [PMID: 7046329]
  • J S Kurzynske, J T Smith. An effect of sulfur nutrition on the metabolism of salicylamide. Drug-nutrient interactions. 1982; 1(2):169-75. doi: NULL. [PMID: 6926825]
  • P K Halstead, D A Roe. Effect of salicylamide on skeletal glycosaminoglycan sulfation and calcification in fetal rat limbs. Drug-nutrient interactions. 1981; 1(1):75-86. doi: NULL. [PMID: 6821388]
  • R S Nanra, V Daniel, M Howard. Analgesic nephropathy induced by common proprietary mixtures. The Medical journal of Australia. 1980 May; 1(10):486-7. doi: 10.5694/j.1326-5377.1980.tb135047.x. [PMID: 7412682]
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  • W O FOYE, R N DUVALL, W E LANGE, M H TALBOT, E L PRIEN. Urinary metabolites of salicylamide in stone-formers. The Journal of pharmacology and experimental therapeutics. 1959 Mar; 125(3):198-201. doi: NULL. [PMID: 13642257]
  • H T BARNIVILLE, R MISK. Urinary glucuronic acid excretion in liver disease and the effect of a salicylamide load. British medical journal. 1959 Feb; 1(5118):337-40. doi: 10.1136/bmj.1.5118.337. [PMID: 13618635]
  • M MELZER, M RAKOWSZCZYK, E ZOHAR. [Treatment of recurrent nephrolithiasis with salicylamide]. Harefuah. 1958 Dec; 55(11):266. doi: NULL. [PMID: 13610137]
  • J H WEIKEL. A comparison of human serum levels of acetylsalicylic acid, salicylamide and N-acetyl-p-aminophenol following oral administration. Journal of the American Pharmaceutical Association. American Pharmaceutical Association. 1958 Jul; 47(7):477-9. doi: 10.1002/jps.3030470705. [PMID: 13563248]
  • A E COMARR, H O CARNE. Acetylsalicylic acid and salicylamide: effect on renal calculosis in patients with spinal cord injury. The Journal of urology. 1958 Jun; 79(6):911-6. doi: 10.1016/s0022-5347(17)66365-1. [PMID: 13539984]
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