Prolylglycine (BioDeep_00000017830)

 

Secondary id: BioDeep_00000605230

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


2-{[(2S)-pyrrolidin-2-yl]formamido}acetic acid

化学式: C7H12N2O3 (172.0847882)
中文名称: L-脯氨酰甘氨酸
谱图信息: 最多检出来源 Homo sapiens(feces) 2.94%

分子结构信息

SMILES: C1CC(NC1)C(=O)NCC(=O)O
InChI: InChI=1S/C7H12N2O3/c10-6(11)4-9-7(12)5-2-1-3-8-5/h5,8H,1-4H2,(H,9,12)(H,10,11)

描述信息

Prolylglycine is a dipeptide composed of proline and glycine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. It is found in urine (PMID: 3782411).
L-Prolylglycine is an endogenous metabolite.

同义名列表

16 个代谢物同义名

2-{[(2S)-pyrrolidin-2-yl]formamido}acetic acid; Proline-glycine dipeptide; Proline glycine dipeptide; N-L-Prolylglycine; L-Prolinylglycine; L-Prolylglycine; N-Prolylglycine; Prolyl-glycine; Prolylglycine; p-g Dipeptide; PG Dipeptide; L-Pro-gly; NSC 89175; Pro-Gly; P-G; PG



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sami Saidi, Mongi Saoudi, Raja Ben Amar. Valorisation of tuna processing waste biomass: isolation, purification and characterisation of four novel antioxidant peptides from tuna by-product hydrolysate. Environmental science and pollution research international. 2018 Jun; 25(18):17383-17392. doi: 10.1007/s11356-018-1809-5. [PMID: 29654463]
  • Muralikrishna Lella, Radhakrishnan Mahalakshmi. Pro-Gly mediated conformational switch of mycobacteriophage D29 holin transmembrane domain I is lipid concentration driven. Chemical communications (Cambridge, England). 2013 Oct; 49(83):9594-6. doi: 10.1039/c3cc45058a. [PMID: 24018990]
  • L A Andreeva, N F Myasoedov, T A Shubina, M E Grigorieva, L A Ljapina. Arginine-containing tripeptide Pro-Arg-Gly is involved in the regulation of the function of anticoagulation and insular systems under persistent hyperglycemia. Bulletin of experimental biology and medicine. 2012 Sep; 153(5):651-4. doi: 10.1007/s10517-012-1789-2. [PMID: 23113248]
  • Yasutaka Shigemura, Misako Nakaba, Eri Shiratsuchi, Masashi Suyama, Michio Yamada, Tamami Kiyono, Kazuna Fukamizu, Eun Young Park, Yasusi Nakamura, Kenji Sato. Identification of food-derived elastin peptide, prolyl-glycine (Pro-Gly), in human blood after ingestion of elastin hydrolysate. Journal of agricultural and food chemistry. 2012 May; 60(20):5128-33. doi: 10.1021/jf300497p. [PMID: 22548376]
  • Choonghee Lee, Hyung-Hwan Kim, Kyung Mi Choi, Kyung Won Chung, Yien Kyoung Choi, Mi Jung Jang, Tong-Soo Kim, Nam-Jun Chung, Ho-Gun Rhie, Ho-Sa Lee, Youngjoo Sohn, Hyuck Kim, Sung-Jae Lee, Hyeong-Woo Lee. Murine immune responses to a Plasmodium vivax-derived chimeric recombinant protein expressed in Brassica napus. Malaria journal. 2011 Apr; 10(?):106. doi: 10.1186/1475-2875-10-106. [PMID: 21529346]
  • Deanna M Navaroli, Haley E Melikian. Insertion of tetracysteine motifs into dopamine transporter extracellular domains. PloS one. 2010 Feb; 5(2):e9113. doi: 10.1371/journal.pone.0009113. [PMID: 20161733]
  • Xinmiao Fu, Zengyi Chang. Identification of a highly conserved pro-gly doublet in non-animal small heat shock proteins and characterization of its structural and functional roles in Mycobacterium tuberculosis Hsp16.3. Biochemistry. Biokhimiia. 2006; 71 Suppl 1(?):S83-90. doi: 10.1134/s0006297906130141. [PMID: 16487074]
  • Hervé Duclohier, Glenn Alder, Karol Kociolek, Miroslaw T Leplawy. Channel properties of template assembled alamethicin tetramers. Journal of peptide science : an official publication of the European Peptide Society. 2003 Nov; 9(11-12):776-83. doi: 10.1002/psc.523. [PMID: 14658797]
  • V E Pastorova, L A Liapina, I P Alshmarin, P U Ostrovskaia, T A Gudasheva, E V Lugovskoĭ. [Fibrin-depolymerization activity and the antiplatelet effect of small cyclic and linear proline-containing peptides]. Izvestiia Akademii nauk. Seriia biologicheskaia. 2001 Sep; ?(5):593-6. doi: NULL. [PMID: 15926323]
  • K A Cherkasova, L A Lyapina, I P Ashmarin. Comparative study of modulatory effects of Semax and primary proline-containing peptides on hemostatic reactions. Bulletin of experimental biology and medicine. 2001 Jul; 132(1):625-6. doi: 10.1023/a:1012503606536. [PMID: 11687836]
  • H Inoue, H Iguch, A Kouno, Y Tsuruta. Fluorometric determination of N-terminal prolyl dipeptides, proline and hydroxyproline in human serum by pre-column high-performance liquid chromatography using 4-(5,6-dimethoxy-2-phthalimidinyl)-2-methoxyphenylsufonyl chloride. Journal of chromatography. B, Biomedical sciences and applications. 2001 Jun; 757(2):369-73. doi: 10.1016/s0378-4347(01)00162-1. [PMID: 11417884]
  • V E Pastorova, L A Liapina, T Iu Smolina, I P Ashmarin. [Anticoagulant and fibrinolytic effects of proline-containing peptides]. Izvestiia Akademii nauk. Seriia biologicheskaia. 1998 May; ?(3):390-4. doi: NULL. [PMID: 9644912]
  • I P Ashmarin, E P Karazeeva, L A Lyapina, G E Samonina. The simplest proline-containing peptides PG, GP, PGP, and GPGG: regulatory activity and possible sources of biosynthesis. Biochemistry. Biokhimiia. 1998 Feb; 63(2):119-24. doi: . [PMID: 9526102]
  • T A Gudasheva, S S Boyko, R U Ostrovskaya, T A Voronina, V K Akparov, S S Trofimov, G G Rozantsev, A P Skoldinov, V P Zherdev, S B Seredenin. The major metabolite of dipeptide piracetam analogue GVS-111 in rat brain and its similarity to endogenous neuropeptide cyclo-L-prolylglycine. European journal of drug metabolism and pharmacokinetics. 1997 Jul; 22(3):245-52. doi: 10.1007/bf03189814. [PMID: 9358206]
  • M Codini, C A Palmerini, C Fini, C Lucarelli, A Floridi. High-performance liquid chromatographic method for the determination of prolyl peptides in urine. Journal of chromatography. 1991 Jan; 536(1-2):337-41. doi: 10.1016/s0021-9673(01)89267-0. [PMID: 2050773]
  • M C Fonteles, J V Oliveira, K M Carvalho. Metabolism of dipeptides by isolated and perfused nonfiltering kidneys. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 1990; 23(9):785-7. doi: NULL. [PMID: 2101317]