Diethyl hexyl phthalic acid (BioDeep_00000178245)

   

human metabolite blood metabolite natural product


代谢物信息卡片


4,5-diethyl-3-hexylbenzene-1,2-dicarboxylic acid

化学式: C18H26O4 (306.1830996)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 93.75%

分子结构信息

SMILES: CCCCCCC1=C(C(=CC(=C1C(=O)O)C(=O)O)CC)CC
InChI: InChI=1S/C18H26O4/c1-4-7-8-9-10-14-13(6-3)12(5-2)11-15(17(19)20)16(14)18(21)22/h11H,4-10H2,1-3H3,(H,19,20)(H,21,22)

描述信息

同义名列表

3 个代谢物同义名

4,5-diethyl-3-hexylbenzene-1,2-dicarboxylic acid; Diethyl hexyl phthalic acid; Diethyl hexyl phthalate



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Costas Koufaris, Jayne Wright, Richard A Currie, Nigel J Gooderham. Hepatic microRNA profiles offer predictive and mechanistic insights after exposure to genotoxic and epigenetic hepatocarcinogens. Toxicological sciences : an official journal of the Society of Toxicology. 2012 Aug; 128(2):532-43. doi: 10.1093/toxsci/kfs170. [PMID: 22584684]
  • Joseph R Bidwell, Carol Becker, Steve Hensley, Richard Stark, Michael T Meyer. Occurrence of organic wastewater and other contaminants in cave streams in northeastern Oklahoma and northwestern Arkansas. Archives of environmental contamination and toxicology. 2010 Feb; 58(2):286-98. doi: 10.1007/s00244-009-9388-6. [PMID: 19763679]
  • David Gunnarsson, Gunnar Selstam, Yvonne Ridderstråle, Lena Holm, Elisabeth Ekstedt, Andrzej Madej. Effects of dietary phytoestrogens on plasma testosterone and triiodothyronine (T3) levels in male goat kids. Acta veterinaria Scandinavica. 2009 Dec; 51(?):51. doi: 10.1186/1751-0147-51-51. [PMID: 20003293]
  • Béatrice Desvergne, Jérôme N Feige, Cristina Casals-Casas. PPAR-mediated activity of phthalates: A link to the obesity epidemic?. Molecular and cellular endocrinology. 2009 May; 304(1-2):43-8. doi: 10.1016/j.mce.2009.02.017. [PMID: 19433246]
  • Han Lin, Qing-Quan Lian, Guo-Xin Hu, Yuan Jin, Yunhui Zhang, Dianne O Hardy, Guo-Rong Chen, Zhong-Qiu Lu, Chantal M Sottas, Matthew P Hardy, Ren-Shan Ge. In utero and lactational exposures to diethylhexyl-phthalate affect two populations of Leydig cells in male Long-Evans rats. Biology of reproduction. 2009 May; 80(5):882-8. doi: 10.1095/biolreprod.108.072975. [PMID: 19144960]
  • Somnath Singh, Alekha K Dash. Paclitaxel in cancer treatment: perspectives and prospects of its delivery challenges. Critical reviews in therapeutic drug carrier systems. 2009; 26(4):333-72. doi: 10.1615/critrevtherdrugcarriersyst.v26.i4.10. [PMID: 20001890]
  • Melissa Runge-Morris, Thomas A Kocarek. Regulation of sulfotransferase and UDP-glucuronosyltransferase gene expression by the PPARs. PPAR research. 2009; 2009(?):728941. doi: 10.1155/2009/728941. [PMID: 19680455]
  • Mary S Wolff, Stephanie M Engel, Gertrud S Berkowitz, Xiaoyun Ye, Manori J Silva, Chenbo Zhu, James Wetmur, Antonia M Calafat. Prenatal phenol and phthalate exposures and birth outcomes. Environmental health perspectives. 2008 Aug; 116(8):1092-7. doi: 10.1289/ehp.11007. [PMID: 18709157]
  • Keisuke Tachibana, Daisuke Yamasaki, Kenji Ishimoto, Takefumi Doi. The Role of PPARs in Cancer. PPAR research. 2008; 2008(?):102737. doi: 10.1155/2008/102737. [PMID: 18584037]
  • Ren-Shan Ge, Guo-Rong Chen, Qiang Dong, Benson Akingbemi, Chantal M Sottas, Michelle Santos, Stuart C Sealfon, Daniel J Bernard, Matthew P Hardy. Biphasic effects of postnatal exposure to diethylhexylphthalate on the timing of puberty in male rats. Journal of andrology. 2007 Jul; 28(4):513-20. doi: 10.2164/jandrol.106.001909. [PMID: 17287459]
  • P D Steffan Loff, Ulrike Subotic, Jasmina Oulmi-Kagermann, Bettina Kränzlin, Maria-Franziska Reinecke, Christiane Staude. Diethylhexylphthalate extracted by typical newborn lipid emulsions from polyvinylchloride infusion systems causes significant changes in histology of rabbit liver. JPEN. Journal of parenteral and enteral nutrition. 2007 May; 31(3):188-93. doi: 10.1177/0148607107031003188. [PMID: 17463143]
  • Mikael Turunen, Sophia Schedin-Weiss. Defect in fatty acid esterification of dolichol in Niemann-Pick type C1 mouse livers in vivo. Biochimica et biophysica acta. 2007 Apr; 1771(4):506-13. doi: 10.1016/j.bbalip.2007.01.002. [PMID: 17292665]
  • Richard A Currie, Vincent Bombail, Jason D Oliver, David J Moore, Fei Ling Lim, Victoria Gwilliam, Ian Kimber, Kevin Chipman, Jonathan G Moggs, George Orphanides. Gene ontology mapping as an unbiased method for identifying molecular pathways and processes affected by toxicant exposure: application to acute effects caused by the rodent non-genotoxic carcinogen diethylhexylphthalate. Toxicological sciences : an official journal of the Society of Toxicology. 2005 Aug; 86(2):453-69. doi: 10.1093/toxsci/kfi207. [PMID: 15901911]
  • Jane Delaney, Mark P Hodson, Hansa Thakkar, Susan C Connor, Brian C Sweatman, Steve P Kenny, Paul J McGill, Julie C Holder, Kathryn A Hutton, John N Haselden, Catherine J Waterfield. Tryptophan-NAD+ pathway metabolites as putative biomarkers and predictors of peroxisome proliferation. Archives of toxicology. 2005 Apr; 79(4):208-23. doi: 10.1007/s00204-004-0625-5. [PMID: 15838709]
  • T Wei, B Liao, B L Ackermann, R A Jolly, J A Eckstein, N H Kulkarni, L M Helvering, K M Goldstein, J Shou, S T Estrem, T P Ryan, J-M Colet, C E Thomas, J L Stevens, J E Onyia. Data-driven analysis approach for biomarker discovery using molecular-profiling technologies. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2005 Mar; 10(2-3):153-72. doi: 10.1080/13547500500107430. [PMID: 16076730]
  • Steffan Loff, U Subotic, F Reinicke, H Wischmann, J Brade. Extraction of di-ethylhexyl-phthalate from perfusion lines of various material, length and brand by lipid emulsions. Journal of pediatric gastroenterology and nutrition. 2004 Oct; 39(4):341-5. doi: 10.1097/00005176-200410000-00008. [PMID: 15448422]
  • Holger M Koch, Luis M Gonzalez-Reche, Jürgen Angerer. On-line clean-up by multidimensional liquid chromatography-electrospray ionization tandem mass spectrometry for high throughput quantification of primary and secondary phthalate metabolites in human urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jan; 784(1):169-82. doi: 10.1016/s1570-0232(02)00785-7. [PMID: 12504195]
  • M J Bartosiewicz, D Jenkins, S Penn, J Emery, A Buckpitt. Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants. The Journal of pharmacology and experimental therapeutics. 2001 Jun; 297(3):895-905. doi: NULL. [PMID: 11356909]
  • R D Storer, J E French, J Haseman, G Hajian, E K LeGrand, G G Long, L A Mixson, R Ochoa, J E Sagartz, K A Soper. P53+/- hemizygous knockout mouse: overview of available data. Toxicologic pathology. 2001; 29 Suppl(?):30-50. doi: 10.1080/019262301753178465. [PMID: 11695560]