Diamfenetide (BioDeep_00000178168)
human metabolite blood metabolite
代谢物信息卡片
化学式: C20H24N2O5 (372.1685134)
中文名称: 双胺酚醚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC1=CC=C(C=C1)OCCOCCOC2=CC=C(C=C2)NC(=O)C
InChI: InChI=1S/C20H24N2O5/c1-15(23)21-17-3-7-19(8-4-17)26-13-11-25-12-14-27-20-9-5-18(6-10-20)22-16(2)24/h3-10H,11-14H2,1-2H3,(H,21,23)(H,22,24)
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 37384
- HMDB: HMDB0251133
- ChEMBL: CHEMBL2104259
- MeSH: Diamfenetide
- CAS: 36141-82-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - H R Anderson, I Fairweather. Fasciola hepatica: ultrastructural changes to the tegument of juvenile flukes following incubation in vitro with the deacetylated (amine) metabolite of diamphenethide.
International journal for parasitology.
1995 Mar; 25(3):319-33. doi:
10.1016/0020-7519(94)00105-w. [PMID: 7601590] - G N Zolotareva, L I Khrustaleva. [Manifestation of the mutagenic effect of acemidophen depending on its metabolism in various mammalian species (acemidophen--a promutagen)].
TSitologiia i genetika.
1988 Jul; 22(4):52-5. doi:
NULL. [PMID: 3194967] - D C Jenkins, P Topley, E B Rapson. Fasciola hepatica in vitro: increased susceptibility to fasciolicides in a defined serum-free medium.
Parasitology.
1987 Aug; 95 ( Pt 1)(?):165-71. doi:
10.1017/s0031182000057644. [PMID: 3670897] - P J Skuce, H R Anderson, I Fairweather. The interaction between the deacetylated (amine) metabolite of diamphenethide (DAMD) and cytochemically demonstrable Na+/K+-ATPase activity in the tegument of Fasciola hepatica.
Parasitology research.
1987; 74(2):161-7. doi:
10.1007/bf00536028. [PMID: 2830613] - D T Rowlands, R B Clampitt, I S Macpherson. The ability of diamphenethide to control immature Fasciola hepatica in sheep at a lower than standard dose level.
The Veterinary record.
1985 Feb; 116(7):182-4. doi:
10.1136/vr.116.7.182. [PMID: 2859685] - R E Hanna, D L Hughes, S M Taylor. Fasciola hepatica: antibody levels in sheep serum before and after treatment with anthelmintic.
Research in veterinary science.
1982 Nov; 33(3):328-32. doi:
10.1016/s0034-5288(18)32310-5. [PMID: 6760303] - R S Rew, Colglazier, F D Enzie. Effect of diamfenetide on experimental infections of Fasciola hepatica in lambs: anthelmintic and clinical investigations.
The Journal of parasitology.
1978 Apr; 64(2):290-4. doi:
10.2307/3279675. [PMID: 25319] - H J Over, C P Gaasenbeek, J J Pekelder, L J van Tiggele. The efficiency of diamphenethide in controlling natural infestations of Fasciola hepatica in lambs.
Tijdschrift voor diergeneeskunde.
1978 Jan; 103(2):129-39. doi:
NULL. [PMID: 24284] - J D Whitehead. Observations on the repeated treatment for fascioliasis of stock on a farm in south-west England.
The Veterinary record.
1976 Jan; 98(1):5-9. doi:
10.1136/vr.98.1.5. [PMID: 943881] - S B Kendall, J W Parfitt. Chemotherapy of infection with Fasciola hepatica in cattle.
The Veterinary record.
1975 Jul; 97(1):9-12. doi:
10.1136/vr.97.1.9. [PMID: 1146190]