Devd-cho (BioDeep_00000178127)
human metabolite blood metabolite
代谢物信息卡片
4-(2-amino-3-carboxypropanamido)-4-({1-[(1-carboxy-3-oxopropan-2-yl)carbamoyl]-2-methylpropyl}carbamoyl)butanoic acid
化学式: C18H28N4O10 (460.18053480000003)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C(C(=O)NC(CC(=O)O)C=O)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)N
InChI: InChI=1S/C18H28N4O10/c1-8(2)15(18(32)20-9(7-23)5-13(26)27)22-17(31)11(3-4-12(24)25)21-16(30)10(19)6-14(28)29/h7-11,15H,3-6,19H2,1-2H3,(H,20,32)(H,21,30)(H,22,31)(H,24,25)(H,26,27)(H,28,29)
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015853 - Cysteine Proteinase Inhibitors
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Toshiaki Kume, Ryota Taguchi, Hiroshi Katsuki, Masaharu Akao, Hachiro Sugimoto, Shuji Kaneko, Akinori Akaike. Serofendic acid, a neuroprotective substance derived from fetal calf serum, inhibits mitochondrial membrane depolarization and caspase-3 activation.
European journal of pharmacology.
2006 Aug; 542(1-3):69-76. doi:
10.1016/j.ejphar.2006.04.038. [PMID: 16806165] - Ji-Seon Lee, Jong-Sun Chang, Ji Youl Lee, Jung-Ae Kim. Capsaicin-induced apoptosis and reduced release of reactive oxygen species in MBT-2 murine bladder tumor cells.
Archives of pharmacal research.
2004 Nov; 27(11):1147-53. doi:
10.1007/bf02975121. [PMID: 15595419] - Paul Alexander Jones, Gillian Ruth May, Joyee Ann McLuckie, Akinori Iwashita, John Sharkey. Apoptosis is not an invariable component of in vitro models of cortical cerebral ischaemia.
Cell research.
2004 Jun; 14(3):241-50. doi:
10.1038/sj.cr.7290225. [PMID: 15225418] - Antoine Danon, Vitalie I Rotari, Anna Gordon, Nathalie Mailhac, Patrick Gallois. Ultraviolet-C overexposure induces programmed cell death in Arabidopsis, which is mediated by caspase-like activities and which can be suppressed by caspase inhibitors, p35 and Defender against Apoptotic Death.
The Journal of biological chemistry.
2004 Jan; 279(1):779-87. doi:
10.1074/jbc.m304468200. [PMID: 14573611] - M Dontenwill, G Pascal, J E Piletz, M Chen, J Baldwin, P Rondé, L Dupuy, D Urosevic, H Greney, K Takeda, P Bousquet. IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells.
Cell death and differentiation.
2003 Aug; 10(8):933-5. doi:
10.1038/sj.cdd.4401275. [PMID: 12868002] - Steven H Keller, Sanjay K Nigam. Biochemical processing of E-cadherin under cellular stress.
Biochemical and biophysical research communications.
2003 Jul; 307(2):215-23. doi:
10.1016/s0006-291x(03)01143-4. [PMID: 12859942] - Steven M Harwood, David A Allen, Alistair M S Chesser, David I New, Martin J Raftery, Muhammad M Yaqoob. Calpain is activated in experimental uremia: is calpain a mediator of uremia-induced myocardial injury?.
Kidney international.
2003 Mar; 63(3):866-77. doi:
10.1046/j.1523-1755.2003.00823.x. [PMID: 12631067] - Saeed S Al-Ghamdi, Martin J Raftery, Muhammad M Yaqoob. Organic solvent-induced proximal tubular cell toxicity via caspase-3 activation.
Journal of toxicology. Clinical toxicology.
2003; 41(7):941-5. doi:
10.1081/clt-120026515. [PMID: 14705839] - Tiina Kainulainen, Alexandra Pender, Mario D'Addario, Yuanyi Feng, Predrag Lekic, Christopher A McCulloch. Cell death and mechanoprotection by filamin a in connective tissues after challenge by applied tensile forces.
The Journal of biological chemistry.
2002 Jun; 277(24):21998-2009. doi:
10.1074/jbc.m200715200. [PMID: 11909861] - M L Bajt, S L Vonderfecht, H Jaeschke. Differential protection with inhibitors of caspase-8 and caspase-3 in murine models of tumor necrosis factor and Fas receptor-mediated hepatocellular apoptosis.
Toxicology and applied pharmacology.
2001 Sep; 175(3):243-52. doi:
10.1006/taap.2001.9242. [PMID: 11559023] - L Piacenza, G Peluffo, R Radi. L-arginine-dependent suppression of apoptosis in Trypanosoma cruzi: contribution of the nitric oxide and polyamine pathways.
Proceedings of the National Academy of Sciences of the United States of America.
2001 Jun; 98(13):7301-6. doi:
10.1073/pnas.121520398. [PMID: 11404465] - D O Kennedy, A Kojima, Y Yano, T Hasuma, S Otani, I Matsui-Yuasa. Growth inhibitory effect of green tea extract in Ehrlich ascites tumor cells involves cytochrome c release and caspase activation.
Cancer letters.
2001 May; 166(1):9-15. doi:
10.1016/s0304-3835(01)00396-2. [PMID: 11295281] - M J Bonneau, R Poulin. Spermine oxidation leads to necrosis with plasma membrane phosphatidylserine redistribution in mouse leukemia cells.
Experimental cell research.
2000 Aug; 259(1):23-34. doi:
10.1006/excr.2000.4974. [PMID: 10942576] - W Hamabe, N Fukushima, A Yoshida, H Ueda. Serum-free induced neuronal apoptosis-like cell death is independent of caspase activity.
Brain research. Molecular brain research.
2000 May; 78(1-2):186-91. doi:
10.1016/s0169-328x(00)00074-7. [PMID: 10891599] - P R Turner, S Mefford, S Christakos, R A Nissenson. Apoptosis mediated by activation of the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein (PTHrP).
Molecular endocrinology (Baltimore, Md.).
2000 Feb; 14(2):241-54. doi:
10.1210/mend.14.2.0417. [PMID: 10674397] - J N Keller, F F Huang, W R Markesbery. Decreased levels of proteasome activity and proteasome expression in aging spinal cord.
Neuroscience.
2000; 98(1):149-56. doi:
10.1016/s0306-4522(00)00067-1. [PMID: 10858621] - M Bryckaert, X Guillonneau, C Hecquet, Y Courtois, F Mascarelli. Both FGF1 and bcl-x synthesis are necessary for the reduction of apoptosis in retinal pigmented epithelial cells by FGF2: role of the extracellular signal-regulated kinase 2.
Oncogene.
1999 Dec; 18(52):7584-93. doi:
10.1038/sj.onc.1203200. [PMID: 10602518] - C Volbracht, M Leist, P Nicotera. ATP controls neuronal apoptosis triggered by microtubule breakdown or potassium deprivation.
Molecular medicine (Cambridge, Mass.).
1999 Jul; 5(7):477-89. doi:
10.1007/bf03403541. [PMID: 10449809] - Y Takeda, M Tashima, A Takahashi, T Uchiyama, T Okazaki. Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3.
The Journal of biological chemistry.
1999 Apr; 274(15):10654-60. doi:
10.1074/jbc.274.15.10654. [PMID: 10187863] - A Ortiz, C Lorz, M Catalán, A Ortiz, S Coca, J Egido. Cyclosporine A induces apoptosis in murine tubular epithelial cells: role of caspases.
Kidney international. Supplement.
1998 Dec; 68(?):S25-9. doi:
10.1046/j.1523-1755.1998.06808.x. [PMID: 9839279] - A Keppler-Hafkemeyer, U Brinkmann, I Pastan. Role of caspases in immunotoxin-induced apoptosis of cancer cells.
Biochemistry.
1998 Dec; 37(48):16934-42. doi:
10.1021/bi980995m. [PMID: 9836586] - R Schäfer, D Karbach, J Hoppe. Multiple intracellular pathways interfere with the activation of a CPP32-like protease induced by serum deprivation of AKR-2B cells.
Experimental cell research.
1998 Apr; 240(1):28-39. doi:
10.1006/excr.1997.3928. [PMID: 9570918] - E Yasugi, K Nakata, Y Yokoyama, K Kano, T Dohi, M Oshima. Dihydroheptaprenyl and dihydrodecaprenyl monophosphates induce apoptosis mediated by activation of caspase-3-like protease.
Biochimica et biophysica acta.
1998 Jan; 1389(2):132-40. doi:
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